R. Dirksen

H. McBride, R. Dirksen, Ellie M. Carrell, 2016, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Inducible depletion of adult skeletal muscle stem cells impairs the regeneration of neuromuscular junctions

R. Dirksen, J. Chakkalakal, L. Wei-LaPierre, 2015, eLife.

Dynamic alterations in myoplasmic Ca2+ in malignant hyperthermia and central core disease.

R. Dirksen, Sanjeewa A. Goonasekera, A. Lyfenko, 2004, Biochemical and biophysical research communications.

Reactive oxygen/nitrogen species and the aged brain: Radical impact of ion channel function

R. Dirksen, 2002, Neurobiology of Aging.

Autonomic modulation of action potential and tension in guinea pig papillary muscles.

J. Arreola, R. Dirksen, P. Pérez-Cornejo, 1994, European journal of pharmacology.

Single Channel Characterization of the Mitochondrial Ryanodine Receptor in Heart Mitoplasts*

Shin-Young Ryu, K. Kinnally, S. Sheu, 2011, The Journal of Biological Chemistry.

Suramin Interacts with the Calmodulin Binding Site on the Ryanodine Receptor, RYR1*

S. Hamilton, R. Dirksen, R. Papineni, 2002, The Journal of Biological Chemistry.

Loss of adult skeletal muscle stem cells drives age-related neuromuscular junction degeneration

P. Miura, R. Dirksen, J. Chakkalakal, 2017, eLife.

Single calcium channel behavior in native skeletal muscle

K. Beam, R. Dirksen, 1995, The Journal of general physiology.

Role of the Sequence Surrounding Predicted Transmembrane Helix M4 in Membrane Association and Function of the Ca2+ Release Channel of Skeletal Muscle Sarcoplasmic Reticulum (Ryanodine Receptor Isoform 1)*

G. Ávila, D. Maclennan, Parveen Sharma, 2004, Journal of Biological Chemistry.

Cardiac metabolic effects of KNa1.2 channel deletion and evidence for its mitochondrial localization

S. Nadtochiy, P. Brookes, Yves T. Wang, 2018, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Cardiac metabolic effects of KNa1.2 channel deletion, and evidence for its mitochondrial localization.

S. Nadtochiy, P. Brookes, Yves T. Wang, 2018 .

Evidence for, and Metabolic Consequences of, a Cardiac Mitochondrial KNa1.2 Channel

S. Nadtochiy, P. Brookes, Yves T. Wang, 2017, bioRxiv.

Updated Variant Curation Expert Panel Criteria and Pathogenicity Classifications for 251 Variants for RYR1-related Malignant Hyperthermia Susceptibility

L. Biesecker, J. Johnston, R. Robinson, 2022, bioRxiv.

Rapamycin and FK506 reduce skeletal muscle voltage sensor expression and function.

G. Ávila, R. Dirksen, 2005, Cell calcium.

Calmodulin Binding to the 3614–3643 Region of RyR1 Is Not Essential for Excitation–Contraction Coupling in Skeletal Myotubes

G. Meissner, R. Dirksen, K. O'connell, 2002, The Journal of general physiology.

Risk of cardiac events in Long QT syndrome patients when taking antiseizure medications

A. Moss, R. Gross, S. McNitt, 2018, Translational research : the journal of laboratory and clinical medicine.

Postdevelopmental knockout of Orai1 improves muscle pathology in a mouse model of Duchenne muscular dystrophy

A. Michelucci, M. García-Castañeda, R. Dirksen, 2022, The Journal of general physiology.

Variants in ASPH cause exertional heat illness and are associated with malignant hyperthermia susceptibility

S. Jung, J. Dowling, M. Shaw, 2022, Nature Communications.

Muscle-specific SMN reduction reveals motor neuron-independent disease in spinal muscular atrophy models.

Jeong-Ki Kim, U. Monani, C. Chiriboga, 2020, The Journal of clinical investigation.

A variably spliced region in the type 1 ryanodine receptor may participate in an inter-domain interaction.

