S. Sacks

发表

Inhibition of TLR2 promotes graft function in a murine model of renal transplant ischemia‐reperfusion injury

A. Parker, B. Keogh, C. Farrar, 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Urinary tract infections: new insights into a common problem

P. Dasgupta, N. Sheerin, S. Sacks, 2005, Postgraduate Medical Journal.

Kinetics of mast cell migration during transplantation tolerance.

W. Wong, S. Sacks, G. Bond, 2015, Transplant immunology.

Protection against anti‐glomerular basement membrane (GBM)‐mediated nephritis in C3‐ and C4‐deficient mice

M. Carroll, S. Sacks, B. Hartley, 1997, Clinical and experimental immunology.

Does the Lectin Complement Pathway Link Kawasaki Disease and SARS-CoV-2?

L. Klavinskis, S. Sacks, S. Grigoriadou, 2021, Frontiers in Immunology.

CD59a deficiency exacerbates ischemia-reperfusion injury in mice.

M. Walport, B. Morgan, Wuding Zhou, 2004, The American journal of pathology.

Local tissue complement synthesis--fine tuning a blunt instrument.

S. Sacks, J. Marsh, W. Zhou, 2001, Archivum immunologiae et therapiae experimentalis.

Locally Produced Complement and its Role in Renal Allograft Rejection

Wuding Zhou, S. Sacks, 2003, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Fc γ RIII and Fc γ RIV are indispensable for acute glomerular inflammation induced by switch variant monoclonal antibodies1

J. Ravetch, F. Nimmerjahn, S. Sacks, 2012 .

Toll-Like Receptor 4 Ligation on Intrinsic Renal Cells Contributes to the Induction of Antibody-Mediated Glomerulonephritis via CXCL 1 and CXCL 2

W. Buurman, S. Sacks, T. Wolfs, 2007 .

Toll-like receptor 4 ligation on intrinsic renal cells contributes to the induction of antibody-mediated glomerulonephritis via CXCL1 and CXCL2.

W. Buurman, S. Sacks, T. Wolfs, 2007, Journal of the American Society of Nephrology : JASN.

TLR2 Stimulation of Intrinsic Renal Cells in the Induction of Immune-Mediated Glomerulonephritis1

S. Sacks, M. Robson, H. Lock, 2006, The Journal of Immunology.

Toll-like receptor 2 agonists exacerbate accelerated nephrotoxic nephritis.

S. Sacks, M. Robson, H. J. Brown, 2006, Journal of the American Society of Nephrology : JASN.

The membrane attack complex, C5b‐9, up regulates collagen gene expression in renal tubular epithelial cells

N. Sheerin, K. Abe, S. Sacks, 2004, Clinical and experimental immunology.

Chronic Interstitial Damage in Proteinuria

N. Sheerin, S. Sacks, 1999, Kidney and Blood Pressure Research.

Fucose as a new therapeutic target in renal transplantation

S. Sacks, M. Howard, Christopher L. Nauser, 2020, Pediatric Nephrology.

Synthesis of complement protein C3 in the kidney is an important mediator of local tissue injury

P. Risley, W. Wong, K. Abe, 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

The allogeneic T and B cell response is strongly dependent on complement components C3 and C4.

S. Jurcevic, M. Carroll, S. Sacks, 2001, Transplantation.

Complement activation is a crucial driver of acute kidney injury in rhabdomyolysis.

V. Gnemmi, P. de Lonlay, P. Garred, 2020, Kidney international.

Natural killer-cell activity after human renal transplantation in relation to killer immunoglobulin-like receptors and human leukocyte antigen mismatch1

R. Vaughan, P. Norman, W. Wong, 2003, Transplantation.

Accumulation of immune complexes in glomerular disease is independent of locally synthesized c3.

N. Sheerin, P. Risley, K. Abe, 2006, Journal of the American Society of Nephrology : JASN.

Protection and injury: the differing roles of complement in the development of glomerular injury

N. Sheerin, K. Abe, S. Sacks, 2001, European journal of immunology.

Collectin-11 Promotes the Development of Renal Tubulointerstitial Fibrosis.

C. Liu, Wuding Zhou, C. Farrar, 2017, Journal of the American Society of Nephrology : JASN.

Apical proteins stimulate complement synthesis by cultured human proximal tubular epithelial cells.

