D. Macêdo

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Bothrops pauloensis Snake Venom-derived Asp-49 and Lys-49 Phospholipases A2 mediates acute kidney injury by oxidative stress and release of inflammatory cytokines.

R. Jorge, J. Silveira, M. Toyama, 2020, Toxicon : official journal of the International Society on Toxinology.

Bothrops alternatus snake venom induces cytokine expression and oxidative stress on renal function.

T. L. Sampaio, R. Jorge, A. D. Marinho, 2019, Current topics in medicinal chemistry.

Perinatal Inflammation and Adult Psychopathology: From Preclinical Models to Humans

B. Baune, M. Parnham, A. Teixeira, 2020 .

N-acetylcysteine attenuates nicotine-induced kindling in female periadolescent rats

D. Macêdo, S. Vasconcelos, A. Okamura, 2016, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

Susceptibility to caspofungin of Candida spp. strains isolated in Ceará, Northeastern Brazil

B. Cavalcanti, D. Macêdo, R. Campos, 2011 .

N-3 polyunsaturated fatty acids and clozapine abrogates poly I: C-induced immune alterations in primary hippocampal neurons

V. M. Neto, C. Gama, D. Macêdo, 2019, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

Alpha-lipoic acid alone and combined with clozapine reverses schizophrenia-like symptoms induced by ketamine in mice: Participation of antioxidant, nitrergic and neurotrophic mechanisms

C. Gama, D. Macêdo, S. Vasconcelos, 2015, Schizophrenia Research.

Early Withdrawal From Repeated Cocaine Administration Upregulates Muscarinic and Dopaminergic D2-Like Receptors in Rat Neostriatum

D. Macêdo, M. Marinho, G. Viana, 1999, Pharmacology Biochemistry and Behavior.

Advantages of the Alpha-lipoic Acid Association with Chlorpromazine in a Model of Schizophrenia Induced by Ketamine in Rats: Behavioral and Oxidative Stress evidences

D. Macêdo, S. Vasconcelos, C. N. S. Sousa, 2018, Neuroscience.

Sex influences in the preventive effects of N-acetylcysteine in a two-hit animal model of schizophrenia

F. Miyajima, C. Gama, M. Seeman, 2020, Journal of psychopharmacology.

Effect of one-week ethanol treatment on monoamine levels and dopaminergic receptors in rat striatum.

L. Lima, D. Macêdo, S. Vasconcelos, 2003, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

Involvement of monoaminergic targets in the antidepressant- and anxiolytic-like effects of the synthetic alkamide riparin IV: Elucidation of further mechanisms through pharmacological, neurochemistry and computational approaches

C. Andrade, D. Macêdo, J. Barbosa-Filho, 2020, Behavioural Brain Research.

Differences in vulnerability to nicotine-induced kindling between female and male periadolescent rats

A. Carvalho, N. Grunberg, T. Hyphantis, 2012, Psychopharmacology.

The Psychological Defensive Profile of Hemodialysis Patients and Its Relationship to Health-Related Quality of Life

A. Carvalho, T. Hyphantis, D. Macêdo, 2013, The Journal of nervous and mental disease.

The relationship between religious coping, psychological distress and quality of life in hemodialysis patients.

A. Carvalho, K. Pargament, T. Hyphantis, 2012, Journal of psychosomatic research.

Perinatal Inflammation and Adult Psychopathology: From Preclinical Models to Humans

B. Baune, M. Parnham, A. Teixeira, 2020, Progress in Inflammation Research.

G Protein-Coupled Estrogen Receptor 1 (GPER) as a Novel Target for Schizophrenia Drug Treatment

M. Seeman, David De Lucena, A. J. M. Chaves Filho, 2020, Schizophrenia Bulletin Open.

Proconvulsant effects of sildenafil citrate on pilocarpine-induced seizures: Involvement of cholinergic, nitrergic and pro-oxidant mechanisms

D. Macêdo, A. Chaves-Filho, M. L. Feitosa, 2019, Brain Research Bulletin.

Clozapine Prevents Poly (I:C) Induced Inflammation by Modulating NLRP3 Pathway in Microglial Cells

F. Petronilho, A. Teixeira, J. Quevedo, 2020, Cells.

Evidence for Host Epigenetic Signatures Arising From Arbovirus Infections: A Systematic Review

F. Miyajima, M. E. D. de Moraes, D. Macêdo, 2019, Front. Immunol..

Animal models of prenatal immune challenge and their contribution to the study of schizophrenia: a systematic review

A. Carvalho, J. Hallak, J. Crippa, 2012, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

Stress, Spirituality and Altruism of Brazilian Medical Students during the Covid-19 Pandemic: A Cross-sectional Analysis

Bruna Sobreira Kubrusly, Ridson Guilherme Parente de Aguiar, M. Kubrusly, 2020, Research, Society and Development.

