J. N. Topper

发表

Adaptation of the endothelium to fluid flow: in vitro analyses of gene expression and in vivo implications

S. Wasserman, J. N. Topper, 2004, Vascular medicine.

Gene program for cardiac cell survival induced by transient ischemia in conscious pigs

S. Vatner, D. Vatner, C. Depré, 2001, Proceedings of the National Academy of Sciences of the United States of America.

D Falb, J. Wrana, H. Hayashi, 1997, Cell.

J. Wrana, H. Hayashi, S. Abdollah, 1997, Cell.

New insights into endothelial diversity

J. Tomlinson, J. N. Topper, 2003, Current atherosclerosis reports.

Endothelial Dysfunction, Hemodynamic Forces, and Atherogenesis a

G. Garcı́a-Cardeña, M. Gimbrone, K. R. Anderson, 2000, Annals of the New York Academy of Sciences.

Flow Loading Induces Macrophage Antioxidative Gene Expression in Experimental Aneurysms

P. Tsao, R. Dalman, K. Hoshina, 2002, Arteriosclerosis, thrombosis, and vascular biology.

Characterization of pDJA1, a cardiac-specific chaperone found by genomic profiling of the post-ischemic swine heart.

S. Vatner, M. Abdellatif, C. Depré, 2003, Cardiovascular research.

C of pDJA1, a cardiac-specific chaperone found by genomic profiling of the post-ischemic swine heart

S. Vatner, M. Abdellatif, C. Depré, 2003 .

MEKK-1, a Component of the Stress (Stress-activated Protein Kinase/c-Jun N-terminal Kinase) Pathway, Can Selectively Activate Smad2-mediated Transcriptional Activation in Endothelial Cells*

J. D. Brown, M. Gimbrone, K. R. Anderson, 1999, The Journal of Biological Chemistry.

Common Genomic Response in Different Mouse Models of &bgr;-Adrenergic–Induced Cardiomyopathy

S. Liggett, E. Olson, M. Lohse, 2003, Circulation.

Cardiomyopathy Induced −-Adrenergic β Common Genomic Response in Different Mouse Models of Print

S. Liggett, E. Olson, M. Lohse, 2003 .

Transforming Growth Factor-β (TGF-β) and Vascular Disease: CARP as a Putative TGF-β Target Gene in the Vessel Wall

J. N. Topper, 2001 .

TGF-beta in the cardiovascular system: molecular mechanisms of a context-specific growth factor.

J. N. Topper, James N. Topper, 2000, Trends in cardiovascular medicine.

Transforming growth factor-β receptors localize to caveolae and regulate endothelial nitric oxide synthase in normal human endothelial cells

P. Tsao, E. Schwartz, J. N. Topper, 2005 .

Transforming growth factor-beta receptors localize to caveolae and regulate endothelial nitric oxide synthase in normal human endothelial cells.

P. Tsao, E. Schwartz, J. N. Topper, 2005, The Biochemical journal.

Identification of transcriptional regulatory elements in human mitochondrial DNA by linker substitution analysis

D. A. Clayton, J. N. Topper, D. Clayton, 1989, Molecular and cellular biology.

Human prostaglandin transporter gene (hPGT) is regulated by fluid mechanical stimuli in cultured endothelial cells and expressed in vascular endothelium in vivo.

F. Schoen, G. Stavrakis, M. Gimbrone, 1998, Circulation.

Expression of the bumetanide-sensitive Na-K-Cl cotransporter BSC2 is differentially regulated by fluid mechanical and inflammatory cytokine stimuli in vascular endothelium.

M. Gimbrone, K. R. Anderson, S. Wasserman, 1997, The Journal of clinical investigation.

Atherosclerotic Vascular Disease Conference: Writing Group III: pathophysiology.

V. Fuster, P. Libby, J. Loscalzo, 2004, Circulation.

Water‐soluble 17 and 23 kDa polypeptides restore oxygen evolution activity by creating a high‐affinity binding site for Ca2+ on the oxidizing side of Photosystem II

C. Yocum, J. N. Topper, G. Babcock, 1984 .

Epidermal growth factor induces Egr-1 promoter activity in hepatocytes in vitro and in vivo.

W. Aird, K. Spokes, J. Tsai, 2001, American journal of physiology. Gastrointestinal and liver physiology.

The egr‐1 promoter contains information for constitutive and inducible expression in transgenic mice

W. Aird, J. Tsai, J. N. Topper, 2000, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

A role for RNAse MRP in mitochondrial RNA processing

J. N. Topper, J. L. Bennett, D. Clayton, 1992, Cell.

The gene for the RNA component of the mitochondrial RNA-processing endoribonuclease is located on human chromosome 9p and on mouse chromosome 4.

D. Chang, U. Francke, C. Hsieh, 1990, Genomics.

Characterization of human MRP/Th RNA and its nuclear gene: full length MRP/Th RNA is an active endoribonuclease when assembled as an RNP.