A. Dulhunty, N. Beard, S. Pace, 2007, The Biochemical journal.

Multi-minicore disease and atypical periodic paralysis associated with novel mutations in the skeletal muscle ryanodine receptor (RYR1) gene

F. Muntoni, S. Al-Sarraj, Haiyan Zhou, 2010, Neuromuscular Disorders.

Murine Fig4 is dispensable for muscle development but required for muscle function

M. Meisler, J. Dowling, A. Reifler, 2013, Skeletal Muscle.

Modulation of ventricular action potential by alpha 1-adrenoceptors and protein kinase C.

R. Dirksen, S. Sheu, 1990, The American journal of physiology.

The S5-S6 linker of repeat I is a critical determinant of L-type Ca2+ channel conductance.

J. Nakai, K. Imoto, K. Beam, 1997, Biophysical journal.

The 65th Symposium of the Society for General Physiologists: Energizing research in mitochondrial physiology and medicine

E. Pugh, S. Sheu, R. Dirksen, 2011, The Journal of General Physiology.

contraction: what we know and what we don't Invited Review: Redox modulation of skeletal muscle

S. Perrey, C. Roussos, P. Cozzone, 2015 .

Dendritic cell-specific transmembrane protein is required for synovitis and bone resorption in inflammatory arthritis

E. Schwarz, J. Rangel-Moreno, C. Ritchlin, 2022, Frontiers in Immunology.

Ca v 1.1 in Malignant Hyperthermia

R. Dirksen, V. Yarotskyy, Viktor Yarotskyy, 2014 .

Phospholipase C (cid:1) Modulates (cid:2) -Adrenergic Receptor Dependent Cardiac Contraction and Inhibits Cardiac Hypertrophy

Huan Wang, K. Vikstrom, B. Blaxall, 2022 .

Excitation–contraction coupling in cardiac, skeletal, and smooth muscle

E. Ríos, K. Sipido, R. Dirksen, 2022, The Journal of general physiology.

Ca2+ permeation and/or binding to CaV1.1 fine-tunes skeletal muscle Ca2+ signaling to sustain muscle function

Amy D. Hanna, M. Dickinson, Pumin Zhang, 2015, Skeletal Muscle.

Expression of Ecto-ATPase NTPDase2 in Human Dental Pulp

J. Sévigny, J. Pelletier, R. Dirksen, 2012, Journal of dentistry research.

Adrenergic signaling regulates mitochondrial Ca2+ uptake through Pyk2-dependent tyrosine phosphorylation of the mitochondrial Ca2+ uniporter.

Godfrey L. Smith, Shangcheng Xu, R. Rizzuto, 2014, Antioxidants & redox signaling.

How mutations in RYR1 that cause malignant hyperthermia increase RYR1 sensitivity to activators.

M. Baker, S. Hamilton, R. Dirksen, 2021, Cell calcium.

Ca2+ Release in Muscle Fibers Expressing R4892W and G4896V Type 1 Ryanodine Receptor Disease Mutants

R. Lefebvre, V. Jacquemond, L. Groom, 2013, PloS one.

Identical de novo Mutation in the Type 1 Ryanodine Receptor Gene Associated with Fatal, Stress-induced Malignant Hyperthermia in Two Unrelated Families

B. Brandom, N. Sambuughin, L. Groom, 2011, Anesthesiology.

Two central core disease (CCD) deletions in the C‐terminal region of RYR1 alter muscle excitation–contraction (EC) coupling by distinct mechanisms

S. Ducreux, A. Ferreiro, S. Treves, 2007, Human mutation.

Material for : Adrenergic signaling regulates mitochondrial Ca 2 + uptake through Pyk 2-dependent tyrosine phosphorylation of the mitochondrial Ca 2 + uniporter

Godfrey L. Smith, Shangcheng Xu, R. Rizzuto, 2014 .

Enhanced Ca²⁺ influx from STIM1-Orai1 induces muscle pathology in mouse models of muscular dystrophy.

