Zhaofei Liu

发表

177Lu-labeled antibodies for EGFR-targeted SPECT/CT imaging and radioimmunotherapy in a preclinical head and neck carcinoma model.

Fan Wang, Zhaofei Liu, Teng Ma, 2014, Molecular pharmaceutics.

Noninvasive Imaging of CD206-Positive M2 Macrophages as an Early Biomarker for Post-Chemotherapy Tumor Relapse and Lymph Node Metastasis

L. Zhong, Fan Wang, Zhaofei Liu, 2017, Theranostics.

68Ga-labeled cyclic RGD dimers with Gly3 and PEG4 linkers: promising agents for tumor integrin αvβ3 PET imaging

Fan Wang, Jiyun Shi, Shuanglong Liu, 2009, European Journal of Nuclear Medicine and Molecular Imaging.

Improving tumor-targeting capability and pharmacokinetics of (99m)Tc-labeled cyclic RGD dimers with PEG(4) linkers.

Young-Seung Kim, Fan Wang, Bing Jia, 2009, Molecular pharmaceutics.

99mTc-labeled RGD-BBN peptide for small-animal SPECT/CT of lung carcinoma.

Fan Wang, Zhaofei Liu, Bing Jia, 2012, Molecular pharmaceutics.

Improving tumor uptake and pharmacokinetics of (64)Cu-labeled cyclic RGD peptide dimers with Gly(3) and PEG(4) linkers.

Young-Seung Kim, Jiyun Shi, Xiaoyuan Chen, 2009, Bioconjugate chemistry.

NaGdF4 nanoparticle-based molecular probes for magnetic resonance imaging of intraperitoneal tumor xenografts in vivo.

F. Fang, Xuxia Wang, H. Lei, 2013, ACS Nano.

Nanoparticle-mediated local depletion of tumour-associated platelets disrupts vascular barriers and augments drug accumulation in tumours

T. Ji, Xiao Zhao, Yinlong Zhang, 2017, Nature Biomedical Engineering.

Molecular Imaging Reveals Trastuzumab-Induced Epidermal Growth Factor Receptor Downregulation In Vivo

Yuehua Wu, Fan Wang, Zhaofei Liu, 2014, The Journal of Nuclear Medicine.

Noninvasive Imaging of CD 206-Positive M 2 Macrophages as an Early Biomarker for Post-Chemotherapy Tumor Relapse and Lymph Node Metastasis

L. Zhong, Zhaofei Liu, Bing Jia, 2017 .

Inhibition of tumor growth and metastasis by photoimmunotherapy targeting tumor-associated macrophage in a sorafenib-resistant tumor model.

Fan Wang, Zhaofei Liu, Hao Liu, 2016, Biomaterials.

Linker effects on biological properties of 111In-labeled DTPA conjugates of a cyclic RGDfK dimer.

Fan Wang, Shuang Liu, Zhaofei Liu, 2008, Bioconjugate chemistry.

Potential therapeutic radiotracers: preparation, biodistribution and metabolic characteristics of 177Lu-labeled cyclic RGDfK dimer

Fan Wang, Zhaofei Liu, Hui-yun Zhao, 2010, Amino Acids.

Small-Animal PET of Tumors with 64Cu-Labeled RGD-Bombesin Heterodimer

Xiaoyuan Chen, Fan Wang, Zibo Li, 2009, Journal of Nuclear Medicine.

Optical imaging of integrin alphavbeta3 expression with near-infrared fluorescent RGD dimer with tetra(ethylene glycol) linkers.

Xiaoyuan Chen, Fan Wang, G. Niu, 2010, Molecular imaging.

In-vitro internalization and in-vivo tumor uptake of anti-EGFR monoclonal antibody LA22 in A549 lung cancer cells and animal model.

Fan Wang, Zhaofei Liu, Zilin Yu, 2009, Cancer biotherapy & radiopharmaceuticals.

68Ga-labeled NOTA-RGD-BBN peptide for dual integrin and GRPR-targeted tumor imaging

Fan Wang, Xiaoyuan Chen, G. Niu, 2009, European Journal of Nuclear Medicine and Molecular Imaging.

(18)F, (64)Cu, and (68)Ga labeled RGD-bombesin heterodimeric peptides for PET imaging of breast cancer.

