I. Nissim

发表

Metabolic studies of rat renal tubule cells loaded with cystine: the cystine dimethylester model of cystinosis.

E. Avner, W. Sweeney, J. Foreman, 1995, Journal of the American Society of Nephrology : JASN.

Down-regulation of Hepatic Urea Synthesis by Oxypurines

M. Tuchman, I. Nissim, M. Yudkoff, 2011, The Journal of Biological Chemistry.

Ketogenic diet, amino acid metabolism, and seizure control

I. Nissim, M. Yudkoff, I. Nissim, 2001, Journal of neuroscience research.

Cerebral Alanine Transport and Alanine Aminotransferase Reaction: Alanine as a Source of Neuronal Glutamate

M. Yudkoff, I. Nissim, Y. Daikhin, 1994, Journal of neurochemistry.

Cerebral Aspartate Utilization: Near‐Equilibrium Relationships in Aspartate Aminotransferase Reaction

Dennis P. Nelson, M. Erecińska, D. Pleasure, 1993, Journal of neurochemistry.

Astrocyte Leucine Metabolism: Significance of Branched‐Chain Amino Acid Transamination

D. Pleasure, I. Nissim, M. Yudkoff, 1996, Journal of neurochemistry.

Precursors of glutamic acid nitrogen in primary neuronal cultures: Studies with15N

M. Yudkoff, L. Hertz, I. Nissim, 1990, Neurochemical Research.

New secondary metabolites of phenylbutyrate in humans and rats.

D. Kerr, S. Wehrli, H. Brunengraber, 2004, Drug metabolism and disposition: the biological fate of chemicals.

Identification of phenylbutyrylglutamine, a new metabolite of phenylbutyrate metabolism in humans.

D. Kerr, H. Brunengraber, B. Comte, 2002, Journal of mass spectrometry : JMS.

Regulation of Glucagon Secretion in Normal and Diabetic Human Islets by γ-Hydroxybutyrate and Glycine*

C. Stanley, I. Nissim, M. Yudkoff, 2012, The Journal of Biological Chemistry.

Gene therapy for guanidinoacetate methyltransferase deficiency restores cerebral and myocardial creatine while resolving behavioral abnormalities

A. Schulze, G. Lipshutz, Lindsay M. Lueptow, 2022, Molecular therapy. Methods & clinical development.

Troglitazone acts by PPARγ and PPARγ-independent pathways on LLC-PK1-F+ acid-base metabolism

F. Turturro, I. Nissim, E. Friday, 2004 .

Glycogen metabolism is dispensable for tumor progression in clear cell renal cell carcinoma

M. Simon, I. Nissim, N. Skuli, 2021, Nature Metabolism.

Ketogenic diet, brain glutamate metabolism and seizure control.

I. Nissim, M. Yudkoff, I. Nissim, 2004, Prostaglandins, leukotrienes, and essential fatty acids.

Metabolism of brain amino acids following pentylenetetrazole treatment

I. Nissim, M. Yudkoff, I. Nissim, 2003, Epilepsy Research.

Brain amino acid metabolism and ketosis

I. Nissim, M. Yudkoff, I. Nissim, 2001, Journal of neuroscience research.

Effects of Ketone Bodies on Astrocyte Amino Acid Metabolism

I. Nissim, M. Yudkoff, I. Nissim, 1997, Journal of neurochemistry.

Newer aspects of glutamine/glutamate metabolism: the role of acute pH changes.

I. Nissim, I. Nissim, 1999, American journal of physiology. Renal physiology.

Agmatine Stimulates Hepatic Fatty Acid Oxidation

S. Wehrli, B. Luhovyy, I. Nissim, 2006, Journal of Biological Chemistry.

3-Isobutylmethylxanthine Inhibits Hepatic Urea Synthesis

S. Wehrli, I. Nissim, M. Yudkoff, 2008, Journal of Biological Chemistry.

Troglitazone and pioglitazone interactions via PPAR-gamma-independent and -dependent pathways in regulating physiological responses in renal tubule-derived cell lines.

F. Turturro, I. Nissim, E. Friday, 2007, American journal of physiology. Cell physiology.

Glutathione Turnover in Cultured Astrocytes: Studies with [15N]Glutamate

D. Pleasure, I. Nissim, M. Yudkoff, 1990, Journal of neurochemistry.

Intermittent lipid nanoparticle mRNA administration prevents cortical dysmyelination associated with arginase deficiency

S. Cederbaum, K. Burke, P. Martini, 2022, Molecular therapy. Nucleic acids.

The Molecular and Metabolic Influence of Long Term Agmatine Consumption*

S. Wehrli, I. Nissim, M. Yudkoff, 2014, The Journal of Biological Chemistry.

Endogenous synthesis of galactose in normal men and patients with hereditary galactosaemia

G. Berry, I. Nissim, A. Mazur, 1995, The Lancet.

Newer aspects of glutamine/glutamate metabolism: the role of acute pH changes.

