T. Hünig

R. Abe, Xiao‐Kang Li, S. Takahara, 2008, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

Autonomous induction of proliferation, JNK and NF‐κB activation in primary resting T cells by mobilized CD28

T. Hünig, A. Beyers, T. Hara, 2000, European journal of immunology.

A Superagonistic Monoclonal Antibody for CD28 Ameliorates Crescentic Glomerulonephritis in Wistar-Kyoto Rats

H. Rakugi, Xiao‐Kang Li, S. Takahara, 2011, Molecular medicine.

Efficient expansion of regulatory T cells in vitro and in vivo with a CD 28

T. Hünig, S. Lin, 2003 .

Efficient expansion of regulatory T cells in vitro and in vivo with a CD28 superagonist

T. Hünig, Chia‐Huey Lin, 2003, European journal of immunology.

TCR Repertoire Th17 and Regulatory T Cells and an Altered Critically Linked to an Imbalance between Type 1 Diabetes in BioBreeding Rats Is

H. Reichardt, L. Walter, I. Klöting, 2010 .

T cells respond preferentially to antigens that are similar to self H-2.

M. Bevan, T. Hünig, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Impaired survival of T cell receptor Vγ3+ cells in interleukin‐4 transgenic mice

T. Hanke, T. Hünig, A. Schimpl, 1995 .

Antigen recognition by cloned cytotoxic T lymphocytes follows rules predicted by the altered-self hypothesis

M. Bevan, T. Hünig, T. Hünig, 1982, The Journal of experimental medicine.

Short‐term cytokine stimulation reveals regulatory T cells with down‐regulated Foxp3 expression in human peripheral blood

I. T. Ten Berge, P. Tabares, B. Sawitzki, 2018, European journal of immunology.

Regulatory T cells facilitate the nuclear accumulation of inducible cAMP early repressor (ICER) and suppress nuclear factor of activated T cell c1 (NFATc1)

T. Sparwasser, F. Berberich-Siebelt, E. Serfling, 2011, Proceedings of the National Academy of Sciences.

Foxp3+ Regulatory T Cells Control Persistence of Viral CNS Infection

T. Sparwasser, T. Hünig, J. Schneider-Schaulies, 2012, PloS one.

Sequential Induction of Effector Function, Tissue Migration and Cell Death during Polyclonal Activation of Mouse Regulatory T-Cells

S. Kneitz, M. Lutz, T. Gogishvili, 2012, PloS one.

Ligation of the CD4 receptor induces activation-independent down-regulation of L-selectin.

B. Freiberg, A. Kupfer, T. Hünig, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Polyclonal expansion of regulatory T cells interferes with effector cell migration in a model of multiple sclerosis.

R. Gold, A. Weishaupt, K. Toyka, 2006, Brain : a journal of neurology.

Inhibition of Notch signaling biases rat thymocyte development towards the NK cell lineage

M. Wolfe, M. Schott, H. Reichardt, 2004, European journal of immunology.

Monoclonal anti-Lyt-2.2 antibody blocks lectin-dependent cellular cytotoxicity of H-2-negative target cells

T. Hünig, Dr. K. Fischer-Lindahi, 1984, The Journal of experimental medicine.

Induction of T regulatory cells by the superagonistic anti‐CD28 antibody D665 leads to decreased pathogenic IgG autoantibodies against desmoglein 3 in a HLA‐transgenic mouse model of pemphigus vulgaris

R. Eming, G. Sønderstrup, M. Hertl, 2016, Experimental dermatology.

CD8+ T cell help is required for efficient induction of EAE in Lewis rats

A. Weishaupt, K. Toyka, H. Reichardt, 2013, Journal of Neuroimmunology.

Antigen-Specific Blockade of Lethal CD8 T-Cell Mediated Autoimmunity in a Mouse Model of Multiple Sclerosis1

H. Wiendl, S. Meuth, S. Na, 2009, The Journal of Immunology.

Cellular distribution and costimulatory function of rat CD28. Regulated expression during thymocyte maturation and induction of cyclosporin A sensitivity of costimulated T cell responses by phorbol ester.