Xiaoyuan Chen, Zhaofei Liu, Shuanglong Liu, 2009, Bioconjugate chemistry.

Enhancing Anti-PD-1/PD-L1 Immune Checkpoint Inhibitory Cancer Therapy by CD276-Targeted Photodynamic Ablation of Tumor Cells and Tumor Vasculature.

Suping Li, Zhaofei Liu, Yang Zhao, 2018, Molecular pharmaceutics.

Clinical Translation of a 68Ga-Labeled Integrin αvβ6–Targeting Cyclic Radiotracer for PET Imaging of Pancreatic Cancer

Xiaoping Zhou, Fan Wang, Zhaofei Liu, 2020, The Journal of Nuclear Medicine.

Small-animal SPECT/CT imaging of cancer xenografts and pulmonary fibrosis using a 99mTc-labeled integrin αvβ6-targeting cyclic peptide with improved in vivo stability

L. Zhong, Zhaofei Liu, Hao Liu, 2018, Biophysics reports.

Integrin AvB3-Targeted Radioimmunotherapy of Glioblastoma

W. Cai, V. Tse, Xiaoyuan Chen, 2008 .

RGD-Based Molecular Probes for Integrin α v β 3 Imaging

Zhaofei Liu, Fan Wang, 2013 .

(99m)Tc-labeled dimeric octreotide peptide: a radiotracer with high tumor uptake for single-photon emission computed tomography imaging of somatostatin receptor subtype 2-positive tumors.

L. Zhong, Fan Wang, Zhaofei Liu, 2013, Molecular pharmaceutics.

99mTc-3PRGD2 for Integrin Receptor Imaging of Lung Cancer: A Multicenter Study

Fan Wang, Feng Wang, Zhaofei Liu, 2012, The Journal of Nuclear Medicine.

Two ⁹⁰Y-labeled multimeric RGD peptides RGD4 and 3PRGD2 for integrin targeted radionuclide therapy.

Xiaoyuan Chen, Fan Wang, Jie Tian, 2011, Molecular pharmaceutics.

Integrin alpha(v)beta(3)-Targeted Cancer Therapy.

Xiaoyuan Chen, Fan Wang, Zhaofei Liu, 2008, Drug development research.

Ceria Nanoparticles Meet Hepatic Ischemia‐Reperfusion Injury: The Perfect Imperfection

Zachary T. Rosenkrans, W. Cai, J. Engle, 2019, Advanced materials.

Molybdenum-based nanoclusters act as antioxidants and ameliorate acute kidney injury in mice

Steve Y. Cho, W. Cai, J. Engle, 2018, Nature Communications.

Evaluation of 64Cu radiolabeled anti-hPD-L1 Nb6 for positron emission tomography imaging in lung cancer tumor mice model.

Yakun Wan, Guanghui Li, Zhaofei Liu, 2019, Bioorganic & medicinal chemistry letters.

Epidermal Growth Factor Receptor–Targeted Radioimmunotherapy of Human Head and Neck Cancer Xenografts Using 90Y-Labeled Fully Human Antibody Panitumumab

Xiaoyuan Chen, Zhaofei Liu, Hui-yun Zhao, 2010, Molecular Cancer Therapeutics.

A self-triggered radioligand therapy agent for fluorescence imaging of the treatment response in prostate cancer

Jingming Zhang, Yiguang Wang, Youngjoo Byun, 2022, European Journal of Nuclear Medicine and Molecular Imaging.

Anti-tumor Effect of Integrin Targeted 177Lu-3PRGD2 and Combined Therapy with Endostar

Fan Wang, Zhaofei Liu, Hao Liu, 2014, Theranostics.

Molecular Imaging of Post-Src Inhibition Tumor Signatures for Guiding Dasatinib Combination Therapy

Fan Wang, Zhaofei Liu, Hao Liu, 2015, The Journal of Nuclear Medicine.

Noninvasive Detection of Human-Induced Pluripotent Stem Cell (hiPSC)-Derived Teratoma with an Integrin-Targeting Agent 99mTc-3PRGD2

Fan Wang, Zhaofei Liu, Bing Jia, 2013, Molecular Imaging and Biology.

Inhibition of human tumor xenograft growth in nude mice by a conjugate of monoclonal antibody LA22 to epidermal growth factor receptor with anti-tumor antibiotics mitomycin C.

