K. Kosai

发表

Acceleration of the Healing Process and Myocardial Regeneration May Be Important as a Mechanism of Improvement of Cardiac Function and Remodeling by Postinfarction Granulocyte Colony–Stimulating Factor Treatment

M. Arai, G. Takemura, S. Minatoguchi, 2004, Circulation.

Alterations of Gene Expression and Glutamate Clearance in Astrocytes Derived from an MeCP2-Null Mouse Model of Rett Syndrome

T. Matsuishi, Y. Okabe, Tomoyuki Takahashi, 2012, PloS one.

Adenoviral-mediated herpes simplex virus-thymidine kinase gene transfer in vivo for treatment of experimental human melanoma.

B. Bonnekoh, T. Krieg, R. Roop, 1996, The Journal of investigative dermatology.

Identification and isolation of embryonic stem cell-derived target cells by adenoviral conditional targeting.

H. Ushikoshi, G. Takemura, T. Kunisada, 2006, Molecular therapy : the journal of the American Society of Gene Therapy.

Efficient cardiomyogenic differentiation of embryonic stem cell by fibroblast growth factor 2 and bone morphogenetic protein 2.

H. Ushikoshi, H. Fujiwara, Tomoyuki Takahashi, 2004, Circulation journal : official journal of the Japanese Circulation Society.

Novel Lentiviral Vectors Target Tumorigenic Cells

Stuart P. Atkinson, K. Kosai, 2018 .

Combined therapy with cardioprotective cytokine administration and antiapoptotic gene transfer in postinfarction heart failure.

G. Takemura, S. Minatoguchi, H. Fujiwara, 2009, American journal of physiology. Heart and circulatory physiology.

Infarct Tissue Dynamics and Attenuates Left Ventricular Remodeling and Heart Failure Signal Modulates β Postinfarction Gene Therapy Against Transforming Growth

G. Takemura, S. Minatoguchi, H. Fujiwara, 2005 .

Postinfarction Gene Therapy Against Transforming Growth Factor-β Signal Modulates Infarct Tissue Dynamics and Attenuates Left Ventricular Remodeling and Heart Failure

G. Takemura, S. Minatoguchi, H. Fujiwara, 2005 .

Critical Roles for the Fas/Fas Ligand System in Postinfarction Ventricular Remodeling and Heart Failure

G. Takemura, S. Minatoguchi, H. Fujiwara, 2004, Circulation research.

Postinfarction Treatment With an Adenoviral Vector Expressing Hepatocyte Growth Factor Relieves Chronic Left Ventricular Remodeling and Dysfunction in Mice

H. Mizuguchi, G. Takemura, S. Minatoguchi, 2003, Circulation.

Gene therapy for hepatocellular carcinoma: long-term remission of primary and metastatic tumors in mice by interleukin-2 gene therapy in vivo.

S. Woo, M. Finegold, K. Kosai, 1996, Gene therapy.

Genetic Modification of Hepatocytes towards Hepatocyte Transplantation and Liver Tissue Engineering

G. Bumgardner, K. Ohashi, K. Kosai, 2006, Cell transplantation.

Genetic modification of hepatocytes towards hepatocyte transplantation and liver tissue engineering.

G. Bumgardner, K. Ohashi, K. Kosai, 2006, Cell transplantation.

Cell cycle-specific changes in hTERT promoter activity in normal and cancerous cells in adenoviral gene therapy: a promising implication of telomerase-dependent targeted cancer gene therapy.

T. Matsuishi, H. Fujiwara, Tomoyuki Takahashi, 2006, International journal of oncology.

Local overexpression of HB-EGF exacerbates remodeling following myocardial infarction by activating noncardiomyocytes

H. Ushikoshi, G. Takemura, S. Minatoguchi, 2005, Laboratory Investigation.

Hepatocyte growth factor prevents endotoxin‐induced lethal hepatic failure in mice

Toshikazu Nakamura, Kunio Matsumoto, K. Kosai, 1999, Hepatology.

Combination therapy with suicide and cytokine genes for hepatic metastases of lung cancer.

Y. Kwong, S. Woo, Shu-Hsia Chen, 1997, Chest.

Molecular mechanisms of non-apoptosis by Fas stimulation alone versus apoptosis with an additional actinomycin D in cultured cardiomyocytes.

T. Aoyama, G. Takemura, S. Minatoguchi, 2002, Cardiovascular research.

Powerful and controllable angiogenesis by using gene-modified cells expressing human hepatocyte growth factor and thymidine kinase.

