P. Ponsaerts

发表

CCR2 deficiency in monocytes impairs angiogenesis and functional recovery after ischemic stroke in mice

C. Justicia, A. Planas, M. Pasparakis, 2020, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

The Toll-like receptor 7/8 agonist resiquimod greatly increases the immunostimulatory capacity of human acute myeloid leukemia cells

Z. Berneman, E. Smits, E. Lion, 2009, Cancer Immunology, Immunotherapy.

The use of TLR7 and TLR8 ligands for the enhancement of cancer immunotherapy.

Z. Berneman, E. Smits, V. V. Van Tendeloo, 2008, The oncologist.

Cancer immunotherapy using RNA‐loaded dendritic cells

P. Ponsaerts, Z. Berneman, V. V. van Tendeloo, 2003, Clinical and experimental immunology.

Ex vivo induction of viral antigen‐specific CD8+ T cell responses using mRNA‐electroporated CD40‐activated B cells

G. Vanham, M. Lenjou, G. Nijs, 2005, Clinical and experimental immunology.

Labeling of Luciferase/eGFP-Expressing Bone Marrow-Derived Stromal Cells with Fluorescent Micron-Sized Iron Oxide Particles Improves Quantitative and Qualitative Multimodal Imaging of Cellular Grafts In Vivo

G. Vanhoutte, A. Linden, P. Pauwels, 2011, Molecular Imaging and Biology.

Injury-Dependent Retention of Intraportally Administered Mesenchymal Stromal Cells Following Partial Hepatectomy of Steatotic Liver Does Not Lead to Improved Liver Recovery

A. Van der Linden, Z. Berneman, P. Ponsaerts, 2013, PloS one.

High-level transgene expression in primary human T lymphocytes and adult bone marrow CD34+ cells via electroporation-mediated gene delivery

C. Broeckhoven, M. Vanhove, M. Lenjou, 2000, Gene Therapy.

Multimodal in vivo imaging reveals limited allograft survival, intrapulmonary cell trapping and minimal evidence for ischemia-directed BMSC homing

A. Van der Linden, C. Vrints, J. Timmermans, 2012, BMC Biotechnology.

Proinflammatory response of human leukemic cells to dsRNA transfection linked to activation of dendritic cells

Z. Berneman, M. Lenjou, G. Nijs, 2007, Leukemia.

Cell-Based Delivery of Interleukin-13 Directs Alternative Activation of Macrophages Resulting in Improved Functional Outcome after Spinal Cord Injury

T. Vangansewinkel, S. Hendrix, P. Ponsaerts, 2016, Stem cell reports.

Interleukin‐13 immune gene therapy prevents CNS inflammation and demyelination via alternative activation of microglia and macrophages

H. Goossens, M. Verhoye, A. Van der Linden, 2016, Glia.

In Vivo Interleukin‐13‐Primed Macrophages Contribute to Reduced Alloantigen‐Specific T Cell Activation and Prolong Immunological Survival of Allogeneic Mesenchymal Stem Cell Implants

H. Goossens, A. Van der Linden, C. Verfaillie, 2016, Stem cells.

Early Inflammatory Responses following Cell Grafting in the CNS Trigger Activation of the Subventricular Zone: A Proposed Model of Sequential Cellular Events

H. Goossens, A. Van der Linden, N. Hens, 2015, Cell transplantation.

Promising Strategies for the Development of Advanced In Vitro Models with High Predictive Power in Ischaemic Stroke Research

P. Ponsaerts, Elise Van Breedam, 2022, International journal of molecular sciences.

Macrophage-based delivery of interleukin-13 improves functional and histopathological outcomes following spinal cord injury

A. Quarta, S. Hendrix, D. Sommer, 2022, Journal of neuroinflammation.

Effect of Oral Allylnitrile Administration on Cochlear Functioning in Mice Following Comparison of Different Anesthetics for Hearing Assessment

P. D. De Deyn, V. van Rompaey, O. Vanderveken, 2021, Frontiers in Toxicology.

Murine induced pluripotent stem cell‐derived neuroimmune cell culture models emphasize opposite immune‐effector functions of interleukin 13‐primed microglia and macrophages in terms of neuroimmune toxicity