The interplay between ventro striatal BDNF levels and the effects of valproic acid on the acquisition of ethanol-induced conditioned place preference in mice

D. Macêdo, S. Vasconcelos, G. Vasconcelos, 2017, Neuroscience Letters.

The GLP-1 receptor agonist liraglutide reverses mania-like alterations and memory deficits induced by D-amphetamine and augments lithium effects in mice: Relevance for bipolar disorder

J. Quevedo, D. Macêdo, S. Valvassori, 2020, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

Effects of Ethanol or Naltrexone after Ethanol Exposure on Plasma Levels of Hepatic Enzymes, Lipid Profile and Apolipoprotein in Rats

R. M. Freitas, D. Macêdo, S. Vasconcelos, 2008 .

Neuroprotective effects of dimethyl fumarate against depression-like behaviors via astrocytes and microglia modulation in mice: possible involvement of the HCAR2/Nrf2 signaling pathway

C. Andrade, D. Macêdo, M. Mottin, 2022, Naunyn-Schmiedeberg's Archives of Pharmacology.

Inhibition of ketamine‐induced hyperlocomotion in mice by the essential oil of Alpinia zerumbet: possible involvement of an antioxidant effect

A. Carvalho, M. E. D. de Moraes, D. Macêdo, 2011, The Journal of pharmacy and pharmacology.

Major depression model induced by repeated and intermittent lipopolysaccharide administration: Long-lasting behavioral, neuroimmune and neuroprogressive alterations.

M. Maes, J. Quevedo, F. Miyajima, 2018, Journal of psychiatric research.

Central nervous system effects of the essential oil of the leaves of Alpinia zerumbet in mice.

D. Macêdo, S. Vasconcelos, L. Leal, 2009, The Journal of pharmacy and pharmacology.

The tetrapartite synapse in neuropsychiatric disorders: Matrix metalloproteases (MMPs) as promising targets for treatment and rational drug design.

C. Andrade, D. Lós, A. J. M. Chaves Filho, 2022, Biochimie.

Sex influences in the preventive effects of peripubertal supplementation with N-3 polyunsaturated fatty acids in mice exposed to the two-hit model of schizophrenia.

D. Macêdo, G. Vasconcelos, Nayana Soares Gomes, 2021, European journal of pharmacology.

Tetracyclines, a promise for neuropsychiatric disorders: from adjunctive therapy to the discovery of new targets for rational drug design in psychiatry

C. Andrade, A. J. M. Chaves Filho, D. Macêdo, 2021, Behavioural pharmacology.

Sex and Age Influence in The Effects of Perinatal Immune Activation in Animals

D. Macêdo, S. Vasconcelos, G. Vasconcelos, 2020 .

Effects of early or late prenatal immune activation in mice on behavioral and neuroanatomical abnormalities relevant to schizophrenia in the adulthood

D. Macêdo, D. C. Medeiros, M. Moraes, 2017, International Journal of Developmental Neuroscience.

Nicotine-Induced Kindling: Influences of Age, Sex, and Prevention by Antioxidants

David De Lucena, A. J. M. Chaves Filho, D. Macêdo, 2019, Neuroscience of Nicotine.

Lectin isolated from the red marine alga Solieria filiformis (Kützing) P.W. Gabrielson: Secondary structure and antidepressant-like effect in mice submitted to the lipopolysaccharide-induced inflammatory model of depression

R. Mohana-Borges, N. Benevides, D. Macêdo, 2022, Algal Research.

Differences in eotaxin serum levels patients with recent onset and in chronic stable schizophrenia: A clue for understanding accelerating aging profile

M. Pedrini, P. Belmonte-de-Abreu, Raffael Massuda, 2014, Schizophrenia Research.

Anxiolytic Effect of Carvedilol in Chronic Unpredictable Stress Model

D. Macêdo, S. Vasconcelos, L. Leal, 2022, Oxidative medicine and cellular longevity.

Alterations in monoamine levels after cocaine-induced status epilepticus and death in striatum and prefrontal cortex of mice

D. Macêdo, S. Vasconcelos, G. Viana, 2004, Neuroscience Letters.

Angiotensin receptor blockers for bipolar disorder.

David De Lucena, D. Macêdo, B. Ribeiro, 2013, Medical hypotheses.

Anti-inflammatory activities of the hydroalcoholic extracts from Erythrina velutina and E. mulungu in mice

D. Macêdo, J. Barbosa-Filho, S. Vasconcelos, 2011 .

Ad libitum consumption of milk supplemented with omega 3, 6, and 9 oils from infancy to middle age alters behavioral and oxidative outcomes in male mice

A. J. M. Chaves Filho, D. Macêdo, L. M. D. Silva Neto, 2022, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

Reversal of cocaine withdrawal-induced anxiety by ondansetron, buspirone and propranolol

D. J. Woods, D. Macêdo, S. Vasconcelos, 2012, Behavioural Brain Research.

Brain antioxidant effect of mirtazapine and reversal of sedation by its combination with alpha-lipoic acid in a model of depression induced by corticosterone.