J. Molkentin, R. Dirksen, Federica Accornero, 2014, Human molecular genetics.

Malignant Hyperthermia Susceptibility

N. Sambuughin, R. Dirksen, S. Riazi, 2013 .

A novel zebrafish model of SPEG-related centronuclear myopathy (CNM): characterization and comparison with other CNM model zebrafish

J. Dowling, I. Scott, L. Groom, 2021, bioRxiv.

Functional Effects of Central Core Disease Mutations in the Cytoplasmic Region of the Skeletal Muscle Ryanodine Receptor

G. Ávila, R. Dirksen, 2001, The Journal of general physiology.

Cheng et al. reply

M. Dong, Xianhua Wang, Heping Cheng, 2014, Nature.

The elusive role of the SPRY2 domain in RyR1

M. Casarotto, A. Dulhunty, E. Gallant, 2011, Channels.

Unitary behavior of skeletal, cardiac, and chimeric L-type Ca2+ channels expressed in dysgenic myotubes

K. Beam, R. Dirksen, 1996, The Journal of general physiology.

Enhanced dihydropyridine receptor channel activity in the presence of ryanodine receptor

Hanh T. Nguyen, J. Nakai, K. Beam, 1996, Nature.

Adaptive thermogenesis enhances the life-threatening response to heat in mice with an Ryr1 mutation

Amy D. Hanna, M. Baker, R. Pautler, 2020, Nature Communications.

AICAR Prevents Heat Induced Sudden Death in RyR1 Mutant Mice Independent of AMPK Activation

Dimitra K. Georgiou, S. Hamilton, J. Lanner, 2011, Nature Medicine.

Role of STIM1/ORAI1-mediated store-operated Ca2+ entry in skeletal muscle physiology and disease.

A. Michelucci, S. Boncompagni, M. García-Castañeda, 2018, Cell calcium.

Mouse model of severe recessive RYR1-related myopathy.

J. Dowling, A. Michelucci, M. García-Castañeda, 2019, Human molecular genetics.

Triadopathies: An Emerging Class of Skeletal Muscle Diseases

J. Dowling, M. Lawlor, R. Dirksen, 2014, Neurotherapeutics.

F. van Petegem, N. Voermans, R. Dirksen, 2022, Journal of neuromuscular diseases.

Mitochondrial superoxide flashes: metabolic biomarkers of skeletal muscle activity and disease

Gheorghe Salahura, S. Boncompagni, F. Protasi, 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Distinct effects on Ca2+ handling caused by malignant hyperthermia and central core disease mutations in RyR1.

G. Ávila, R. Dirksen, 2004, Biophysical journal.

Accelerated Activation of SOCE Current in Myotubes from Two Mouse Models of Anesthetic- and Heat-Induced Sudden Death

F. Protasi, R. Dirksen, V. Yarotskyy, 2013, PloS one.

Orai1-dependent Calcium Entry Promotes Skeletal Muscle Growth and Limits Fatigue

S. Boncompagni, F. Protasi, R. Dirksen, 2013, Nature Communications.

Mitochondrial ryanodine receptors and other mitochondrial Ca2+ permeable channels

Shin-Young Ryu, K. Kinnally, S. Sheu, 2010, FEBS letters.

Phospholipase C (cid:1) Modulates (cid:2) -Adrenergic Receptor Dependent Cardiac Contraction and Inhibits Cardiac Hypertrophy

Alan V. Smrcka, Huan Wang, Huan Wang, 2005 .

Mice with the R176Q cardiac ryanodine receptor mutation exhibit catecholamine-induced ventricular tachycardia and cardiomyopathy

Wei Zhang, Dan M. Roden, Robia G. Pautler, 2006, Proceedings of the National Academy of Sciences.

Correction of ClC-1 splicing eliminates chloride channelopathy and myotonia in mouse models of myotonic dystrophy.

J. Lueck, M. Swanson, T. M. Wheeler, 2007, Journal of Clinical Investigation.

Iron Dysregulation in Mitochondrial Dysfunction and Alzheimer’s Disease

R. Dirksen, J. Onukwufor, Andrew P. Wojtovich, 2022, Antioxidants.

Pathophysiology of Muscle Disorders Linked to Mutations in the Skeletal Muscle Ryanodine Receptor

G. Ávila, R. Dirksen, 2005 .

Functional analysis of the R1086H malignant hyperthermia mutation in the DHPR reveals an unexpected influence of the III-IV loop on skeletal muscle EC coupling.

