R. Hoffman

G. Chalasani, R. Hoffman, M. Oberbarnscheidt, 2010, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Tumor necrosis factor alpha inhibits hepatocyte mitochondrial respiration.

T. Billiar, B. Harbrecht, R. Simmons, 1992, Annals of surgery.

The role of inducible nitric oxide synthetase during graft-versus-host disease.

R. Simmons, R. Hoffman, J. Langrehr, 1992, Transplantation proceedings.

Comparison of the nitric oxide synthase inhibitors methylarginine and aminoguanidine as prophylactic and therapeutic agents in rat adjuvant arthritis.

C. Evans, R. Hoffman, M. Stefanovic-Racic, 1995, The Journal of rheumatology.

B cells mediate chronic allograft rejection independently of antibody production.

T. Singh, G. Chalasani, P. Randhawa, 2014, The Journal of clinical investigation.

Induction of cytotoxic T lymphocyte development from murine thymocytes by IL-1 and IL-6.

H. Ford, R. Simmons, R. Hoffman, 1991, Journal of pediatric surgery.

Lymphocyte recruitment, regional blood flow, and vascular permeability at sites of allogeneic cellular interactions.

R. Simmons, U. Hopt, R. Hoffman, 1982, Journal of immunology.

Nitric oxide protects thymocytes from gamma-irradiation-induced apoptosis in correlation with inhibition of p53 upregulation and mitochondrial damage.

H. Ford, R. Simmons, R. Hoffman, 2001, Cellular immunology.

Macrophages Produce Nitric Oxide at Allograft Sites

R. Simmons, R. Hoffman, D. White, 1993, Annals of surgery.

Macrophage synthesis of nitric oxide in the mouse mixed leucocyte reaction.

R. Simmons, M. Jordan, R. Hoffman, 1994, Transplant immunology.

Toll-Like Receptor 4 Regulates Platelet Function and Contributes to Coagulation Abnormality and Organ Injury in Hemorrhagic Shock and Resuscitation

T. Billiar, Guoqiang Chen, D. Hackam, 2014, Circulation. Cardiovascular genetics.

Interleukin‐33 contributes to ILC2 activation and early inflammation‐associated lung injury during abdominal sepsis

T. Billiar, H. Turnquist, Jing Xu, 2018, Immunology and cell biology.

FK-506 inhibits proliferation and IL-4 messenger RNA production by a T-helper 2 cell line.

D. Tweardy, S. C. Wang, R. Simmons, 1992, The Journal of surgical research.

Nitric Oxide Induces Thymocyte Apoptosis Via a Caspase-1-Dependent Mechanism1

H. Ford, R. Simmons, R. Hoffman, 2000, The Journal of Immunology.

Nitric Oxide Induces Thymocyte Apoptosis

H. Ford, R. Hoffman, Xiaoru Zhang, 2000 .

Alloantigen-induced activation of rat splenocytes is regulated by the oxidative metabolism of L-arginine.

T. Billiar, R. Simmons, R. Hoffman, 1990, Journal of immunology.

Enhanced cytolytic activity of intestinal intraepithelial lymphocytes in patients with Crohn’s disease

P. Neuhaus, R. Hoffman, A. Bauer, 2000, Langenbeck's Archives of Surgery.

Cellular Basis of Allograft Rejection

R. Simmons, R. Hoffman, N. Ascher, 1984, Immunological reviews.

Induction of nitric oxide synthase in mouse dendritic cells by IFN-gamma, endotoxin, and interaction with allogeneic T cells: nitric oxide production is associated with dendritic cell apoptosis.

Simon C Watkins, L. Lu, A. Thomson, 1996, Journal of immunology.

NK1.1+ cells promote sustained tissue injury and inflammation after trauma with hemorrhagic shock

T. Billiar, A. Demetris, M. Scott, 2017, Journal of leukocyte biology.

Nitric oxide‐mediated inhibition of caspase‐dependent T lymphocyte proliferation

Y. Vodovotz, T. Billiar, R. Simmons, 2003, Journal of leukocyte biology.

Nitric oxide regulation of lymphocyte function

H. Ford, R. Hoffman, 2001 .

Bacterial translocation during graft-versus-host disease after small bowel transplantation is reduced following inhibition of inducible nitric oxide synthesis.

P. Neuhaus, A. Nüssler, K. Leder, 2000, Transplantation.

Allosensitized helper and cytotoxic T-lymphocyte clones differentially modulate endotoxin-stimulated macrophage function.