H. Goossens, N. Hens, Z. Berneman, 2020, Glia.

CD56 Homodimerization and Participation in Anti-Tumor Immune Effector Cell Functioning: A Role for Interleukin-15

Z. Berneman, E. Smits, V. V. Van Tendeloo, 2019, Cancers.

Connecting the Dots in the Neuroglobin-Protein Interaction Network of an Unstressed and Ferroptotic Cell Death Neuroblastoma Model

S. Dewilde, G. Baggerman, W. Vanden Berghe, 2019, Cells.

Current Challenges for the Advancement of Neural Stem Cell Biology and Transplantation Research

A. Linden, P. Pauwels, Z. Berneman, 2011, Stem Cell Reviews and Reports.

Biochemical Parameters for Longitudinal Monitoring of Liver Function in Rat Models of Partial Hepatectomy Following Liver Injury

P. Ponsaerts, K. D. De Greef, D. Ysebaert, 2013, PloS one.

Multimodal imaging of micron-sized iron oxide particles following in vitro and in vivo uptake by stem cells: down to the nanometer scale.

A. Van der Linden, D. Adriaensen, S. Bals, 2014, Contrast media & molecular imaging.

Increased caspase activation and decreased TDP‐43 solubility in progranulin knockout cortical cultures

C. van Broeckhoven, J. Timmermans, S. Kumar-Singh, 2010, Journal of neurochemistry.

Recognition of cellular implants by the brain's innate immune system

A. Linden, P. Pauwels, Z. Berneman, 2011, Immunology and cell biology.

Expression of Translocator Protein and [18F]-GE180 Ligand Uptake in Multiple Sclerosis Animal Models

C. Schmitz, P. Bartenstein, A. Rominger, 2019, Cells.

Increased soluble amyloid-beta causes early aberrant brain network hypersynchronisation in a mature-onset mouse model of amyloidosis

Georgios A. Keliris, M. Verhoye, A. Linden, 2019, Acta Neuropathologica Communications.

Biological and Physicochemical Characterization of a Serum-and Xeno-Free Chemically Defined Cryopreservation Procedure for Adult Human Progenitor Cells

J. C. Schulz, S. Hoerstrup, A. Kolbus, 2011, Cell transplantation.

Messenger RNA Electroporation of Human Monocytes, Followed by Rapid In Vitro Differentiation, Leads to Highly Stimulatory Antigen-Loaded Mature Dendritic Cells1

C. van Broeckhoven, Z. Berneman, M. Lenjou, 2002, The Journal of Immunology.

Antigen-Loaded Mature Dendritic Cells Differentiation , Leads to Highly Stimulatory Monocytes , Followed by Rapid In Vitro Messenger RNA Electroporation of Human Berneman and

C. Broeckhoven, M. Lenjou, G. Nijs, 2002 .

Efficient removal of LoxP-flanked genes by electroporation of Cre-recombinase mRNA.

Z. Berneman, D. V. van Bockstaele, V. V. Van Tendeloo, 2003, Biochemical and biophysical research communications.

Transduction Efficiency and Immunogenicity of Viral Vectors for Cochlear Gene Therapy: A Systematic Review of Preclinical Animal Studies

V. van Rompaey, P. Ponsaerts, G. Van Camp, 2021, Frontiers in Cellular Neuroscience.

mRNA-based gene transfer as a tool for gene and cell therapy.

Z. Berneman, V. V. Van Tendeloo, P. Ponsaerts, 2007, Current opinion in molecular therapeutics.

Messenger Rna Electroporation: an Efficient Tool in Immunotherapy and Stem Cell Research

D. V. van Bockstaele, P. Ponsaerts, Z. Berneman, 2022 .

mRNA-electroporated mature dendritic cells retain transgene expression, phenotypical properties and stimulatory capacity after cryopreservation

C. Broeckhoven, Z. Berneman, M. Lenjou, 2002, Leukemia.

General consensus on multimodal functions and validation analysis of perinatal derivatives for regenerative medicine applications

M. Pozzobon, R. Piva, R. Di Pietro, 2022, Frontiers in Bioengineering and Biotechnology.

Sensitive detection of human papillomavirus type 16 E7-specific T cells by ELISPOT after multiple in vitro stimulations of CD8+ T cells with peptide-pulsed autologous dendritic cells

Z. Berneman, M. Lenjou, G. Nijs, 2006, Molecular Cancer.

Modulation of cellular behavior by exogenous messenger RNA

P. Ponsaerts, Z. Berneman, 2006, Leukemia.

Multipotent adult progenitor cells improve the hematopoietic function in myelodysplasia.

