T. Arai

发表

Edaravone directly reacts with singlet oxygen and protects cells from attack.

S. Adachi, Yoko Nishinaka, H. Mori, 2010, Life sciences.

Endogenous interleukin 10 prevents apoptosis in macrophages during Salmonella infection.

Y. Nimura, Y. Yoshikai, H. Ishida, 1995, Biochemical and biophysical research communications.

IL-10 is involved in the protective effect of dibutyryl cyclic adenosine monophosphate on endotoxin-induced inflammatory liver injury.

Y. Nimura, Y. Yoshikai, H. Ishida, 1995, Journal of immunology.

Antioxidative activity of 5,6,7,8-tetrahydrobiopterin and its inhibitory effect on paraquat-induced cell toxicity in cultured rat hepatocytes.

H. Mori, T. Arai, K. Kubota, 1995, Free radical research.

Singlet oxygen is essential for neutrophil extracellular trap formation.

S. Adachi, A. Takaori-Kondo, Yoko Nishinaka, 2011, Biochemical and biophysical research communications.

Uric acid induces NADPH oxidase-independent neutrophil extracellular trap formation.

Tomohiro Watanabe, M. Morita, S. Adachi, 2014, Biochemical and biophysical research communications.

Enhancement of Radiation-induced Apoptosis by 6-Formylpterin

Zheng-Guo Cui, Qing‐Li Zhao, T. Kondo, 2004, Free radical research.

Inhibitory Effect of 6-Formylpterin on HIF-1α Protein Accumulation

K. Hirota, K. Makino, T. Kodaki, 2007 .

Ozone production by amino acids contributes to killing of bacteria

K. Makino, T. Uchiyama, N. Endo, 2008, Proceedings of the National Academy of Sciences.

Neuroprotective effects of pterin-6-aldehyde in gerbil global brain ischemia: comparison with those of α-phenyl-N-tert-butyl nitrone

H. Mori, N. Endo, T. Arai, 1998, Neuroscience Letters.

Novel 6-formylpterin derivatives: chemical synthesis and O2 to ROS conversion activities.

S. Pack, K. Makino, T. Kodaki, 2006, Organic & biomolecular chemistry.

Lactosylceramide stimulates human neutrophils to upregulate Mac-1, adhere to endothelium, and generate reactive oxygen metabolites in vitro.

A. Bhunia, T. Arai, G. Bulkley, 1998, Circulation research.

LPS-induced ROS generation and changes in glutathione level and their relation to the maturation of human monocyte-derived dendritic cells.

K. Fukuda, H. Yamada, T. Uchiyama, 2006, Life sciences.

Toll-like receptors 2 and 4 are differentially involved in Fas dependent apoptosis in Peyer’s patch and the liver at an early stage after bile duct ligation in mice

S. Akira, K. Takeda, Y. Nimura, 2005, Gut.

Protective effects of intracellular reactive oxygen species generated by 6-formylpterin on tumor necrosis factor-alpha-induced apoptotic cell injury in cultured rat hepatocytes.

K. Fukuda, H. Yamada, K. Makino, 2005, Life sciences.

The Radical Scavenger Edaravone (3-Methyl-1-phenyl-2-pyrazolin-5-one) Reacts with a Pterin Derivative and Produces a Cytotoxic Substance That Induces Intracellular Reactive Oxygen Species Generation and Cell Death

K. Fukuda, K. Makino, H. Mori, 2008, Journal of Pharmacology and Experimental Therapeutics.

Effects of edaravone on singlet oxygen released from activated human neutrophils.

K. Makino, H. Mori, Takashi Miyoshi, 2007, Journal of pharmacological sciences.

Effects of 6-formylpterin, a xanthine oxidase inhibitor and a superoxide scavenger, on production of nitric oxide in RAW 264.7 macrophages.

K. Fukuda, K. Hirota, K. Makino, 2000, Biochimica et biophysica acta.

6-formylpterin, a xanthine oxidase inhibitor, intracellularly generates reactive oxygen species involved in apoptosis and cell proliferation.