M. Maes, D. Macêdo, S. Vasconcelos, 2017, Journal of affective disorders.

Preclinical Evidences for an Antimanic Effect of Carvedilol

A. Carvalho, J. Quevedo, David De Lucena, 2015, Neural plasticity.

Cocaine alters catalase activity in prefrontal cortex and striatum of mice

D. Macêdo, S. Vasconcelos, F. Sousa, 2005, Neuroscience Letters.

Antidepressant and Antiaging Effects of Açaí (Euterpe oleracea Mart.) in Mice

R. Burbano, D. Macêdo, H. Rogez, 2019, Oxidative medicine and cellular longevity.

Gastroprotective activity of isopulegol on experimentally induced gastric lesions in mice: investigation of possible mechanisms of action

D. Macêdo, S. Vasconcelos, G. S. Barros Viana, 2009, Naunyn-Schmiedeberg's Archives of Pharmacology.

Effects of isopulegol on pentylenetetrazol-induced convulsions in mice: possible involvement of GABAergic system and antioxidant activity.

D. P. de Sousa, D. Macêdo, S. Vasconcelos, 2009, Fitoterapia.

Augmentation therapy with alpha-lipoic acid and desvenlafaxine: A future target for treatment of depression?

D. Macêdo, S. Vasconcelos, F. Sousa, 2013, Naunyn-Schmiedeberg's Archives of Pharmacology.

Antidepressants of different classes cause distinct behavioral and brain pro- and anti-inflammatory changes in mice submitted to an inflammatory model of depression.

Wei Jiang, A. Teixeira, A. J. M. Chaves Filho, 2020, Journal of affective disorders.

B vitamins attenuate haloperidol-induced orofacial dyskinesia in rats: possible involvement of antioxidant mechanisms

A. Carvalho, D. Macêdo, S. Vasconcelos, 2011, Behavioural pharmacology.

Involvement of anti-inflammatory, antioxidant, and BDNF up-regulating properties in the antipsychotic-like effect of the essential oil of Alpinia zerumbet in mice: a comparative study with olanzapine

A. J. M. Chaves Filho, D. Macêdo, S. Vasconcelos, 2021, Metabolic Brain Disease.

α-Lipoic Acid as Adjunctive Treatment for Schizophrenia

A. J. M. Chaves Filho, D. Macêdo, S. Vasconcelos, 2023, Journal of clinical psychopharmacology.

GBR 12909 administration as an animal model of bipolar mania: time course of behavioral, brain oxidative alterations and effect of mood stabilizing drugs

J. Quevedo, D. Macêdo, L. M. Cavalcante, 2015, Metabolic Brain Disease.

Anticonvulsant action of Calotropis procera latex proteins

D. Macêdo, M. V. Ramos, S. Vasconcelos, 2012, Epilepsy & Behavior.

Development and validation of the Intrinsic Religiousness Inventory (IRI).

A. Carvalho, D. Macêdo, A. Moreira-Almeida, 2012, Revista brasileira de psiquiatria.

Oxidative Stress and Epilepsy: Literature Review

D. Macêdo, S. Vasconcelos, Edna Maria Camelo Chaves, 2012, Oxidative medicine and cellular longevity.

Neonatal Immune Challenge with Lipopolysaccharide Triggers Long-lasting Sex- and Age-related Behavioral and Immune/Neurotrophic Alterations in Mice: Relevance to Autism Spectrum Disorders

G. Réus, J. Quevedo, D. Macêdo, 2017, Molecular Neurobiology.

Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review

D. Macêdo, S. Vasconcelos, E.B.C. Lima, 2015, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

Involvement of the dopaminergic system in the antidepressant-like effect of the lectin isolated from the red marine alga Solieria filiformis in mice.

N. Benevides, D. Macêdo, E. F. Mota, 2017, International journal of biological macromolecules.

Antidepressant-like effect of Hoodia gordonii in a forced swimming test in mice: evidence for involvement of the monoaminergic system

D. Macêdo, S. Vasconcelos, F. Sousa, 2014, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

Effects of standard ethanolic extract from Erythrina velutina in acute cerebral ischemia in mice.

D. Macêdo, S. Vasconcelos, L. Leal, 2017, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Antidepressant‐like effect of bis‐eugenol in the mice forced swimming test: evidence for the involvement of the monoaminergic system

D. Macêdo, J. Barbosa Filho, S. Vasconcelos, 2013, Fundamental & clinical pharmacology.

Antidepressant‐like effect of carvacrol (5‐Isopropyl‐2‐methylphenol) in mice: involvement of dopaminergic system

D. Macêdo, M. Fonteles, G. Viana, 2011, Fundamental & clinical pharmacology.

Effects of Agomelatine on Oxidative Stress in the Brain of Mice After Chemically Induced Seizures

D. Macêdo, S. Vasconcelos, Edna Maria Camelo Chaves, 2013, Cellular and Molecular Neurobiology.

Coumarin effects on amino acid levels in mice prefrontal cortex and hippocampus

D. Macêdo, J. Barbosa-Filho, S. Vasconcelos, 2009, Neuroscience Letters.

Synergistic Effects of Amiodarone and Fluconazole on Candida tropicalis Resistant to Fluconazole

B. Cavalcanti, T. B. Grangeiro, M. Lobo, 2013, Antimicrobial Agents and Chemotherapy.

Doxycycline reverses cognitive impairment, neuroinflammation and oxidative imbalance induced by D-amphetamine mania model in mice: A promising drug repurposing for bipolar disorder treatment?