Wuding Zhou, S. Sacks, Z. Brown, 1999, Journal of the American Society of Nephrology : JASN.

MECHANISMS OF NEPHROTOXICITY

J. Campistol, S. Sacks, Barcelona Spain, 2000, Transplantation.

Leaked protein and interstitial damage in the kidney: is complement the missing link?

S. Sacks, N. Sheerin, Neil S. Sheerin, 2002, Clinical and experimental immunology.

Transferrin but not albumin mediates stimulation of complement C3 biosynthesis in human proximal tubular epithelial cells.

T. Chan, K. Lai, S. Sacks, 2001, American journal of kidney diseases : the official journal of the National Kidney Foundation.

Role of Complement in Tubulointerstitial Injury from Proteinuria

K. Lai, S. Sacks, S. Tang, 2002, Kidney and Blood Pressure Research.

Non-Invasive whole-body detection of complement activation using radionuclide imaging in a mouse model of myocardial ischaemia-reperfusion injury

R. Smith, F. Kampmeier, A. Badar, 2017, Scientific Reports.

Noninvasive Imaging of Activated Complement in Ischemia‐Reperfusion Injury Post–Cardiac Transplant

F. Kampmeier, A. Badar, E. Sharif-Paghaleh, 2015, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

The effect of locally synthesised complement on acute renal allograft rejection

Wuding Zhou, S. Sacks, 2003, Journal of Molecular Medicine.

Triptolide is a potent suppressant of C3, CD40 and B7h expression in activated human proximal tubular epithelial cells.

Wuding Zhou, S. Sacks, Yuzhi Hong, 2002, Kidney international.

Expression and tissue localization of donor‐specific complement C3 synthesized in human renal allografts

P. Mathieson, Wuding Zhou, S. Sacks, 1995, European journal of immunology.

C3 to the Circulating Pool in Humans Contribution of Renal Secreted Complement

R. Vaughan, N. Sheerin, Wuding Zhou, 1999 .

Thrombalexin: Use of a Cytotopic Anticoagulant to Reduce Thrombotic Microangiopathy in a Highly Sensitized Model of Kidney Transplantation

S. Knechtle, S. Sacks, J. Kwun, 2017, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Allograft immune response with sCR1 intervention.

S. Sacks, M. Hibbs, R. Smith, 1996, Transplant immunology.

Complement fragments C3a and C5a: The salt and pepper of the immune response

S. Sacks, 2010, European journal of immunology.

Kidney Specificity of Rat Chromosome 1 Blood Pressure Quantitative Trait Locus Region

N. Samani, J. Clemitson, S. Sacks, 2002, Hypertension.

C1 Esterase Inhibitor Reduces Lower Extremity Ischemia/Reperfusion Injury and Associated Lung Damage

S. Miescher, R. Rieben, Y. Banz, 2013, PloS one.

Fc-dependent depletion of activated T cells occurs through CD40L-specific antibody rather than costimulation blockade

E. Simpson, N. Monk, R. Hargreaves, 2003, Nature Medicine.

Direct visualisation of cytomegalovirus-specific CD8+ T cells in renal transplant recipients.

R. Hargreaves, C. O'Callaghan, R. Hilton, 2002, Transplantation proceedings.

Ultra-localization of Foxp3+ T cells within renal allografts shows infiltration of tubules mimicking rejection.

K. Brown, W. Wong, S. Sacks, 2007, The American journal of pathology.

Extensive and bidirectional transfer of major histocompatibility complex class II molecules between donor and recipient cells in vivo following solid organ transplantation

K. Brown, W. Wong, S. Sacks, 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Mechanisms of rejection: role of complement

C. Farrar, S. Sacks, 2014, Current opinion in organ transplantation.

Pivotal role of CD4+ T cells in renal fibrosis following ureteric obstruction.

N. Sheerin, P. Chowdhury, K. Brown, 2010, Kidney international.

PD-L1 signaling on human memory CD4+ T cells induces a regulatory phenotype

R. Lechler, S. Quezada, R. Noelle, 2021, PLoS biology.

Coexpression of Donor Peptide/Recipient MHC Complex and Intact Donor MHC: Evidence for a Link between the Direct and Indirect Pathways

K. Brown, W. Wong, S. Sacks, 2011, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Complement C5a inhibition moderates lipid metabolism and reduces tubulointerstitial fibrosis in diabetic nephropathy

K. Lai, Wuding Zhou, S. Sacks, 2018, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Intraglomerular C3 synthesis in rats with passive Heymann nephritis.