Fan Wang, J. Sato, Zhaofei Liu, 2006, Biochemical and biophysical research communications.

Noninvasive small-animal imaging of galectin-1 upregulation for predicting tumor resistance to radiotherapy.

Zhaofei Liu, Bing Jia, Chenran Zhang, 2018, Biomaterials.

Nuclear imaging-guided PD-L1 blockade therapy increases effectiveness of cancer immunotherapy

Yakun Wan, Zhaofei Liu, Jiyun Shi, 2020, Journal for ImmunoTherapy of Cancer.

Noninvasive interrogation of CD8+ T cell effector function for monitoring early tumor responses to immunotherapy

Zhaofei Liu, Xing Yang, Li Zhang, 2022, The Journal of clinical investigation.

MicroPET Imaging of Breast Cancer with a Dual-Targeted Molecular Probe 68 Ga-RGD-BBN: MicroPET Imaging of Breast Cancer with a Dual-Targeted Molecular Probe 68 Ga-RGD-BBN

Zhaofei Liu, Hui-yun Zhao, Fan Wang, 2011 .

99mTc-labeled bombesin(7-14)NH2 with favorable properties for SPECT imaging of colon cancer.

Xiaoyuan Chen, Fan Wang, Shuang Liu, 2008, Bioconjugate chemistry.

PET tracers based on (86)Y.

Zhaofei Liu, L. Cui, Jinming Huang, 2011, Current radiopharmaceuticals.

99mTc-labeled cyclic RGDfK dimer: initial evaluation for SPECT imaging of glioma integrin alphavbeta3 expression.

Fan Wang, Shuang Liu, Zhaofei Liu, 2006, Bioconjugate chemistry.

Galectin expression detected by 68Ga-galectracer PET as a predictive biomarker of radiotherapy resistance

Jinming Zhang, Zhaofei Liu, D. Lu, 2022, European Journal of Nuclear Medicine and Molecular Imaging.

ICAM-1 orchestrates the abscopal effect of tumor radiotherapy

Zhaofei Liu, Yang Zhao, D. Lu, 2021, Proceedings of the National Academy of Sciences.

Integrin αvβ3‐targeted cancer therapy

Fan Wang, Xiaoyuan Chen, Zhaofei Liu, 2008 .

68Ga-PRGD2 PET/CT in the Evaluation of Glioma: A Prospective Study

Xiaoyuan Chen, Liwei Zhang, Deling Li, 2014, Molecular pharmaceutics.

Molybdenum-based nanoclusters act as antioxidants and ameliorate acute kidney injury in mice

Steve Y. Cho, W. Cai, J. Engle, 2018, Nature Communications.

Chemotherapy-Induced Macrophage Infiltration into Tumors Enhances Nanographene-Based Photodynamic Therapy.

Fan Wang, Zhaofei Liu, Bing Jia, 2017, Cancer research.

The deubiquitylase OTUD3 stabilizes GRP78 and promotes lung tumorigenesis

Yongsheng Fan, Lingqiang Zhang, Zhaofei Liu, 2019, Nature Communications.

Technetium 99m–Labeled VQ Peptide: A New Imaging Agent for the Early Detection of Tumors or Premalignancies

Fan Wang, Zhaofei Liu, Hui-yun Zhao, 2013, Molecular imaging.

Technetium 99 m – Labeled VQ Peptide : A New Imaging Agent for the Early Detection of Tumors or

Fan Wang, Zhaofei Liu, Hui-yun Zhao, 2013 .

Molecular imaging of diabetes and diabetic complications: Beyond pancreatic β-cell targeting.

Jichun Yang, T. Hong, Zhaofei Liu, 2019, Advanced drug delivery reviews.

Serial in vivo imaging using a fluorescence probe allows identification of tumor early response to cetuximab immunotherapy.

Fan Wang, Zhaofei Liu, Teng Ma, 2014, Molecular pharmaceutics.

Radiolabeled novel mAb 4G1 for immunoSPECT imaging of EGFRvIII expression in preclinical glioblastoma xenografts

Fan Wang, Zhaofei Liu, Teng Ma, 2016, Oncotarget.

A novel type of dual-modality molecular probe for MR and nuclear imaging of tumor: preparation, characterization and in vivo application.

Mingyuan Gao, Bing Jia, Zilin Yu, 2009, Molecular pharmaceutics.