C. Andrade, C. Peixoto, D. Macêdo, 2020, European Neuropsychopharmacology.

Effects of ethanol and haloperidol on plasma levels of hepatic enzymes, lipid profile, and apolipoprotein in rats.

R. M. Freitas, D. Macêdo, S. Vasconcelos, 2004, Biochemistry and cell biology = Biochimie et biologie cellulaire.

Impact of the Chronic Omega‐3 Fatty Acids Supplementation in Hemiparkinsonism Model Induced by 6‐Hydroxydopamine in Rats

M. Bezerra, R. B. Souza, D. Macêdo, 2017, Basic & clinical pharmacology & toxicology.

Neuroprotective evidence of alpha-lipoic acid and desvenlafaxine on memory deficit in a neuroendocrine model of depression

O. Kebir, D. Macêdo, S. Vasconcelos, 2018, Naunyn-Schmiedeberg's Archives of Pharmacology.

Phosphodiesterase-5 inhibitors: Shedding new light on the darkness of depression?

J. Quevedo, C. Peixoto, D. Macêdo, 2020, Journal of affective disorders.

Implications of Efavirenz for Neuropsychiatry: A Review

D. Macêdo, S. Vasconcelos, M. Fonteles, 2010, The International journal of neuroscience.

HIV antiretroviral drug Efavirenz induces anxiety‐like and depression‐like behavior in rats: evaluation of neurotransmitter alterations in the striatum

D. Macêdo, S. Vasconcelos, E. Rios, 2017, European journal of pharmacology.

Antidepressant-like effect of nitric oxide synthase inhibitors and sildenafil against lipopolysaccharide-induced depressive-like behavior in mice

J. Quevedo, D. Macêdo, S. Vasconcelos, 2014, Neuroscience.

Melatonin: Pharmacological Aspects and Clinical Trends

D. Macêdo, S. Vasconcelos, M. Fonteles, 2010, The International journal of neuroscience.

Shared microglial mechanisms underpinning depression and chronic fatigue syndrome and their comorbidities

D. Macêdo, A. Chaves-Filho, Michael Maes, 2019, Behavioural Brain Research.

Maternal Immune Activation as a Risk Factor for Schizophrenia: Evidence From Preclinical and Clinical Studies

V. Giridharan, D. Macêdo, T. Barichello, 2020 .

Antidepressants, antimicrobials or both? Gut microbiota dysbiosis in depression and possible implications of the antimicrobial effects of antidepressant drugs for antidepressant effectiveness.

J. Quevedo, D. Macêdo, T. Barichello, 2017, Journal of affective disorders.

Shared neuroimmune and oxidative pathways underpinning Chagas disease and major depressive disorder

C. Peixoto, W. Savino, D. Macêdo, 2020, Translational Psychiatry.

Protective Effects Of A Lipid Transfer Protein Isolated from Morinda citrifolia Seeds in Gentamicin-Induced Nephrotoxicity in Rats

T. L. Sampaio, R. Jorge, J. Silveira, 2020, Revista Brasileira de Farmacognosia.

Average spectral power changes at the hippocampal electroencephalogram in schizophrenia model induced by ketamine

D. Macêdo, S. Vasconcelos, T. Q. Oliveira, 2018, Fundamental & clinical pharmacology.

Early life experience contributes to the developmental programming of depressive-like behaviour, neuroinflammation and oxidative stress.

H. Abelaira, G. Réus, J. Quevedo, 2017, Journal of psychiatric research.

Effects of lithium on oxidative stress and behavioral alterations induced by lisdexamfetamine dimesylate: Relevance as an animal model of mania

A. Carvalho, R. McIntyre, J. Quevedo, 2013, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

Effects of alpha‐lipoic acid in an animal model of mania induced by d‐amphetamine

A. Carvalho, R. McIntyre, T. Hyphantis, 2012, Bipolar disorders.

Minocycline protects against oxidative damage and alters energy metabolism parameters in the brain of rats subjected to chronic mild stress

H. Abelaira, G. Réus, J. Quevedo, 2015, Metabolic Brain Disease.

Peritoneal endometriosis induces time-related depressive- and anxiety-like alterations in female rats: involvement of hippocampal pro-oxidative and BDNF alterations

J. Quevedo, A. J. M. Chaves Filho, D. Macêdo, 2019, Metabolic Brain Disease.

Peritoneal endometriosis induces time-related depressive- and anxiety-like alterations in female rats: involvement of hippocampal pro-oxidative and BDNF alterations

J. Quevedo, A. J. M. Chaves Filho, D. Macêdo, 2019, Metabolic Brain Disease.

CCL-11 or Eotaxin-1: An Immune Marker for Ageing and Accelerated Ageing in Neuro-Psychiatric Disorders

D. Macêdo, Michael Maes, M. Murdjeva, 2020, Pharmaceuticals.

Reversal of schizophrenia-like symptoms and immune alterations in mice by immunomodulatory drugs.

