N. Rhaleb

发表

N-acetyl-seryl-aspartyl-lysyl-proline prevents cardiac remodeling and dysfunction induced by galectin-3, a mammalian adhesion/growth-regulatory lectin.

O. Carretero, H. Gabius, S. André, 2009, American journal of physiology. Heart and circulatory physiology.

Ac-SDKP suppresses TNF-α-induced ICAM-1 expression in endothelial cells via inhibition of IκB kinase and NF-κB activation.

B. Janic, O. Carretero, P. Harding, 2016, American journal of physiology. Heart and circulatory physiology.

Role of kinins and nitric oxide in the antihypertrophic effect of ramipril.

O. Carretero, N. Rhaleb, X. Yang, 1994, Hypertension.

Inhibition of p38 mitogen-activated protein kinase protects the heart against cardiac remodeling in mice with heart failure resulting from myocardial infarction.

S. Sankey, O. Carretero, Yun-he Liu, 2005, Journal of cardiac failure.

Reactive oxygen species: role in the relaxation induced by bradykinin or arachidonic acid via EDHF in isolated porcine coronary arteries.

O. Carretero, N. Rhaleb, S. Pomposiello, 1999, Journal of cardiovascular pharmacology.

Protective role of AT(2) and B(1) receptors in kinin B(2)-receptor-knockout mice with myocardial infarction.

O. Carretero, James J. Yang, N. Rhaleb, 2013, Clinical science.

The kallikrein-kinin system as a regulator of cardiovascular and renal function.

O. Carretero, N. Rhaleb, Xiao‐ping Yang, 2011, Comprehensive Physiology.

Structure-activity studies of bradykinin and related peptides. B2-receptor antagonists.

N. Rhaleb, D. Regoli, G. Drapeau, 1991, Hypertension.

Kinin Receptor Subtypes

N. Rhaleb, D. Regoli, G. Drapeau, 1990, Journal of cardiovascular pharmacology.

Thymosin-β4 prevents cardiac rupture and improves cardiac function in mice with myocardial infarction.

O. Carretero, Hongmei Peng, N. Rhaleb, 2014, American journal of physiology. Heart and circulatory physiology.

N-acetyl-seryl-aspartyl-lysyl-proline stimulates angiogenesis in vitro and in vivo.

O. Carretero, Yun-he Liu, T. Liao, 2004, American journal of physiology. Heart and circulatory physiology.

Kinins and Cardiovascular Disease

O. Carretero, N. Rhaleb, Xiao‐ping Yang, 2009 .

Chapter 20 – The Kallikrein-Kinin System as a Regulator of Cardiovascular and Renal Function

O. Carretero, N. Rhaleb, Xiao‐ping Yang, 2005 .

Receptors for substance P and neurokinins. Correlation between binding and biological activities.

N. Rhaleb, D. Regoli, P. D'Orléans-Juste, 1987, European journal of pharmacology.

N-acetyl-seryl-aspartyl-lysyl-proline treatment protects heart against excessive myocardial injury and heart failure in mice.

Hongmei Peng, N. Rhaleb, Xiao‐ping Yang, 2019, Canadian journal of physiology and pharmacology.

Draft 1 AC-SDKP treatment protects heart against excessive myocardial injury and heart failure in mice

Hongmei Peng, N. Rhaleb, Xiao‐ping Yang, 2019 .

Cardiac-deleterious role of galectin-3 in chronic angiotensin II-induced hypertension.

B. Janic, O. Carretero, Yun-he Liu, 2016, American journal of physiology. Heart and circulatory physiology.

Renal protective effects of N-acetyl-Ser-Asp-Lys-Pro in deoxycorticosterone acetate–salt hypertensive mice

O. Carretero, N. Rhaleb, U. Sharma, 2011, Journal of hypertension.

Novel anti-inflammatory mechanisms of N-Acetyl-Ser-Asp-Lys-Pro in hypertension-induced target organ damage.