I. Nissim, I. Nissim, 1999, The American journal of physiology.

Mitochondrial dysfunction during hypoxia/reoxygenation and its correction by anaerobic metabolism of citric acid cycle intermediates.

J. Weinberg, M. Venkatachalam, I. Nissim, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Effects of palmitate on astrocyte amino acid contents

D. Pleasure, I. Nissim, M. Yudkoff, 1989, Neurochemical Research.

Prevention Ifosfamide-Induced Nephrotoxicity : Mechanism and Updated

B. Luhovyy, I. Nissim, M. Yudkoff, 2006 .

Ifosfamide‐induced nephrotoxicity : Mechanism and prevention

B. Luhovyy, I. Nissim, M. Yudkoff, 2006, Cancer research.

Dynamic aspects of amino acid metabolism in alloxan-induced diabetes and insulin-treated rabbits: in vivo studies with 15N and gas chromatography-mass spectrometry.

I. Nissim, A. Lapidot, I. Nissim, 1986, Biochemical medicine and metabolic biology.

The roles of insulin and glucagon in the regulation of amino acid turnover rate and pool size: in vivo study with [15N]glycine and gas chromatography--mass spectrometry.

I. Nissim, A. Lapidot, I. Nissim, 1984, Biochemical medicine.

Regulation of pool sizes and turnover rates of amino acids in humans: 15N-glycine and 15N-alanine single-dose experiments using gas chromatography-mass spectrometry analysis.

I. Nissim, A. Lapidot, 1980, Metabolism: clinical and experimental.

Glitazones regulate glutamine metabolism by inducing a cellular acidosis in MDCK cells.

I. Nissim, T. Welbourne, H. Battarbee, 2002, American journal of physiology. Endocrinology and metabolism.

Regulation of mitochondrial glutamine/glutamate metabolism by glutamate transport: studies with (15)N.

I. Nissim, T. Welbourne, I. Nissim, 2001, American journal of physiology. Cell physiology.

Glutamate Dehydrogenase Reaction as a Source of Glutamic Acid in Synaptosomes

Dennis P. Nelson, M. Erecińska, M. Yudkoff, 1991, Journal of neurochemistry.

Neuronal Metabolism of Branched‐Chain Amino Acids: Flux Through the Aminotransferase Pathway in Synaptosomes

M. Erecińska, M. Yudkoff, I. Nissim, 1996, Journal of neurochemistry.

Interrelationships of Leucine and Glutamate Metabolism in Cultured Astrocytes

D. Pleasure, M. Yudkoff, I. Nissim, 1994, Journal of neurochemistry.

Inhibition of Astrocyte Glutamine Production by α‐Ketoisocaproic Acid

D. Pleasure, I. Nissim, M. Yudkoff, 1994 .

Modulating Glucose Metabolism and Lactate Synthesis in Injured Mouse Tendons: Treatment With Dichloroacetate, a Lactate Synthesis Inhibitor, Improves Tendon Healing

L. Soslowsky, Kairui Zhang, Y. Usami, 2018, The American journal of sports medicine.

Response of brain amino acid metabolism to ketosis

S. Wehrli, B. Luhovyy, I. Nissim, 2005, Neurochemistry International.

Regulation of urea synthesis by agmatine in the perfused liver: studies with 15N.

I. Nissim, M. Yudkoff, I. Nissim, 2002, American journal of physiology. Endocrinology and metabolism.

Troglitazone acts by PPAR (cid:1) and PPAR (cid:1) -independent pathways on LLC-PK 1 -F (cid:2) acid-base metabolism

F. Turturro, I. Nissim, E. Friday, 2003 .

Acidosis and astrocyte amino acid metabolism

I. Nissim, M. Yudkoff, I. Nissim, 2000, Neurochemistry International.

proximal tubules hypoxia-reoxygenation-induced mitochondrial injury in Preservation of complex I function during

A. Kribben, J. Weinberg, T. Feldkamp, 2016 .

Preservation of complex I function during hypoxia-reoxygenation-induced mitochondrial injury in proximal tubules.

A. Kribben, J. Weinberg, T. Feldkamp, 2004, American journal of physiology. Renal physiology.

Ketosis and brain handling of glutamate, glutamine, and GABA

I. Nissim, M. Yudkoff, I. Nissim, 2008, Epilepsia.

Association of Obesity With Maternal and Cord Blood Penicillin Levels in Women With Group B Streptococcus Colonization.

