M. Hacker

发表

Mechanisms of asbestos-induced nitric oxide production by rat alveolar macrophages in inhalation and in vitro models.

J. Torino, P. O’Shaughnessy, D. Taatjes, 1998, Free radical biology & medicine.

Effect of cytotoxic monoclonal antibody depletion of T-lymphocyte subpopulations on bleomycin-induced lung damage in C57BL/6J mice.

M. Hacker, D. Janick-Buckner, G. Ranges, 1989, Toxicology and applied pharmacology.

Increased oxidant resistance of alveolar macrophages isolated from rats repeatedly exposed to cadmium aerosols.

M. Hacker, Q. Gong, B. Hart, 1996, Toxicology.

Correlation of altered tyrosine phosphorylation with methotrexate resistance in a cisplatin-resistant subline of L1210 cells.

A. Bhushan, M. Hacker, T. Tritton, 1996, Biochemical pharmacology.

Characterization of anthracenediones and their photoaffinity analogs.

M. Hacker, K. Chou, D. Horn, 2002, Biochemical pharmacology.

Characterization of lymphocyte activating factor from mouse tumor cell lines and human leukocytes

M. Hacker, R. Handschumacher, L. Lachman, 1976 .

Efficacy and toxicity of 4-(2-sulfonatoethylthio)-cyclophosphamide cyclohexylamine salt (ASTA Z 7557, INN mafosfamide) after intraperitoneal administration to mice

John D. Roberts, R. Newman, M. Hacker, 2004, Investigational New Drugs.

Hypoxia activated prodrugs of a 9-aza-anthrapyrazole derivative that has promising anticancer activity.

P. Erhardt, M. Hacker, Nicholas L. Adamski, 2011, Journal of medicinal chemistry.

B16 murine melanoma and aging: slower growth and longer survival in old mice.

W. Ershler, M. Hacker, J. Stewart, 1984, Journal of the National Cancer Institute.

Formation of nitric oxide hemoglobin in erythrocytes co-cultured with alveolar macrophages taken from bleomycin treated rats.

R. Smith, M. Hacker, A. Huot, 1992, Biochemical and biophysical research communications.

Specific antibody synthesis in vitro. II. Age-associated thymosin enhancement of antitetanus antibody synthesis.

A. Goldstein, W. Ershler, M. Hacker, 1984, Immunopharmacology.

Role of reactive nitrogen intermediate production in alveolar macrophage-mediated cytostatic activity induced by bleomycin lung damage in rats.

M. Hacker, A. Huot, Miles P. Hacker, 1990, Cancer research.

Something Old, New, Borrowed, Blue: Anthracenedione Agents for Treatment of Multiple Sclerosis

M. Hacker, W. Gunning, B. Koffman, 2016, Clinical neuropharmacology.

Collateral methotrexate resistance in cisplatin-selected murine leukemia cells.

A. Bhushan, M. Hacker, T. Tritton, 1999, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

Immobilized adriamycin: toxic potential in vivo and in vitro.

J. Lazo, M. Hacker, T. Tritton, 1989, Selective cancer therapeutics.

Preparation of lymphocyte-activating factor from continuous murine macrophage cell lines.

M. Hacker, R. Handschumacher, L. Lachman, 1977, Cellular immunology.

Alteration of bronchoalveolar lavage cell populations following bleomycin treatment in mice.

M. Hacker, D. Janick-Buckner, G. Ranges, 1989, Toxicology and applied pharmacology.

The Toxicity of Anticancer Drugs

G. Powis, G. Carlon, M. Hacker, 1991 .

Adriamycin-mediated inhibition of creatine phosphokinase binding to heart mitochondrial membrane.

R. Newman, M. Hacker, M. A. Fagan, 1982, Biochemical pharmacology.

Multiple mechanisms confer drug resistance to mitoxantrone in the human 8226 myeloma cell line.

W. Dalton, A. Cress, L. Hazlehurst, 1999, Cancer research.

Enhanced Ia expression by alveolar macrophages following intratracheal administration of bleomycin to rats.

M. Hacker, P. Kimberly, A. Huot, 1992, Immunological investigations.

Nitric oxide modulates lymphocyte proliferation but not secretion of IL-2.

John D. Roberts, M. Hacker, J. Roberts, 1993, Immunological investigations.

Effect of osmotic diuresis on gentamicin-induced nephrotoxicity in rats

R. Newman, L. Weinstock, J. Yates, 1980, Archives of Toxicology.

Cisplatin Efficacy and Toxicity: Are they Separable?