O. Carretero, P. Harding, Hongmei Peng, 2008, American journal of physiology. Heart and circulatory physiology.

Angiotensin, the Kinins, and Smooth Muscle

N. Rhaleb, D. Regoli, 1994 .

Effects of Cardiac Overexpression of the Angiotensin II Type 2 Receptor on Remodeling and Dysfunction in Mice Post–Myocardial Infarction

Ying Sun, O. Carretero, P. Harding, 2014, Hypertension.

N-acetyl-seryl-aspartyl-lysyl-proline reduces cardiac collagen cross-linking and inflammation in angiotensin II-induced hypertensive rats.

O. Carretero, Yun-he Liu, T. Liao, 2014, Clinical science.

Tβ4-Ac-SDKP pathway: Any relevance for the cardiovascular system?

Hongmei Peng, N. Rhaleb, Kamal M. Kassem, 2019, Canadian journal of physiology and pharmacology.

Renal Protective Effect of N-Acetyl-Seryl-Aspartyl-Lysyl-Proline in Dahl Salt-Sensitive Rats

B. Janic, O. Carretero, M. D’Ambrosio, 2015, Hypertension.

Treatment with N-acetyl-seryl-aspartyl-lysyl-proline prevents experimental autoimmune myocarditis in rats.

O. Carretero, Yun-he Liu, T. Liao, 2012, American journal of physiology. Heart and circulatory physiology.

Long-Term Effect of N-Acetyl-Seryl-Aspartyl-Lysyl-Proline on Left Ventricular Collagen Deposition in Rats With 2-Kidney, 1-Clip Hypertension

E. Ezan, O. Carretero, Yun-he Liu, 2001, Circulation.

Antifibrotic effect of Ac-SDKP and angiotensin-converting enzyme inhibition in hypertension

M. Cavasin, O. Carretero, A. Sánchez-Mendoza, 2004, Journal of hypertension.

Antifibrotic Effects of N -Acetyl-Seryl-Aspartyl-Lysyl-Proline on the Heart and Kidney in Aldosterone-Salt Hypertensive Rats

A. Kapke, O. Carretero, L. Raij, 2001, Hypertension.

Ac-SDKP Reverses Cardiac Fibrosis in Rats With Renovascular Hypertension

O. Carretero, Hongmei Peng, N. Rhaleb, 2003, Hypertension.

Effect of N-Acetyl-Seryl-Aspartyl-Lysyl-Proline on DNA and Collagen Synthesis in Rat Cardiac Fibroblasts

O. Carretero, P. Harding, Hongmei Peng, 2001, Hypertension.

New selective bradykinin receptor antagonists and bradykinin B2 receptor characterization.

N. Rhaleb, D. Regoli, G. Drapeau, 1990, Trends in pharmacological sciences.

Role of N-Acetyl-Seryl-Aspartyl-Lysyl-Proline in the Antifibrotic and Anti-Inflammatory Effects of the Angiotensin-Converting Enzyme Inhibitor Captopril in Hypertension

O. Carretero, T. Liao, Hongmei Peng, 2007, Hypertension.

Isolated Arterial and Venous Vessels as Selective Pharmacological Preparations for Neurokinins

N. Rhaleb, D. Regoli, P. D'Orléans-Juste, 1987 .

Basic Science and Experimental Studies Role of a Selective Aldosterone Blocker in Mice with Chronic Heart Failure

O. Carretero, Yun-he Liu, N. Rhaleb, 2004 .

DuP 753 Is a Specific Antagonist for the Angiotensin Receptor

F. Nantel, N. Rhaleb, D. Regoli, 1991, Hypertension.

Effect of Chronic Blockade of the Kallikrein-Kinin System on the Development of Hypertension in Rats

O. Carretero, N. Rhaleb, Xiao‐ping Yang, 2001, Hypertension.

The Anti‐Inflammatory Peptide Ac‐SDKP is Released from Thymosin β4 by Meprin α and Prolyl Oligopeptidase

B. Janic, O. Carretero, N. Rhaleb, 2016, American journal of physiology. Renal physiology.

Pharmacological characterization of a new highly potent B2 receptor antagonist (HOE 140: D-Arg-[Hyp3,Thi5,D-Tic7,Qic8]bradykinin).