Noninvasive imaging of tumor integrin expression using 18F-labeled RGD dimer peptide with PEG4 linkers

Fan Wang, Shuanglong Liu, Xiaoyuan Chen, 2009, European Journal of Nuclear Medicine and Molecular Imaging.

Integrin Targeted Delivery of Radiotherapeutics

Xiaoyuan Chen, Fan Wang, Zhaofei Liu, 2011, Theranostics.

Enhanced Anti-Tumor Efficacy through a Combination of Integrin αvβ6-Targeted Photodynamic Therapy and Immune Checkpoint Inhibition

Fan Wang, Zhaofei Liu, Hao Liu, 2016, Theranostics.

Phage display peptide probes for imaging early response to bevacizumab treatment

Xiaoyuan Chen, G. Niu, Kai Chen, 2011, Amino Acids.

18F-Labeled Galacto and PEGylated RGD Dimers for PET Imaging of αvβ3 Integrin Expression

Kai Chen, Frederick T. Chin, Hans-Jürgen Wester, 2010, Molecular Imaging and Biology.

Molecular imaging of integrin αvβ6 expression in living subjects.

Yuehua Wu, Fan Wang, Zhaofei Liu, 2014, American journal of nuclear medicine and molecular imaging.

Integrin αvβ6–Targeted SPECT Imaging for Pancreatic Cancer Detection

Fan Wang, Zhaofei Liu, Teng Ma, 2014, The Journal of Nuclear Medicine.

Phage display applications for molecular imaging.

Jiong Cai, Zhaofei Liu, Fang Li, 2010, Current pharmaceutical biotechnology.

Noninvasive PET tracking of post-transplant gut microbiota in living mice

Chenran Zhang, Yanpu Wang, Zhaofei Liu, 2020, European Journal of Nuclear Medicine and Molecular Imaging.

Metabolic radiolabeling and in vivo PET imaging of cytotoxic T lymphocytes to guide combination adoptive cell transfer cancer therapy

Zhaofei Liu, D. Lu, Hua Zhu, 2021, Journal of Nanobiotechnology.

Inhibiting Metastasis and Preventing Tumor Relapse by Triggering Host Immunity with Tumor-Targeted Photodynamic Therapy Using Photosensitizer-Loaded Functional Nanographenes.

Fan Wang, Bing Jia, Xiaoyuan Chen, 2017, ACS nano.

A near-infrared phthalocyanine dye-labeled agent for integrin αvβ6-targeted theranostics of pancreatic cancer.

Fan Wang, Bing Jia, Chenran Zhang, 2015, Biomaterials.

In vivo gamma imaging of the secondary tumors of transplanted human fetal striatum neural stem cells-derived primary tumor cells

Jun Zhang, Fan Wang, Bing Jia, 2008, Neuroreport.

Highlight selection of radiochemistry and radiopharmacy developments by editorial board

Y. Seimbille, B. Cornelissen, A. Duatti, 2022, EJNMMI Radiopharmacy and Chemistry.

PET imaging of neovascularization with (68)Ga-3PRGD2 for assessing tumor early response to Endostar antiangiogenic therapy.

Fan Wang, Zhaofei Liu, Zhongxia Jin, 2014, Molecular pharmaceutics.

Longitudinal monitoring of tumor antiangiogenic therapy with near-infrared fluorophore-labeled agents targeted to integrin αvβ3 and vascular endothelial growth factor

Yuehua Wu, Fan Wang, Zhaofei Liu, 2014, European Journal of Nuclear Medicine and Molecular Imaging.

Improving tumor uptake and excretion kinetics of 99mTc-labeled cyclic arginine-glycine-aspartic (RGD) dimers with triglycine linkers.

Young-Seung Kim, Jiyun Shi, Xiaoyuan Chen, 2008, Journal of medicinal chemistry.

Molecular Imaging of Tumor-Infiltrating Macrophages in a Preclinical Mouse Model of Breast Cancer

Fan Wang, Zhaofei Liu, Xianlei Sun, 2015, Theranostics.

Evaluation of 188Re-MAG2-RGD-bombesin for potential prostate cancer therapy.

Zhaofei Liu, Bing Jia, Fang Li, 2013, Nuclear medicine and biology.

