P. Mühlradt

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Lipopolysaccharide-Inducible Genes the Expression of a Subset of Activation of IFN-Regulatory Factor 3 and MyD 88-Independent Pathway and Results in Lipopolysaccharide Stimulates the and Shizuo

S. Akira, Shintaro Sato, T. Kawai, 2001 .

Differential recognition of structural details of bacterial lipopeptides by toll-like receptors.

S. Akira, O. Takeuchi, M. Simon, 2002, European journal of immunology.

Involvement of interleukin-1 (IL-1), IL-6, IL-2, and IL-4 in generation of cytolytic T cells from thymocytes stimulated by a Mycoplasma fermentans-derived product

H. Quentmeier, E. Schmitt, P. Mühlradt, 1991, Infection and immunity.

MDHM, a macrophage-stimulatory product of Mycoplasma fermentans, leads to in vitro interleukin-1 (IL-1), IL-6, tumor necrosis factor, and prostaglandin production and is pyrogenic in rabbits

U. Schade, P. Mühlradt, 1991, Infection and immunity.

Purification and partial biochemical characterization of a Mycoplasma fermentans-derived substance that activates macrophages to release nitric oxide, tumor necrosis factor, and interleukin-6

P. Mühlradt, M. Frisch, 1994, Infection and immunity.

Identification of S-(2,3-dihydroxypropyl)cystein in a macrophage-activating lipopeptide from Mycoplasma fermentans.

P. Mühlradt, R. Jansen, H. Meyer, 1996, Biochemistry.

Gangliosides: differentiation markers for murine T helper lymphocyte subpopulations TH1 and TH2.

J. Peter-Katalinic, E. Schmitt, P. Mühlradt, 1992, Biochemistry.

Tumour suppression induced by the macrophage activating lipopeptide MALP-2 in an ultrasound guided pancreatic carcinoma mouse model

T. Sauerbruch, C. Ziske, I. Schmidt-Wolf, 2003, Gut.

Gangliosides of murine T lymphocyte subpopulations.

J. Peter-Katalinic, H. Egge, P. Mühlradt, 1989, Biochemistry.

Detection of gangliosides of the GM1b type on high-performance thin-layer chromatography plates by immunostaining after neuraminidase treatment.

P. Mühlradt, J. Müthing, 1988, Analytical biochemistry.

Structural characterization of gangliosides from murine T lymphocytes.

H. Egge, P. Mühlradt, J. Müthing, 1987, European journal of biochemistry.

Induction of proto-oncogene and cytokine expression in human peripheral blood monocytes and the monocytic cell line THP-1 after stimulation with mycoplasma-derived material MDHM.

H. Quentmeier, H. Drexler, P. Mühlradt, 1994, Leukemia research.

Structure and Specific Activity of Macrophage-Stimulating Lipopeptides from Mycoplasma hyorhinis

G. Jung, M. Kiess, R. Süssmuth, 1998, Infection and Immunity.

Surface expression of Forssman glycosphingolipid antigen on murine bone marrow-derived macrophages is subject to both temporal and population-specific regulation and is modulated by IL-4 and IL-6.

P. Mühlradt, D. Monner, 1993, Immunobiology.

Intracutaneous injection of the macrophage‐activating lipopeptide‐2 (MALP‐2) which accelerates wound healing in mice – a phase I trial in 12 patients

M. Wittmann, T. Werfel, P. Mühlradt, 2008, Experimental dermatology.

The macrophage‐activating lipopeptide‐2 accelerates wound healing in diabetic mice

J. Barsig, P. Mühlradt, B. Tawil, 2004, Experimental dermatology.

Isolation, Structure Elucidation, and Synthesis of a Macrophage Stimulatory Lipopeptide from Mycoplasma fermentans Acting at Picomolar Concentration

G. Jung, M. Kiess, R. Süssmuth, 1997, The Journal of experimental medicine.

MALP-2, a Mycoplasma lipopeptide with classical endotoxic properties: end of an era of LPS monopoly?

C. Galanos, M. Freudenberg, E. Jirillo, 2000, Journal of endotoxin research.

Biosynthesis of Salmonella lipopolysaccharide. The in vitro transfer of phosphate to the heptose moiety of the core.