M. Maes, D. Macêdo, A. S. Monte, 2017, Journal of psychiatric research.

Effects of doxycycline on depressive-like behavior in mice after lipopolysaccharide (LPS) administration.

A. Carvalho, R. McIntyre, J. Soczynska, 2013, Journal of psychiatric research.

The translocator protein (18kDa) and its role in neuropsychiatric disorders

J. Quevedo, V. Giridharan, F. Dal-Pizzol, 2017, Neuroscience & Biobehavioral Reviews.

The translocator protein ( 18 kDa ) and its role in neuropsychiatric disorders Running title : TSPO and neuropsychiatric disorders

J. Quevedo, V. Giridharan, D. Macêdo, 2017 .

Effect of anxiolytic, antidepressant, and antipsychotic drugs on cocaine-induced seizures and mortality

D. Macêdo, S. Vasconcelos, M. Fonteles, 2004, Epilepsy & Behavior.

Antidepressant Combination Strategies for Major Depressive Disorder

A. Carvalho, R. McIntyre, T. Hyphantis, 2013 .

Novel insights into the mechanisms underlying depression-associated experimental autoimmune encephalomyelitis

C. Peixoto, D. Macêdo, Michael Maes, 2019, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

Thymol reverses depression‐like behaviour and upregulates hippocampal BDNF levels in chronic corticosterone‐induced depression model in female mice

D. Macêdo, José Tiago Valentim, I. Oliveira, 2019, The Journal of pharmacy and pharmacology.

Gender and estrous cycle influences on behavioral and neurochemical alterations in adult rats neonatally administered ketamine

A. Carvalho, J. Quinn, M. Seeman, 2016, Developmental neurobiology.

Evidences for a progressive microglial activation and increase in iNOS expression in rats submitted to a neurodevelopmental model of schizophrenia: Reversal by clozapine

C. Gama, D. Macêdo, M. L. Vale, 2013, Schizophrenia Research.

Behavioral alterations and pro-oxidant effect of a single ketamine administration to mice

D. Macêdo, S. Vasconcelos, M. Fonteles, 2010, Brain Research Bulletin.

Inflammation as a Mechanism of Bipolar Disorder Neuroprogression.

J. Quevedo, D. Macêdo, T. Barichello, 2020, Current topics in behavioral neurosciences.

IDO chronic immune activation and tryptophan metabolic pathway: A potential pathophysiological link between depression and obesity

D. Macêdo, S. Vasconcelos, Michael Maes, 2018, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

Shared Microglial Mechanisms Underpinning Depression and Fatigue and Their Comorbidities

M. Maes, D. Macêdo, Adriano José Maia Chaves Filho, 2019 .

Prevention of haloperidol-induced alterations in brain acetylcholinesterase activity by vitamins B co-administration in a rodent model of tardive dyskinesia

A. Carvalho, T. Hyphantis, D. Macêdo, 2013, Metabolic Brain Disease.

Riparin II ameliorates corticosterone-induced depressive-like behavior in mice: Role of antioxidant and neurotrophic mechanisms

D. Macêdo, J. Barbosa Filho, José Tiago Valentim, 2018, Neurochemistry International.

Reversal of corticosterone-induced BDNF alterations by the natural antioxidant alpha-lipoic acid alone and combined with desvenlafaxine: Emphasis on the neurotrophic hypothesis of depression

D. Macêdo, S. Vasconcelos, D. D. Lucena, 2015, Psychiatry Research.

Neuroprotective effects of caffeine in the model of 6-hydroxydopamine lesion in rats

D. Macêdo, S. Vasconcelos, F. Sousa, 2006, Pharmacology Biochemistry and Behavior.

Screening for bipolar depression in family medicine practices: prevalence and clinical correlates.

A. Carvalho, R. McIntyre, J. Soczynska, 2014, Journal of affective disorders.

Lipoic acid prevents mirtazapine-induced weight gain in mice without impairs its antidepressant-like action in a neuroendocrine model of depression

D. Macêdo, S. Vasconcelos, Adriano José Maia Chaves Filho, 2021, Behavioural Brain Research.

Evidence for protective effect of lipoic acid and desvenlafaxine on oxidative stress in a model depression in mice

D. Macêdo, S. Vasconcelos, L. Leal, 2016, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

(-)-α-Bisabolol-induced gastroprotection is associated with reduction in lipid peroxidation, superoxide dismutase activity and neutrophil migration.