N. Rhaleb, D. Regoli, S. Henke, 1992, European journal of pharmacology.

Lack of Inducible NO Synthase Reduces Oxidative Stress and Enhances Cardiac Response to Isoproterenol in Mice With Deoxycorticosterone Acetate–Salt Hypertension

Ying Sun, O. Carretero, James J. Yang, 2005, Hypertension.

, Salt Hypertension − to Isoproterenol in Mice With Deoxycorticosterone Acetate Lack of Inducible NO Synthase Reduces Oxidative Stress and Enhances Cardiac Response

Ying Sun, O. Carretero, James J. Yang, 2005 .

Vasoactive peptides and their receptors.

N. Rhaleb, D. Regoli, P. D'Orléans-Juste, 1990, Blood vessels.

Conversion of kinins and their antagonists into B1 receptor activators and blockers in isolated vessels.

P. Rovero, N. Rhaleb, P. Ward, 1986, European journal of pharmacology.

Activation of sensory nerves by kinins: pharmacologic tools for studying kinin receptors.

N. Rhaleb, D. Regoli, C. Tousignant, 1991, Advances in experimental medicine and biology.

Receptors for bradykinin and related kinins: a critical analysis.

N. Rhaleb, D. Regoli, F. Gobeil, 1993, Canadian journal of physiology and pharmacology.

Vasoactive peptides and characterization of their receptors

N. Rhaleb, D. Regoli, P. D'Orléans-Juste, 1993, Regulatory Peptides.

Characterization of a novel binding site for 125I-Tyr-D-Arg-[Hyp3,D-Phe7,Leu8]bradykinin on epithelial membranes of guinea pig ileum.

G. Guillemette, N. Rhaleb, D. Regoli, 1992, European journal of pharmacology.

Kinin receptor classification.

N. Rhaleb, D. Regoli, C. Tousignant, 1992, Agents and actions. Supplements.

125I-Tyr,D-Arg[Hyp3,D-Phe7,Leu8]BK, a radiolabelled B2 antagonist specifically interacts with two distinct binding sites on epithelial membranes of guinea pig ileum.

G. Guillemette, N. Rhaleb, D. Regoli, 1992, Agents and actions. Supplements.

Structure-activity study of neurokinins: antagonists for the neurokinin-2 receptor.

E. Naline, F. Nantel, N. Rhaleb, 1990, Pharmacology.

Characterization of kinin binding sites: identity of B2 receptors in the epithelium and the smooth muscle of the guinea pig ileum.

G. Guillemette, N. Rhaleb, D. Regoli, 1991, Canadian journal of physiology and pharmacology.

Characterization of bombesin receptors in peripheral contractile organs

F. Nantel, N. Rhaleb, D. Regoli, 1991, British journal of pharmacology.

Structure‐activity studies on bradykinin and related peptides: agonists

N. Rhaleb, D. Regoli, G. Drapeau, 1990, British journal of pharmacology.

[Phe8 psi(CH2-NH)Arg9]bradykinin, a B2 receptor selective agonist which is not broken down by either kininase I or kininase II.

N. Rhaleb, D. Regoli, G. Drapeau, 1988, European journal of pharmacology.

Bradykinin antagonism: differentiation between peptide antagonists and antiinflammatory agents.

R. G. Browne, N. Rhaleb, D. Regoli, 1988, European journal of pharmacology.

Non-selectivity of new bradykinin antagonists for B1 receptors.

N. Rhaleb, D. Regoli, F. Gobeil, 1992, Life sciences.

Angiotensin II‐induced dilated cardiomyopathy in Balb/c but not C57BL/6J mice

O. Carretero, P. Harding, M. D’Ambrosio, 2011, Experimental physiology.

Interleukin 4: Its Role in Hypertension, Atherosclerosis, Valvular, and Nonvalvular Cardiovascular Diseases

N. Rhaleb, Kamal M. Kassem, Mahboob Ali, 2020, Journal of cardiovascular pharmacology and therapeutics.

Profibrotic Role for Interleukin-4 in Cardiac Remodeling and Dysfunction

B. Janic, O. Carretero, Hongmei Peng, 2015, Hypertension.

Combination Treatment With N-Acetyl-Seryl-Aspartyl-Lysyl-Proline and Tissue Plasminogen Activator Provides Potent Neuroprotection in Rats After Stroke

M. Chopp, Q. Jiang, Zhenggang Zhang, 2014, Stroke.

Neurokinin A. A pharmacological study.

