C. Sodhi

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Intestinal Epithelial TLR-4 Activation Is Required for the Development of Acute Lung Injury after Trauma/Hemorrhagic Shock via the Release of HMGB1 from the Gut

Charlotte E. Egan, Xiaorong Zhu, T. Billiar, 2015, The Journal of Immunology.

Cognitive impairments induced by necrotizing enterocolitis can be prevented by inhibiting microglial activation in mouse brain

S. Mori, A. Fatemi, M. Pletnikov, 2018, Science Translational Medicine.

Study of oxidative-stress in isoniazid-rifampicin induced hepatic injury in young rats.

S. Rana, K. Vaiphei, C. Sodhi, 1997, Drug and chemical toxicology.

A Dynamic Variation of Pulmonary ACE2 Is Required to Modulate Neutrophilic Inflammation in Response to Pseudomonas aeruginosa Lung Infection in Mice

Mitchell R. Ladd, J. Alcorn, M. Holtzman, 2019, The Journal of Immunology.

of Necrotizing Enterocolitis Treatment and TLR9 in the Pathogenesis and Reciprocal Expression and Signaling of TLR4

J. Ozolek, C. Sodhi, Sohail R Shah, 2013 .

Reciprocal Expression and Signaling of TLR4 and TLR9 in the Pathogenesis and Treatment of Necrotizing Enterocolitis1

J. Ozolek, D. Hackam, C. Sodhi, 2009, The Journal of Immunology.

Increased expression and internalization of the endotoxin coreceptor CD14 in enterocytes occur as an early event in the development of experimental necrotizing enterocolitis.

D. Hackam, C. Sodhi, K. Mollen, 2008, Journal of pediatric surgery.

Fat composition in infant formula contributes to the severity of necrotising enterocolitis

J. Ozolek, D. Hackam, C. Sodhi, 2018, British Journal of Nutrition.

Evidence-based feeding strategies before and after the development of necrotizing enterocolitis

D. Hackam, C. Sodhi, M. Good, 2014, Expert review of clinical immunology.

A Critical Role for TLR4 in the Pathogenesis of Necrotizing Enterocolitis by Modulating Intestinal Injury and Repair1

D. Hackam, C. Sodhi, M. Branca, 2007, The Journal of Immunology.

Interferon-gamma inhibits enterocyte migration by reversibly displacing connexin43 from lipid rafts.

Jennifer R. Bruns, O. Weisz, J. Ozolek, 2008, American journal of physiology. Gastrointestinal and liver physiology.

Interferon- inhibits enterocyte migration by reversibly displacing connexin43 from lipid rafts

Jennifer R. Bruns, O. Weisz, D. Hackam, 2008 .

Toll-like receptor-4 inhibits enterocyte proliferation via impaired beta-catenin signaling in necrotizing enterocolitis.

D. Hackam, C. Sodhi, R. Shapiro, 2010, Gastroenterology.

Nucleotide-binding oligomerization domain-2 inhibits toll-like receptor-4 signaling in the intestinal epithelium.

J. Ozolek, R. Siggers, A. Afrazi, 2010, Gastroenterology.

Amniotic fluid inhibits Toll-like receptor 4 signaling in the fetal and neonatal intestinal epithelium

Charlotte E. Egan, J. Ozolek, R. Siggers, 2012, Proceedings of the National Academy of Sciences.

Intracellular Heat Shock Protein-70 Negatively Regulates TLR4 Signaling in the Newborn Intestinal Epithelium

E. Chang, J. Ozolek, R. Siggers, 2012, The Journal of Immunology.

A Critical Role for TLR4 Induction of Autophagy in the Regulation of Enterocyte Migration and the Pathogenesis of Necrotizing Enterocolitis

J. Ozolek, A. Afrazi, D. Hackam, 2013, The Journal of Immunology.

Discovery and Validation of a New Class of Small Molecule Toll-Like Receptor 4 (TLR4) Inhibitors

P. Wipf, J. Brodsky, J. Ozolek, 2013, PloS one.

Hypoxia causes an increase in phagocytosis by macrophages in a HIF‐1α‐dependent manner