D. Macêdo, P. Soares, G. Oliveira, 2011, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

CSC, an adenosine A2A receptor antagonist and MAO B inhibitor, reverses behavior, monoamine neurotransmission, and amino acid alterations in the 6-OHDA-lesioned rats

D. Macêdo, S. Vasconcelos, Aline A. Oliveira, 2008, Brain Research.

Involvement of oxidative pathways and BDNF in the antidepressant effect of carvedilol in a depression model induced by chronic unpredictable stress

D. Macêdo, S. Vasconcelos, Caren Nádia Soares de Sousa, 2022, Psychopharmacology.

31 Ethanol Interference on Adenosine System

D. Macêdo, M. Fonteles, P. Soares, 2018 .

Ethanol Interference on Adenosine System

D. Macêdo, S. Vasconcelos, M. Fonteles, 2012 .

Is there a role for curcumin in the treatment of bipolar disorder?

A. Carvalho, R. McIntyre, A. Zugman, 2013, Medical hypotheses.

Shared metabolic and neuroimmune mechanisms underlying Type 2 Diabetes Mellitus and Major Depressive Disorder

C. Peixoto, D. Macêdo, Michael Maes, 2021, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

Prevention of pentylenetetrazole-induced kindling and behavioral comorbidities in mice by levetiracetam combined with the GLP-1 agonist liraglutide: Involvement of brain antioxidant and BDNF upregulating properties.

D. Macêdo, Michele Albuquerque Jales de Carvalho, Alana Gomes de Souza, 2019, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Ego defense mechanisms in COPD: impact on health-related quality of life and dyspnoea severity

E. R. Carvalho, A. Carvalho, T. Hyphantis, 2011, Quality of Life Research.

Alpha-lipoic acid in the treatment of psychiatric and neurological disorders: a systematic review

O. Kebir, D. Macêdo, S. Vasconcelos, 2018, Metabolic Brain Disease.

Leptin Prevents Lipopolysaccharide-Induced Depressive-Like Behaviors in Mice: Involvement of Dopamine Receptors

A. Carvalho, M. Maes, D. Macêdo, 2019, Front. Psychiatry.

Involvement of monoaminergic system in the antidepressant‐like effect of riparin I from Aniba riparia (Nees) Mez (Lauraceae) in mice

D. Macêdo, S. Vasconcelos, F. Sousa, 2014, Fundamental & clinical pharmacology.

N-acetylcysteine augmentation to tranylcypromine in treatment-resistant major depression.

A. Carvalho, T. Hyphantis, D. Macêdo, 2013, Journal of clinical psychopharmacology.

Neonatal Immune Challenge with Lipopolysaccharide Triggers Long-lasting Sex- and Age-related Behavioral and Immune/Neurotrophic Alterations in Mice: Relevance to Autism Spectrum Disorders

G. Réus, F. Miyajima, J. Quevedo, 2017, Molecular Neurobiology.

Electroencephalographic study of chlorpromazine alone or combined with alpha-lipoic acid in a model of schizophrenia induced by ketamine in rats.

D. Macêdo, S. Vasconcelos, O. C. Vale, 2017, Journal of psychiatric research.

Major depressive disorder in breast cancer: a critical systematic review of pharmacological and psychotherapeutic clinical trials.

A. Carvalho, R. McIntyre, N. Pavlidis, 2014, Cancer treatment reviews.

In vitro immunogenic profile of recombinant SARS-CoV2 S1-RBD peptide in murine macrophage and microglial cells

D. Lós, J. U. Yaochite, D. Macêdo, 2023, Memorias do Instituto Oswaldo Cruz.

Protective effects of N-acetylserotonin against 6-hydroxydopamine-induced neurotoxicity.

R. M. de Freitas, D. Macêdo, G. S. de Barros Viana, 2005, Life sciences.

Prevention and reversal of ketamine-induced schizophrenia related behavior by minocycline in mice: Possible involvement of antioxidant and nitrergic pathways

A. Carvalho, R. McIntyre, J. Soczynska, 2013, Journal of psychopharmacology.

Effects of Agomelatine on Oxidative Stress in the Brain of Mice After Chemically Induced Seizures

D. Macêdo, S. Vasconcelos, Edna Maria Camelo Chaves, 2013, Cellular and molecular neurobiology.

Anticonvulsant effects of agomelatine in mice

D. Macêdo, S. Vasconcelos, Edna Maria Camelo Chaves, 2012, Epilepsy & Behavior.

Ivabradine possesses anticonvulsant and neuroprotective action in mice.

D. Macêdo, Antonio Eufrásio Vieira Neto, A. Campos, 2019, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Affective temperaments and ego defense mechanisms associated with somatic symptom severity in a large sample.

A. Carvalho, T. Hyphantis, K. Fountoulakis, 2013, Journal of affective disorders.

Antidepressant Effect of Aminophylline After Ethanol Exposure

D. Macêdo, S. Vasconcelos, P. Soares, 2012, Scientia pharmaceutica.

Central nervous system effects of the essential oil of the leaves of Alpinia zerumbet in mice

D. Macêdo, S. Vasconcelos, L. Leal, 2009 .

Differences in vulnerability to nicotine-induced kindling between female and male periadolescent rats

A. Carvalho, N. Grunberg, T. Hyphantis, 2012, Psychopharmacology.

Two-hit model of schizophrenia induced by neonatal immune activation and peripubertal stress in rats: Study of sex differences and brain oxidative alterations

C. Gama, M. Seeman, D. Macêdo, 2017, Behavioural Brain Research.

Effects of muscle inhibition technique on relief of masticatory pain in patients with temporomandibular disorders: an experimental study

Clarissa B A Magalhães, R. Macena, D. Macêdo, 2013 .