M. Dallman, T. Hünig, G. Clark, 1995, Journal of immunology.

Encephalitogenic, myelin basic protein‐specific T cells from naive rat thymus: preferential use of the T cell receptor gene Vβ8.2 and expression of the CD4− CD8− phenotype

H. Wekerle, T. Hünig, J. Gehrmann, 1995, European journal of immunology.

Impaired survival of T cell receptor V gamma 3+ cells in interleukin-4 transgenic mice.

T. Hanke, G. Stingl, T. Hünig, 1995, European journal of immunology.

Interruption of CD28-mediated costimulation during allergen challenge protects mice from allergic airway disease.

S. Goebbels, S. Beer-Hammer, K. Pfeffer, 2012, The Journal of allergy and clinical immunology.

T-cell function and specificity in athymic mice

T. Hünig, 1983 .

Tolerance Induction by Intrathymic Expression of P01

R. Gold, A. Weishaupt, K. Toyka, 2004, The Journal of Immunology.

Inducible Deletion of CD28 Prior to Secondary Nippostrongylus brasiliensis Infection Impairs Worm Expulsion and Recall of Protective Memory CD4+ T Cell Responses

F. Brombacher, T. Hünig, W. Horsnell, 2014, PLoS pathogens.

Targeting of the WT191–138 fragment to human dendritic cells improves leukemia-specific T-cell responses providing an alternative approach to WT1-based vaccination

D. Weisenberger, H. Einsele, H. Wajant, 2017, Cancer Immunology, Immunotherapy.

The cell surface molecule recognized by the erythrocyte receptor of T lymphocytes. Identification and partial characterization using a monoclonal antibody

T. Hünig, 1985, The Journal of experimental medicine.

This information is current as Expression of P 0 Tolerance Induction by Intrathymic GoldH

Ralf, A. Weishaupt, K. Toyka, 2004 .

Regulatory T Cells Ameliorate Intrauterine Growth Retardation in a Transgenic Rat Model for Preeclampsia

G. Wallukat, F. Luft, R. Dechend, 2015, Hypertension.

Specificity of T-cell clones illustrates altered self hypothesis

M. Bevan, T. Hünig, 1981, Nature.

Superagonistic CD28 stimulation of allogeneic T cells protects from acute graft-versus-host disease.

T. Hünig, N. Beyersdorf, T. Kerkau, 2009, Blood.

The role of CD2/LFA-3 interaction in antigen- and mitogen-induced activation of human T cells.

T. Hünig, G. Tiefenthaler, 1989, International immunology.

Cross‐linking of the T cell antigen receptor interferes with the generation of CD4+8+ thymocytes from their immediate CD4−8+ precursors

T. Hünig, 1988, European journal of immunology.

The role of accessory cells in polyclonal T cell activation III. No requirement for recognition of H‐2‐encoded antigens on accessory cells

T. Hünig, 1984, European journal of immunology.

Protection of Mice from Acute Graft-versus-Host Disease Requires CD28 Co-stimulation on Donor CD4+ Foxp3+ Regulatory T Cells

T. Hünig, N. Beyersdorf, F. Lühder, 2017, Front. Immunol..

CD28 and IL-4: two heavyweights controlling the balance between immunity and inflammation

F. Brombacher, R. Guler, A. Cutler, 2010, Medical Microbiology and Immunology.

Abnormal thymocyte development and generation of autoreactive T cells in mixed and cortical thymomas.

H. Müller-Hermelink, A. Marx, R. Nenninger, 1998, Laboratory investigation; a journal of technical methods and pathology.

Proliferative signals mediated by CD28 superagonists require the exchange factor Vav1 but not phosphoinositide 3‐kinase in primary peripheral T cells

K. Okkenhaug, T. Gogishvili, T. Hünig, 2008, European journal of immunology.

Identification and characterization of rat gamma/delta T lymphocytes in peripheral lymphoid organs, small intestine, and skin with a monoclonal antibody to a constant determinant of the gamma/delta T cell receptor.

T. Hünig, T. Herrmann, J. H. Park, 1994, Journal of immunology.

Control of the rat T cell response to retroviral and bacterial superantigens by class II MHC products and Tcrb-V8.2 alleles.