D. Hackam, C. Sodhi, R. Anand, 2007, Journal of leukocyte biology.

Precision-based modeling approaches for necrotizing enterocolitis

D. Hackam, C. Sodhi, M. Kovler, 2020, Disease Models & Mechanisms.

Toll-Like Receptor–Mediated Intestinal Inflammatory Imbalance in the Pathogenesis of Necrotizing Enterocolitis

D. Hackam, C. Sodhi, 2018, Cellular and molecular gastroenterology and hepatology.

Intestinal epithelial Toll-Like Receptor 4 Prevents Metabolic Syndrome by Regulating Interactions Between Microbes and Intestinal Epithelial Cells in Mice

K. Bibby, M. Morowitz, D. Hackam, 2017, Mucosal Immunology.

New Insights Into the Pathogenesis and Treatment of Necrotizing Enterocolitis: Toll-Like Receptors and Beyond

R. Siggers, A. Afrazi, D. Hackam, 2011, Pediatric Research.

Osteopontin mediates hypoxia-induced proliferation of cultured mesangial cells: role of PKC and p38 MAPK.

D. Batlle, A. Sahai, C. Sodhi, 2000, Kidney international.

Breast milk protects against the development of necrotizing enterocolitis through inhibition of Toll Like Receptor 4 in the intestinal epithelium via activation of the epidermal growth factor receptor

Charlotte E. Egan, J. Ozolek, A. Afrazi, 2015, Mucosal Immunology.

Activated macrophages inhibit enterocyte gap junctions via the release of nitric oxide.

D. Stolz, F. Qureshi, D. Hackam, 2008, American journal of physiology. Gastrointestinal and liver physiology.

Isoniazid – and rifampicin–induced oxidative hepatic injury – protection by N–acetylcysteine

S. Rana, S. Attri, K. Vaiphei, 2000, Human & experimental toxicology.

Normative values for circulating intestinal fatty acid binding protein and calprotectin across gestational ages

A. Everett, D. Hackam, C. Sodhi, 2020, BMC Pediatrics.

Normative Values for Potential Necrotizing Enterocolitis Biomarkers Across Gestational Ages

A. Everett, D. Hackam, C. Sodhi, 2020 .

This information is current as Necrotizing Enterocolitis Migration and the Pathogenesis of Autophagy in the Regulation of Enterocyte A Critical Role for TLR 4 Induction of Ozolek and

J. Ozolek, A. Afrazi, D. Hackam, 2013 .

Bench to bedside — new insights into the pathogenesis of necrotizing enterocolitis

D. Hackam, C. Sodhi, 2022, Nature Reviews Gastroenterology & Hepatology.

Mechanisms of gut barrier failure in the pathogenesis of necrotizing enterocolitis: Toll-like receptors throw the switch.

D. Hackam, C. Sodhi, M. Good, 2013, Seminars in pediatric surgery.

The role of in utero endotoxin exposure in the development of inflammatory bowel disease in mice

D. Hackam, I. Burd, C. Sodhi, 2020, American journal of reproductive immunology.

IgG binding and expression of its receptor in rat intestine during postnatal development.

C. Sodhi, J. Nagpaul, R. Gill, 1999, Indian journal of biochemistry & biophysics.

Attenuation of pulmonary ACE2 activity impairs inactivation of des-Arg9 bradykinin/BKB1R axis and facilitates LPS-induced neutrophil infiltration.

C. Wohlford-Lenane, D. Hackam, P. McCray, 2018, American journal of physiology. Lung cellular and molecular physiology.

Endothelial TLR4 activation impairs intestinal microcirculatory perfusion in necrotizing enterocolitis via eNOS–NO–nitrite signaling

M. Gladwin, T. Billiar, J. Ozolek, 2013, Proceedings of the National Academy of Sciences.

The role of epithelial Toll‐like receptor signaling in the pathogenesis of intestinal inflammation

D. Hackam, C. Sodhi, R. Anand, 2008, Journal of leukocyte biology.

Genetic Deletion of Toll-Like Receptor 4 on Platelets Attenuates Experimental Pulmonary Hypertension

T. Billiar, D. Hackam, C. Sodhi, 2014, Circulation Research.

Hypoxia stimulates osteopontin expression and proliferation of cultured vascular smooth muscle cells: potentiation by high glucose.