T. Koji, P. Verroust, P. Nakane, 1997, The American journal of pathology.

Functional and biochemical subtypes of the haplotype HLA-DR3 in patients with celiac disease or idiopathic membranous nephropathy.

D. Jewell, A. McMichael, K. Wood, 1987, Human immunology.

Analysis of complement C4 loci in Caucasoids and Japanese with idiopathic membranous nephropathy.

R. Vaughan, S. Sacks, S. Nomura, 1992, Kidney international.

Ex vivo delivery of Mirococept: A dose‐finding study in pig kidney after showing a low dose is insufficient to reduce delayed graft function in human kidney

P. Friend, A. Douiri, T. Kassimatis, 2020, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

A double-blind randomised controlled investigation into the efficacy of Mirococept (APT070) for preventing ischaemia reperfusion injury in the kidney allograft (EMPIRIKAL): study protocol for a randomised controlled trial

A. Douiri, T. Kassimatis, R. Smith, 2017, Trials.

C3a and C5a promote renal ischemia-reperfusion injury.

Wuding Zhou, S. Sacks, L. Smyth, 2012, Journal of the American Society of Nephrology : JASN.

Control of innate immunological mechanisms as a route to drug minimization

C. Farrar, S. Sacks, E. Asgari, 2014, Current opinion in organ transplantation.

The role of complement in the early immune response to transplantation

Wuding Zhou, S. Sacks, 2012, Nature Reviews Immunology.

Functional modulation of human monocytes derived DCs by anaphylatoxins C3a and C5a

G. Lombardi, Wuding Zhou, S. Sacks, 2012, Immunobiology.

Targeting the complement system.

S. Sacks, J. Marsh, J. Pratt, 1999, Current opinion in nephrology and hypertension.

CD46 (Membrane Cofactor Protein) Acts as a Human Epithelial Cell Receptor for Internalization of Opsonized Uropathogenic Escherichia coli1

N. Sheerin, S. Sacks, M. Feito, 2006, The Journal of Immunology.

Escherichia coli Internalization of Opsonized Uropathogenic Human Epithelial Cell Receptor for CD 46 ( Membrane Cofactor Protein ) Acts as a

N. Sheerin, S. Sacks, M. Feito, 2006 .

Breaching host defenses in the urinary tract

N. Sheerin, S. Sacks, T. Springall, 2002 .

C5aR1 promotes acute pyelonephritis induced by uropathogenic E. coli

Yun Song, Zong-fang Li, Ting Zhang, 2017, JCI insight.

The complement factor 5a receptor 1 has a pathogenic role in chronic inflammation and renal fibrosis in a murine model of chronic pyelonephritis

Yun Song, Ting Zhang, Kun-yi Wu, 2016, Kidney international.

The complement factor 5a receptor 1 has a renal fibrosis in a murine model of chronic pyelonephritis

Yun Song, Ting Zhang, Kun-yi Wu, 2016 .

Synergy between type 1 fimbriae expression and C3 opsonisation increases internalisation of E. coli by human tubular epithelial cells

N. Sheerin, Wuding Zhou, S. Sacks, 2009, BMC Microbiology.

Epithelial secretion of C3 promotes colonization of the upper urinary tract by Escherichia coli

V. Holers, N. Sheerin, K. Abe, 2001, Nature Medicine.

Complement synthesis in the injured kidney: does it have a role in immune complex glomerulonephritis?

S. Sacks, N. Sheerin, W. Zhou, 1996, Journal of the American Society of Nephrology : JASN.

Toll-like receptor 4 stimulation triggers crescentic glomerulonephritis by multiple mechanisms including a direct effect on renal cells.