C. Verfaillie, C. Deroose, E. Wolfs, 2017, Cytotherapy.

Interleukin-25 is detrimental for recovery after spinal cord injury in mice

S. Hendrix, P. Ponsaerts, D. Dooley, 2016, Journal of Neuroinflammation.

Perinatal derivatives: How to best validate their immunomodulatory functions

L. O’Driscoll, M. Gazouli, M. Pozzobon, 2022, Frontiers in Bioengineering and Biotechnology.

Altered basal forebrain function during whole-brain network activity at pre- and early-plaque stages of Alzheimer’s disease in TgF344-AD rats

Georgios A. Keliris, Mohit H. Adhikari, M. Verhoye, 2022, Alzheimer's Research & Therapy.

Intracerebral transplantation of interleukin 13-producing mesenchymal stem cells limits microgliosis, oligodendrocyte loss and demyelination in the cuprizone mouse model

H. Goossens, M. Verhoye, A. Van der Linden, 2016, Journal of Neuroinflammation.

Efficient generation of stably electrotransfected human hematopoietic cell lines without drug selection by consecutive FACsorting.

C. Broeckhoven, C. van Broeckhoven, Z. Berneman, 2000, Cytometry.

Immune remodelling of stromal cell grafts in the central nervous system: therapeutic inflammation or (harmless) side‐effect?

Jan R. Detrez, H. Goossens, W. D. De Vos, 2017, Journal of tissue engineering and regenerative medicine.

T cell immunity in HSV-1- and VZV-infected neural ganglia.

B. Ogunjimi, K. Laukens, P. Meysman, 2022, Trends in microbiology.

Quantitative and phenotypic analysis of mesenchymal stromal cell graft survival and recognition by microglia and astrocytes in mouse brain.

H. Goossens, A. Van der Linden, N. Hens, 2013, Immunobiology.

Interferon-&ggr; modulates the functional profile of in-vitro-cultured porcine microglia

C. Casteleyn, S. V. Van Cruchten, C. Van Ginneken, 2012, Neuroreport.

Neuroscience and Biobehavioral Reviews Cellular and Molecular Neuropathology of the Cuprizone Mouse Model: Clinical Relevance for Multiple Sclerosis

Annemie Van der Linden, Caroline Guglielmetti, Peter Ponsaerts, 2022 .

mRNA-Mediated Gene Delivery Into Human Progenitor Cells Promotes Highly Efficient Protein Expression

V. Hombach, M. Rojewski, H. Schrezenmeier, 2007, Journal of cellular and molecular medicine.

Highly efficient mRNA-based gene transfer in feeder-free cultured H9 human embryonic stem cells.

P. Jorens, Z. Berneman, V. V. Van Tendeloo, 2004, Cloning and stem cells.

Application of Perinatal Derivatives on Oncological Preclinical Models: A Review of Animal Studies

R. Teixo, M. Laranjo, M. Botelho, 2022, International journal of molecular sciences.

Plasmid-based genetic modification of human bone marrow-derived stromal cells: analysis of cell survival and transgene expression after transplantation in rat spinal cord

E. van Marck, P. Jorens, K. Vermeulen, 2007, BMC Biotechnology.

Meeting report of the first conference of the International Placenta Stem Cell Society (IPLASS).

M. Weiss, A. G. Betz, R. Ofir, 2011, Placenta.

On the pathophysiology of DFNA9: Effect of pathogenic variants in the COCH gene on inner ear functioning in human and transgenic mice

V. van Rompaey, P. Ponsaerts, G. Van Camp, 2020, Hearing Research.

Toward cell therapy using placenta-derived cells: disease mechanisms, cell biology, preclinical studies, and regulatory aspects at the round table.