D. Batlle, A. Sahai, C. Sodhi, 2001, Diabetes.

A Central Role for Lipocalin-2 in the Adaptation to Short-Bowel Syndrome Through Down-Regulation of IL22 in Mice

C. Sears, D. Hackam, C. Sodhi, 2020, Cellular and molecular gastroenterology and hepatology.

Newborn Intestinal Epithelium Negatively Regulates TLR4 Signaling in the Intracellular Heat Shock Protein-70

E. Chang, J. Ozolek, R. Siggers, 2012 .

Generation of mice harbouring a conditional loss-of-function allele of Gata6

S. Duncan, C. Sodhi, Jixuan Li, 2006, BMC Developmental Biology.

Toll-Like Receptor 4 Regulates Platelet Function and Contributes to Coagulation Abnormality and Organ Injury in Hemorrhagic Shock and Resuscitation

T. Billiar, Guoqiang Chen, D. Hackam, 2014, Circulation. Cardiovascular genetics.

Hypoxia and high glucose upregulate AT1 receptor expression and potentiate ANG II-induced proliferation in VSM cells.

Y. Kanwar, A. Sahai, C. Sodhi, 2003, American journal of physiology. Heart and circulatory physiology.

The administration of a pre-digested fat-enriched formula prevents necrotising enterocolitis-induced lung injury in mice

D. Hackam, C. Sodhi, H. Jia, 2021, British Journal of Nutrition.

Lipopolysaccharide Clearance, Bacterial Clearance, and Systemic Inflammatory Responses Are Regulated by Cell Type–Specific Functions of TLR4 during Sepsis

Simon C Watkins, T. Billiar, M. Scott, 2013, The Journal of Immunology.

Myocyte TLR4 enhances enteric and systemic inflammation driving late murine endotoxic ileus.

Y. Vodovotz, T. Billiar, D. Hackam, 2015, American journal of physiology. Gastrointestinal and liver physiology.

of Necrotizing Enterocolitis Treatment and TLR9 in the Pathogenesis and Reciprocal Expression and Signaling of TLR4

J. Ozolek, C. Sodhi, Sohail R Shah, 2013 .

Reciprocal Expression and Signaling of TLR4 and TLR9 in the Pathogenesis and Treatment of Necrotizing Enterocolitis1

J. Ozolek, D. Hackam, C. Sodhi, 2009, The Journal of Immunology.

Increased expression and internalization of the endotoxin co-receptor CD14 in enterocytes occurs as an early event in the development of experimental necrotizing enterocolitis

C. Sodhi, K. Mollen, D. Kaczorowski, 2008 .

This information is current as Intestinal Injury and Repair of Necrotizing Enterocolitis by Modulating A Critical Role for TLR 4 in the Pathogenesis

D. Hackam, C. Sodhi, M. Branca, 2007 .

Cellular‐specific role of toll‐like receptor 4 in hepatic ischemia‐reperfusion injury in mice

D. Stolz, T. Billiar, A. Tsung, 2013, Hepatology.

Evidence-Based Approaches to Minimize the Risk of Developing Necrotizing Enterocolitis in Premature Infants

D. Hackam, C. Sodhi, Jennine H. Weller, 2022, Current Treatment Options in Pediatrics.

Na+/H+ exchange activity and NHE-3 expression in renal tubules from the spontaneously hypertensive rat.

D. Batlle, A. Sahai, C. Sodhi, 2002, Kidney international.

TLR4 Inactivation in Myeloid Cells Accelerates Bone Healing of a Calvarial Defect Model in Mice

T. Billiar, D. Hackam, J. Losee, 2017, Plastic and reconstructive surgery.

Pulmonary Epithelial TLR4 Activation Leads to Lung Injury in Neonatal Necrotizing Enterocolitis

J. Ozolek, D. Hackam, D. Niño, 2016, The Journal of Immunology.

This information is current as Enterocolitis to Lung Injury in Neonatal Necrotizing Pulmonary Epithelial TLR 4 Activation Leads

J. Ozolek, D. Hackam, D. Niño, 2016 .

Toll Like Receptor 4 Mediated Lymphocyte Imbalance Induces Nec-Induced Lung Injury.