S. Sacks, M. Robson, A. Giorgini, 2010, The American journal of pathology.

Local complement synthesis—A process with near and far consequences for ischemia reperfusion injury and transplantation

S. Sacks, Christopher L. Nauser, 2022, Immunological reviews.

Thrombalexins: Cell‐Localized Inhibition of Thrombin and Its Effects in a Model of High‐Risk Renal Transplantation

C. Horsfield, D. Smolarek, C. Farrar, 2017, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Absence of MHC class II gene expression in a patient with a single amino acid substitution in the class II transactivator protein CIITA

A. Kelly, S. Sacks, Virginia Quan, 1999, Immunogenetics.

Complement-here, there and everywhere, but what about the transplanted organ?

R. Smith, S. Sacks, R. Smith, 2016, Seminars in immunology.

New boundaries for complement in renal disease.

Wuding Zhou, S. Sacks, 2008, Journal of the American Society of Nephrology : JASN.

Therapeutic strategy with a membrane-localizing complement regulator to increase the number of usable donor organs after prolonged cold storage.

R. Smith, Wuding Zhou, S. Sacks, 2006, Journal of the American Society of Nephrology : JASN.

Structural and functional diversity of collectins and ficolins and their relationship to disease

C. Farrar, S. Sacks, M. Howard, 2017, Seminars in Immunopathology.

TNF-alpha regulation of C3 gene expression and protein biosynthesis in rat glomerular endothelial cells.

S. Adler, S. Sacks, N. Sheerin, 1997, Kidney international.

SPECT/CT Lymphoscintigraphy of Heterotopic Cardiac Grafts Reveals Novel Sites of Lymphatic Drainage and T Cell Priming

K. Sunassee, P. Blower, G. Mullen, 2011, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Tertiary lymphoid organs in renal allografts can be associated with donor‐specific tolerance rather than rejection

K. Brown, W. Wong, S. Sacks, 2011, European journal of immunology.

Collectin-11 detects stress-induced L-fucose pattern to trigger renal epithelial injury.

Wuding Zhou, C. Farrar, S. Sacks, 2016, The Journal of clinical investigation.

Complement and complement inhibitors: their role in autoimmune and inflammatory diseases

N. Sheerin, S. Sacks, N. Sheerin, 1998, Current opinion in nephrology and hypertension.

Reimplantation of the ureter after unilateral ureteral obstruction provides a model that allows functional evaluation.

K. Brown, S. Sacks, N. Sheerin, 2008, Kidney international.

Intrarenal synthesis of complement.

Wuding Zhou, S. Sacks, J. Marsh, 2001, Kidney international.

In situ localization of C3 synthesis in experimental acute renal allograft rejection.

K. Abe, Wuding Zhou, S. Sacks, 2000, The American journal of pathology.

Evidence for increased synthesis of complement C4 in the renal epithelium of rats with passive Heymann nephritis.

P. Verroust, S. Sacks, B. Hartley, 1997, Journal of the American Society of Nephrology : JASN.

Local transcription of complement C3 in human allograft rejection. Evidence for a pathogenic role and correlation to histology and outcome.

A. Pani, S. Sacks, P. Andrews, 1994, Transplantation.

Endogenous complement C3 synthesis in immune complex nephritis

S. Sacks, B. Hartley, P. Andrews, 1993, The Lancet.

C3 and C4 gene expression and interferon‐gamma‐mediated regulation in human glomerular mesangial cells

R. Campbell, S. Sacks, J. Martin, 1993, Clinical and experimental immunology.

Complement C3 gene expression and regulation in human glomerular epithelial cells.

R. Campbell, A. Pani, Wuding Zhou, 1993, Immunology.

The C5a/C5aR1 axis promotes progression of renal tubulointerstitial fibrosis in a mouse model of renal ischemia/reperfusion injury.

Kun-yi Wu, Wuding Zhou, S. Sacks, 2019, Kidney international.

Analysis of activated T cell infiltrates in rat renal allografts by gamma camera imaging after injection of 123iodine-interleukin 2.

M. Dallman, S. Sacks, I. Abbs, 1993, Transplant immunology.

Donor specific transplant tolerance is dependent on complement receptors

K. Brown, W. Wong, Wuding Zhou, 2013, Transplant international : official journal of the European Society for Organ Transplantation.

Influence of donor C3 allotype on late renal-transplantation outcome.

R. Vaughan, P. Gros, N. Sheerin, 2006, The New England journal of medicine.

Successful pregnancy in cystinosis.