P. Mühlradt, 1969, European journal of biochemistry.

Intralymphatic interleukin-2 treatment of a hemophiliac AIDS patient with defective interleukin-2 production

G. Burmester, N. Heyder, J. Kalden, 1987, Klinische Wochenschrift.

A 31P-nuclear-magnetic-resonance study of the phosphate groups in lipopolysaccharide and lipid A from Salmonella.

V. Wray, V. Lehmann, P. Mühlradt, 1977, European Journal of Biochemistry.

Efficacy of macrophage-activating lipopeptide-2 combined with interferon-gamma in a murine asthma model.

N. Krug, P. Mühlradt, A. Braun, 2005, American journal of respiratory and critical care medicine.

Attenuated pathogenesis of polymicrobial peritonitis in mice after TLR2 agonist pre-treatment involves ST2 up-regulation.

B. Holzmann, H. Weighardt, Carolin Feterowski, 2005, International immunology.

In Vivo Effects of a Synthetic 2-Kilodalton Macrophage-Activating Lipopeptide of Mycoplasma fermentans after Pulmonary Application

R. Pabst, P. Mühlradt, J. E. Gessner, 2002, Infection and Immunity.

Toll-Like Receptor 2- and 6-Mediated Stimulation by Macrophage-Activating Lipopeptide 2 Induces Lipopolysaccharide (LPS) Cross Tolerance in Mice, Which Results in Protection from Tumor Necrosis Factor Alpha but in Only Partial Protection from Lethal LPS Doses

C. Galanos, P. Mühlradt, M. Gumenscheimer, 2003, Infection and Immunity.

Biochemical studies on lipopolysaccharides of Salmonella R mutants 5. Evidence for a phosphorylating enzyme in lipopolysaccharide biosynthesis.

O. Westphal, O. Lüderitz, P. Mühlradt, 1968, European journal of biochemistry.

Interleukin-2 in the ontogeny of human lymphoid tissues.

W. Pichler, H. Peter, P. Mühlradt, 1982, Immunobiology.

Glycosphingolipids of the globo-series are associated with the monocytic lineage of human myeloid cells.

P. Mühlradt, B. Kniep, D. Monner, 1985, European journal of biochemistry.

Outer membrane of salmonella. Sites of export of newly synthesised lipopolysaccharide on the bacterial surface.

V. Speth, P. Mühlradt, J. Golecki, 1973, European journal of biochemistry.

TLR4-Mediated Signaling Pathways Toll-Like Receptor (TLR) 2- and Synergy and Cross-Tolerance Between

K. Takeda, T. Kawai, F. Nomura, 2013 .

Pyrexia, anorexia, adipsia, and depressed motor activity in rats during systemic inflammation induced by the Toll-like receptors-2 and -6 agonists MALP-2 and FSL-1.

J. Roth, P. Mühlradt, J. Mütze, 2006, American journal of physiology. Regulatory, integrative and comparative physiology.

Differential recognition of structural details of bacterial lipopeptides by toll‐like receptors

O. Takeuchi, M. Simon, M. Morr, 2002 .

Immunomodulation by Mycoplasmas: Artifacts, Facts and Active Molecules

P. Mühlradt, 2002 .

MyD 88-Dependent Signaling Pathway Through a Toll-Like Receptor 2-and Lipopeptide-2 Activates Immune Cells Lipopeptide Macrophage-Activating-Stereoisomer of the Mycoplasmal R Cutting Edge : Preferentially the and Shizuo

S. Akira, T. Kawai, O. Takeuchi, 1999 .

Modulation of Forssman glycosphingolipid expression by murine macrophages: coinduction with class II MHC antigen by the lymphokines IL4 and IL6.

E. Schmitt, P. Mühlradt, J. Westermann, 1990, Immunobiology.

Immunohistochemical localization of Forssman glycosphingolipid-positive macrophages and reticular cells in murine lymphoid tissue.