Mitchell R. Ladd, D. Hackam, C. Sodhi, 2019, Shock.

In vivo phenotyping of the microvasculature in necrotizing enterocolitis with multicontrast optical imaging

N. Thakor, A. Pathak, D. Hackam, 2022, Microcirculation.

Bacterial Peritoneal Infection Phagocytosis and Host Survival after A Role for Connexin43 in Macrophage

D. Hackam, R. Hoffman, C. Sodhi, 2008 .

Protective effect of N-acetylcysteine in isoniazid induced hepatic injury in growing rats.

S. Rana, S. Attri, C. Sodhi, 2001, Indian journal of experimental biology.

Study of oxidative stress in isoniazid-induced hepatic injury in young rats with and without protein-energy malnutrition.

S. Attri, K. Vaiphei, C. Sodhi, 1996, Journal of biochemical toxicology.

Toll-like Receptor 4 Signaling on Dendritic Cells Suppresses Polymorphonuclear Leukocyte CXCR2 Expression and Trafficking via Interleukin 10 During Intra-abdominal Sepsis.

T. Billiar, T. Ma, M. Scott, 2016, The Journal of infectious diseases.

The development of animal models for the study of necrotizing enterocolitis

D. Hackam, C. Sodhi, Ward M. Richardson, 2008, Disease Models & Mechanisms.

Genetic Deletion of TLR4 on Platelets Attenuates Experimental Pulmonary Hypertension

T. Billiar, D. Hackam, C. Sodhi, 2014 .

Hypoxia and high glucose cause exaggerated mesangial cell growth and collagen synthesis: role of osteopontin.

D. Batlle, A. Sahai, C. Sodhi, 2001, American journal of physiology. Renal physiology.

Oxidative-hepatic injury of isoniazid-rifampicin in young rats subjected to protein and energy malnutrition.

S. Attri, C. Sodhi, S. Mehta, 1998, Drug and chemical toxicology.

Study of oxidative-stress in rotavirus infected infant mice.

S. Attri, C. Sodhi, R. Katyal, 1996, The Indian journal of medical research.

Oral aluminum administration and oxidative injury

C. Sodhi, S. Ojha, R. Katyal, 1997, Biological Trace Element Research.

Intestinal stem cell growth and differentiation on a tubular scaffold with evaluation in small and large animals.

Jenna L. Dziki, S. Badylak, J. March, 2016, Regenerative medicine.

Toll-like receptor regulation of intestinal development and inflammation in the pathogenesis of necrotizing enterocolitis.

D. Hackam, C. Sodhi, Peng Lu, 2014, Pathophysiology : the official journal of the International Society for Pathophysiology.

Synthesis of anti-inflammatory α-and β-linked acetamidopyranosides as inhibitors of toll-like receptor 4 (TLR4).

P. Wipf, J. Brodsky, D. Hackam, 2015, Tetrahedron letters.

A Novel Role for Necroptosis in the Pathogenesis of Necrotizing Enterocolitis

Mitchell R. Ladd, D. Hackam, Karen C. Goehring, 2019, Cellular and molecular gastroenterology and hepatology.

Intestinal epithelial Toll-like receptor 4 regulates goblet cell development and is required for necrotizing enterocolitis in mice.