N. Rhaleb, D. Regoli, C. Tousignant, 1990, Pharmacological research.

Prolyl Oligopeptidase Is Involved in Release of the Antifibrotic Peptide Ac-SDKP

M. Cavasin, O. Carretero, N. Rhaleb, 2004, Hypertension.

Effect of ACE inhibitor on DOCA-salt- and aortic coarctation-induced hypertension in mice: do kinin B2 receptors play a role?

O. Carretero, Hongmei Peng, N. Rhaleb, 1999, HYPERTENSION.

N-Acetyl–seryl–aspartyl–lysyl–proline inhibits ET-1-induced collagen production by preserving Src homology 2-containing protein tyrosine phosphatase-2 activity in cardiac fibroblasts

O. Carretero, Hongmei Peng, N. Rhaleb, 2012, Pflügers Archiv - European Journal of Physiology.

Autacoids mediate coronary vasoconstriction induced by nitric oxide synthesis inhibition.

O. Carretero, Yun-he Liu, N. Rhaleb, 1997, Journal of cardiovascular pharmacology.

Selective agonists for receptors of substance P and related neurokinins

N. Rhaleb, D. Regoli, P. D'Orléans-Juste, 1989, Biopolymers.

Characterization of neurokinin receptors in various isolated organs by the use of selective agonists.

N. Rhaleb, D. Regoli, P. D'Orléans-Juste, 1987, Life sciences.

Characterization and localization of Ac-SDKP receptor binding sites using 125I-labeled Hpp-Aca-SDKP in rat cardiac fibroblasts.

O. Carretero, X. Li, J. Zhuo, 2007, American journal of physiology. Heart and circulatory physiology.

Thymosin β4 and its degradation product, Ac-SDKP, are novel reparative factors in renal fibrosis

Li-jun Ma, O. Carretero, A. Fogo, 2013, Kidney international.

Inhibitors of peptidases: how they influence the biological activities of substance P, neurokinins, bradykinin and angiotensin in guinea pig, hamster and rat urinary bladders.

F. Nantel, N. Rhaleb, D. Regoli, 1990, Pharmacology.

N-Acetyl–seryl–aspartyl–lysyl–proline inhibits ET-1-induced collagen production by preserving Src homology 2-containing protein tyrosine phosphatase-2 activity in cardiac fibroblasts

O. Carretero, Hongmei Peng, N. Rhaleb, 2012, Pflügers Archiv - European Journal of Physiology.

The role of B1- and B2-kinin receptors in the renal tubular and hemodynamic response to bradykinin.

G. Plante, M. Lortie, N. Rhaleb, 1992, The American journal of physiology.

Angiotensin II type 2 receptor-stimulated activation of plasma prekallikrein and bradykinin release: role of SHP-1.

Xiao-Ping Yang, Colin Sumners, O. Carretero, 2012, American journal of physiology. Heart and circulatory physiology.

Echocardiographic assessment of cardiac function in conscious and anesthetized mice.

O. Carretero, Yun-he Liu, N. Rhaleb, 1999, American journal of physiology. Heart and circulatory physiology.

The kinin system: current concepts and perspectives

N. Rhaleb, D. Regoli, G. Drapeau, 1992 .

Selective agonists for substance P and neurokinin receptors

N. Rhaleb, D. Regoli, P. D'Orléans-Juste, 1987, Neuropeptides.

Structure-activity studies of neurokinin A

P. Rovero, N. Rhaleb, D. Regoli, 1989, Neuropeptides.

Antagonists for the neurokinin NK-3 receptor evaluated in selective receptor systems

F. Nantel, N. Rhaleb, D. Regoli, 1990, Regulatory Peptides.

Mammalian Neurokinins: Structure-Activity Study of the N- and C- Terminals

P. Rovero, N. Rhaleb, D. Regoli, 1987 .

Neurokinin Fragments and Analogues as Selective Activators of Receptors

P. Rovero, N. Rhaleb, D. Regoli, 1987 .

The rat isolated portal vein: a preparation sensitive to neurokinins, particularly neurokinin B.