P. Mühlradt, C. Dijkstra, D. Monner, 1989, Immunobiology.

Mycoplasma fermentans‐derived lipid inhibits class II major histocompatibility complex expression without mediation by interleukin‐6, interleukin‐10, tumor necrosis factor, transforming growth factor‐β, type I interferon, prostaglandins or nitric oxide

P. Mühlradt, G. Gradehandt, Matthias Frisch, 1996, European journal of immunology.

Biosynthesis of Salmonella lipopolysaccharide. Studies on the transfer of glucose, galactose, and phosphate to the core in a cell free system.

P. Mühlradt, 1971, European journal of biochemistry.

In vivo effects of interleukin 2 on lymphocyte subpopulations in a patient with a combined immunodeficiency.

H. Peter, P. Mühlradt, D. Niethammer, 1984, Immunobiology.

Macrophage-activating lipopeptide-2 (MALP-2) induces a localized inflammatory response in rats resulting in activation of brain sites implicated in fever

J. Roth, P. Mühlradt, R. Gerstberger, 2008, Brain Research.

An improved semi-quantitative enzyme immunostaining procedure for glycosphingolipid antigens on high performance thin layer chromatograms.

P. Mühlradt, J. Müthing, P. Conradt, 1986, Journal of immunological methods.

Mycoplasmal Lipopeptide MALP-2 Induces the Chemoattractant Proteins Macrophage Inflammatory Protein 1α (MIP-1α), Monocyte Chemoattractant Protein 1, and MIP-2 and Promotes Leukocyte Infiltration in Mice

P. Mühlradt, U. Deiters, 1999, Infection and Immunity.

Forssman glycolipid, an antigenic marker for a major subpopulation of macrophages from murine spleen and peripheral lymph nodes.

P. Mühlradt, B. Kniep, U. Bethke, 1987, Journal of immunology.

Induction of Cytokines and Chemokines in Human Monocytes by Mycoplasma fermentans-Derived Lipoprotein MALP-2

D. Gemsa, H. Sprenger, A. Kaufmann, 1999, Infection and Immunity.

Immunochemical detection of glycosphingolipids on thin-layer chromatograms.

P. Mühlradt, B. Kniep, 1990, Analytical biochemistry.

Large scale production and purification of human IL-2 from buffy coat lymphocytes stimulated with 12-O-tetradecanoylphorbol 13-acetate and calcium ionohore A23187

P. Mühlradt, D. Monner, W. Grote, 1987 .

Neutral glycosphingolipids of murine myeloma cells and helper, cytolytic, and suppressor T lymphocytes.

P. Mühlradt, T. Hünig, F. Fitch, 1983, Biochemistry.

Carbohydrate-labelled glycoproteins as markers of human lymphocyte subsets stimulated with mitogen and alloantigen.

P. Mühlradt, R. van Eijk, 2005, European journal of biochemistry.

Peripheral and central cyclooxygenase (COX) products may contribute to the manifestation of brain-controlled sickness responses during localized inflammation induced by macrophage-activating lipopeptide-2 (MALP-2)

J. Roth, P. Mühlradt, C. Rummel, 2010, Neuroscience Letters.

T guided pancreatic carcinoma mouse model activating lipopeptide MALP-2 in an ultrasound Tumour suppression induced by the macrophage

Sauerbruch, C. Ziske, I. Schmidt-Wolf, 2003 .

The glycosphingolipid globoside as a serological marker on cytolytic T lymphocyte precursors and alloantigen‐responsive proliferating T lymphocytes in murine spleen

P. Mühlradt, D. Monner, U. Bethke, 1984, European journal of immunology.

Altered Cell Surface Glycosphingolipids of Murine Lymphocytes Belonging to Different Differentiation Pathways

P. Mühlradt, B. Kniep, R. Gruner, 1982 .

Structure elucidation of marker glycolipids of alloantigen-activated murine T lymphocytes.

P. Mühlradt, R. van Eijk, K. R. Gruner, 1981, Biochemistry.

Activation of nuclear factor‐κB in macrophages by mycoplasmal lipopeptides

E. Wingender, G. Jung, R. Süssmuth, 1998 .

Tetrazolium [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] reduction by mycoplasmas.