R. Simmons, M. Jordan, R. Hoffman, 1988, Archives of surgery.

Splenocyte natural killer cell activity and metastatic potential are inversely dependent on estrous stage.

S. Gruber, R. Sothern, W. Hrushesky, 1988, Surgery.

Characterization of natural killer activity in sponge matrix allografts.

R. Simmons, M. Jordan, R. Hoffman, 1988, Journal of immunology.

TLR9 signaling in fibroblastic reticular cells regulates peritoneal immunity.

T. Billiar, Chenxuan Yang, P. Loughran, 2019, The Journal of clinical investigation.

Constitutive expression of inducible nitric oxide synthase in the mouse ileal mucosa.

Simon C Watkins, H. Ford, R. Simmons, 1997, The American journal of physiology.

Regulation of inducible nitric oxide production by intracellular calcium.

A. Jaquins-Gerstl, D. Geller, M. Jordan, 1995, Surgery.

Regulation production of inducible nitric oxide by intracellular calcium

A. Jaquins-Gerstl, D. Geller, M. Jordan, 1995 .

Reactive nitrogen intermediates suppress the primary immunologic response to Listeria.

R. Simmons, R. Hoffman, E. Wing, 1993, Journal of immunology.

Graft-infiltrating host dendritic cells play a key role in organ transplant rejection

A. Nakao, Quan Liu, Quan Zhuang, 2016, Nature Communications.

Bacterial Peritoneal Infection Phagocytosis and Host Survival after A Role for Connexin43 in Macrophage

D. Hackam, R. Hoffman, C. Sodhi, 2008 .

Functional changes of intestinal intraepithelial lymphocytes during acute graft versus host disease: correlation with phenotype.

R. Simmons, R. Hoffman, N. Nussler, 1996, International immunology.

Severe combined immunodeficiency with quantitatively normal but abnormally differentiated T lymphocytes

Naiman Jl, R. Hoffman, Lobel Js, 1981 .

Bystander injury of host lymphoid tissue during murine graft-verus-host disease is mediated by nitric oxide.

L. M. Berry, R. Simmons, R. Hoffman, 1996, Transplantation.

Evaluation of the mechanism of zymosan-induced resistance to experimental peritonitis.

R. Simmons, L. Joyce, R. Hoffman, 1978, Surgery.

PROSTAGLANDIN E2 MEDIATES SUBSET‐SPECIFIC EFFECTS ON THE FUNCTIONAL RESPONSES OF ALLOSENSITIZED T LYMPHOCYTE CLONES

R. Simmons, M. West, M. Jordan, 1987, Transplantation.

In vitro locomotion of allosensitized T lymphocyte clones in response to metabolites of arachidonic acid is subset specific.

R. Simmons, M. Jordan, R. Hoffman, 1986, Journal of immunology.

EVIDENCE THAT NITRIC OXIDE PRODUCTION BY IN VIVO ALLOSENSITIZED CELLS INHIBITS THE DEVELOPMENT OF ALLOSPECIFIC CTL

T. Billiar, J. Ochoa, S. Ildstad, 1992, Transplantation.

Nitric oxide production by dendritic cells is associated with impairment of T cell responses.

L. Lu, A. Thomson, R. Simmons, 1997, Transplantation proceedings.

Phenotypic Analysis Of Donor Cells Infiltrating The Small Intestinal Epithelium And Spleen During Graft‐Versus-Host Disease

R. Hoffman, S. McCarthy, N. Schattenfroh, 1995, Transplantation.

Donor–Specific Blood Transfusion Inhibits the Allograft Response: Possible Regulation by Nitric Oxide and Prostaglandin E2

S. Koga, M. Jordan, R. Hoffman, 1996, International journal of urology : official journal of the Japanese Urological Association.

Nitric Oxide Synthesis in Sponge Matrix Allografts Coincides with the Initiation of the Allogeneic Response

T. Billiar, R. Simmons, R. Hoffman, 1993 .

Two unique aspects of inducible .N = O synthase in liver cells and accessory cells: hepatic damage is minimized by hepatocyte .N = O production and immunoregulation is mediated by macrophage .N = O production.

T. Billiar, B. Harbrecht, R. Simmons, 1991, Research in immunology.

Evaluation of preservation conditions and various solutions for small bowel preservation.