M. Elovitz, I. Nissim, L. Levine, 2020, Obstetrics and gynecology.

Biosynthesis of agmatine in isolated mitochondria and perfused rat liver: studies with 15N-labelled arginine.

B. Luhovyy, I. Nissim, M. Yudkoff, 2005, The Biochemical journal.

Energetic determinants of tyrosine phosphorylation of focal adhesion proteins during hypoxia/reoxygenation of kidney proximal tubules.

J. Weinberg, M. Venkatachalam, I. Nissim, 2001, The American journal of pathology.

Relationships between intracellular amino acid levels and protection against injury to isolated proximal tubules.

J. Weinberg, I. Nissim, S. Schultz, 1991, The American journal of physiology.

Glycine attenuates Fanconi syndrome induced by maleate or ifosfamide in rats.

J. Weinberg, I. Nissim, 1996, Kidney international.

N-carbamylglutamate Markedly Enhances Ureagenesis in N-acetylglutamate Deficiency and Propionic Acidemia as Measured by Isotopic Incorporation and Blood Biomarkers

M. Tuchman, B. Burton, I. Nissim, 2008, Pediatric Research.

Regulation of [15N]Urea Synthesis from [5-15N]Glutamine

J. Brosnan, M. Yudkoff, I. Nissim, 1996, The Journal of Biological Chemistry.

A Mass Isotopomer Study of Urea and Glutamine Synthesis from 15N-labeled Ammonia in the Perfused Rat Liver*

M. Brosnan, J. Brosnan, I. Nissim, 1996, The Journal of Biological Chemistry.

FunctionGlutamine/Glutamate Couplet and Cellular

M. Yudkoff, R. Routh, I. Nissim, 2016 .

Application of 15N to the study of hepatic nitrogen metabolism.

M. Brosnan, J. Brosnan, I. Nissim, 2002, Advances in enzyme regulation.

The Role of Mitochondrially Bound Arginase in the Regulation of Urea Synthesis

B. Luhovyy, I. Nissim, M. Yudkoff, 2005, Journal of Biological Chemistry.

Dietary branched chain amino acids ameliorate injury-induced cognitive impairment

J. Cole, Jaclynn A. Elkind, I. Nissim, 2009, Proceedings of the National Academy of Sciences.

Metabolism of 15NH3 in Organotypic Cerebellar Explants and Cultured Astrocytes: Studies with Gas Chromatography‐Mass Spectrometry

D. Pleasure, M. Yudkoff, I. Nissim, 1984, Journal of neurochemistry.

Restoration of ureagenesis in N-acetylglutamate synthase deficiency by N-carbamylglutamate.

H. Morizono, M. Tuchman, M. Yudkoff, 2004, The Journal of pediatrics.

Neuronal Glutamine Utilization: Glutamine/Glutamate Homeostasis in Synaptosomes

M. Erecińska, M. Yudkoff, I. Nissim, 1990, Journal of neurochemistry.

N-carbamylglutamate Augments Ureagenesis and Reduces Ammonia and Glutamine in Propionic Acidemia

M. Tuchman, M. Yudkoff, R. McCarter, 2010, Pediatrics.

Effects of a single dose of N-carbamylglutamate on the rate of ureagenesis.

M. Tuchman, I. Nissim, M. Yudkoff, 2009, Molecular genetics and metabolism.

Regulation of brain glutamate metabolism by nitric oxide and S-nitrosylation

K. Sharp, I. Nissim, M. Yudkoff, 2015, Science Signaling.

Fructose-1,6-Bisphosphatase 2 Inhibits Sarcoma Progression by Restraining Mitochondrial Biogenesis.

A. Mancuso, A. Weljie, Peiwei Huangyang, 2019, Cell metabolism.

Elimination of KATP Channels in Mouse Islets Results in Elevated [U-13C]Glucose Metabolism, Glutaminolysis, and Pyruvate Cycling but a Decreased γ-Aminobutyric Acid Shunt*

C. Stanley, I. Nissim, M. Yudkoff, 2008, Journal of Biological Chemistry.

Brain amino acid requirements and toxicity: the example of leucine.

B. Luhovyy, I. Nissim, M. Yudkoff, 2005, The Journal of nutrition.

Glucose and Synaptosomal Glutamate Metabolism: Studies with [15N]Glutamate

M. Yudkoff, I. Nissim, F. Dagani, 1988, Journal of neurochemistry.

Astrocyte Metabolism of [15N]Glutamine: Implications for the Glutamine‐Glutamate Cycle

D. Pleasure, M. Yudkoff, I. Nissim, 1988, Journal of neurochemistry.

In vivo oxidation of [13C]galactose in patients with galactose-1-phosphate uridyltransferase deficiency.