H. Quentmeier, P. Mühlradt, B. Franz, 1992, International journal of systematic bacteriology.

Clearance of interleukin 2 from the blood of normal and T cell‐depleted mice

P. Mühlradt, H. Opitz, Peter F. Mühlradt, 1982, European journal of immunology.

Mitogenic effects of partially purified interleukin 2 on thymocyte subpopulations and spleen T cells of the mouse

P. Mühlradt, R. van Eijk, B. Bödeker, 1980, European journal of immunology.

Purification of the T lymphocyte growth factor interleukin-2 from culture media of human peripheral blood leukocytes (buffy coats).

P. Mühlradt, B. Kniep, D. Monner, 1984, European journal of biochemistry.

MDHM, a macrophage-activating product of Mycoplasma fermentans, stimulates murine macrophages to synthesize nitric oxide and become tumoricidal.

H. Thude, P. Mühlradt, D. Ruschmeyer, 1993, FEMS immunology and medical microbiology.

Synthetic Lipopeptide MALP-2 Inhibits Intracellular Growth of Mycobacterium bovis BCG in Alveolar Macrophages—Preliminary Data

R. Pabst, F. Bange, P. Mühlradt, 2009, Inflammation.

Tissue localization and migration of murine spleen macrophages carrying the Forssman glycosphingolipid antigen.

P. Mühlradt, P. Conradt, R. von Kleist, 1988, Advances in experimental medicine and biology.

Production of five human lymphokines (granulocyte-macrophage colony stimulating factor, interferon-gamma, interleukin 2, macrophage cytotoxicity factor and macrophage migration inhibitory factor) from Con A stimulated lymphocyte cultures in bioreactors.

J. Van Damme, K. Havemann, W. Gassel, 1984, Immunobiology.

Lipopolysaccharide Stimulates the MyD88-Independent Pathway and Results in Activation of IFN-Regulatory Factor 3 and the Expression of a Subset of Lipopolysaccharide-Inducible Genes1

S. Akira, Shintaro Sato, T. Kawai, 2001, The Journal of Immunology.

Effect of MALP-2, a Lipopeptide fromMycoplasma fermentans, on Bone Resorption In Vitro

P. Mühlradt, R. Felix, J. Mirkovitch, 1999, Infection and Immunity.

Resorption In Vitro , on Bone Mycoplasma fermentans Effect of MALP-2 , a Lipopeptide from

P. Mühlradt, R. Felix, J. Mirkovitch, 1999 .

Cutting Edge: Preferentially the R-Stereoisomer of the Mycoplasmal Lipopeptide Macrophage-Activating Lipopeptide-2 Activates Immune Cells Through a Toll-Like Receptor 2- and MyD88-Dependent Signaling Pathway1

S. Akira, T. Kawai, O. Takeuchi, 2000, The Journal of Immunology.

Differential Posttranslational Processing Confers Intraspecies Variation of a Major Surface Lipoprotein and a Macrophage-Activating Lipopeptide of Mycoplasma fermentans

K. Wise, P. Mühlradt, M. Calcutt, 1999, Infection and Immunity.

Mycoplasma fermentans-derived high-molecular-weight material induces interleukin-6 release in cultures of murine macrophages and human monocytes

H. Quentmeier, E. Schmitt, P. Mühlradt, 1990, Infection and immunity.

Glycoconjugates of murine tumor lines with different metastatic capacities. I. Differences in fucose utilization and in glycoprotein patterns

V. Schirrmacher, P. Mühlradt, R. Schwartz, 1984, International journal of cancer.

Glycolipids in mouse thymocytes stimulated by concanavalin A. Characterisation of glycolipids and rate of lipid biosynthesis during stimulation.

P. Mühlradt, R. van Eijk, D. Monner, 1978, European journal of biochemistry.

Metabolic carbohydrate-labelling of glycolipids from mouse splenocytes. Mitogen-stimulated B and T cells show different labelling patterns.

P. Mühlradt, R. van Eijk, G. Rosenfelder, 1979, European journal of biochemistry.

Cell cycle dependent rate of labelling of cellular and secreted glycosaminoglycans in mouse embryonic fibroblasts.