S. Sacks, P. Andrews, W. V. van’t Hoff, 1994, JAMA.

C3aR interaction - allostimulatory function of dendritic cells through C3a Local production and activation of complement up-regulates the

Wuding Zhou, C. Farrar, S. Sacks, 2013 .

C3a mediates epithelial-to-mesenchymal transition in proteinuric nephropathy.

N. Sheerin, Ellen W. Hatch, S. Sacks, 2009, Journal of the American Society of Nephrology : JASN.

Local production and activation of complement up-regulates the allostimulatory function of dendritic cells through C3a-C3aR interaction.

R. Smith, Wuding Zhou, C. Farrar, 2008, Blood.

Molecular mapping of the HLA class II region in HLA-DR3 associated idiopathic membranous nephropathy.

I. Dunham, R. Campbell, S. Sacks, 1993, Kidney international. Supplement.

Local synthesis of complement component C3 regulates acute renal transplant rejection

S. Sacks, J. Pratt, Shamim A. Basheer, 2002, Nature Medicine.

The role of anaphylatoxins C3a and C5a in regulating innate and adaptive immune responses.

Wuding Zhou, S. Sacks, Ke Li, 2009, Inflammation & allergy drug targets.

Monoclonal Anti‐A from a Hybrid‐Myeloma: Evaluation as a Blood Grouping Reagent

C. Milstein, F. Takei, S. Sacks, 1980, Vox sanguinis.

Human blood group isoantigen expression on normal and malignant gastric epithelium studied with anti-A and anti-B monoclonal antibodies.

N. Bleehen, S. Sacks, D. Wight, 1983, Journal of the National Cancer Institute.

Development of a multivariable gene-expression signature targeting T-cell-mediated rejection in peripheral blood of kidney transplant recipients validated in cross-sectional and longitudinal samples

Graham M Lord, D. Ståhl, T. Strom, 2019, EBioMedicine.

Rhesus immunization after renal transplantation.

S. Sacks, A. Payne, P. Andrews, 1996, Transplantation.

Monoclonal Anti‐B as a New Blood‐Typing Reagent

S. Sacks, E. Lennox, E. S. Lennox, 1981, Vox sanguinis.

RNA interference – a new experimental and therapeutic tool

S. Sacks, M. Robson, 2005, Current opinion in nephrology and hypertension.

l‐Fucose prevention of renal ischaemia/reperfusion injury in Mice

R. Wallis, C. Farrar, S. Sacks, 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Long‐ and short‐term outcomes in renal allografts with deceased donors: A large recipient and donor genome‐wide association study

Sarah A. Gagliano, Graham M Lord, M. Weale, 2018, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Long-and short-term outcomes in renal allografts with deceased donors : A

Sarah A. Gagliano, Graham M Lord, M. Weale, 2018 .

Complement in renal transplantation.

P. Chowdhury, S. Sacks, W. Zhou, 2003, Nephron. Clinical practice.

Expression of tissue type plasminogen activator and type 1 plasminogen activator inhibitor, and persistent fibrin deposition in chronic renal allograft failure.

Yufei Wang, S. Sacks, B. Evans, 1997, Kidney international.

Up-regulation of type 1 plasminogen activator inhibitor messenger RNA with thrombotic changes in renal grafts.

Yufei Wang, S. Sacks, M. Olavesen, 1996, Transplantation.

The classical complement pathway plays a critical role in the opsonisation of uropathogenic Escherichia coli.

N. Sheerin, S. Sacks, Ke Li, 2008, Molecular immunology.

The relative importance of local and systemic complement production in ischaemia, transplantation and other pathologies.

Wuding Zhou, S. Sacks, Ke Li, 2007, Molecular immunology.

Collectin-11 (CL-11) Is a Major Sentinel at Epithelial Surfaces and Key Pattern Recognition Molecule in Complement-Mediated Ischaemic Injury

C. Farrar, S. Sacks, M. Howard, 2018, Front. Immunol..

Haplotype analysis of tumour necrosis factor receptor genes in 1p36: no evidence for association with systemic lupus erythematosus

M. Daly, J. Rioux, Katie Miller, 2006, European Journal of Human Genetics.

Allograft rejection: effect of local synthesis of complement

Wuding Zhou, S. Sacks, 2005, Springer Seminars in Immunopathology.