D. Hess, S. Strom, W. Falk, 2010, Stem cells and development.

Neuroprotective modulation of microglia effector functions following priming with interleukin 4 and 13: current limitations in understanding their mode-of-action

Z. Berneman, A. Quarta, P. Ponsaerts, 2020, Brain, Behavior, and Immunity.

Combination of cuprizone and experimental autoimmune encephalomyelitis to study inflammatory brain lesion formation and progression

C. Schmitz, P. Fallier-Becker, C. Beyer, 2017, Glia.

Distinct In Vitro Properties of Embryonic and Extraembryonic Fibroblast-Like Cells are Reflected in their in Vivo Behavior following Grafting in the Adult Mouse Brain

H. Goossens, N. Hens, Z. Berneman, 2015, Cell transplantation.

Insights and future directions for the application of perinatal derivatives in eye diseases: A critical review of preclinical and clinical studies

M. Botelho, P. Ponsaerts, J. Chaves, 2022, Frontiers in Bioengineering and Biotechnology.

Functional consequences of a close encounter between microglia and brain‐infiltrating monocytes during CNS pathology and repair

Z. Berneman, A. Quarta, P. Ponsaerts, 2020, Journal of leukocyte biology.

Phospholipid Scramblase 1 Is Secreted by a Lipid Raft-dependent Pathway and Interacts with the Extracellular Matrix Protein 1 in the Dermal Epidermal Junction Zone of Human Skin*

X. Van Ostade, J. Merregaert, P. Ponsaerts, 2010, The Journal of Biological Chemistry.

Application of Perinatal Derivatives in Ovarian Diseases

P. Ponsaerts, A. Lange-Consiglio, F. Cremonesi, 2022, Frontiers in Bioengineering and Biotechnology.

Microglia: gatekeepers of central nervous system immunology

Peter Ponsaerts, P. Ponsaerts, Bart R Tambuyzer, 2009, Journal of leukocyte biology.

Balancing between immunity and tolerance: an interplay between dendritic cells, regulatory T cells, and effector T cells

Z. Berneman, V. V. Van Tendeloo, P. Ponsaerts, 2007, Journal of leukocyte biology.

Regulatory T Cells and Human Disease

Z. Berneman, V. V. Van Tendeloo, P. Ponsaerts, 2008, Clinical & developmental immunology.

Targeted intracerebral delivery of the anti-inflammatory cytokine IL13 promotes alternative activation of both microglia and macrophages after stroke

A. Van der Linden, M. Hoehn, A. Quarta, 2018, Journal of Neuroinflammation.

Clinical Potential of Intravenous Neural Stem Cell Delivery for Treatment of Neuroinflammatory Disease in Mice?

Herman Goossens, Greetje Vanhoutte, Veerle Baekelandt, 2011, Cell transplantation.

Except for C-C chemokine receptor 7 expression, monocyte-derived dendritic cells from patients with multiple sclerosis are functionally comparable to those of healthy controls.

H. Goossens, G. Nagels, P. Cras, 2014, Cytotherapy.

Immunosuppression induced by immature dendritic cells is mediated by TGF-β/IL-10 double-positive CD4+ regulatory T cells

M. Lenjou, G. Nijs, D. V. van Bockstaele, 2007, Journal of cellular and molecular medicine.

Efficient stimulation of HIV-1-specific T cells using dendritic cells electroporated with mRNA encoding autologous HIV-1 Gag and Env proteins.

Bernard Verrier, Concepción Marañón, Peter Ponsaerts, 2006, Blood.

Antigen-specific cellular immunotherapy of leukemia

H. Stauss, P. Ponsaerts, L. Gao, 2005, Leukemia.

Transmembrane protein 119 is neither a specific nor a reliable marker for microglia

C. Schmitz, S. Amor, A. Wree, 2022, Glia.

Murine iPSC-derived microglia and macrophage cell culture models recapitulate distinct phenotypical and functional properties of classical and alternative neuro-immune polarisation

H. Goossens, N. Hens, M. Hoehn, 2019, Brain, Behavior, and Immunity.

Current Challenges for the Advancement of Neural Stem Cell Biology and Transplantation Research

A. Linden, P. Pauwels, Z. Berneman, 2012, Stem Cell Reviews and Reports.

Activation of Interferon-Stimulated Genes following Varicella-Zoster Virus Infection in a Human iPSC-Derived Neuronal In Vitro Model Depends on Exogenous Interferon-α

G. Mortier, B. Ogunjimi, K. Laukens, 2022, Viruses.

The ratio of SRPK1/SRPK1a regulates erythroid differentiation in K562 leukaemic cells.