J. N. Topper, D. Clayton, 1990, Nucleic acids research.

The RNA processing enzyme RNase MRP is identical to the Th RNP and related to RNase P.

J. N. Topper, H. Gold, J. Craft, 1989, Science.

CREB binding protein is a required coactivator for Smad-dependent, transforming growth factor beta transcriptional responses in endothelial cells.

J. D. Brown, T. Collins, M. Gimbrone, 1998, Proceedings of the National Academy of Sciences of the United States of America.

STRUCTURAL ORGANIZATION OF THE OXIDIZING SIDE OF PHOTOSYSTEM II EXOGENOUS REDUCTANTS REDUCE AND DESTROY THE Mn-COMPLEX IN PHOTOSYSTEMS II MEMBRANES DEPLETED OF THE 17 AND 23 kDa POLYPEPTIDES

J. N. Topper, D. Ghanotakis, Charles F. Youcum, 1984 .

Secondary structure of the RNA component of a nuclear/mitochondrial ribonucleoprotein.

J. N. Topper, D. Clayton, 1990, The Journal of biological chemistry.

A Novel Interleukin-17 Receptor-like Protein Identified in Human Umbilical Vein Endothelial Cells Antagonizes Basic Fibroblast Growth Factor-induced Signaling*

M. Gerritsen, S. Wasserman, Ruey-Bing Yang, 2003, Journal of Biological Chemistry.

Vascular MADs: two novel MAD-related genes selectively inducible by flow in human vascular endothelium.

C. J. Gimeno, F. Schoen, O. Tayber, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Promoter selection in human mitochondria involves binding of a transcription factor to orientation-independent upstream regulatory elements

J. N. Topper, R. Fisher, D. Clayton, 1987, Cell.

Transforming Growth Factor-β1 Inhibits Cytokine-mediated Induction of Human Metalloelastase in Macrophages*

Hong Wang, N. Sibinga, J. N. Topper, 2000, The Journal of Biological Chemistry.

Identification of a Novel Family of Cell-surface Proteins Expressed in Human Vascular Endothelium*

S. Colman, J. Tomlinson, S. Wasserman, 2002, The Journal of Biological Chemistry.

Genetic endothelial systems biology of sickle stroke risk.

Wei Pan, W. Pan, J. Scott, 2008, Blood.

chapter 1 – The Endothelium

S. Wasserman, J. N. Topper, 2006 .

Transforming Growth Factor-β1 Inhibition of Macrophage Activation Is Mediated via Smad3*

N. Sibinga, M. Chin, J. N. Topper, 2000, The Journal of Biological Chemistry.

Inhibition of E-Selectin Gene Expression by Transforming Growth Factor β in Endothelial Cells Involves Coactivator Integration of Smad and Nuclear Factor κB–Mediated Signals

M. Gimbrone, J. N. Topper, M. Dichiara, 2000, The Journal of experimental medicine.

A Novel Secreted, Cell-surface Glycoprotein Containing Multiple Epidermal Growth Factor-like Repeats and One CUB Domain Is Highly Expressed in Primary Osteoblasts and Bones*

M. Tsai, S. Wasserman, Ruey-Bing Yang, 2004, Journal of Biological Chemistry.

Biomechanical activation: an emerging paradigm in endothelial adhesion biology.

M. Gimbrone, J. N. Topper, T. Nagel, 1997, The Journal of clinical investigation.

Identification of vascular endothelial genes differentially responsive to fluid mechanical stimuli: cyclooxygenase-2, manganese superoxide dismutase, and endothelial cell nitric oxide synthase are selectively up-regulated by steady laminar shear stress.

M. Gimbrone, J. N. Topper, J. Cai, 1996, Proceedings of the National Academy of Sciences of the United States of America.

The Critical Role of Mechanical Forces in Blood Vessel Development, Physiology and Pathology

M. Gimbrone, K. R. Anderson, J. N. Topper, 1999 .

Blood flow and vascular gene expression: fluid shear stress as a modulator of endothelial phenotype.

M. Gimbrone, J. N. Topper, M A Gimbrone, 1999, Molecular medicine today.

Conditional Expression of Smad7 in Pancreatic β Cells Disrupts TGF-β Signaling and Induces Reversible Diabetes Mellitus

Xueying Gu, Seung K. Kim, Nora G. Smart, 2006, PLoS biology.

Hemodynamics, Endothelial Gene Expression, and Atherogenesis a

T. Collins, M. Gimbrone, L. Khachigian, 1997, Annals of the New York Academy of Sciences.

Inducible and selective transgene expression in murine vascular endothelium.

T. Quertermous, J. N. Topper, M. Dichiara, 2002, Physiological genomics.

Gene expression profile of human endothelial cells exposed to sustained fluid shear stress.

F. Spriggs, L. Komuves, Ying Zhang, 2002, Physiological genomics.