B. Flucher, P. Allen, R. Dirksen, 2004, American journal of physiology. Cell physiology.

Ryanodinopathies : Muscle Disorders Linked to Mutations in Ryanodine Receptors

J. Lueck, R. Dirksen, Sanjeewa A. Goonasekera, 2004 .

Sarcolemmal-restricted localization of functional ClC-1 channels in mouse skeletal muscle

A. E. Rossi, J. Lueck, K. Campbell, 2010, The Journal of general physiology.

Chloride channelopathy in myotonic dystrophy resulting from loss of posttranscriptional regulation for CLCN1.

J. Lueck, C. Lungu, S. Welle, 2007, American journal of physiology. Cell physiology.

Purinergic Signaling Modulates Survival/Proliferation of Human Dental Pulp Stem Cells

R. Dirksen, X. Liu, L. Ma, 2018, Journal of dental research.

Effects of the affinity ligands 14-β-chloroacetylnaltrexone and 14-β-bromoacetamidomorphine on [3H]-dihydromorphine binding sites in rat brain

M. Reichman, R. Dirksen, L. Abood, 1986 .

Altered Ca2+ Handling and Oxidative Stress Underlie Mitochondrial Damage and Skeletal Muscle Dysfunction in Aging and Disease

A. Michelucci, F. Protasi, R. Dirksen, 2021, Metabolites.

Mitochondria are linked to calcium stores in striated muscle by developmentally regulated tethering structures.

A. E. Rossi, S. Boncompagni, F. Protasi, 2008, Molecular biology of the cell.

Muscle weakness in Ryr1I4895T/WT knock-in mice as a result of reduced ryanodine receptor Ca2+ ion permeation and release from the sarcoplasmic reticulum

G. Meissner, D. Maclennan, R. Dirksen, 2011, The Journal of general physiology.

ryanodine receptor Ca 2+ ion permeation and release from the sarcoplasmic reticulum

G. Meissner, D. Maclennan, R. Dirksen, 2010 .

Reduced threshold for store overload-induced Ca2+ release is a common defect of RyR1 mutations associated with malignant hyperthermia and central core disease.

D. Maclennan, R. Dirksen, Wenting Guo, 2017, The Biochemical journal.

Altered ryanodine receptor function in central core disease: leaky or uncoupled Ca(2+) release channels?

G. Ávila, R. Dirksen, Robert T Dirksen, 2002, Trends in cardiovascular medicine.

Novel excitation-contraction uncoupled RYR1 mutations in patients with central core disease

A. E. Rossi, D. Maclennan, R. Dirksen, 2013, Neuromuscular Disorders.

The I4895T mutation in the type 1 ryanodine receptor induces fiber‐type specific alterations in skeletal muscle that mimic premature aging

S. Boncompagni, C. Franzini-armstrong, R. Dirksen, 2010, Aging cell.

A retrograde signal from RyR1 alters DHP receptor inactivation and limits window Ca2+ release in muscle fibers of Y522S RyR1 knock-in mice

S. Hamilton, R. Dirksen, W. Melzer, 2009, Proceedings of the National Academy of Sciences.

Alternative splicing of RyR1 alters the efficacy of skeletal EC coupling.

J. Lueck, P. Harvey, M. Casarotto, 2009, Cell calcium.

An Ryr1I4895T mutation abolishes Ca2+ release channel function and delays development in homozygous offspring of a mutant mouse line

J. Seidman, A. Gramolini, C. Seidman, 2007, Proceedings of the National Academy of Sciences.

Heat‐ and anesthesia‐induced malignant hyperthermia in an RyR1 knock‐in mouse

J. Lueck, Pumin Zhang, S. Hamilton, 2006, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

The Pore Region of the Skeletal Muscle Ryanodine Receptor Is a Primary Locus for Excitation-Contraction Uncoupling in Central Core Disease

G. Ávila, R. Dirksen, Kristen M. S. O'Connell, 2003, The Journal of general physiology.

Bi-directional coupling between dihydropyridine receptors and ryanodine receptors.