Ketamine ’ s Legacy : New Targets for the Development of Rapid onset Antidepressant Drugs

D. Macêdo, Adriano José Maia Chaves Filho, David, 2016 .

Effects of Dopaminergic Agonists and Antagonists on the Muscarinic and Dopaminergic Receptors from Rat Neostriatum

D. Macêdo, M. Marinho, G. Viana, 1997 .

Animal Model of Neonatal Immune Challenge by Lipopolysaccharide: A Study of Sex Influence in Behavioral and Immune/Neurotrophic Alterations in Juvenile Mice

D. Macêdo, S. Vasconcelos, F. C. F. de Sousa, 2022, Neuroimmunomodulation.

Antimanic-like activity of candesartan in mice: Possible involvement of antioxidant, anti-inflammatory and neurotrophic mechanisms

A. Carvalho, M. Berk, J. Quevedo, 2015, European Neuropsychopharmacology.

The relationship between affective temperaments, defensive styles and depressive symptoms in a large sample.

A. Carvalho, T. Hyphantis, K. Fountoulakis, 2013, Journal of affective disorders.

Screening for bipolar disorder in the primary care: a Brazilian survey.

A. Carvalho, R. McIntyre, F. Kapczinski, 2012, Journal of affective disorders.

Low-dose candesartan prevents schizophrenia-like behavioral alterations in a neurodevelopmental two-hit model of schizophrenia

A. Teixeira, D. Macêdo, S. Vasconcelos, 2021, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

Repurposing of Tetracyclines for COVID-19 Neurological and Neuropsychiatric Manifestations: A Valid Option to Control SARS-CoV-2-Associated Neuroinflammation?

C. Andrade, S. Fonseca, D. Macêdo, 2021, Journal of Neuroimmune Pharmacology.

High Exploratory Phenotype Rats Exposed to Environmental Stressors Present Memory Deficits Accompanied by Immune-Inflammatory/Oxidative Alterations: Relevance to the Relationship Between Temperament and Mood Disorders

J. Quevedo, G. Fries, D. Macêdo, 2019, Front. Psychiatry.

The effect of paroxetine, venlafaxine and bupropion administration alone and combined on spatial and aversive memory performance in rats

A. Carvalho, R. McIntyre, T. Hyphantis, 2018, Pharmacological reports : PR.

&agr;-Lipoic Acid as Adjunctive Treatment for Schizophrenia: An Open-Label Trial

C. Gama, D. Macêdo, F. V. Fechine, 2017, Journal of clinical psychopharmacology.

Sex and the Estrous-Cycle Phase Influence the Expression of G Protein-Coupled Estrogen Receptor 1 (GPER) in Schizophrenia: Translational Evidence for a New Target

M. Seeman, D. Macêdo, R. Nicolato, 2023, Molecular Neurobiology.

Antidepressant, antioxidant and neurotrophic properties of the standardized extract of Cocos nucifera husk fiber in mice

D. Macêdo, S. Vasconcelos, L. Leal, 2016, Journal of Natural Medicines.

Time course of the effects of lipopolysaccharide on prepulse inhibition and brain nitrite content in mice.

A. Carvalho, D. Macêdo, S. Vasconcelos, 2013, European journal of pharmacology.

Cocaine-induced status epilepticus and death generate oxidative stress in prefrontal cortex and striatum of mice

D. Macêdo, S. Vasconcelos, M. Fonteles, 2010, Neurochemistry International.

Targeting the Renin-Angiotensin System (RAS) for Neuropsychiatric Disorders

D. Macêdo, A. S. de Miranda, N. Rocha, 2022, Current neuropharmacology.

Immunoinflammatory and oxidative alterations in subjects with schizophrenia under clozapine: A meta-analysis

C. Gama, D. Macêdo, J. P. Pinto, 2023, European Neuropsychopharmacology.

Antimanic activity of minocycline in a GBR12909-induced model of mania in mice: Possible role of antioxidant and neurotrophic mechanisms.

A. Carvalho, J. Quevedo, D. Macêdo, 2018, Journal of affective disorders.

Sex influences in behavior and brain inflammatory and oxidative alterations in mice submitted to lipopolysaccharide-induced inflammatory model of depression

F. Miyajima, D. Macêdo, S. Vasconcelos, 2018, Journal of Neuroimmunology.

Consequences of Ethanol Exposure on Neurodevelopment

D. Macêdo, S. Vasconcelos, C. N. S. Sousa, 2019, Neuroscience of Alcohol.

Tryptophan catabolites along the indoleamine 2,3-dioxygenase pathway as a biological link between depression and cancer

M. Maes, M. E. D. de Moraes, D. Macêdo, 2018, Behavioural pharmacology.

Reversal effect of Riparin IV in depression and anxiety caused by corticosterone chronic administration in mice

D. Macêdo, S. Vasconcelos, F. Sousa, 2019, Pharmacology Biochemistry and Behavior.

Validity of the Brazilian Portuguese version of the bipolar spectrum diagnostic scale

E. R. Carvalho, A. Carvalho, D. Macêdo, 2010 .

Early maternal separation enhances melanoma progression in adult female mice by immune mechanisms

B. Cavalcanti, D. Macêdo, M. O. M. Moraes Filho, 2021, Annals of the New York Academy of Sciences.

Is Riparin III a promising drug in the treatment for depression?