John D. Roberts, M. Hacker, 1988 .

Investigations on the mechanisms of methotrexate resistance in a cisplatin-resistant L1210 murine leukemia cell subline

A. Bhushan, M. Hacker, T. Tritton, 1996, Cancer Chemotherapy and Pharmacology.

THE HEMODYNAMIC EFFECTS OF DIASPIRIN CROSS-LINKED HEMOGLOBIN IN DOPAMINE-RESISTANT ENDOTOXIC SHOCK IN SWINE *

D. Freilich, M. Hacker, L. Leach, 2002, Artificial cells, blood substitutes, and immobilization biotechnology.

Anticholinesterase activity of the unsymmetric bisquaternary 6-aminoquinoline salt NSC-176319.

M. Hacker, S. Unwin, J. Braddock, 1982, Biochemical pharmacology.

Alveolar macrophage function is selectively altered after endotoxemia in rats

J. Christman, M. Hacker, G. S. Davis, 1988, Infection and immunity.

Amelioration of adriamycin and daunorubicin myocardial toxicity by adenosine.

R. Newman, M. Hacker, I. Krakoff, 1981, Cancer research.

Depression of the Platelet Count after Inoculation of Mice with L1210 or L5178Y Cells

M. Hacker, C. Jackson, D. Roberts, 1977, British journal of haematology.

Fibrogenic structure-activity study of the bleomycin molecule.

R. Newman, M. Hacker, T. Sakai, 1983, Toxicology and applied pharmacology.

VIP Activates Gs and Gi3 in Rat Alveolar Macrophages and Gs in HEK293 Cells Transfected with the Human VPAC1 Receptor

S. Shreeve, M. Morgan, M. Hacker, 2000 .

VM26-induced changes in hepatic intermediary metabolism of mice.

M. Hacker, D. Roberts, 1977, Cancer research.

The synthesis of 6,9‐bis[(aminoalkyl)amino] substituted benzo[g]quinoxaline‐, benzo[g]quinazoline‐ and benzo‐[g]phthalazine‐5,10‐diones via regiospecific displacements

M. Hacker, A. P. Krapcho, K. Rosner, 1993 .

Decreased lactic acidosis and anemia after transfusion of o-raffinose cross-linked and polymerized hemoglobin in severe murine malaria.

D. Freilich, R. Branda, M. Hacker, 1999, The American journal of tropical medicine and hygiene.

Effect of erythrocytes on alveolar macrophage cytostatic activity induced by bleomycin lung damage in rats.

M. Hacker, R. Gundel, A. Huot, 1990, Cancer research.

Impact of the basic amine on the biological activity and intracellular distribution of an aza-anthrapyrazole: BBR 3422.

M. Hacker, K. Chou, A. Paul Krapcho, 2001, Biochemical pharmacology.

Platinum Coordination Complexes in Cancer Chemotherapy

E. Douple, M. Hacker, I. Krakoff, 2011, Developments in Oncology.

Cytotoxicity and antitumor activity of bis(platinum) complexes. A novel class of platinum complexes active in cell lines resistant to both cisplatin and 1,2-diaminocyclohexane complexes.

N. Farrell, Y. Qu, M. Hacker, 1990, Journal of medicinal chemistry.

6,9-Bis[(aminoalkyl)amino]benzo[g]isoquinoline-5,10-diones. A novel class of chromophore-modified antitumor anthracene-9,10-diones: synthesis and antitumor evaluations.

J. Polsenberg, M. Hacker, C. Gallagher, 1994, Journal of medicinal chemistry.

Synthesis and antitumor evaluation of 2,5-disubstituted-indazolo[4, 3-gh]isoquinolin-6(2H)-ones (9-aza-anthrapyrazoles).

G. Pezzoni, M. Hacker, C. Gallagher, 1998, Journal of medicinal chemistry.

SYNTHESIS OF HYDROXY-SUBSTITUTED AZA-ANALOGUES OF ANTITUMOR ANTHRAPYRAZOLES

M. Hacker, A. P. Krapcho, A. Hammach, 1998 .

Chemical properties and antitumor activity of complexes of platinum containing substituted sulfoxides [PtCl(R'R''SO)(diamine)]NO3. Chirality and leaving-group ability of sulfoxide affecting biological activity

N. Farrell, M. Hacker, D. Kiley, 1990 .

Shikimic acid complexes of platinum. Preparation, reactivity, and antitumor activity of (R,R-1,2-diaminocyclohexane) bis(shikimato) platinum(II). Evidence for a novel rearrangement involving platinum-carbon bond formation.