K. Fukuda, K. Hirota, K. Makino, 2001, Free radical biology & medicine.

6‐Formylpterin protects retinal neurons from transient ischemia–reperfusion injury in rats: A morphological and immunohistochemical study

E. Ohama, K. Makino, N. Endo, 2003, Neuropathology : official journal of the Japanese Society of Neuropathology.

Oxypurinol, a xanthine oxidase inhibitor and a superoxide scavenger, did not attenuate ischemic neuronal damage in gerbils.

K. Makino, H. Mori, N. Endo, 1998, Life sciences.

Protein tyrosine phosphorylation mediates TNF-induced endothelial-neutrophil adhesion in vitro.

P. Goldschmidt-Clermont, T. Arai, G. Bulkley, 1998, American journal of physiology. Heart and circulatory physiology.

Effects of 6-formylpterin as an internal source of hydrogen peroxide on cell death of human peripheral blood leukocytes.

K. Fukuda, K. Makino, K. Tajima, 2003, Life sciences.

Effects of injectable propofol emulsion on singlet oxygen released from activated human neutrophils and that chemically generated.

Yoko Nishinaka, H. Mori, N. Endo, 2008, Journal of pharmacological sciences.

Effects of intracellular reactive oxygen species generated by 6-formylpterin on T cell functions.

K. Fukuda, H. Yamada, T. Namba, 2004, Biochemical pharmacology.

6-formylpterin intracellularly generates hydrogen peroxide and restores the impaired bactericidal activity of human neutrophils.

K. Fukuda, K. Makino, K. Tajima, 2001, Biochemical and biophysical research communications.

CD4 expression is important but not essential for infection with exogenous mouse mammary tumor virus.

T. Morishima, T. Arai, K. Hiromatsu, 1996, Immunobiology.

Ambient but not incremental oxidant generation effects intercellular adhesion molecule 1 induction by tumour necrosis factor alpha in endothelium.

M. Takano, P. Goldschmidt-Clermont, T. Arai, 1998, The Biochemical journal.

The role of endothelial interleukin‐8/NADPH oxidase 1 axis in sepsis

T. Uchiyama, Takashi Miyoshi, K. Yamashita, 2010, Immunology.

Substituent effects of pterin derivatives on singlet oxygen scavenging activity.

K. Makino, Yoko Nishinaka, H. Mori, 2010, Biological & pharmaceutical bulletin.

Lactosylceramide Mediates Tumor Necrosis Factor-α-induced Intercellular Adhesion Molecule-1 (ICAM-1) Expression and the Adhesion of Neutrophil in Human Umbilical Vein Endothelial Cells*

A. Bhunia, T. Arai, G. Bulkley, 1998, The Journal of Biological Chemistry.

Synthesis of 6-formylpterin nucleoside analogs and their ROS generation activities in the presence of NADH in the dark.

S. Pack, Y. Kotake, K. Makino, 2007, Organic & biomolecular chemistry.

Reactive oxygen species generation through NADH oxidation by 6-formylpterin derivatives in the dark.

S. Pack, K. Makino, T. Kodaki, 2007, Biochemical and biophysical research communications.

Pterin-6-aldehyde, an inhibitor of xanthine oxidase, has superoxide anion radical scavenging activity.

K. Makino, K. Tajima, H. Mori, 1997, Biochemical and biophysical research communications.

An important role of Tyk2 in APC function of dendritic cells for priming CD8+ T cells producing IFN‐γ

Y. Nimura, T. Yajima, Y. Yoshikai, 2006, European journal of immunology.

Anticancer photodynamic and non-photodynamic effects of pterin derivatives on a pancreatic cancer cell line.

K. Makino, H. Mori, Takashi Miyoshi, 2008, Journal of pharmacological sciences.

Effects of in vivo administration of anti-IL-10 monoclonal antibody on the host defence mechanism against murine Salmonella infection.

Y. Nimura, Y. Yoshikai, H. Ishida, 1995, Immunology.

Hepatic Killing but not Clearance of Systemically Circulating Bacteria is Dependent Upon Peripheral Leukocytes Via MAC-1 (CD11B/CD18)

A. Klein, E. Ceppa, T. Arai, 2003, Shock.

Enhancing potency of neopterin toward B-16 melanoma cell damage induced by UV-A irradiation and its possible application for skin tumor treatment.