P. Rovero, N. Rhaleb, D. Regoli, 1987, European journal of pharmacology.

The rabbit jugular vein is a contractile NK-1 receptor system.

F. Nantel, N. Rhaleb, D. Regoli, 1990, European journal of pharmacology.

Specific agonists for neurokinin B receptors.

N. Rhaleb, D. Regoli, P. D'Orléans-Juste, 1987, European journal of pharmacology.

Reduction of Cardiac Fibrosis Decreases Systolic Performance Without Affecting Diastolic Function in Hypertensive Rats

O. Carretero, Yun-he Liu, N. Rhaleb, 2004, Hypertension.

Ac-SDKP Reverses Inflammation and Fibrosis in Rats With Heart Failure After Myocardial Infarction

O. Carretero, Yun-he Liu, N. Rhaleb, 2004, Hypertension.

Deletion of interleukin-6 prevents cardiac inflammation, fibrosis and dysfunction without affecting blood pressure in angiotensin II-high salt-induced hypertension

O. Carretero, Yun-he Liu, M. D’Ambrosio, 2015, Journal of hypertension.

Pharmacological Evaluation of the Angiotensin, Kinin, and Neurokinin Receptors on the Rabbit Vena Cava

F. Nantel, N. Rhaleb, D. Regoli, 1991, Journal of cardiovascular pharmacology.

Inhibitors of peptidases: how they influence the biological activities of substance P, neurokinins, kinins and angiotensins in isolated vessels.

F. Nantel, N. Rhaleb, D. Regoli, 1990, Pharmacology.

Ac-SDKP inhibits transforming growth factor-beta1-induced differentiation of human cardiac fibroblasts into myofibroblasts.

O. Carretero, Hongmei Peng, N. Rhaleb, 2010, American journal of physiology. Heart and circulatory physiology.

Role of nNOS in blood pressure regulation in eNOS null mutant mice.

O. Carretero, N. Rhaleb, N. Kurihara, 1998, Hypertension.

N-Acetyl-Seryl-Aspartyl-Lysyl-Proline Attenuates Renal Injury and Dysfunction in Hypertensive Rats With Reduced Renal Mass: Council for High Blood Pressure Research

O. Carretero, M. D’Ambrosio, T. Liao, 2010, Hypertension.

Upregulated Expression of Rat Heart Intercellular Adhesion Molecule-1 in Angiotensin II– but Not Phenylephrine- Induced Hypertension

O. Carretero, N. Rhaleb, P. Pagano, 2001, Hypertension.

Deletion of Inducible Nitric Oxide Synthase Provides Cardioprotection in Mice With 2-Kidney, 1-Clip Hypertension

Ying Sun, O. Carretero, James J. Yang, 2009, HYPERTENSION.

Role of a selective aldosterone blocker in mice with chronic heart failure.

O. Carretero, Yun-he Liu, N. Rhaleb, 2004, Journal of cardiac failure.

Role of Kinins in Hypertension and Heart Failure

N. Rhaleb, Kamal M. Kassem, Imane A. Rhaleb, 2020, Pharmaceuticals.

Angiotensin-Converting Enzyme Inhibitors: A New Mechanism of Action

A. Motivala, O. Carretero, T. Liao, 2005, Circulation.

Role of the B1 Kinin Receptor in the Regulation of Cardiac Function and Remodeling After Myocardial Infarction

O. Carretero, James J. Yang, M. Bader, 2005, Hypertension.

N-acetyl-Ser-Asp-Lys-Pro inhibits interleukin-1β-mediated matrix metalloproteinase activation in cardiac fibroblasts

O. Carretero, P. Harding, Hongmei Peng, 2013, Pflügers Archiv - European Journal of Physiology.

Receptors for kinins in isolated arterial vessels of dogs.

N. Rhaleb, D. Regoli, G. Drapeau, 1989, European journal of pharmacology.

Non-selectivity of new bradykinin antagonists for B1 receptors.