R. Dirksen, 2002, Frontiers in bioscience : a journal and virtual library.

Functional Impact of the Ryanodine Receptor on the Skeletal Muscle L-Type Ca2+ Channel

G. Ávila, R. Dirksen, 2000, The Journal of general physiology.

Pre-assembled Ca2+ entry units and constitutively active Ca2+ entry in skeletal muscle of calsequestrin-1 knockout mice

T. Takano, A. Michelucci, S. Boncompagni, 2020, The Journal of General Physiology.

Pre-assembled Ca 2+ entry units and constitutively active Ca 2+ entry in skeletal muscle of calsequestrin-1 knockout mice

T. Takano, A. Michelucci, S. Boncompagni, 2020 .

Allele-Specific Gene Silencing in Two Mouse Models of Autosomal Dominant Skeletal Myopathy

J. Lueck, M. A. Mostajo-Radji, R. Dirksen, 2012, PloS one.

Muscle weakness in myotonic dystrophy associated with misregulated splicing and altered gating of Ca(V)1.1 calcium channel.

R. Moxley, M. Nakamori, K. Sobczak, 2012, Human molecular genetics.

Defects in Ca2+ release associated with local expression of pathological ryanodine receptors in mouse muscle fibres

R. Lefebvre, V. Jacquemond, L. Groom, 2011, The Journal of physiology.

Genomic Screening for Malignant Hyperthermia Susceptibility

L. Biesecker, P. Hopkins, K. Stowell, 2020, Anesthesiology.

Malignant hyperthermia and the clinical significance of type-1 ryanodine receptor gene (RYR1) variants: proceedings of the 2013 MHAUS Scientific Conference

J. Dowling, R. Dirksen, S. Muldoon, 2014, Canadian Journal of Anesthesia/Journal canadien d'anesthésie.

Molecular Diversity of Voltage‐Dependent Calcium Channel

K. Mikoshiba, T. Miyata, K. Beam, 1993, Annals of the New York Academy of Sciences.

Primary structure and functional expression of the ω-conotoxin-sensitive N-type calcium channel from rabbit brain

J. Nakai, K. Mikoshiba, T. Miyata, 1993, Neuron.

Dmpk gene deletion or antisense knockdown does not compromise cardiac or skeletal muscle function in mice.

S. Pandey, C. Thornton, C. Bennett, 2016, Human molecular genetics.

Type 1 ryanodine receptor in cardiac mitochondria: transducer of excitation-metabolism coupling.

Shin-Young Ryu, S. Sheu, R. Dirksen, 2005, Biochimica et biophysica acta.

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for the Use of Potent Volatile Anesthetic Agents and Succinylcholine in the Context of RYR1 or CACNA1S Genotypes

Sephalie Y. Patel, K. Sangkuhl, T. Klein, 2019, Clinical pharmacology and therapeutics.

Identification of drug modifiers for RYR1-related myopathy using a multi-species discovery pipeline

P. Roy, W. Zuercher, J. Dowling, 2020, eLife.

Identification of drug modifiers for RYR1 related myopathy using a multi-species discovery pipeline

P. Roy, W. Zuercher, J. Dowling, 2019, bioRxiv.

Tamoxifen therapy in a murine model of myotubular myopathy

Arun K. Ramani, M. Brudno, J. Dowling, 2018, Nature Communications.

Crystal structure of dimeric cardiac L-type calcium channel regulatory domains bridged by Ca2+·calmodulins

F. Quiocho, M. R. Baker, S. Hamilton, 2009, Proceedings of the National Academy of Sciences.

The II-III Loop of the Skeletal Muscle Dihydropyridine Receptor Is Responsible for the Bi-directional Coupling with the Ryanodine Receptor*

K. Beam, R. Dirksen, K G Beam, 1999, The Journal of Biological Chemistry.

Biophysical mechanisms for QRS- and QTc-interval prolongation in mice with cardiac expression of expanded CUG-repeat RNA

C. Thornton, R. Dirksen, Kevin M. Tylock, 2020, The Journal of general physiology.

Altered mRNA splicing of the skeletal muscle ryanodine receptor and sarcoplasmic/endoplasmic reticulum Ca2+-ATPase in myotonic dystrophy type 1.