T. Billiar, J. Ozolek, B. Firek, 2012, Gastroenterology.

Novel Role for the Innate Immune Receptor Toll-Like Receptor 4 (TLR4) in the Regulation of the Wnt Signaling Pathway and Photoreceptor Apoptosis

A. Hackam, D. Hackam, C. Sodhi, 2012, PloS one.

The human milk oligosaccharide 2′-fucosyllactose attenuates the severity of experimental necrotising enterocolitis by enhancing mesenteric perfusion in the neonatal intestine

J. Ozolek, D. Hackam, Karen C. Goehring, 2016, British Journal of Nutrition.

Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 disease severity

D. Brownfield, J. Spetz, Brian Deskin, 2020, bioRxiv.

Mucosa-Associated Bacterial Diversity in Necrotizing Enterocolitis

B. Firek, M. Morowitz, D. Hackam, 2014, PloS one.

Intestinal stem cells and their roles during mucosal injury and repair.

D. Hackam, M. Neal, C. Sodhi, 2011, The Journal of surgical research.

ASSOCIATION FOR ACADEMIC SURGERY Intestinal Stem Cells and Their Roles During Mucosal Injury and Repair

D. Hackam, M. Neal, C. Sodhi, 2011 .

Necrotizing enterocolitis: new insights into pathogenesis and mechanisms

D. Hackam, D. Niño, C. Sodhi, 2016, Nature Reviews Gastroenterology &Hepatology.

Models of necrotizing enterocolitis.

D. Hackam, C. Sodhi, R. Ahmad, 2022, Seminars in perinatology.

Animal models of gastrointestinal and liver diseases. Animal models of necrotizing enterocolitis: pathophysiology, translational relevance, and challenges.

D. Hackam, C. Sodhi, H. Jia, 2014, American journal of physiology. Gastrointestinal and liver physiology.

A comparison of sterilization techniques for production of decellularized intestine in mice.

Mitchell R. Ladd, D. Hackam, C. Sodhi, 2019, Tissue engineering. Part C, Methods.

Generation of an artificial intestine for the management of short bowel syndrome

Mitchell R. Ladd, J. March, D. Hackam, 2016, Current opinion in organ transplantation.

Innate Immune Signaling in the Pathogenesis of Necrotizing Enterocolitis

A. Afrazi, D. Hackam, C. Sodhi, 2013, Clinical & developmental immunology.

Maternal aryl hydrocarbon receptor activation protects newborns against necrotizing enterocolitis

P. Wipf, D. Hackam, C. Sodhi, 2021, Nature Communications.

Expression of sodium-glucose co-transporter and brush border disaccharidases in Giardia lamblia infected rat intestine.

N. Ganguly, C. Sodhi, S. Mahmood, 2002, Indian journal of biochemistry & biophysics.

No Longer an Innocent Bystander: Epithelial Toll-Like Receptor Signaling in the Development of Mucosal Inflammation

D. Hackam, C. Sodhi, S. Gribar, 2008, Molecular medicine.

The human milk oligosaccharides 2’-Fucosyllactose and 6’-Sialyllactose protect against the development of necrotizing enterocolitis by inhibiting Toll-Like Receptor 4 signaling.

Mitchell R. Ladd, P. Wipf, D. Hackam, 2020, Pediatric Research.

Interleukin 22 disrupts pancreatic function in newborn mice expressing IL-23

J. Faith, S. Lira, S. Durum, 2019, Nature Communications.

Toll-like Receptor 4 Is Expressed on Intestinal Stem Cells and Regulates Their Proliferation and Apoptosis via the p53 Up-regulated Modulator of Apoptosis*

Charlotte E. Egan, J. Ozolek, A. Afrazi, 2012, The Journal of Biological Chemistry.

Toll-like receptor 4–mediated enteric glia loss is critical for the development of necrotizing enterocolitis

P. Wipf, D. Hackam, C. Sodhi, 2021, Science Translational Medicine.

Myocardial oxidative stress correlates with left ventricular dysfunction on strain echocardiography in a rodent model of sepsis

T. Abraham, B. O’Rourke, D. Hackam, 2017, Intensive Care Medicine Experimental.

The endocytotic pathway is required for increased A beta 42 secretion during apoptosis.