B. Huber, T. Hünig, T. Herrmann, 1994, Journal of immunology.

Analysis of CD3 and antigen receptor expression on T cell subpopulations of aged athymic mice

T. Hünig, A. Lawetzky, 1988, European journal of immunology.

site-specific mouse anti-mouse CD28 mAb Protection from graft versus host disease with a novel B7 binding

G. Blank, T. Hünig, K. Dennehy, 2013 .

mouse CD28 monoclonal antibody - specific mouse anti - Protection from graft-versus-host disease with a novel B7 binding site

G. Blank, T. Hünig, K. Dennehy, 2013 .

CD28 superagonist-induced regulatory T cell expansion ameliorates mesangioproliferative glomerulonephritis in rats

H. Kawachi, H. Rakugi, Xiao‐Kang Li, 2011, Clinical and Experimental Nephrology.

Protection from graft-versus-host disease with a novel B7 binding site-specific mouse anti-mouse CD28 monoclonal antibody.

G. Blank, T. Hünig, K. Dennehy, 2008, Blood.

Protection from graft versus host disease with a novel B7 binding site-specific mouse anti-mouse CD28 mAb Short title: Immunotherapy with novel mouse anti-mouse CD28 mAb

G. Blank, T. Hünig, K. Dennehy, 2008 .

Self H-2 antigens influence the specificity of alloreactive cells

M. Bevan, T. Hünig, T. Hünig, 1980, The Journal of experimental medicine.

Prolonged allograft survival but no tolerance induction by modulating CD28 antibody JJ319 after high-responder rat heart transplantation.

C. Vahl, G. Szabo, B. Sido, 1999, Transplantation.

From TGN 1412 to TAB 08 : the return of CD 28 superagonist therapy to clinical development for the treatment of rheumatoid arthritis

P. Tabares, T. Hünig, A. Matskevich, 2016 .

Ligation of human CD4 interferes with antigen-induced activation of primary T cells.

J. Cambier, T. Hünig, T. Finkel, 2002, Immunology letters.

Neutral glycosphingolipids of murine myeloma cells and helper, cytolytic, and suppressor T lymphocytes.

P. Mühlradt, T. Hünig, F. Fitch, 1983, Biochemistry.

Hsp90 inhibition ameliorates CD4+ T cell‐mediated acute Graft versus Host disease in mice

H. Einsele, T. Hünig, N. Beyersdorf, 2016, Immunity, inflammation and disease.

Abnormal T Lymphocyte Development in Myasthenia Gravis-Associated Thymomas

H. Müller-Hermelink, A. Marx, R. Nenninger, 1997 .

γ/δ Cells in Fetal, Neonatal, and Adult Rat Lymphoid Organs

A. Zapata, A. Varas, Á. Vicente, 1995, Developmental immunology.

Specificity of cytotoxic T cells from athymic mice

M. Bevan, T. Hünig, T. Hünig, 1980, The Journal of experimental medicine.

Restricted expression of CD2 among subsets of sheep thymocytes and T lymphocytes.

M. Miyasaka, T. Hünig, G. Giegerich, 1989, Immunology.

The role of accessory cells in polyclonal T cell activation II. Induction of interleukin 2 responsiveness requires cell‐cell contact

T. Hünig, 1983, European journal of immunology.

Gamma delta T cells down-regulate primary IgE responses in rats to inhaled soluble protein antigens.

P. Holt, T. Hünig, C. Mcmenamin, 1995, Journal of immunology.

From TGN1412 to TAB08: the return of CD28 superagonist therapy to clinical development for the treatment of rheumatoid arthritis.

P. Tabares, T. Hünig, A. Matskevich, 2016, Clinical and experimental rheumatology.

The role of accessory cells in polyclonal T cell activation. I. Both induction of interleukin 2 production and of interleukin 2 responsiveness by concanavalin A are accessory cell dependent

T. Hünig, A. Schimpl, M. Loos, 1983, European journal of immunology.

Clinical validation of a novel enzyme‐linked immunosorbent spot assay‐based in vitro diagnostic assay to monitor cytomegalovirus‐specific cell‐mediated immunity in kidney transplant recipients: a multicenter, longitudinal, prospective, observational study

B. Banas, R. Wagner, C. Sommerer, 2018, Transplant international : official journal of the European Society for Organ Transplantation.