S. Ogawa, K. Fukuda, Toshikazu Nakamura, 2004, Journal of the American College of Cardiology.

Intravenous Administration of Endothelial Colony‐Forming Cells Overexpressing Integrin β1 Augments Angiogenesis in Ischemic Legs

I. Kawamura, H. Ushikoshi, M. Kawasaki, 2016, Stem cells translational medicine.

In vivo hepatic HB-EGF gene transduction inhibits Fas-induced liver injury and induces liver regeneration in mice: a comparative study to HGF.

H. Ushikoshi, H. Fujiwara, N. C. Khai, 2006, Journal of hepatology.

Hepatocyte Growth Factor Gene Therapy Slows Down the Progression of Diabetic Nephropathy in db/db Mice

G. Takemura, H. Fujiwara, Tomoyuki Takahashi, 2003, Nephron Physiology.

Efficacy of autologous fat injection laryngoplasty with an adenoviral vector expressing hepatocyte growth factor in a canine model

T. Nakashima, H. Umeno, K. Sato, 2009, The Journal of Laryngology & Otology.

Treatment with an adenoviral vector encoding hepatocyte growth factor mitigates established cardiac dysfunction in doxorubicin-induced cardiomyopathy.

H. Ushikoshi, G. Takemura, S. Minatoguchi, 2008, American journal of physiology. Heart and circulatory physiology.

In vivo hepatocyte growth factor gene transfer reduces myocardial ischemia-reperfusion injury through its multiple actions.

M. Arai, S. Yasuda, H. Ushikoshi, 2007, Journal of cardiac failure.

Anti-Fas gene therapy prevents doxorubicin-induced acute cardiotoxicity through mechanisms independent of apoptosis.

K. Nishigaki, G. Takemura, S. Minatoguchi, 2010, The American journal of pathology.

Postinfarction gene therapy against transforming growth factor-beta signal modulates infarct tissue dynamics and attenuates left ventricular remodeling and heart failure.

G. Takemura, S. Minatoguchi, H. Fujiwara, 2004, Circulation.

Disturbance of cardiac gene expression and cardiomyocyte structure predisposes Mecp2-null mice to arrhythmias

T. Matsuishi, M. Takano, G. Takemura, 2015, Scientific Reports.

Heparin-binding epidermal growth factor-like growth factor and hepatocyte growth factor inhibit cholestatic liver injury in mice through different mechanisms

N. C. Khai, K. Kosai, H. Matsufuji, 2016, International journal of molecular medicine.

Bone marrow-derived myocyte-like cells and regulation of repair-related cytokines after bone marrow cell transplantation.

M. Arai, G. Takemura, S. Minatoguchi, 2006, Cardiovascular research.

APPLICATION OF AN ADENOVIRAL VECTOR ENCODING SOLUBLE TRANSFORMING GROWTH FACTOR‐β TYPE II RECEPTOR TO THE TREATMENT OF DIABETIC NEPHROPATHY IN MICE

G. Takemura, S. Minatoguchi, H. Fujiwara, 2008, Clinical and experimental pharmacology & physiology.

Combination gene therapy for liver metastasis of colon carcinoma in vivo.

X. -. Chen, S. Woo, M. Finegold, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Conditionally replicating adenovirus prevents pluripotent stem cell–derived teratoma by specifically eliminating undifferentiated cells

K. Mitsui, K. Kosai, Kanako Ide, 2015, Molecular therapy. Methods & clinical development.

Survivin-responsive conditionally replicating adenovirus kills rhabdomyosarcoma stem cells more efficiently than their progeny

S. Natsugoe, K. Mitsui, K. Kosai, 2014, Journal of Translational Medicine.

588. Hepatic HB-EGF (Heparin-Binding EGF-Like Growth Factor) Gene Therapy for Fulminant Hepatic Failure in Mice: More Potent Protective and Mitogenic Effects for Hepatocytes Than HGF (Hepatocyte Growth Factor)

N. C. Khai, Tomoyuki Takahashi, K. Kosai, 2006 .

An optimal therapeutic expression level is crucial for suicide gene therapy for hepatic metastatic cancer in mice

K. Shirouzu, Z. Guo, K. Kosai, 2003, Hepatology.

Neural development of methyl-CpG-binding protein 2 null embryonic stem cells: A system for studying Rett syndrome

H. Higashi, T. Matsuishi, Y. Okabe, 2010, Brain Research.

A Novel Construction of Lentiviral Vectors for Eliminating Tumorigenic Cells from Pluripotent Stem Cells

K. Mitsui, K. Kosai, Kanako Ide, 2018, Stem cells.

Assessment of an altered E1B promoter on the specificity and potency of triple-regulated conditionally replicating adenoviruses: implications for the generation of ideal m-CRAs

K. Kosai, S. Nagano, S. Komiya, 2011, Cancer Gene Therapy.

Adenoviral gene transduction of hepatocyte growth factor elicits inhibitory effects for hepatoma.

Toshikazu Nakamura, H. Ushikoshi, H. Fujiwara, 2005, International journal of oncology.