E. Koo, C. Sodhi, R. Perez, 2004, Brain Research. Molecular Brain Research.

TLR 4 Regulates Platelet Function and Contributes to Coagulation Abnormality and Organ Injury in Hemorrhagic Shock and Resuscitation

T. Billiar, Guoqiang Chen, D. Hackam, 2014 .

Peroxisome Proliferator-activated Receptor-γ Coactivator 1-α (PGC1α) Protects against Experimental Murine Colitis*

D. Stolz, S. Ranganathan, B. Firek, 2016, The Journal of Biological Chemistry.

Prostaglandin-dependent modulation of dopaminergic neurotransmission elicits inflammation-induced aversion in mice.

C. Saper, A. Blomqvist, T. Billiar, 2016, The Journal of clinical investigation.

Enhanced Calvarial Bone Healing in CD11c-TLR4−/− and MyD88−/− Mice

T. Billiar, D. Hackam, J. Losee, 2017, Plastic and reconstructive surgery.

The administration of amnion-derived multipotent cell secretome ST266 protects against necrotizing enterocolitis in mice and piglets.

D. Hackam, C. Sodhi, H. Jia, 2022, American journal of physiology. Gastrointestinal and liver physiology.

Tissue engineering for the treatment of short bowel syndrome in children

Mitchell R. Ladd, J. March, D. Hackam, 2017, Pediatric Research.

Toll-like receptor 4-mediated lymphocyte influx induces neonatal necrotizing enterocolitis.

J. Ozolek, D. Hackam, D. Niño, 2016, The Journal of clinical investigation.

Toll-like Receptor 4-mediated Endoplasmic Reticulum Stress in Intestinal Crypts Induces Necrotizing Enterocolitis*

Charlotte E. Egan, A. Kaser, T. Billiar, 2014, The Journal of Biological Chemistry.

New insights into necrotizing enterocolitis: From laboratory observation to personalized prevention and treatment.

D. Hackam, C. Sodhi, M. Good, 2019, Journal of pediatric surgery.

A Role for Connexin43 in Macrophage Phagocytosis and Host Survival after Bacterial Peritoneal Infection1

D. Hackam, R. Hoffman, C. Sodhi, 2008, The Journal of Immunology.

Lactobacillus rhamnosus HN001 decreases the severity of necrotizing enterocolitis in neonatal mice and preterm piglets: evidence in mice for a role of TLR9.

K. Bibby, J. Ozolek, B. Firek, 2014, American journal of physiology. Gastrointestinal and liver physiology.

Toll Like Receptor 4 (TLR4) Regulates the Recruitment of CD4+ T Cells in the Newborn Intestine in the Pathogenesis of Necrotizing Enterocolitis

A. Afrazi, D. Hackam, C. Sodhi, 2013 .

Necrotizing enterocolitis induces T lymphocyte–mediated injury in the developing mammalian brain

Meaghan Morris, D. Hackam, D. Niño, 2021, Science Translational Medicine.

Retinoic Acid Improves Incidence and Severity of Necrotizing Enterocolitis by Lymphocyte Balance Restitution and Repopulation of LGR5+ Intestinal Stem Cells

J. Ozolek, D. Hackam, D. Niño, 2017, Shock.

Early detection of necrotizing enterocolitis using broadband optical spectroscopy.

Robert J. Beaulieu, A. Banerjee, D. Hackam, 2018, Journal of pediatric surgery.

Development of Intestinal Scaffolds that Mimic Native Mammalian Intestinal Tissue.

Mitchell R. Ladd, J. March, D. Hackam, 2019, Tissue engineering. Part A.

The recruitment of extra-intestinal cells to the injured mucosa promotes healing in radiation enteritis and chemical colitis in a mouse parabiosis model.

L. Voltaggio, D. Hackam, D. Čiháková, 2018, Mucosal Immunology.

Phosphorylation of β-amyloid precursor protein (APP) cytoplasmic tail facilitates amyloidogenic processing during apoptosis

C. Sodhi, R. Perez, N. Gottardi-Littell, 2008, Brain Research.

EXTRACELLULAR HIGH MOBILITY GROUP BOX1 (HMGB1) INHIBITS ENTEROCYTE MIGRATION VIA ACTIVATION OF TOLL LIKE RECEPTOR 4 AND INCREASED CELL

D. Hackam, C. Sodhi, R. Shapiro, 2009 .