J. Lueck, S. Sakoda, M. Nakamori, 2005, Human molecular genetics.

Ryanodinopathies: RyR-Linked Muscle Diseases.

R. Dirksen, Lan Wei, 2010, Current topics in membranes.

PharmGKB summary: very important pharmacogene information for CACNA1S

R. Altman, K. Sangkuhl, T. Klein, 2019, Pharmacogenetics and genomics.

Understanding malignant hyperthermia: each move forward opens our eyes to the distance left to travel.

P. Allen, R. Dirksen, J. R. López, 2019, British journal of anaesthesia.

Antipsychotic pimozide is a potent Ca2+ channel blocker in heart.

S. Sheu, R. Dirksen, J J Enyeart, 1990, Molecular pharmacology.

Receptor‐Mediated Inotropic Effect in Heart

M. Jou, S. Sheu, R. Dirksen, 1991 .

Sarcoplasmic reticulum-mitochondrial through-space coupling in skeletal muscle.

R. Dirksen, 2009, Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.

Epac and Phospholipase Cϵ Regulate Ca2+ Release in the Heart by Activation of Protein Kinase Cϵ and Calcium-Calmodulin Kinase II*

B. Blaxall, R. Dirksen, A. Smrcka, 2009, Journal of Biological Chemistry.

Epac-mediated Activation of Phospholipase Cϵ Plays a Critical Role in β-Adrenergic Receptor-dependent Enhancement of Ca2+ Mobilization in Cardiac Myocytes*

Huan Wang, K. Kaproth-Joslin, B. Blaxall, 2007, Journal of Biological Chemistry.

Phospholipase C epsilon modulates beta-adrenergic receptor-dependent cardiac contraction and inhibits cardiac hypertrophy.

Burns C Blaxall, K. Vikstrom, B. Blaxall, 2005, Circulation research.

Muscle Chloride Channel Dysfunction in Two Mouse Models of Myotonic Dystrophy

J. Lueck, M. Swanson, C. Thornton, 2007, The Journal of general physiology.

Adrenergic Signaling Regulates Mitochondrial Ca ( 2 + ) Uptake Through Pyk 2-Dependent Tyrosine Phosphorylation of the Mitochondrial Ca ( 2 + )

Godfrey L. Smith, Shangcheng Xu, R. Rizzuto, 2017 .

Reconstitution of local Ca2+ signaling between cardiac L-type Ca2+ channels and ryanodine receptors: insights into regulation by FKBP12.6.

R. Dirksen, Sanjeewa A. Goonasekera, S. Chen, 2005, American journal of physiology. Cell physiology.

Mitochondrial Flash: Integrative Reactive Oxygen Species and pH Signals in Cell and Organelle Biology

Xianhua Wang, Heping Cheng, S. Sheu, 2016, Antioxidants & redox signaling.

Characterization of ryanodine receptor type 1 single channel activity using "on-nucleus" patch clamp.

L. Groom, R. Dirksen, D. Yule, 2014, Cell calcium.

Role of Calcium Permeation in Dihydropyridine Receptor Function

K. Beam, R. Dirksen, 1999, The Journal of general physiology.

Adrenergic Signaling Controls RGK-Dependent Trafficking of Cardiac Voltage-Gated L-Type Ca2+ Channels Through PKD1

Ji Young Kim, Coeli M B Lopes, R. Dirksen, 2012, Circulation research.

Mena associates with Rac1 and modulates connexin 43 remodeling in cardiomyocytes.

B. Blaxall, R. Dirksen, Andrew P. Wescott, 2014, American journal of physiology. Heart and circulatory physiology.

Exercise-dependent formation of new junctions that promote STIM1-Orai1 assembly in skeletal muscle

A. Michelucci, S. Boncompagni, F. Protasi, 2017, Scientific Reports.

Prolonged depolarization promotes fast gating kinetics of L‐type Ca2+ channels in mouse skeletal myotubes

R. Dirksen, Kristen M. S. O'Connell, 2000, The Journal of physiology.

Addendum: Exercise-dependent formation of new junctions that promote STIM1-Orai1 assembly in skeletal muscle

A. Michelucci, S. Boncompagni, F. Protasi, 2018, Scientific Reports.

Respective Contribution of Mitochondrial Superoxide and pH to Mitochondria-targeted Circularly Permuted Yellow Fluorescent Protein (mt-cpYFP) Flash Activity*

David I. Yule, Heping Cheng, Xianhua Wang, 2013, The Journal of Biological Chemistry.