R. Hoffman, W. Schraut, M. Nalesnik, 1994, Transplantation.

Memory T Cells Migrate to and Reject Vascularized Cardiac Allografts Independent of the Chemokine Receptor CXCR3

A. Demetris, Fadi G Lakkis, J. Walch, 2011, Transplantation.

Stimulation of the nitric oxide synthase pathway in human hepatocytes by cytokines and endotoxin

A. Nussler, T. Billiar, D. Geller, 1992, The Journal of experimental medicine.

Mucosal glutaminase activity and histology as parameters of small bowel preservation injury.

R. Hoffman, W. Schraut, M. Nalesnik, 1994, The Journal of surgical research.

EVIDENCE THAT SMALL BOWEL PRESERVATION CAUSES PRIMARILY BASEMENT MEMBRANE AND ENDOTHELIAL RATHER THAN EPITHELIAL CELL INJURY

R. Hoffman, W. Schraut, P. Rao, 1993, Transplantation.

Bone marrow-derived CD8alpha+TCR- cells that facilitate allogeneic bone marrow transplantation are a mixed population of lymphoid and myeloid progenitors.

J. Luketich, Hongmei Shen, R. Hoffman, 2007, Experimental hematology.

Evidence that production of interleukin 6 within the rejecting allograft coincides with cytotoxic T lymphocyte development.

H. Ford, D. Tweardy, R. Simmons, 1991, Transplantation.

Lymphocyte traffic and distribution after sponge matrix allograft using limiting dilution analysis.

S. Clemmings, R. Hoffman, N. Ascher, 1988, Transplantation proceedings.

Characterization of wound cytokines in the sponge matrix model.

H. Ford, D. Magee, R. Simmons, 1989, Archives of surgery.

The effects of administration of nitric oxide inhibitors during small bowel preservation and reperfusion.

A. Nussler, T. Billiar, R. Hoffman, 1994, Transplantation.

Phenotypic and functional characteristics of intestinal intraepithelial lymphocytes during acute rejection of

P. Neuhaus, R. Hoffman, W. Schraut, 1997 .

Systemic inflammation and end organ damage following trauma involves functional TLR4 signaling in both bone marrow‐derived cells and parenchymal cells

Timothy R Billiar, Yoram Vodovotz, Y. Vodovotz, 2008, Journal of leukocyte biology.

Tumor necrosis factor, macrophage colony-stimulating factor, and interleukin 1 production within sponge matrix allografts.

H. Ford, D. Magee, R. Simmons, 1990, Transplantation.

Carbon Monoxide Inhibits T Lymphocyte Proliferation via Caspase-Dependent Pathway1

A. Choi, R. Flavell, D. Seol, 2004, The Journal of Immunology.

Specific and nonspecific infiltration of sponge matrix allografts by specifically sensitized cytotoxic lymphocytes.

R. Simmons, R. Hoffman, N. Ascher, 1980, Cellular immunology.

TLR 4 Regulates Platelet Function and Contributes to Coagulation Abnormality and Organ Injury in Hemorrhagic Shock and Resuscitation

T. Billiar, Guoqiang Chen, D. Hackam, 2014 .

Nitric oxide production by mouse bone marrow-derived dendritic cells: implications for the regulation of allogeneic T cell responses.

L. Lu, A. Thomson, R. Simmons, 1996, Transplantation.

Intraepithelial lymphocytes coinduce nitric oxide synthase in intestinal epithelial cells.

R. Hoffman, 2000, American journal of physiology. Gastrointestinal and liver physiology.

Use of a Clostridium perfringens vector to express high levels of SIV p27 protein for the development of an oral SIV vaccine.

Simon C Watkins, Phalguni Gupta, B. McClane, 2004, Virology.

Lymphokine-activated killer (LAK) cells can be focused at sites of tumor growth by products of macrophage activation.

S. Gruber, F. Bach, R. Simmons, 1987, Surgery.

Nitric oxide production in host-versus-graft and graft-versus-host reactions in the rat.

P. Neuhaus, R. Simmons, R. Hoffman, 1992, The Journal of clinical investigation.

Allograft Outcomes in Outbred Mice

A. Demetris, D. Rothstein, Fadi G Lakkis, 2013, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

EPR detection of heme and nonheme iron-containing protein nitrosylation by nitric oxide during rejection of rat heart allograft.

J. Lancaster, R. Simmons, R. Hoffman, 1992, The Journal of biological chemistry.

EVIDENCE THAT INDEFINITE SURVIVAL OF SMALL BOWEL ALLOGRAFTS ACHIEVED BY A BRIEF COURSE OF CYCLOSPORINE OR FK506 IS NOT DUE TO SYSTEMIC HYPORESPONSIVENESS

P. Neuhaus, A. Demetris, S. Wren, 1992, Transplantation.

Characterization of the immunosuppressive effects of nitric oxide in graft vs host disease.