D. Macêdo, S. Vasconcelos, M. Fonteles, 2021, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Effects of dopaminergic and cholinergic interactions on rat behavior.

D. Macêdo, M. Fonteles, G. Viana, 2001, Life sciences.

Decrease in cognitive performance and increase of the neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios with higher doses of antipsychotics in women with schizophrenia: a cross-sectional study

D. Lós, M. Seeman, D. Macêdo, 2023, BMC Psychiatry.

Alpha-lipoic acid in the treatment of psychiatric and neurological disorders: a systematic review

O. Kebir, D. Macêdo, S. Vasconcelos, 2018, Metabolic Brain Disease.

(-)-α-Bisabolol-induced gastroprotection is associated with reduction in lipid peroxidation, superoxide dismutase activity and neutrophil migration.

D. Macêdo, P. Soares, G. Oliveira, 2011, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Neuroprotective evidence of alpha-lipoic acid and desvenlafaxine on memory deficit in a neuroendocrine model of depression

O. Kebir, D. Macêdo, S. Vasconcelos, 2018, Naunyn-Schmiedeberg's Archives of Pharmacology.

Reversal of corticosterone-induced BDNF alterations by the natural antioxidant alpha-lipoic acid alone and combined with desvenlafaxine: Emphasis on the neurotrophic hypothesis of depression

D. Macêdo, S. Vasconcelos, D. D. Lucena, 2015, Psychiatry Research.

Antidepressant, antioxidant and neurotrophic properties of the standardized extract of Cocos nucifera husk fiber in mice

D. Macêdo, S. Vasconcelos, L. Leal, 2016, Journal of Natural Medicines.

Antidepressants, antimicrobials or both? Gut microbiota dysbiosis in depression and possible implications of the antimicrobial effects of antidepressant drugs for antidepressant effectiveness.

J. Quevedo, D. Macêdo, T. Barichello, 2017, Journal of affective disorders.

Time course of the effects of lipopolysaccharide on prepulse inhibition and brain nitrite content in mice.

A. Carvalho, D. Macêdo, S. Vasconcelos, 2013, European journal of pharmacology.

Cocaine Treatment Causes Early and Long-Lasting Changes in Muscarinic and Dopaminergic Receptors

D. Macêdo, G. Viana, F. Sousa, 2004, Cellular and Molecular Neurobiology.

Different times of withdrawal from cocaine administration cause changes in muscarinic and dopaminergic receptors in rat premotor cortex

D. Macêdo, S. Vasconcelos, G. Viana, 2001, Neuroscience Letters.

Sex influences in behavior and brain inflammatory and oxidative alterations in mice submitted to lipopolysaccharide-induced inflammatory model of depression

F. Miyajima, D. Macêdo, S. Vasconcelos, 2018, Journal of Neuroimmunology.

Antimanic-like activity of candesartan in mice: Possible involvement of antioxidant, anti-inflammatory and neurotrophic mechanisms

A. Carvalho, M. Berk, J. Quevedo, 2015, European Neuropsychopharmacology.

Screening for bipolar depression in family medicine practices: prevalence and clinical correlates.

A. Carvalho, R. McIntyre, J. Soczynska, 2014, Journal of affective disorders.

α-Lipoic Acid as Adjunctive Treatment for Schizophrenia

D. Macêdo, S. Vasconcelos, Maria Goreti Rodrigues de Queiroz, 2023, Journal of clinical psychopharmacology.

Prevention of haloperidol-induced alterations in brain acetylcholinesterase activity by vitamins B co-administration in a rodent model of tardive dyskinesia

A. Carvalho, T. Hyphantis, D. Macêdo, 2012, Metabolic Brain Disease.

Differential Effects of Cocaine-Induced Seizures and Lethality on M1-Like Muscarinic and Dopaminergic D1- and D2-Like Binding Receptors in Mice Brain

D. Macêdo, S. Vasconcelos, M. Fonteles, 2006, Cellular and Molecular Neurobiology.

Antidepressant‐like effect of riparin II from Aniba riparia in mice: evidence for the involvement of the monoaminergic system

D. Macêdo, J. Barbosa-Filho, G. S. de Barros Viana, 2013, Fundamental & clinical pharmacology.

Inhibition of ketamine‐induced hyperlocomotion in mice by the essential oil of Alpinia zerumbet: possible involvement of an antioxidant effect

D. Macêdo, S. Vasconcelos, P. Gomes, 2011, The Journal of pharmacy and pharmacology.