Blood Clearance Kinetics, Biodistribution, and Radiation Dosimetry of a Kit-Formulated Integrin αvβ3-Selective Radiotracer 99mTc-3PRGD2 in Non-Human Primates

Xiaona Jin, Fan Wang, Bing Jia, 2011, Molecular Imaging and Biology.

Integrin αvβ3-Targeted Radioimmunotherapy of Glioblastoma Multiforme

Fan Wang, Kai Chen, Bing Jia, 2008, Clinical Cancer Research.

Specific Targeting of Human Integrin α v β 3 with 111 In-Labeled Abegrin™ in Nude

Xiaoyuan Chen, Zhaofei Liu, Hui-yun Zhao, 2011 .

Specific Targeting of Human Integrin αvβ3 with 111In-Labeled Abegrin™ in Nude Mouse Models

Fan Wang, Bing Jia, Huiyun Zhao, 2011, Molecular Imaging and Biology.

Tumor uptake of the RGD dimeric probe (99m)Tc-G3-2P4-RGD2 is correlated with integrin αvβ3 expressed on both tumor cells and neovasculature.

Fan Wang, Shuang Liu, Zhaofei Liu, 2010, Bioconjugate chemistry.

Optical Imaging of Integrin αvβ3 Expression with Near-Infrared Fluorescent RGD Dimer with Tetra(ethylene glycol) Linkers

Fan Wang, Xiaoyuan Chen, Shuanglong Liu, 2010 .

Molecular imaging is speeding up drug development

Jie Tian, Zhaofei Liu, Fan Wang, 2010 .

Nanoparticle-mediated local depletion of tumour-associated platelets disrupts vascular barriers and augments drug accumulation in tumours

T. Ji, Xiao Zhao, Yinlong Zhang, 2017, Nature Biomedical Engineering.

Synergistic enzymatic and bioorthogonal reactions for selective prodrug activation in living systems

Peng R. Chen, Xingyu Jiang, Ye Liu, 2018, Nature Communications.

Dual-Modality Monitoring of Tumor Response to Cyclophosphamide Therapy in Mice with Bioluminescence Imaging and Small-Animal Positron Emission Tomography

Xin Yang, Shouping Zhu, Xibo Ma, 2011, Molecular imaging.

HOXB13 networking with ABCG1/EZH2/Slug mediates metastasis and confers resistance to cisplatin in lung adenocarcinoma patients

M. Ye, H. Bai, Jie Wang, 2019, Theranostics.

99mTc-Labeled Cyclic RGDfK Dimer: Initial Evaluation for SPECT Imaging of Glioma Integrin αvβ3 Expression

Bing Jia, Jiyun Shi, Fan Wang, 2006 .

Radioimmunotherapy of human colon cancer xenografts with 131I-labeled anti-CEA monoclonal antibody.

Fan Wang, Zhaofei Liu, Hui-yun Zhao, 2010, Bioconjugate chemistry.

Dual integrin and gastrin-releasing peptide receptor targeted tumor imaging using 18F-labeled PEGylated RGD-bombesin heterodimer 18F-FB-PEG3-Glu-RGD-BBN.

Fan Wang, Xiaoyuan Chen, F. Chin, 2009, Journal of medicinal chemistry.

Integrin Imaging with 99mTc-3PRGD2 SPECT/CT Shows High Specificity in the Diagnosis of Lymph Node Metastasis from Non-Small Cell Lung Cancer.

Fan Wang, Zhaofei Liu, Jiyun Shi, 2016, Radiology.

HOXB13 networking with ABCG1/EZH2/Slug mediates metastasis and confers resistance to cisplatin in lung adenocarcinoma patients

M. Ye, H. Bai, Jie Wang, 2019, Theranostics.

JFK Is a Hypoxia-Inducible Gene That Functions to Promote Breast Carcinogenesis

Jie Shi, Lin He, F. Pei, 2021, Frontiers in Cell and Developmental Biology.

Radioligand saturation binding for quantitative analysis of ligand-receptor interactions

Fan Wang, Chengyan Dong, Zhaofei Liu, 2016, Biophysics reports.