S. Wren, R. Simmons, S. Ildstad, 1993, Journal of immunology.

Mechanisms of the adjuvant effect of hemoglobin in experimental peritonitis. I. In vivo inhibition of peritoneal leukocytosis.

R. Simmons, R. Hoffman, T. Hau, 1978, Surgery.

INDUCTION OF GRAFT‐VERSUS-HOST DISEASE AND REJECTION BY SENSITIZED SMALL BOWEL ALLOGRAFTS

R. Hoffman, W. Schraut, J. Langrehr, 1991, Transplantation.

Maturation of cytotoxic effector cells at the site of allograft rejection.

R. Simmons, R. Hoffman, N. Ascher, 1981, Transplantation proceedings.

Migratory behavior of lymphocytes during allograft rejection.

R. Simmons, R. Hoffman, N. Ascher, 1981, Transplantation Proceedings.

Effect of cytochalasin B on human lymphocyte responses to mitogens: time and concentration dependence.

R. Simmons, R. Hoffman, R. Ferguson, 1977, Journal of immunology.

Nitric oxide synthesis in the in vivo allograft response: a possible regulatory mechanism.

T. Billiar, R. Simmons, R. Hoffman, 1991, Surgery.

Generation of nitric oxide by mouse dendritic cells and its implications for immune response regulation.

L. Lu, A. Thomson, R. Simmons, 1997, Advances in experimental medicine and biology.

Role of the IL-33-ST2 axis in sepsis

T. Billiar, H. Turnquist, R. Hoffman, 2017, Military Medical Research.

A Role for Connexin43 in Macrophage Phagocytosis and Host Survival after Bacterial Peritoneal Infection1

D. Hackam, R. Hoffman, C. Sodhi, 2008, The Journal of Immunology.

IL33-mediated ILC2 activation and neutrophil IL5 production in the lung response after severe trauma: A reverse translation study from a human cohort to a mouse trauma model

Y. Vodovotz, T. Billiar, H. Turnquist, 2017, PLoS medicine.

Nitric oxide--a new endogenous immunomodulator.

J. R. Lancaster, R. Simmons, R. Hoffman, 1993, Transplantation.

Cognate antigen directs CD8+ T cell migration to vascularized transplants.

D. Rothstein, Fadi G Lakkis, J. Walch, 2013, The Journal of clinical investigation.

Lipoxygenase pathway inhibition impairs the allograft response.

R. Simmons, M. Jordan, R. Hoffman, 1987, Surgery.

N-monomethyl arginine, an inhibitor of nitric oxide synthase, suppresses the development of adjuvant arthritis in rats.

C. Evans, R. Hoffman, C. Meschter, 1994, Arthritis and rheumatism.

INHIBITION OF THE ALLOGRAFT RESPONSE BY DONOR SPECIFIC BLOOD TRANSFUSION: ASSOCIATION WITH REDUCED LOCAL TH1 CYTOKINES AND NITRIC OXIDE BUT ENHANCED PROSTAGLANDIN E 2 PRODUCTION1

A. Jaquins-Gerstl, S. Specht, A. Thomson, 2000, Transplantation.

IN SILICO AND IN VIVO STUDIES MODELING THE AGED ACUTE INFLAMMATORY RESPONSE

G. Clermont, Y. Vodovotz, J. Bartels, 2006 .

Effect of endogenous nitric oxide on mitochondrial respiration of rat hepatocytes in vitro and in vivo.

T. Billiar, B. Harbrecht, R. Simmons, 1991, Archives of surgery.

Combined In Silico, In Vivo, and In Vitro Studies Shed Insights into the Acute Inflammatory Response in Middle-Aged Mice

Y. Vodovotz, J. Bartels, R. Zamora, 2013, PloS one.

Nitric oxide mediates dendritic cell apoptosis by downregulating inhibitors of apoptosis proteins and upregulating effector caspase activity.

H. Ford, R. Zamora, R. Hoffman, 2001, Surgery.

Cellular events within the rejecting allograft.