H. Mori, T. Arai, S. Kojima, 1995, Anticancer research.

NK T cells stimulated with a ligand for TLR2 at least partly contribute to liver injury caused by Escherichia coli infection in mice

Y. Nimura, T. Matsuguchi, T. Yajima, 2003, European journal of immunology.

Effects of neopterin on ischemic neuronal damage in gerbils

H. Kimura, I. Tooyama, H. Mori, 1994, Neuroscience Letters.

Lethal shock is inducible by lipopolysaccharide but not by superantigen in mice with retrovirus-induced immunodeficiency syndrome.

Y. Yoshikai, H. Ishida, J. Usami, 1995, Journal of immunology.

Auto-oxidation of 5,6,7 ,8-tetrahydroneopterin

Toshinori Suzuki, H. Mori, T. Arai, 1998 .

Effects of Neopterin on Focal Cerebral Ischemia In Rats

H. Mori, T. Arai, S. Kojima, 1996 .

Geranylgeranylacetone enhances expression of thioredoxin and suppresses ethanol-induced cytotoxicity in cultured hepatocytes.

H. Nakamura, J. Yodoi, K. Fukuda, 2000, Biochemical and biophysical research communications.

NB4 cells treated with all-trans retinoic acid generate toxic reactive oxygen species that cause endothelial hyperpermeability.

T. Uchiyama, Takashi Miyoshi, K. Yamashita, 2010, Leukemia research.

Use of M4PO and oxygen-17 in the study on hydroxyl radical generation in the hypoxanthine-xanthine oxidase reaction.

K. Makino, H. Mori, T. Arai, 1994, Biochemistry and molecular biology international.

Gene expression in enhanced apoptosis of human lymphoma U937 cells treated with the combination of different free radical generators and hyperthermia

Zheng-Guo Cui, Y. Tabuchi, I. Takasaki, 2007, Free radical research.

Does the reduced form of neopterin serve as an antioxidant?

Toshinori Suzuki, K. Makino, H. Mori, 1996, Biochemistry and molecular biology international.

Overexpression of interleukin-15 protects against Escherichia coli-induced shock accompanied by inhibition of tumor necrosis factor-alpha-induced apoptosis.

Y. Nimura, T. Matsuguchi, T. Yajima, 2003, The Journal of infectious diseases.

Expression of a neutrophil chemotactic protein LECT2 in human hepatocytes revealed by immunochemical studies using polyclonal and monoclonal antibodies to a recombinant LECT2.

K. Suzuki, S. Mizuno, S. Yamagoe, 1997, Biochemical and biophysical research communications.

Dibutyryl cyclic adenosine monophosphate protects mice against tumor necrosis factor-alpha-induced hepatocyte apoptosis accompanied by increased heat shock protein 70 expression.

Y. Nimura, Y. Yoshikai, T. Arai, 1998, Cell stress & chaperones.

α-Phenyl-N-tert-butyl Nitrone Has Scavenging Activity Against Singlet Oxygen (1O2) and Attenuates 1O2-Induced Neuronal Cell Death

K. Hirota, Yoko Nishinaka, H. Mori, 2008 .

Reactive oxygen species generation through NADH oxidation by pterin derivatives.

S. Pack, K. Makino, T. Kodaki, 2008, Nucleic acids symposium series.

The Radical Scavenger Edaravone (3-Methyl-1-phenyl-2-pyrazolin-5-one) Reacts with a Pterin Derivative and Produces a Cytotoxic Substance That Induces Intracellular Reactive Oxygen Species Generation and Cell Death

K. Fukuda, K. Makino, H. Mori, 2008, Journal of Pharmacology and Experimental Therapeutics.

A hydrogen peroxide-generating agent, 6-formylpterin, enhances heat-induced apoptosis

Zheng-Guo Cui, T. Kondo, M. Shoji, 2005, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.