N. Farrell, M. Hacker, J. Roberts, 1991, Journal of inorganic biochemistry.

Synthesis and antitumor activity of platinum complexes containing neutral and protonated amino-olefin ligands

A. Khokhar, M. Hacker, J. McCormack, 1982 .

The synthesis of 6,9-difluorobenzo[g]quinoline-5,10-dione. Displacements of the fluorides by diamines which lead to 6,9-bis[(aminoalkyl)amino]benzo[g]quinoline-5,10-diones

J. Polsenberg, M. Hacker, A. P. Krapcho, 1993 .

Synthesis and antineoplastic evaluations of 5,8-bis[(aminoalkyl)amino]-1-azaanthracene-9,10-diones.

M. Hacker, A. P. Krapcho, J. McCormack, 1985, Journal of medicinal chemistry.

Water-soluble N-substituted iminodiacetato(1,2-diaminocyclohexane)-platinum(II) complexes as potential antitumor agents.

D. Brown, A. Khokhar, M. Hacker, 1986, Cancer Research.

Sulfoxides as leaving groups. Effect of sterically hindered aliphatic sulfoxides on the antitumor activity of chloro(substituted sulfoxide)(1,1-diaminomethylcyclohexane)platinum(II) nitrate

N. Farrell, M. Hacker, J. Landi, 1992 .

Chemical and biological characterization of a series of water soluble 1,2-diaminocyclohexane platinum(II) complexes

A. Khokhar, M. Hacker, 1991 .

Properties of a chloroquine adduct of rhodium acetate

N. Farrell, M. Hacker, 1989 .

Water soluble DACHPt(II) complexes: Problems of purification; Stability of complexes with nitrogen-containing ligands

John D. Roberts, W. Tong, M. Hacker, 1988 .

New biologically active cyclophosphazene derivatives

R. Newman, J. A. MacKay, M. Hacker, 1982 .

Antineoplastic cyclic peptides from the marine tunicate Lissoclinum patella

Chris M. Ireland, C. Ireland, R. Newman, 1982 .

Potential DNA bis-intercalating agents: synthesis and antitumor activity of novel, conformationally restricted bis(9-aminoacridines)

G. Gribble, M. Hacker, G. Jaycox, 1987 .

Cremophor and Emulphor induced alterations of serum lipids and lipoprotein electrophoretic patterns of dogs.

M. Hacker, M. A. Fagan, C. Hong, 1981, Research communications in chemical pathology and pharmacology.

Cimetidine and the immune response. I. In vivo augmentation of nonspecific and specific immune response.

W. Ershler, M. Hacker, C. F. Myers, 1983, Clinical immunology and immunopathology.

Dissociation of antitumor potency from anthracycline cardiotoxicity in a doxorubicin analog.

B. Sikic, N. F. Friend, E. Acton, 1985, Science.

Assessment of bleomycin-, tallysomycin-, and polyamine-mediated acute lung toxicity by pulmonary lavage angiotensin-converting enzyme activity.

R. Newman, M. Hacker, P. Kimberly, 1981, Toxicology and applied pharmacology.

Heterosubstituted Anthracene‐9,10‐dione Analogues. The Synthesis and Antitumor Evaluation of 5,8‐Bis((aminoalkyl)amino)naphtho(2,3‐b) thiophene‐4,9‐diones.

M. Hacker, A. P. Krapcho, M. Petry, 1991 .

Synthesis and antitumor evaluations of symmetrically and unsymmetrically substituted 1,4-bis[(aminoalkyl)amino]anthracene-9,10-diones and 1,4-bis[(aminoalkyl)amino]-5,8-dihydroxyanthracene-9,10-diones.

C. Manzotti, G. Pezzoni, M. Hacker, 1991, Journal of medicinal chemistry.

Heterosubstituted anthracene-9,10-dione analogues. The synthesis and antitumor evaluation of 5,8-bis[(aminoalkyl)amino]naphtho[2,3-b] thiophene-4,9-diones.

M. Hacker, A. P. Krapcho, M. Petry, 1990, Journal of medicinal chemistry.

Synthesis and Antitumor Evaluations of Symmetrically and Unsymmetrically Substituted 1,4-Bis((aminoalkyl)amino)anthracene-9,10- diones and 1,4-Bis((aminoalkyl)amino)-5,8-dihydroxyanthracene-9,10- diones.