R. Simmons, R. Hoffman, N. Ascher, 1983, Transplantation.

Disparate Recruitment and Retention of Plasmacytoid Dendritic Cells to The Small Intestinal Mucosa between Young and Aged Mice

A. Vallejo, G. Chalasani, R. Hoffman, 2021, Aging and disease.

Selective roles for toll-like receptors 2, 4, and 9 in systemic inflammation and immune dysfunction following peripheral tissue injury

T. Billiar, Linda M I Schroeder, M. Scott, 2013, The journal of trauma and acute care surgery.

EVIDENCE FOR EARLY Th 2 T CELL PREDOMINANCE IN XENOREACTIVITY

B. Conrad, J. Fung, Stewart C. Wang, 1993, Transplantation.

Nitric oxide generation following intrahepatic human-to-rat islet transplantation is blocked by NG-monomethyl-L-arginine.

C. Ricordi, J. R. Lancaster, R. Simmons, 1994, Transplantation proceedings.

The influence of donor and recipient strains in isolated small bowel transplantation in rats.

S. Todo, A. Demetris, J. Fung, 1994, Transplantation proceedings.

CROSS‐SPECIES GRAFT‐VERSUS-HOST‐DISEASE IS ACCOMPANIED BY A DONOR‐DERIVED CELLULAR

Simon C Watkins, R. Hoffman, M. Nalesnik, 1993, Transplantation.

HYALURONIC ACID AND PURINE NUCLEOSIDE PHOSPHORYLASE IN VASCULAR AND LUMINAL EFFLUENTS OF SMALL BOWEL GRAFTS AS PARAMETERS OF PRESERVATION INJURY

R. Hoffman, W. Schraut, P. Rao, 1993, Transplantation.

Maturation of cytotoxic T cells within sponge matrix allografts.

R. Simmons, R. Hoffman, N. Ascher, 1983, Journal of immunology.

Graft-infiltrating host dendritic cells play a key role in organ transplant rejection

A. Nakao, Quan Liu, Quan Zhuang, 2016, Nature Communications.

Inducible Nitric Oxide Synthase Contributes to Immune Dysfunction Following Trauma

T. Billiar, B. Pitt, H. Pape, 2012, Shock.

Detection of nitric oxide by electron paramagnetic resonance spectroscopy during rejection and graft-versus-host disease after small-bowel transplantation in the rat.

J. Lancaster, R. Simmons, R. Hoffman, 1992, Surgery.

7 – Role of Nitric Oxide in Allograft Rejection

R. Simmons, R. Hoffman, J. Langrehr, 1996 .

A role for inducible nitric oxide biosynthesis in the liver in inflammation and in the allogeneic immune response.

T. Billiar, R. Simmons, R. Hoffman, 1992, The Journal of laboratory and clinical medicine.

NITRIC OXIDE PRODUCTION BY MOUSE SPONGE MATRIX ALLOGRAFT‐INFILTRATING CELLS COMPARISON WITH THE RAT SPECIES

R. Simmons, R. Hoffman, J. Langrehr, 1993, Transplantation.

Platelet HMGB1 is required for efficient bacterial clearance in intra-abdominal bacterial sepsis in mice.

T. Billiar, M. Scott, Chenxuan Yang, 2018, Blood Advances.

Toll-Like Receptor 4 Regulates Platelet Function and Contributes to Coagulation Abnormality and Organ Injury in Hemorrhagic Shock and Resuscitation

T. Billiar, Guoqiang Chen, D. Hackam, 2014, Circulation. Cardiovascular genetics.

Function of nitric oxide during reperfusion of cold preserved small bowel grafts.

P. Neuhaus, A. Nussler, R. Hoffman, 1994, Transplantation Proceedings.

Upregulation of intraepithelial lymphocyte (IEL) function in the small intestinal mucosa in sepsis.

U. Settmacher, P. Neuhaus, A. Nussler, 2001, Shock.

Allograft Outcomes in Outbred Mice

A. Demetris, D. Rothstein, Fadi G Lakkis, 2013, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Nitric oxide production regulates alloactivation in rat splenocyte mixed lymphocyte cultures.

T. Billiar, R. Simmons, R. Hoffman, 1991, Transplantation proceedings.

MIGRATION AND CELL RECRUITING ACTIVITY OF SPECIFICALLY SENSITIZED LYMPHOCYTES IN SPONGE MATRIX ALLOGRAFTS

R. Simmons, U. Hopt, R. Hoffman, 1980, Transplantation.

Graft-infiltrating cell nitric oxide production is stimulated by TNF alpha.

R. Simmons, R. Hoffman, J. Langrehr, 1992, Transplantation proceedings.

Sponge allograft effector cells exert suppressor function via an L-arginine-dependent mechanism.

T. Billiar, R. Simmons, R. Hoffman, 1991, Transplantation proceedings.