T11TS, the cell surface molecule binding to the “erythrocyte receptor” of T lymphocytes: cellular distribution, purification to homogeneity and biochemical properties

M. Miyasaka, T. Hünig, R. Mitnacht, 1986, European journal of immunology.

Cyclic AMP underpins suppression by regulatory T cells

H. Schild, E. Serfling, E. Schmitt, 2012, European journal of immunology.

Induction of proliferative and cytotoxic responses in resting Lyt‐2+ T cells with lectin and recombinant interleukin 2

T. Hünig, H. Vohr, 1985, European journal of immunology.

MEK Activity Regulates Negative Selection of Immature CD4+CD8+ Thymocytes1

U. Bommhardt, Y. Scheuring, R. Zamoyska, 2000, The Journal of Immunology.

Control of TCR V alpha-mediated positive repertoire selection and alloreactivity by differential J alpha usage and CDR3 alpha composition.

A. Deutschländer, T. Hünig, B. Arden, 1997, International immunology.

Control of TCR V α-mediated positive repertoire selection and alloreactivity by differential J α usage and CDR 3 α composition

A. Deutschländer, T. Hünig, B. Arden, 1997 .

Expansion of regulatory T cells by CD28 superagonistic antibodies attenuates neurodegeneration in A53T-α-synuclein Parkinson’s disease mice

J. Volkmann, J. Brotchie, M. Lutz, 2022, Journal of Neuroinflammation.

Selective targeting of regulatory T cells with CD28 superagonists allows effective therapy of experimental autoimmune encephalomyelitis

R. Gold, K. Toyka, T. Hanke, 2005, The Journal of experimental medicine.

Control of T cell hyperactivation in IL‐2‐deficient mice by CD4+CD25– and CD4+CD25+ T cells: evidence for two distinct regulatory mechanisms

T. Hünig, A. Schimpl, M. Wolf, 2001, European journal of immunology.

Superagonistic CD28 Antibody Induces Donor‐Specific Tolerance in Rat Renal Allografts

Y. Kitazawa, Y. Isaka, T. Hünig, 2008, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Serologic cross-reactivity of T11 target structure and lymphocyte function-associated antigen 3. Evidence for structural homology of the sheep and human ligands of CD2.

Michael Loran Dustin, T. Springer, T. Hünig, 1987, Journal of immunology.

Crystal structure of a soluble CD28-Fab complex

D. Stuart, R. Esnouf, T. Hanke, 2005, Nature Immunology.

The storm has cleared: lessons from the CD28 superagonist TGN1412 trial

T. Hünig, 2012, Nature Reviews Immunology.

A Th17‐like developmental process leads to CD8+ Tc17 cells with reduced cytotoxic activity

M. Huber, H. Mittrücker, Sylvia Heink, 2009, European journal of immunology.

Collateral neuronal apoptosis in CNS gray matter during an oligodendrocyte‐directed CD8+ T cell attack

H. Wiendl, S. Meuth, S. Bittner, 2009, Glia.

Topological Requirements and Signaling Properties of T Cell–activating, Anti-CD28 Antibody Superagonists

T. Hanke, I. Müller, T. Hünig, 2003, The Journal of experimental medicine.

Immature dendritic cells convert anergic nonregulatory T cells into Foxp3−IL‐10+ regulatory T cells by engaging CD28 and CTLA‐4

F. Berberich-Siebelt, M. Lutz, Theresa Schneider, 2015, European journal of immunology.

The ligand of the erythrocyte receptor of T lymphocytes: expression on white blood cells and possible involvement in T cell activation.

T. Hünig, 1986, Journal of immunology.

Triggering of T cell proliferation through CD28 induces GATA‐3 and promotes T helper type 2 differentiation in vitro and in vivo

T. Hünig, M. Rodríguez‐Palmero, T. Hara, 1999 .

High-density preculture of PBMCs restores defective sensitivity of circulating CD8 T cells to virus- and tumor-derived antigens.

S. Stevanović, C. Scholz, S. Hackenberg, 2015, Blood.

Manipulation of regulatory T-cell number and function with CD28-specific monoclonal antibodies.