N. Rhaleb, D. Regoli, F. Gobeil, 1992, Life Science.

N-Acetyl-Seryl-Aspartyl-Lysyl-Proline: mechanisms of renal protection in mouse model of systemic lupus erythematosus.

B. Janic, O. Carretero, M. D’Ambrosio, 2015, American journal of physiology. Renal physiology.

Prevention of aortic fibrosis by N-acetyl-seryl-aspartyl-lysyl-proline in angiotensin II-induced hypertension.

O. Carretero, M. D’Ambrosio, T. Liao, 2008, American journal of physiology. Heart and circulatory physiology.

Effects of Angiotensin-Converting Enzyme Inhibitor and Angiotensin Type 1 Receptor Antagonist in Deoxycorticosterone Acetate–Salt Hypertensive Mice Lacking Ren-2 Gene

O. Carretero, Hongmei Peng, N. Rhaleb, 2001, Hypertension.

Echocardiographic assessment of cardiac function in conscious and anesthetized mice.

Xiao-Ping Yang, O. Carretero, Yun-he Liu, 1999, American journal of physiology. Heart and circulatory physiology.

Receptors for Neurokinins, Tachykinins, and Bombesin: A Pharmacological Study a

N. Rhaleb, D. Regoli, P. D'Orléans-Juste, 1988 .

Role of B1 and B2 receptors and of nitric oxide in bradykinin-induced relaxation and contraction of isolated rat duodenum.

O. Carretero, N. Rhaleb, 1994, Life sciences.

and Function in Hypertensive Rats Reduction of Cardiac Fibrosis Decreases Systolic Performance Without Affecting Diastolic

O. Carretero, Yun-he Liu, N. Rhaleb, 2004 .

Ren-2 Gene Salt Hypertensive Mice Lacking − Antagonist in Deoxycorticosterone Acetate Effects of Angiotensin-converting Enzyme Inhibitor and Angiotensin Type 1 Receptor

O. Carretero, Hongmei Peng, N. Rhaleb, 2022 .

Cardiac-deleterious role of galectin-3 in chronic angiotensin II-induced hypertension.

B. Janic, O. Carretero, Yun-he Liu, 2016, American journal of physiology. Heart and circulatory physiology.

Ac-SDKP attenuates ER stress-stimulated collagen production in cardiac fibroblasts by inhibiting CHOP-mediated NF-κB expression

Hongmei Peng, N. Rhaleb, Hamid Suhail, 2024, Frontiers in Pharmacology.

The anti-inflammatory peptide Ac-SDKP is released from thymosin-β4 by renal meprin-α and prolyl oligopeptidase.

J. Shaw, B. Janic, E. Ongeri, 2016, American journal of physiology. Renal physiology.

Ac-SDKP inhibits transforming growth factor-beta1-induced differentiation of human cardiac fibroblasts into myofibroblasts.

O. Carretero, Hongmei Peng, N. Rhaleb, 2010, American journal of physiology. Heart and circulatory physiology.

N-acetyl-Ser-Asp-Lys-Pro inhibits interleukin-1β-mediated matrix metalloproteinase activation in cardiac fibroblasts

O. Carretero, P. Harding, Hongmei Peng, 2013, Pflügers Archiv - European Journal of Physiology.

Interleukin‐1β Disruption Protects Male Mice From Heart Failure With Preserved Ejection Fraction Pathogenesis

S. Belmadani, K. Matrougui, N. Rhaleb, 2023, Journal of the American Heart Association.

Deletion of Inducible Nitric Oxide Synthase Provides Cardioprotection in Mice With 2-Kidney, 1-Clip Hypertension

Ying Sun, O. Carretero, James J. Yang, 2009, Hypertension.

The kinin B1 receptor contributes to the cardioprotective effect of angiotensin‐converting enzyme inhibitors and angiotensin receptor blockers in mice

O. Carretero, M. Bader, N. Rhaleb, 2009, Experimental physiology.

Basic pharmacology of kinins: pharmacologic receptors and other mechanisms.

P. Devillier, N. Rhaleb, D. Regoli, 1989, Advances in experimental medicine and biology.