L. Elsas, P. Klein, G. Berry, 1995, Biochemical and molecular medicine.

Arginase 2 Suppresses Renal Carcinoma Progression via Biosynthetic Cofactor Pyridoxal Phosphate Depletion and Increased Polyamine Toxicity.

K. Nathanson, J. Ochocki, J. Alwine, 2018, Cell metabolism.

Quantitative assessment of whole body galactose metabolism in galactosemic patients

L. Elsas, P. Klein, G. Berry, 1997, European Journal of Pediatrics.

mTOR Regulates Lysosomal ATP-Sensitive Two-Pore Na+ Channels to Adapt to Metabolic State

David E. Clapham, D. Clapham, I. Nissim, 2013, Cell.

Mechanism of Hyperinsulinism in Short-chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency Involves Activation of Glutamate Dehydrogenase*

C. Stanley, T. Smith, H. Collins, 2010, The Journal of Biological Chemistry.

Effects of a GTP-insensitive Mutation of Glutamate Dehydrogenase on Insulin Secretion in Transgenic Mice*♦

Thomas J Petty, C. Stanley, I. Nissim, 2006, Journal of Biological Chemistry.

Metabolic Enzyme DLST Promotes Tumor Aggression and Reveals a Vulnerability to OXPHOS Inhibition in High-Risk Neuroblastoma

A. Look, T. Tao, G. Qing, 2021, Cancer Research.

Fructose-1, 6-bisphosphatase opposes renal carcinoma progression

J. Ochocki, A. Mancuso, Z. Walton, 2014, Nature.

Targeting glutamine metabolism slows soft tissue sarcoma growth

A. Weljie, Peiwei Huangyang, M. Simon, 2020, Nature Communications.

Functional and Metabolomic Consequences of KATP Channel Inactivation in Human Islets

J. Schug, K. Kaestner, C. Stanley, 2017, Diabetes.

Effect of glutamine on heat‐shock‐induced mRNA and stress proteins

J. Pleasure, I. Nissim, I. Nissim, 1993, Journal of cellular physiology.

Albumin Synthesis in Premature Infants: Determination of Turnover with [15N]Glycine

R. Polin, M. Yudkoff, I. Nissim, 1987, Pediatric Research.

Creatine synthesis: hepatic metabolism of guanidinoacetate and creatine in the rat in vitro and in vivo.

M. Brosnan, J. Brosnan, I. Nissim, 2009, American journal of physiology. Endocrinology and metabolism.

ASS1 and ASL suppress growth in clear cell renal cell carcinoma via altered nitrogen metabolism

M. Simon, H. Ischiropoulos, B. Keith, 2021, Cancer & metabolism.

Regulation of nuclear epigenome by mitochondrial DNA heteroplasmy

Larry N. Singh, B. Garcia, D. Wallace, 2019, Proceedings of the National Academy of Sciences.

Anaerobic and aerobic pathways for salvage of proximal tubules from hypoxia-induced mitochondrial injury.

J. Weinberg, M. Venkatachalam, I. Nissim, 2000, American journal of physiology. Renal physiology.

Effects of a glucokinase activator on hepatic intermediary metabolism: study with 13C-isotopomer-based metabolomics.

S. Wehrli, I. Nissim, M. Yudkoff, 2012, The Biochemical journal.

Targeting glutamine metabolism slows soft tissue sarcoma growth

A. Weljie, Peiwei Huangyang, M. Simon, 2020, Nature Communications.

Malic Enzyme Couples Mitochondria with Aerobic Glycolysis in Osteoblasts

I. Nissim, Fanxin Long, Xing Ji, 2020, Cell reports.

The determination of amino acid pool sizes and turnover rates by gas chromatographic mass spectrometric analysis of stable isotope enrichment.

C. S. Irving, I. Nissim, A. Lapidot, 1978, Biomedical mass spectrometry.

Alanine Metabolism in the Perfused Rat Liver

M. Brosnan, J. Brosnan, I. Nissim, 2001, The Journal of Biological Chemistry.

Pharmacologic and Metabolic Mitochondrial Rescue

J. Weinberg, M. Venkatachalam, I. Nissim, 2002 .

The Diurnal Rhythms in Plasma Glycine Pool Sizes and Turnover Rates: 15N‐Glycine Single Dose Experiments Employing Gas Chromatographic — Mass Spectrometric Analysis

C. S. Irving, I. Nissim, A. Lapidot, 1978 .

Plasma amino acid turnover rates and pools in rabbits: in vivo studies using stable isotopes.