T. Hünig, 2007, Advances in immunology.

Type 1 Diabetes in BioBreeding Rats Is Critically Linked to an Imbalance between Th17 and Regulatory T Cells and an Altered TCR Repertoire

H. Reichardt, L. Walter, I. Klöting, 2010, The Journal of Immunology.

Combination of donor-specific blood transfusion with anti-CD28 antibody synergizes to prolong graft survival in rat liver transplantation.

D. Ostanin, M. Grisham, T. Hünig, 2006, Transplantation proceedings.

Sequence and diversity of rat T-cell receptor Tcra V8 gene segments

K. Toyka, M. Stangel, T. Hünig, 2004, Immunogenetics.

Purified lymphocyte function‐associated antigen‐3 and T11 target structure are active in CD2‐mediated T cell stimulation

Michael Loran Dustin, T. Springer, S. Meuer, 1987, European journal of immunology.

Isolation, biochemical analysis, and N-terminal amino acid sequence of a cell surface glycoprotein that binds to the "erythrocyte receptor" of T-lymphocytes.

F. Lottspeich, T. Hünig, R. Mitnacht, 1987, Haematology and blood transfusion.

The "erythrocyte receptor" of T-lymphocytes and T11 target structure (T11TS): complementary cell interaction molecules involved in T-cell activation.

F. Lottspeich, S. Meuer, T. Hünig, 1987, Behring Institute Mitteilungen.

Suppression and prevention of adjuvant arthritis in rats by a monoclonal antibody to the alpha/beta T cell receptor.

F. Emmrich, R. Kinne, S. Yoshino, 1990, European journal of immunology.

In vivo activation of Treg cells with a CD28 superagonist prevents and ameliorates chronic destructive arthritis in mice

A. Kühl, T. Kamradt, T. Sparwasser, 2016, European journal of immunology.

Induction of interleukin 2 receptor beta chain expression by self- recognition in the thymus

T. Hanke, T. Hünig, R. Boyd, 1994, The Journal of experimental medicine.

Primate testing of TGN1412: right target, wrong cell

M. Pallardy, T. Hünig, 2010, British journal of pharmacology.

Superagonist CD28 antibody preferentially expanded Foxp3-expressing nTreg cells and prevented graft-versus-host diseases.

N. Ichimaru, N. Nonomura, Xiao‐Kang Li, 2009, Cell transplantation.

In vitro polyclonal activation of conventional T cells with a CD28 superagonist protects mice from acute graft versus host disease

T. Hünig, N. Beyersdorf, T. Kerkau, 2015, European journal of immunology.

Rapid Regulatory T-Cell Response Prevents Cytokine Storm in CD28 Superagonist Treated Mice

R. Gold, T. Gogishvili, T. Hünig, 2009, PloS one.

The rise and fall of the CD28 superagonist TGN1412 and its return as TAB08: a personal account

T. Hünig, 2016, The FEBS journal.

T cells produce TRF in response to Con A and factors in T cell hybridoma supernatants.

D. Raulet, T. Hünig, D. Parker, 1982, Journal of Immunology.

Response to 'Storm forecasting: additional lessons from the CD28 superagonist TGN1412 trial'

T. Hünig, 2012, Nature Reviews Immunology.

Large‐scale expansion of rat CD4+ CD25+ Treg cells in the absence of T‐cell receptor stimulation

T. Hünig, N. Beyersdorf, T. Kerkau, 2006, Immunology.

Anti-protease and Immunomodulatory Activities of Bacteria Associated with Caribbean Sponges

P. Tabares, U. Hentschel, T. Schirmeister, 2011, Marine Biotechnology.

Proliferation of endogenous regulatory T cells improve the pathophysiology associated with placental ischaemia of pregnancy

G. Wallukat, R. Dechend, L. Amaral, 2017, American journal of reproductive immunology.

Treatment of Arthritis in Lewis Rats by a Monoclonal Antibody against αβ T Cell Receptor: Differential Sensitivity of Yersinia-Induced Arthritis versus Adjuvant Arthritis