Author Correction: Nanoparticle-mediated local depletion of tumour-associated platelets disrupts vascular barriers and augments drug accumulation in tumours

T. Ji, Xiao Zhao, Yinlong Zhang, 2017, Nature Biomedical Engineering.

Early Assessment of Tumor Response to Gefitinib Treatment by Noninvasive Optical Imaging of Tumor Vascular Endothelial Growth Factor Expression in Animal Models

Fan Wang, Zhaofei Liu, Teng Ma, 2014, The Journal of Nuclear Medicine.

SPECT/NIRF Dual Modality Imaging for Detection of Intraperitoneal Colon Tumor with an Avidin/Biotin Pretargeting System

L. Zhong, Fan Wang, Zhaofei Liu, 2016, Scientific Reports.

Noninvasive de novo imaging of human embryonic stem cell-derived teratoma formation.

Kai Chen, Weibo Cai, W. Cai, 2009, Cancer research.

Dual-targeted molecular probes for cancer imaging.

Zhaofei Liu, Fan Wang, 2010, Current pharmaceutical biotechnology.

Small-Animal SPECT/CT of the Progression and Recovery of Rat Liver Fibrosis by Using an Integrin αvβ3-targeting Radiotracer.

H. Liu, Yuehua Wu, Fan Wang, 2016, Radiology.

A self-triggered radioligand therapy agent for fluorescence imaging of the treatment response in prostate cancer

Jingming Zhang, Yiguang Wang, Youngjoo Byun, 2022, European Journal of Nuclear Medicine and Molecular Imaging.

Synergistic enzymatic and bioorthogonal reactions for selective prodrug activation in living systems

Peng R. Chen, Xingyu Jiang, Ye Liu, 2018, Nature Communications.

Inhibiting Metastasis and Preventing Tumor Relapse by Triggering Host Immunity with Tumor-Targeted Photodynamic Therapy Using Photosensitizer-Loaded Functional Nanographenes.

L. Zhong, Fan Wang, Xiaoyuan Chen, 2017, ACS nano.

(68)Ga-labeled 3PRGD2 for dual PET and Cerenkov luminescence imaging of orthotopic human glioblastoma.

Bing Jia, Di Fan, Jiyun Shi, 2015, Bioconjugate chemistry.

Evaluation of 188Re-MAG2-RGD-bombesin for potential prostate cancer therapy.

Zhaofei Liu, Bing Jia, Fang Li, 2013, Nuclear Medicine and Biology.

PET imaging of neovascularization with (68)Ga-3PRGD2 for assessing tumor early response to Endostar antiangiogenic therapy.

Fan Wang, Zhaofei Liu, Zhongxia Jin, 2014, Molecular pharmaceutics.

Serial in vivo imaging using a fluorescence probe allows identification of tumor early response to cetuximab immunotherapy.

Fan Wang, Zhaofei Liu, Teng Ma, 2014, Molecular pharmaceutics.

177Lu-labeled antibodies for EGFR-targeted SPECT/CT imaging and radioimmunotherapy in a preclinical head and neck carcinoma model.

Fan Wang, Zhaofei Liu, Teng Ma, 2014, Molecular pharmaceutics.

Small-Animal SPECT/CT of the Progression and Recovery of Rat Liver Fibrosis by Using an Integrin αvβ3-targeting Radiotracer.

H. Liu, Yuehua Wu, Fan Wang, 2016, Radiology.

Dual integrin and gastrin-releasing peptide receptor targeted tumor imaging using 18F-labeled PEGylated RGD-bombesin heterodimer 18F-FB-PEG3-Glu-RGD-BBN.

Xiaoyuan Chen, F. Chin, Zhaofei Liu, 2009, Journal of medicinal chemistry.

Highlight selection of radiochemistry and radiopharmacy developments by editorial board

Ming-Rong Zhang, R. M. van Dam, P. Laverman, 2022, EJNMMI Radiopharmacy and Chemistry.

Integrin Targeted Delivery of Radiotherapeutics

F. Kiessling, Zhaofei Liu, M. Palmowski, 2011, Theranostics.

(18)F, (64)Cu, and (68)Ga labeled RGD-bombesin heterodimeric peptides for PET imaging of breast cancer.

Xiaoyuan Chen, Zhaofei Liu, Shuanglong Liu, 2009, Bioconjugate chemistry.

Molecular PET/CT Profiling of ACE2 Expression In Vivo: Implications for Infection and Outcome from SARS‐CoV‐2

D. Thorek, Lei Li, Zhaofei Liu, 2021, Advanced science.