C. Manzotti, G. Pezzoni, M. Hacker, 1991 .

Synthesis and antitumor activities of 5-methyl-1- and 2-[[2-dimethylaminoethyl]amino]-aza-thiopyranoindazoles.

M. Hacker, S. Haydar, A. P. Krapcho, 2000, Bioorganic & medicinal chemistry letters.

Synthesis of 4‐hydroxy‐6,9‐difluorobenz[g]isoquinoline‐5,10‐diones and conversions to 4‐hydroxy‐6,9‐bis[(aminoalkyl)amino]‐benz[g]isoquinoline‐5,10‐diones

M. Hacker, C. Gallagher, A. P. Krapcho, 1995 .

Experimental tumors and aging: local factors that may account for the observed age advantage in the B16 murine melanoma model

R. Gamelli, W. Ershler, M. Hacker, 1984, Experimental Gerontology.

Effect of disulfiram (tetraethylthiuram disulfide) amd diethyldithiocarbamate on the bladder toxicity and antitumor activity of cyclophosphamide in mice.

R. Gamelli, R. Newman, W. Ershler, 1982, Cancer research.

Synthesis and antitumor activity of a series of (aminoethylpyrrolidine) platinum complexes

A. Khokhar, M. Hacker, J. McCormack, 2004, Cancer Chemotherapy and Pharmacology.

Metabolism of tiazofurin by human erythrocytes and mononuclear blood cells in vitro.

W. Tong, M. Hacker, J. Roberts, 1986, Cancer letters.

Pharmacology: Principles and Practice

M. Hacker, K. Bachmann, Kenneth Bachmann, 2008 .

Ascorbato(1,2-diaminocyclohexane):platinum(II) complexes, a new series of water-soluble antitumor drugs.

D. Brown, A. Khokhar, M. Hacker, 1985, Cancer research.

Partial purification of human lymphocyte-activating factor (LAF) by ultrafiltration and electrophoretic techniques.

M. Hacker, R. Handschumacher, L. Lachman, 1977, Journal of immunology.

Overexpression of metallothionein confers resistance to anticancer drugs.

D. Hamer, B. Teicher, J. Lazo, 1988, Science.

Vinblastine pharmacokinetics measured by a sensitive enzyme-linked immunosorbent assay.

W. Ershler, M. Hacker, J. R. Dank, 1984, Cancer research.

16alpha-bromoepiandrosterone, a dehydroepiandrosterone (DHEA) analogue, inhibits Plasmodium falciparum and Plasmodium berghei growth.

D. Freilich, M. Hacker, C. Ahlem, 2000, The American journal of tropical medicine and hygiene.

Correlation of DNA reactivity and cytotoxicity of a new class of anticancer agents: aza-anthracenediones.

M. Hacker, A. P. Krapcho, L. Hazlehurst, 1995, Cancer letters.

A novel aza-anthrapyrazole blocks the progression of experimental autoimmune encephalomyelitis after the priming of autoimmunity.

M. Hacker, A. Quinn, A. Kiraly, 2011, Clinical immunology.

Comparison of aza-anthracenedione-induced DNA damage and cytotoxicity in experimental tumor cells.

M. Hacker, A. P. Krapcho, L. Hazlehurst, 1995, Biochemical pharmacology.

Synthesis and antitumor activities of unsymmetrically substituted 1,4-bis[(aminoalkyl)amino]anthracene-9,10-diones and related systems.

M. Hacker, D. Phinney, A. P. Krapcho, 1986, Journal of medicinal chemistry.

Activity of two novel anthracene-9,10-diones against human leukemia cells containing intercalator-sensitive or -resistant forms of topoisomerase II.

L. Zwelling, M. Hacker, T. Tritton, 1993, Biochemical pharmacology.

Nutritional folate deficiency augments the in vivo mutagenic and lymphocytotoxic activities of alkylating agents

R. Branda, J. Nicklas, J. O’Neill, 1998, Environmental and molecular mutagenesis.

Prevention of cyclophosphamide-induced haemorrhagic cystitis by disulfiram

R. Gamelli, W. Ershler, M. Hacker, 1982, Blut.

The prevention of cyclophosphamide-induced cystitis in mice by disulfiram.