J. Heesemann, T. Hünig, K. Gaede, 1995 .

The T cell-selective IL-2 mutant AIC284 mediates protection in a rat model of Multiple Sclerosis

A. Weishaupt, T. Hünig, N. Beyersdorf, 2015, Journal of Neuroimmunology.

Cell Contact–Dependent Priming and Fc Interaction with CD32+ Immune Cells Contribute to the TGN1412-Triggered Cytokine Response

J. Castle, P. Tabares, V. Boisguérin, 2014, The Journal of Immunology.

Direct Binding of the pH-Regulated Protein 1 (Pra1) from Candida albicans Inhibits Cytokine Secretion by Mouse CD4+ T Cells

T. Hughes, P. Zipfel, A. Brakhage, 2017, Front. Microbiol..

CD28 superagonists put a break on autoimmunity by preferentially activating CD4+CD25+ regulatory T cells.

T. Hanke, T. Hünig, N. Beyersdorf, 2006, Autoimmunity reviews.

The secreted Candida albicans protein Pra1 disrupts host defense by broadly targeting and blocking complement C3 and C3 activation fragments

A. Hartmann, P. Zipfel, C. Skerka, 2018, Molecular immunology.

Expression of T-Cell Receptor β-Chain mRNA and Protein in γ/δ T-Cells from Euthymic and Athymic Rats: Implications for T-Cell Lineage Divergence

Jung-Hyun Park, T. Hünig, A. Bischof, 2000, Developmental Immunology.

Alleles of highly homologous rat T cell receptor beta-chain variable segments 8.2 and 8.4: strain-specific expression, reactivity to superantigens, and binding of the mAb R78.

T. Hünig, T. Herrmann, K. Hofmann, 1996, Journal of immunology.

Preferential TCR V usage in rat repertoire selection: V alpha 8 imparts both positive thymic selection by and alloreactivity to RT1f.

T. Hünig, T. Herrmann, N. Torres-Nagel, 1994, International immunology.

Structural analysis of the rat T-cell receptor Tcra V4 gene family

M. Stangel, T. Hünig, N. Torres-Nagel, 2004, Immunogenetics.

Taking the thymus to pieces.

B. Kyewski, T. Hünig, 1992, Immunology today.

Triggering of T cell proliferation through CD28 induces GATA‐3 and promotes T helper type 2 differentiation in vitro and in vivo

T. Hünig, M. Rodríguez‐Palmero, T. Hara, 1999, European journal of immunology.

Superagonistic anti-CD28 antibodies: potent activators of regulatory T cells for the therapy of autoimmune diseases

T. Hanke, T. Hünig, N. Beyersdorf, 2005, Annals of the rheumatic diseases.

Investigation of the immunosuppressive potential of anti-CD28 antibodies for selective inhibition of the T-cell mediated alloresponse.

S. Feuerlein, T. Hünig, K. Ulrichs, 2002, Transplantation proceedings.

A novel multicolor immunostaining method using ethynyl deoxyuridine for analysis of in situ immunoproliferative response

Y. Kitazawa, T. Hünig, K. Matsuno, 2015, Histochemistry and Cell Biology.

Molecular and cellular mechanisms of T Cell development

T. Hünig, U. Bommhardt, H. Reichardt, 2004, Cellular and Molecular Life Sciences CMLS.

T-cell subpopulations expressing distinct forms of the TCR in normal, athymic, and neonatally TCR alpha beta-suppressed rats.

R. Kubo, T. Hünig, G. Tiefenthaler, 1989, Cold Spring Harbor symposia on quantitative biology.

Regulatory T Cells Ameliorate Intrauterine Growth Retardation in a Transgenic Rat Model for Preeclampsia

G. Wallukat, F. Luft, R. Dechend, 2015, HYPERTENSION.

Human regulatory T cells are selectively activated by low‐dose application of the CD28 superagonist TGN1412/TAB08

H. Einsele, P. Tabares, H. Tony, 2014, European journal of immunology.

Autonomous induction of proliferation, JNK and NF‐κB activation in primary resting T cells by mobilized CD28

T. Hünig, A. Beyers, T. Hara, 2000 .

Ident i f icat ion and Partial Character izat ion Using a Monoclonal An t ibody

T. Hünig, 2003 .