I. Nissim, A. Lapidot, I. Nissim, 1979, The American journal of physiology.

Role of the glutamate dehydrogenase reaction in furnishing aspartate nitrogen for urea synthesis: studies in perfused rat liver with 15N.

B. Luhovyy, I. Nissim, M. Yudkoff, 2003, The Biochemical journal.

The Ketogenic Diet

I. Nissim, M. Yudkoff, I. Nissim, 2004 .

The Ketogenic Diet and Brain Metabolism

I. Nissim, M. Yudkoff, I. Nissim, 2012 .

Orally Administered Alpha Lipoic Acid as a Treatment for Geographic Atrophy: A Randomized Clinical Trial.

G. Ying, A. Edwards, M. Maguire, 2020, Ophthalmology. Retina.

A window into cellular metabolism: hepatic metabolism of (15)N-labelled substrates.

M. Brosnan, J. Brosnan, I. Nissim, 2004, Metabolic Engineering.

Probucol ameliorates renal and metabolic sequelae of primary CoQ deficiency in Pdss2 mutant mice

Marni J. Falk, M. Falk, Zhe Zhang, 2011, EMBO molecular medicine.

Measuring in vivo ureagenesis with stable isotopes.

M. Tuchman, I. Nissim, M. Yudkoff, 2010, Molecular genetics and metabolism.

Decreased serotonin transporter activity in the mitral valve contributes to progression of degenerative mitral regurgitation

Vaishali V. Inamdar, A. Krieger, L. Rauova, 2023, Science Translational Medicine.

The ketogenic diet and brain metabolism of amino acids: relationship to the anticonvulsant effect.

I. Nissim, M. Yudkoff, U. Sonnewald, 2007, Annual review of nutrition.

Metabolic pathway profiling of mitochondrial respiratory chain mutants in C. elegans.

Marni J. Falk, E. Daikhin, I. Nissim, 2008, Molecular genetics and metabolism.

Regulation of Glucagon Secretion in Normal and Diabetic Human Islets by γ-Hydroxybutyrate and Glycine*

C. Stanley, I. Nissim, M. Yudkoff, 2012, The Journal of Biological Chemistry.

Short-term fasting, seizure control and brain amino acid metabolism

I. Nissim, M. Yudkoff, I. Nissim, 2006, Neurochemistry International.

Brain glutamate metabolism: neuronal-astroglial relationships.

M. Erecińska, D. Pleasure, M. Yudkoff, 1993, Developmental neuroscience.

A mechanism of glycine and alanine cytoprotective action: stimulation of stress-induced HSP70 mRNA.

J. Pleasure, I. Nissim, I. Nissim, 1992, Kidney international.

Fibronectin turnover in the premature neonate measured with [15N]glycine.

R. Polin, M. Yudkoff, M. Yoder, 1989, The American journal of clinical nutrition.

A model for determination of total body protein synthesis based upon compartmental analysis of the plasma [15N] glycine decay curve.

M. Yudkoff, I. Nissim, S. Segal, 1983, Metabolism: clinical and experimental.

In vivo nitrogen metabolism in ornithine transcarbamylase deficiency.

M. Yudkoff, M. Batshaw, I. Nissim, 1996, The Journal of clinical investigation.

N-carbamylglutamate Augments Ureagenesis and Reduces Ammonia and Glutamine in Propionic Acidemia

M. Tuchman, M. Yudkoff, R. McCarter, 2010, Pediatrics.

Down-regulation of Hepatic Urea Synthesis by Oxypurines

M. Tuchman, I. Nissim, M. Yudkoff, 2011, The Journal of Biological Chemistry.

Studies of Hepatic Glutamine Metabolism in the Perfused Rat Liver with 15N-Labeled Glutamine*

M. Brosnan, J. Brosnan, I. Nissim, 1999, The Journal of Biological Chemistry.

Nitrogen metabolism: neuronal-astroglial relationships.

M. Yudkoff, I. Nissim, David E Pleasure, 1992, Progress in brain research.

Gas chromatography-mass spectrometry determination of [15N]ammonia enrichment in blood and urine.

T. Terwilliger, M. Yudkoff, I. Nissim, 1981, Analytical biochemistry.

[15N]aspartate metabolism in cultured astrocytes. Studies with gas chromatography-mass spectrometry.

D. Pleasure, M. Yudkoff, I. Nissim, 1987, The Biochemical journal.