C. Lenz, A. Kolbus, Ioannis Sanidas, 2010, Biochimica et biophysica acta.

Heparin-based, injectable microcarriers for controlled delivery of interleukin-13 to the brain.

B. Newland, C. Werner, A. Rosser, 2020, Biomaterials science.

Stem cell therapy for multiple sclerosis: preclinical evidence beyond all doubt?

A. Van der Linden, Z. Berneman, P. Ponsaerts, 2012, Regenerative medicine.

Unraveling the immune signature of herpes zoster: Insights into pathophysiology and the HLA risk profile

P. Meysman, A. Suls, H. Jansens, 2023, medRxiv.

RNA-based gene transfer for adult stem cells and T cells

M. Lenjou, G. Nijs, P. Ponsaerts, 2004, Leukemia.

Current challenges in human embryonic stem cell research: directed differentiation and transplantation tolerance.

D. V. van Bockstaele, P. Jorens, P. Ponsaerts, 2004, Journal of biological regulators and homeostatic agents.

Concise Review: Innate and Adaptive Immune Recognition of Allogeneic and Xenogeneic Cell Transplants in the Central Nervous System

H. Goossens, Z. Berneman, A. Quarta, 2017, Stem cells translational medicine.

Neuroglobin Expression Models as a Tool to Study Its Function

S. Dewilde, P. Ponsaerts, Evi Luyckx, 2019, Oxidative medicine and cellular longevity.

Highly efficient gene delivery by mRNA electroporation in human hematopoietic cells: superiority to lipofection and passive pulsing of mRNA and to electroporation of plasmid cDNA for tumor antigen loading of dendritic cells.

C. van Broeckhoven, Z. Berneman, M. Lenjou, 2001, Blood.

Cellular Immunotherapy for Cytomegalovirus and HIV-1 Infection

G. Vanham, Z. Berneman, D. V. van Bockstaele, 2006, Journal of immunotherapy.

Intracerebral delivery of the M2 polarizing cytokine interleukin 13 using mesenchymal stem cell implants in a model of temporal lobe epilepsy in mice

S. Dedeurwaerdere, P. Ponsaerts, Idrish Ali, 2017, Epilepsia.

Identification and characterization of Huntington related pathology: An in vivo DKI imaging study

Jan Sijbers, Jelle Veraart, Trygve B. Leergaard, 2012, NeuroImage.

Cell-Based Therapies in Lower Urinary Tract Disorders

J. Wyndaele, P. Ponsaerts, Chaitanya Gopinath, 2015, Cell transplantation.

Smooth muscle cell transplantation improves bladder contractile function in streptozocin-induced diabetic rats.

P. Pauwels, E. Fransen, J. Wyndaele, 2013, Cytotherapy.

Altered dynamics of glymphatic flow in a mature-onset Tet-off APP mouse model of amyloidosis

Georgios A. Keliris, A. Van der Linden, Verdi Vanreusel, 2023, Alzheimer's Research & Therapy.

Dynamics of brain-fluid circulation are altered in the mature-onset Tet-off APP mouse model of amyloidosis

Georgios A. Keliris, A. Van der Linden, Verdi Vanreusel, 2022, bioRxiv.

Tackling the physiological barriers for successful mesenchymal stem cell transplantation into the central nervous system

A. Van der Linden, Z. Berneman, P. Ponsaerts, 2013, Stem Cell Research & Therapy.

Intracerebral transplantation of interleukin 13-producing mesenchymal stem cells limits microgliosis, oligodendrocyte loss and demyelination in the cuprizone mouse model

H. Goossens, M. Verhoye, A. Van der Linden, 2016, Journal of Neuroinflammation.

Morpho-functional comparison of differentiation protocols to create iPSC-derived cardiomyocytes

H. Heidbuchel, W. D. De Vos, E. Fransen, 2022, Biology open.

Diffusion kurtosis imaging probes cortical alterations and white matter pathology following cuprizone induced demyelination and spontaneous remyelination

J. Sijbers, M. Verhoye, J. Van Audekerke, 2016, NeuroImage.

Longitudinal monitoring of metabolic alterations in cuprizone mouse model of multiple sclerosis using 1H-magnetic resonance spectroscopy

Annemarie van der Linden, Marleen Verhoye, Caroline Guglielmetti, 2015, NeuroImage.