A. Otto, P. Mühlradt, 1980, Journal of supramolecular structure.

Lateral mobility and surface density of lipopolysaccharide in the outer membrane of Salmonella typhimurium.

V. Speth, P. Mühlradt, J. Golecki, 1974, European journal of biochemistry.

Glycoconjugates of murine tumor lines with different metastatic capacities. II. Diversity of glycolipid composition

P. Mühlradt, J. Müthing, B. Kniep, 1985, International journal of cancer.

Gangliotriaosylceramide (asialo GM2), a glycosphingolipid marker for cell lines derived from patients with Hodgkin's disease.

V. Diehl, P. Mühlradt, B. Kniep, 1983, Journal of Immunology.

Carbohydrate incorporation in plasma membranes of mouse thymocytes stimulated by concanavalin A.

P. Mühlradt, R. van Eijk, 1977, European journal of biochemistry.

Discrimination of bacterial lipoproteins by Toll-like receptor 6.

S. Akira, K. Takeda, T. Kawai, 2001, International immunology.

Asymmetrical distribution and artifactual reorientation of lipopolysaccharide in the outer membrane bilayer of Salmonella typhimurium.

P. Mühlradt, J. Golecki, P F Mühlradt, 1975, European journal of biochemistry.

Characterization of thymus extracts which stimulate incorporation of galactose into glycoconjugates of rat bone marrow cells.

P. Mühlradt, D. Monner, 1979, Advances in experimental medicine and biology.

Vitamin B6 analogs. An improved synthesis of 5f-deoxypyridoxal.

P. Mühlradt, E. Snell, 1967, Journal of medicinal chemistry.

Synergy and Cross-Tolerance Between Toll-Like Receptor (TLR) 2- and TLR4-Mediated Signaling Pathways1

S. Akira, Shintaro Sato, K. Takeda, 2000, The Journal of Immunology.

Effects of pyocyanine, a phenazine dye from Pseudomonas aeruginosa, on oxidative burst and bacterial killing in human neutrophils

K. Krohn, P. Müller, P. Mühlradt, 1989, Infection and immunity.

Toll-like receptor 2/6 stimulation promotes angiogenesis via GM-CSF as a potential strategy for immune defense and tissue regeneration.

H. Drexler, G. Salguero, P. Mühlradt, 2010, Blood.

Metabolic carbohydrate labelling of glycoproteins from mitogen-stimulated mouse lymphocytes. Glycoproteins as biochemical markers for lymphocyte subpopulations.

P. Mühlradt, R. van Eijk, G. Rosenfelder, 1979, European journal of biochemistry.

The Mucosal Adjuvant Macrophage-Activating Lipopeptide-2 Directly Stimulates B Lymphocytes via the TLR2 without the Need of Accessory Cells 1

K. Kretschmer, C. Guzmán, S. Weiss, 2005, The Journal of Immunology.

TLR 2 without the Need of Accessory Cells Directly Stimulates B Lymphocytes via the Macrophage-Activating Lipopeptide-2 The Mucosal Adjuvant and

K. Kretschmer, C. Guzmán, S. Weiss, 2005 .

High seroprevalence of anti-Mycoplasma fermentans antibodies in patients with malignant aphthosis.

C. Zouboulis, P. Mühlradt, J. R. Turnbull, 2003, The Journal of investigative dermatology.

Topography of outer membrane assembly in Salmonella.

P. Mühlradt, 1976, Journal of supramolecular structure.

Monoclonal antibodies against the human lymphocyte differentiation antigen CD 76 bind to gangliosides

B. Dörken, R. Vilella, P. Mühlradt, 1990, FEBS letters.

Intratumoural injection of the toll-like receptor-2/6 agonist ‘macrophage-activating lipopeptide-2’ in patients with pancreatic carcinoma: a phase I/II trial

D. Jäger, M. Büchler, T. Welsch, 2007, British Journal of Cancer.

Intralymphatic interleukin 2 treatment in patients with acquired immunodeficiency syndrome: preliminary experience in three cases.