R. Newman, W. Ershler, M. Hacker, 1982, Research communications in chemical pathology and pharmacology.

APPROACHES TO STUDIES OF PLATINATE TOXICITIES

A. Guarino, M. Hacker, S. Arnold, 1980 .

Chapter 13 – Adverse Drug Reactions

M. Hacker, 2009 .

Effect of VM-26 on the haematological responses of mice to L1210 leukaemia.

M. Hacker, C. Jackson, D. Roberts, 1980, British Journal of Cancer.

Toxicity and antitumor activity of cis-bis-cyclopentenecarboxylato-1,2-diaminocyclohexane platinum(II) encapsulated in multilamellar vesicles.

R. Perez-soler, A. Khokhar, G. Lopez-Berestein, 1986, Cancer research.

Further pharmacological studies of 2,4-diamino-5-methyl-6-[(3,4,5- -trimethoxyanilino)methyl]quinazoline (nsc 249008; tmq). Abstr.

M. Hacker, J. J. Heusner, J. McCormack, 1981 .

Anthracene-9,10-Diones and Aza Bioisosteres as Antitumor Agents

G. Pezzoni, M. Hacker, L. Hazelhurst, 1995, Current Medicinal Chemistry.

Water-soluble / V-substituted Iminodiacetato ( l , 2-diaminocyclohexane )-platinum ( II ) Complexes as Potential Antitumor Agents 1

D. Brown, A. Khokhar, M. Hacker, 2006 .

Synthesis and antitumor activity of organometallic cis-dichloro(enamine)(amine) platinum(II) complexes

A. Khokhar, M. Hacker, D. Brown, 1987 .

Water-soluble Antitumor Drugs1

A. Khokhar, M. Hacker, I. Krakoff, 1985 .

Atmospheric pressure effects on tumor growth: hypobaric anoxia and growth of a murine transplantable tumor.

M. Hacker, B. Herndon, J. Lally, 1983, Journal of the National Cancer Institute.

Regional fibrosis after intraperitoneal administration of mafosfamide

R. Newman, M. Hacker, P. Kimberly, 2004, Investigational new drugs.

Reduction of acute adriamycin toxicity in mice treated with adenosine.

R. Newman, M. Hacker, 1983, European journal of cancer & clinical oncology.

Acute, chronic and terminal toxicity to 4'-demethylepipodophyllotoxin thenylidene glucoside (VM26) in mice.

M. Hacker, D. Roberts, 1975, Cancer research.

Specific in vivo and in vitro antibody response to tetanus toxoid immunization.

W. Ershler, M. Hacker, A. L. Moore, 1982, Clinical and experimental immunology.

Specific antibody synthesis in vitro. I. Technical considerations.

W. Ershler, M. Hacker, A. L. Moore, 1984, Journal of immunological methods.

The synthesis and antitumor properties of a series of water soluble carboxylato-( 1,2-diaminocyclohexane) platinum(II) complexes

A. Khokhar, M. Hacker, I. Krakoff, 1985 .

Commentary on the hypothesis regarding the protective role of metallothioneins against the toxicity of DNA interactive anticancer drugs

M. Hacker, 1990 .

Organ Directed Toxicities of Anticancer Drugs

J. Lazo, M. Hacker, T. Tritton, 1988, Developments in Oncology.

Toxicity of platinum based anticancer drugs

M. Hacker, 1991 .

Drug Resistance

L. Hazlehurst, M. Hacker, R. Rovin, 2004 .

The effect of disulfiram on cyclophosphamide-mediated myeloid toxicity

R. Gamelli, R. Foster, W. Ershler, 2004, Cancer Chemotherapy and Pharmacology.

Aza and diaza bioisosteric anthracene-9,10-diones as antitumor agents.

M. Hacker, F. Giuliani, S. Spinelli, 1995, Acta Biochimica Polonica.

The Synthesis of 6,9-Difluorobenzo(g)quinoline-5,10-dione. Displacements of the Fluorides by Diamines Which Lead to 6,9-Bis(( aminoalkyl)amino)benzo(g)quinoline-5,10-diones.

J. Polsenberg, M. Hacker, S. Spinelli, 1994 .

The effect of L-3, 4-dehydroproline on the antitumor activity and toxicity of bleomycin.

R. Newman, M. Hacker, C. Hong, 1983, Toxicology and applied pharmacology.

The reticuloendothelial system: A comprehensive treatise

Gaston, F. Rapp, E. Douple, 1984, British Journal of Cancer.