Cuprizone-induced demyelination and demyelination-associated inflammation result in different proton magnetic resonance metabolite spectra

M. Verhoye, A. Van der Linden, N. Hens, 2015, NMR in biomedicine.

Distinct spatial distribution of microglia and macrophages following mesenchymal stem cell implantation in mouse brain

H. Goossens, N. Hens, Z. Berneman, 2014, Immunology and cell biology.

Multimodal imaging of subventricular zone neural stem/progenitor cells in the cuprizone mouse model reveals increased neurogenic potential for the olfactory bulb pathway, but no contribution to remyelination of the corpus callosum

Frederik Maes, Annemarie van der Linden, Marleen Verhoye, 2014, NeuroImage.

Histological characterization and quantification of cellular events following neural and fibroblast(-like) stem cell grafting in healthy and demyelinated CNS tissue.

H. Goossens, A. Van der Linden, N. Hens, 2014, Methods in molecular biology.

Tackling the physiological barriers for successful mesenchymal stem cell transplantation into the central nervous system

A. Van der Linden, Z. Berneman, P. Ponsaerts, 2013, Stem Cell Research & Therapy.

Quantitative evaluation of stem cell grafting in the central nervous system of mice by in vivo bioluminescence imaging and postmortem multicolor histological analysis.

A. Van der Linden, Z. Berneman, P. Ponsaerts, 2013, Methods in molecular biology.

Spatiotemporal evolution of early innate immune responses triggered by neural stem cell grafting

H. Goossens, A. Van der Linden, Z. Berneman, 2012, Stem Cell Research & Therapy.

Cell Type-Associated Differences in Migration, Survival, and Immunogenicity following Grafting in CNS Tissue

Herman Goossens, Niel Hens, Patrick Pauwels, 2012, Cell transplantation.

Multimodal imaging of stem cell implantation in the central nervous system of mice.

A. Van der Linden, Z. Berneman, P. Ponsaerts, 2012, Journal of visualized experiments : JoVE.

Allogeneic stromal cell implantation in brain tissue leads to robust microglial activation

H. Goossens, E. van Marck, P. Jorens, 2009, Immunology and cell biology.

Reporter gene-expressing bone marrow-derived stromal cells are immune-tolerated following implantation in the central nervous system of syngeneic immunocompetent mice

Herman Goossens, Veerle Baekelandt, Dirk Ysebaert, 2009, BMC biotechnology.

PapRIV, a BV-2 microglial cell activating quorum sensing peptide

Christel Claes, A. Quarta, Yorick Janssens, 2020, Scientific Reports.

Attitudes of Potential Participants Towards Potential Gene Therapy Trials in Autosomal Dominant Progressive Sensorineural Hearing Loss

E. van Wijk, R. Pennings, V. van Rompaey, 2020, Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology.

Clinical and immunological control of experimental autoimmune encephalomyelitis by tolerogenic dendritic cells loaded with MOG-encoding mRNA

H. Goossens, G. Molenberghs, M. Verhoye, 2019, Journal of Neuroinflammation.

Focal white matter lesions induce long-lasting axonal degeneration, neuroinflammation and behavioral deficits

B. Denecke, S. Amor, P. Ponsaerts, 2021, Neurobiology of Disease.

Oxidation of Innate Immune Checkpoint CD47 on Cancer Cells with Non-Thermal Plasma

A. Bogaerts, P. Ponsaerts, Jamoliddin Razzokov, 2021, Cancers.

Messenger RNA electroporation is highly efficient in mouse embryonic stem cells: successful FLPe- and Cre-mediated recombination

P. Jorens, J. Merregaert, P. Ponsaerts, 2004, Gene Therapy.

Interleukin-25 is detrimental for recovery after spinal cord injury in mice

S. Hendrix, P. Ponsaerts, D. Dooley, 2016, Journal of Neuroinflammation.

Immune recognition of syngeneic, allogeneic and xenogeneic stromal cell transplants in healthy retinas

M. Vidal-Sanz, P. Ponsaerts, D. García-Bernal, 2022, Stem cell research & therapy.