Gene therapy eradicating distant disseminated micro-metastases by optimal cytokine expression in the primary lesion only: novel concepts for successful cytokine gene therapy.

H. Fujiwara, K. Kosai, S. Nagano, 2004, International journal of oncology.

Adenoviral herpes simplex virus thymidine kinase gene therapy in an orthotopic lung cancer model.

K. Shirouzu, K. Kosai, M. Fukunaga, 2002, The Annals of thoracic surgery.

Safe and low-dose but therapeutically effective adenovirus-mediated hepatocyte growth factor gene therapy for type 1 diabetes in mice.

K. Kosai, Eriko Matsuda, Y. Obama, 2021, Life sciences.

Intramuscular injection of adenoviral hepatocyte growth factor at a distal site ameliorates dextran sodium sulfate-induced colitis in mice

H. Fujiwara, N. C. Khai, Tomoyuki Takahashi, 2014, International journal of molecular medicine.

Clinicopathological study of liver involvement in cytomegalovirus infection in infant autopsy cases

M. Kojiro, M. Kage, K. Kosai, 1991, Journal of gastroenterology and hepatology.

Diffuse encephaloventriculitis and substantial leukoencephalopathy after intraventricular administration of recombinant adenovirus

M. Israel, J. Dunn, S. Ohara, 2005, Neurological research.

Retrovirus-mediated in vivo gene transfer in the replicating liver using recombinant hepatocyte growth factor without liver injury or partial hepatectomy.

R. Schwall, G. Darlington, S. Woo, 1998, Human gene therapy.

Adenovirus-mediated interleukin-12 gene therapy for metastatic colon carcinoma.

Y. Kwong, B. Xu, S. Woo, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Viral Vector-Based Innovative Approaches to Directly Abolishing Tumorigenic Pluripotent Stem Cells for Safer Regenerative Medicine

K. Mitsui, Tomoyuki Takahashi, K. Kosai, 2017, Molecular therapy. Methods & clinical development.

Recombinant soluble form of heparin‐binding epidermal growth factor‐like growth factor protein therapy drastically inhibits Fas‐mediated fulminant hepatic failure: Implications in clinical application

N. C. Khai, K. Kosai, H. Matsufuji, 2011, Hepatology research : the official journal of the Japan Society of Hepatology.

Abrogation of Fas-induced fulminant hepatic failure in mice by hepatocyte growth factor.

K. Matsumoto, T. Nakamura, S. Nagata, 1998, Biochemical and biophysical research communications.

Adenoviral‐Mediated Herpes Simplex Virus Thymidine Kinase Gene Transfer: Regression of Hepatic Metastasis of Pancreatic Tumors

S. Woo, Shu-Hsia Chen, M. Finegold, 1997, Pancreas.

The role of interleukin-2 in combination adenovirus gene therapy for head and neck cancer.

L. Duan, S. Woo, K. Kosai, 1997, Molecular endocrinology.

Hepatitis C virus RNA present in saliva but absent in breast‐milk of the hepatitis C carrier mother

M. Sata, M. Kojiro, K. Shimamatsu, 1997, Journal of gastroenterology and hepatology.

FAD-dependent lysine-specific demethylase-1 regulates cellular energy expenditure

M. Nakao, T. Umehara, S. Yokoyama, 2012, Nature Communications.

Tumor suppressor WARTS ensures genomic integrity by regulating both mitotic progression and G1 tetraploidy checkpoint function

H. Saya, D. Pallas, T. Hirota, 2004, Oncogene.

Combination suicide and cytokine gene therapy for hepatic metastases of colon carcinoma: sustained antitumor immunity prolongs animal survival.

C. Contant, S. Woo, Shu-Hsia Chen, 1996, Cancer research.

Hepatitis C virus RNA in saliva and breastmilk of hepatitis C carrier mothers

M. Kojiro, K. Shimamatsu, M. Kage, 1993, The Lancet.

Leptin gene therapy in the fight against diabetes

A. Asakawa, A. Inui, K. Kosai, 2010, Expert opinion on biological therapy.

c-myc induces autophagy in rat 3Y1 fibroblast cells.

T. Umata, M. Tsuneoka, Y. Koda, 2003, Cell structure and function.

A Definitive Role of RhoC in Metastasis of Orthotopic Lung Cancer in Mice

H. Fujiwara, Tomoyuki Takahashi, K. Kosai, 2004, Clinical Cancer Research.

Efficient elimination of pancreatic cancer stem cells by hedgehog/GLI inhibitor GANT61 in combination with mTOR inhibition

S. Takao, K. Kosai, M. Yoshimitsu, 2016, Molecular Cancer.

Adenovirus Biology, Recombinant Adenovirus, and Adenovirus Usage in Gene Therapy

K. Kosai, H. Kawakami, Maki Watanabe, 2021, Viruses.

Ultrastructural studies of the bile duct in alcoholic liver disease.