Sarcoplasmic Reticulum-Mitochondrial Symbiosis: Bidirectional Signaling in Skeletal Muscle

A. E. Rossi, S. Boncompagni, R. Dirksen, 2009, Exercise and sport sciences reviews.

Glutathione supports lipid abundance in vivo

Ying Chen, V. Vasiliou, I. Harris, 2023, bioRxiv.

Age-dependent uncoupling of mitochondria from Ca2+ release units in skeletal muscle

H. Kern, A. Michelucci, S. Boncompagni, 2015, Oncotarget.

Checking your SOCCs and feet: the molecular mechanisms of Ca2+ entry in skeletal muscle

R. Dirksen, 2009, The Journal of physiology.

analysis of human vastus lateralis muscle ( hVLM ) from climbers after mountaineering expedition to Himalayas

A. E. Rossi, C. Franzini-armstrong, S. Hamilton, 2022 .

Superoxide flashes: illuminating new insights into cardiac ischemia/reperfusion injury.

Heping Cheng, S. Sheu, Wang Wang, 2008, Future cardiology.

Regions of ryanodine receptors that influence activation by the dihydropyridine receptor β1a subunit

M. Casarotto, A. Dulhunty, N. Beard, 2015, Skeletal Muscle.

Monovalent cationic channel activity in the inner membrane of nuclei from skeletal muscle fibers.

R. Dirksen, V. Yarotskyy, Viktor Yarotskyy, 2014, Biophysical journal.

Ca2+ Binding/Permeation via Calcium Channel, CaV1.1, Regulates the Intracellular Distribution of the Fatty Acid Transport Protein, CD36, and Fatty Acid Metabolism*

R. Pautler, S. Hamilton, R. Dirksen, 2015, The Journal of Biological Chemistry.

Genetic biomarkers for the risk of seizures in long QT syndrome

A. Moss, W. Zareba, R. Gross, 2016, Neurology.

Epac-mediated activation of phospholipase C(epsilon) plays a critical role in beta-adrenergic receptor-dependent enhancement of Ca2+ mobilization in cardiac myocytes.

Huan Wang, K. Kaproth-Joslin, B. Blaxall, 2007, The Journal of biological chemistry.

Ca2+ current and Ca2+ transients under action potential clamp in guinea pig ventricular myocytes.

J. Arreola, R. Dirksen, D. Williford, 1991, The American journal of physiology.

Isolating a reverse-mode ATP synthase–dependent mechanism of mitoflash activation

R. Dirksen, L. Wei-LaPierre, Wei-LaPierre Lan, 2019, The Journal of general physiology.

Substrate-dependent and cyclophilin D-independent regulation of mitochondrial flashes in skeletal and cardiac muscle.

R. Dirksen, Kevin M. Tylock, L. Wei-LaPierre, 2019, Archives of biochemistry and biophysics.

Oxidative stress, mitochondrial damage, and cores in muscle from calsequestrin-1 knockout mice

A. Michelucci, C. Reggiani, F. Protasi, 2015, Skeletal Muscle.

Differential dependence of store‐operated and excitation‐coupled Ca2+ entry in skeletal muscle on STIM1 and Orai1

R. Dirksen, A. Lyfenko, 2008, The Journal of physiology.

FKBP12 Binding to RyR1 Modulates Excitation-Contraction Coupling in Mouse Skeletal Myotubes*

P. Allen, Eun Hui Lee, G. Ávila, 2003, Journal of Biological Chemistry.

Constitutive assembly of Ca2+ entry units in soleus muscle from calsequestrin knockout mice