G. Burmester, N. Heyder, J. Kalden, 1986, Immunobiology.

The TLR-2/TLR-6 agonist macrophage-activating lipopeptide-2 augments human NK cell cytotoxicity when PGE2 production by monocytes is inhibited by a COX-2 blocker

R. Jacobs, R. Schmidt, P. Mühlradt, 2015, Cancer Immunology, Immunotherapy.

Synthetic mycoplasma-derived lipopeptide MALP-2 induces maturation and function of dendritic cells.

N. Krug, P. Mühlradt, A. Braun, 2003, Immunobiology.

The Mycoplasma‐derived lipopeptide MALP‐2 is a potent mucosal adjuvant

B. Ensoli, C. Guzmán, M. Morr, 2002, European journal of immunology.

Activation of nuclear factor-kappaB in macrophages by mycoplasmal lipopeptides.

E. Wingender, G. Jung, R. Süssmuth, 1998, European journal of immunology.

Association of Mycoplasma fermentans with Adamantiades-Behçet's disease.

C. Zouboulis, P. Mühlradt, J. R. Turnbull, 2003, Advances in experimental medicine and biology.

Role of IL-6, IL-2, and IL-4 in the in vitro induction of cytotoxic T cells.

H. Quentmeier, H. Drexler, P. Mühlradt, 1992, Journal of immunology.

Evidence from a carbohydrate incorporation assay for direct activation of bone marrow myelopoietic precursor cells by bacterial cell wall constitutents

P. Mühlradt, D. Monner, J. Gmeiner, 1981, Infection and immunity.

Synthesis of high molecular weight polyphosphate with a partially purified enzyme from Salmonella.

P. Mühlradt, 1971, Journal of General Microbiology.

Efficient mucosal delivery of the HIV‐1 Tat protein using the synthetic lipopeptide MALP‐2 as adjuvant

A. Scoglio, F. Nappi, B. Ensoli, 2003, European journal of immunology.

Identification of the mouse helper T lymphocyte differentiation antigen 3G11 as the ganglioside IV3(NeuAc)2-GgOse4Cer.

P. Mühlradt, M. Nimtz, K. Hayakawa, 1994, Biochemical and biophysical research communications.

F5 – ACTIVATION OF MACROPHAGES AND MONOCYTES BY MYCOPLASMAS

A. Avron, P. Mühlradt, R. Gallily, 1995 .

Gangliosides: differentiation markers for murine T helper lymphocyte subpopulations TH1 and TH2.

J. Peter-Katalinic, P. Mühlradt, B. Kniep, 1992, Biochemistry.

Intracutaneous injection of the macrophage‐activating lipopeptide‐2 (MALP‐2) which accelerates wound healing in mice – a phase I trial in 12 patients

M. Wittmann, T. Werfel, P. Mühlradt, 2008, Experimental Dermatology.

Zeitschrift Für Immunitätsforschung Editors Editor-in-chief Gustav Fischer Verlag @bullet Stuttgart @bullet New York @bullet 1993 Tumor-induced Macrophage Tumor Necrosis Factor-oc Production Suppresses Autoreactive T Cell Proliferation 430 Induction of Ige and Iggl in Human B Cell Cultures with Stap

R. Brezinschek, G. Vanham, S. Euvrard, 2011 .

Stimulation of mouse bone marrow cell membrane glycoconjugate synthesis by colony stimulating factor (CSF): basis for a rapid, simple assay for CSF.

P. Mühlradt, D. Monner, 1984, Journal of immunological methods.

Biphasic rate of synthesis of glycoconjugates, phospholipids and DNA in concanavalin A‐stimulated mouse thymocytes. Involvement of cortisone‐sensitive and ‐resistant subpopulations

P. Mühlradt, Ronald V. W. van Eijk, Peter F. Mühlradt, 1979, European journal of immunology.

Effects of pyocyanine, a blue pigment from Pseudomonas aeruginosa, on separate steps of T cell activation: Interleukin 2 (IL 2) production, IL 2 receptor formation, proliferation and induction of cytolytic activity

P. Mühlradt, H. Tsai, P. Conradt, 1986, European journal of immunology.