M. Kojiro, K. Shimamatsu, M. Kage, 1992, The Kurume medical journal.

Postinfarction gene therapy with adenoviral vector expressing decorin mitigates cardiac remodeling and dysfunction.

I. Kawamura, G. Takemura, S. Minatoguchi, 2009, American journal of physiology. Heart and circulatory physiology.

Induction of the cytokine signal regulator SOCS3/CIS3 as a therapeutic strategy for treating inflammatory arthritis.

Takafumi Yoshida, A. Yoshimura, Y. Hanakawa, 2001, The Journal of clinical investigation.

Activation of STAT3 by the Hepatitis C Virus Core Protein Leads to Cellular Transformation

Takeshi Tokuhisa, Takafumi Yoshida, A. Yoshimura, 2002, The Journal of experimental medicine.

Regenerating livers of old rats contain high levels of C/EBPalpha that correlate with altered expression of cell cycle associated proteins

Arlan Richardson, Nikolai A. Timchenko, Margaret Wilde, 1998, Nucleic Acids Res..

Pathogenesis of Lethal Aspiration Pneumonia in Mecp2-null Mouse Model for Rett Syndrome

T. Matsuishi, T. Taniwaki, M. Okamoto, 2017, Scientific Reports.

An efficient construction of conditionally replicating adenoviruses that target tumor cells with multiple factors

H. Fujiwara, K. Kosai, S. Nagano, 2005, Gene Therapy.

Survivin-responsive conditionally replicating adenovirus exhibits cancer-specific and efficient viral replication.

T. Matsuishi, H. Fujiwara, K. Kosai, 2005, Cancer research.

Infantile cholestasis due to cytomegalovirus infection of the liver. A possible cause of paucity of interlobular bile ducts.

M. Kojiro, M. Kage, K. Kosai, 1993, Archives of pathology & laboratory medicine.

A survivin-responsive, conditionally replicating adenovirus induces potent cytocidal effects in adult T-cell leukemia/lymphoma

Shinsuke Suzuki, K. Uozumi, K. Kosai, 2019, BMC Cancer.

Therapeutic effects of vitamin A on experimental cholestatic rats with hepatic fibrosis

S. Tsuyama, K. Kosai, Y. Hayashida, 2011, Pediatric Surgery International.

Increased Angiogenic Growth Factor in Cyanotic Congenital Heart Disease

J. Furui, Y. Maeno, T. Murohara, 2003, Pediatric Cardiology.

Targeting CD9 produces stimulus-independent antiangiogenic effects predominantly in activated endothelial cells during angiogenesis: a novel antiangiogenic therapy.

T. Sakamoto, N. C. Khai, Hiroto Terasaki, 2011, Biochemical and biophysical research communications.

Efficient elimination of pancreatic cancer stem cells by hedgehog/GLI inhibitor GANT61 in combination with mTOR inhibition

S. Takao, K. Kosai, M. Yoshimitsu, 2016, Molecular Cancer.

Adenoviral-mediated suicide gene therapy for hepatic metastases of breast cancer.

Y. Kwong, S. Woo, M. Finegold, 1996, Cancer gene therapy.

A survivin-responsive, conditionally replicating adenovirus induces potent cytocidal effects in adult T-cell leukemia/lymphoma

Shinsuke Suzuki, K. Uozumi, K. Kosai, 2019, BMC cancer.

Survivin-responsive conditionally replicating adenovirus kills rhabdomyosarcoma stem cells more efficiently than their progeny

S. Natsugoe, K. Mitsui, K. Kosai, 2014, Journal of Translational Medicine.

Optimization of adenoviral gene transfer in human pluripotent stem cells.

K. Mitsui, Tomoyuki Takahashi, K. Kosai, 2021, Biochemical and biophysical research communications.

Requirement of CD9 on the egg plasma membrane for fertilization.

E. Mekada, M. Okabe, S. Yamada, 2000, Science.

Anti-Fas gene therapy prevents doxorubicin-induced acute cardiotoxicity through mechanisms independent of apoptosis.

K. Nishigaki, G. Takemura, S. Minatoguchi, 2010, The American journal of pathology.

Efficient cardiomyogenic differentiation of embryonic stem cell by fibroblast growth factor 2 and bone morphogenetic protein 2.

H. Ushikoshi, H. Fujiwara, Tomoyuki Takahashi, 2004, Circulation Journal.

An optimal promoter regulating cytokine transgene expression is crucial for safe and effective oncolytic virus immunotherapy

K. Kosai, N. Ijichi, Maki Watanabe, 2024, Translational Research.