A. Michelucci, S. Boncompagni, F. Protasi, 2022, The Journal of general physiology.

Response to the letter: “On the localization of ClC-1 in skeletal muscle fibers”

A. E. Rossi, J. Lueck, K. Campbell, 2011, The Journal of General Physiology.

Acute exposure to extracellular BTP2 does not inhibit Ca2+ release during EC coupling in intact skeletal muscle fibers

L. Groom, R. Dirksen, L. Wei-LaPierre, 2021, The Journal of general physiology.

Molecular Mechanism of Store Operated Ca2+ Entry in Adult Mammalian Skeletal Muscle

R. Dirksen, A. Lyfenko, 2010 .

Exercise-dependent formation of new junctions that promote STIM1-Orai1 assembly in skeletal muscle

A. Michelucci, S. Boncompagni, F. Protasi, 2017, Scientific Reports.

New method for determining total calcium content in tissue applied to skeletal muscle with and without calsequestrin

F. Protasi, É. Rousseau, P. Bouchard, 2015, The Journal of general physiology.

Emerging questions about the macromolecular machines of muscle

E. Pugh, R. Dirksen, 2010, The Journal of general physiology.

Ca2+ Release through Ryanodine Receptors Regulates Skeletal Muscle L-type Ca2+ Channel Expression*

G. Ávila, L. Groom, R. Dirksen, 2001, The Journal of Biological Chemistry.

Regions of ryanodine receptors that influence activation by the dihydropyridine receptor β1a subunit

M. Casarotto, A. Dulhunty, N. Beard, 2015, Skeletal Muscle.

Endurance exercise attenuates juvenile irradiation-induced skeletal muscle functional decline and mitochondrial stress

Jacqueline P. Williams, C. Johnston, R. Dirksen, 2022, Skeletal muscle.

Mitochondria take center stage

E. Pugh, S. Sheu, R. Dirksen, 2012, The Journal of general physiology.

Sarcoplasmic Reticulum-Mitochondrial Symbiosis: Bidirectional Signaling in Skeletal Muscle

A. E. Rossi, S. Boncompagni, R. Dirksen, 2009, Exercise and sport sciences reviews.

Antioxidants Protect Calsequestrin-1 Knockout Mice from Halothane- and Heat-induced Sudden Death

A. Michelucci, C. Reggiani, F. Protasi, 2015, Anesthesiology.

Identification of Cysteines Involved in S-Nitrosylation, S-Glutathionylation, and Oxidation to Disulfides in Ryanodine Receptor Type 1*

S. Hamilton, C. Hidalgo, R. Dirksen, 2006, Journal of Biological Chemistry.

Function of a mutant ryanodine receptor (T4709M) linked to congenital myopathy

L. Groom, R. Dirksen, Zsuzsanna É Magyar, 2023, Scientific reports.

Multi-minicore disease and atypical periodic paralysis associated with novel mutations in the skeletal muscle ryanodine receptor (RYR1) gene

F. Muntoni, S. Al-Sarraj, Haiyan Zhou, 2010, Neuromuscular Disorders.

Single Channel Characterization of the Mitochondrial Ryanodine Receptor in Heart Mitoplasts*

Shin-Young Ryu, K. Kinnally, S. Sheu, 2011, The Journal of Biological Chemistry.

Differential impact of mitochondrial positioning on mitochondrial Ca(2+) uptake and Ca(2+) spark suppression in skeletal muscle.

A. E. Rossi, S. Boncompagni, F. Protasi, 2011, American journal of physiology. Cell physiology.

Characterization of ryanodine receptor type 1 single channel activity using "on-nucleus" patch clamp.

L. Groom, R. Dirksen, D. Yule, 2014, Cell calcium.

Trojan triplets: RNA-based pathomechanisms for muscle dysfunction in Huntington’s disease

R. Dirksen, M. Skov, 2017, The Journal of general physiology.

Congenital myopathy results from misregulation of a muscle Ca2+ channel by mutant Stac3

Jeremy W. Linsley, J. Y. Kuwada, C. Franzini-armstrong, 2016, Proceedings of the National Academy of Sciences.

Potentiated L-type Ca2+ Channels Rectify

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