Influence of complement on the allospecific antibody response to a primary vascularized organ graft

S. Sacks, J. Levin, J. Pratt, 1997, European journal of immunology.

Predominant role for C5b-9 in renal ischemia/reperfusion injury.

K. Abe, Wuding Zhou, C. Farrar, 2000, The Journal of clinical investigation.

Rationale for targeting complement in COVID‐19

R. Wallis, L. Klavinskis, C. Farrar, 2020, EMBO molecular medicine.

Mechanical stretch induces vascular permeability factor in human mesangial cells: mechanisms of signal transduction.

G. Gruden, G. Viberti, S. Sacks, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Complement in Renal Transplantation

P. Chowdhury, Wuding Zhou, S. Sacks, 2003, Nephron Clinical Practice.

Dendritic Cell Synthesis of C3 Is Required for Full T Cell Activation and Development of a Th1 Phenotype1

Wuding Zhou, S. Sacks, Ke Li, 2006, The Journal of Immunology.

Complement Recognition Pathways in Renal Transplantation.

C. Farrar, S. Sacks, Christopher L. Nauser, 2017, Journal of the American Society of Nephrology : JASN.

Mannan‐binding lectin‐associated serine protease 2 is critical for the development of renal ischemia reperfusion injury and mediates tissue injury in the absence of complement C4

Wuding Zhou, C. Farrar, S. Sacks, 2014, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

The innate immune system and transplantation.

J. Kupiec-Weglinski, C. Farrar, S. Sacks, 2013, Cold Spring Harbor perspectives in medicine.

Which pathways trigger the role of complement in ischaemia/reperfusion injury?

C. Farrar, S. Sacks, W. Schwaeble, 2012, Front. Immun..

Targeting of mannan-binding lectin-associated serine protease-2 confers protection from myocardial and gastrointestinal ischemia/reperfusion injury

N. Samani, T. Fujita, R. Wallis, 2011, Proceedings of the National Academy of Sciences.

Deficiency of C5aR prolongs renal allograft survival.

Qijun Li, Wuding Zhou, C. Farrar, 2010, Journal of the American Society of Nephrology : JASN.

Local Extravascular Pool of C3 Is a Determinant of Postischemic Acute Renal Failure

Wuding Zhou, C. Farrar, S. Sacks, 2022 .

Nontransgenic hyperexpression of a complement regulator in donor kidney modulates transplant ischemia/reperfusion damage, acute rejection, and chronic nephropathy.

R. Smith, P. Chowdhury, Wuding Zhou, 2003, The American journal of pathology.

Role of the lectin complement pathway in kidney transplantation.

Wuding Zhou, C. Farrar, S. Sacks, 2016, Immunobiology.

Role of dendritic cell synthesis of complement in the allospecific T cell response.

Wuding Zhou, S. Sacks, Ke Li, 2007, Molecular immunology.

Mechanisms of Disease: the complement system in renal injury—new ways of looking at an old foe

N. Sheerin, S. Sacks, K. M. Brown, 2007, Nature Clinical Practice Nephrology.

Systematic assessment of the influence of complement gene polymorphisms on kidney transplant outcome.

M. Weale, R. Vaughan, N. Sheerin, 2016, Immunobiology.

KEY POINTS Control of the complement cascade provides new opportunities for limiting the inflammatory response and avoiding sensitisation of the recipient against donor alloantigen

C. Farrar, S. Sacks, E. Asgari, 2014 .

Homeostatic Proliferation of Lymphocytes Results in Augmented Memory-Like Function and Accelerated Allograft Rejection1

K. Brown, W. Wong, S. Sacks, 2008, The Journal of Immunology.

Contribution of renal secreted complement C3 to the circulating pool in humans.

R. Vaughan, N. Sheerin, Wuding Zhou, 1998, Journal of immunology.

ISN Nexus 2016 Symposia: Translational Immunology in Kidney Disease—The Berlin Roadmap

A. Levin, B. Rovin, G. Remuzzi, 2016, Kidney International Reports.

Regulation of complement C3 and C4 synthesis in human peritoneal mesothelial cells by peritoneal dialysis fluid

K. Lai, Wuding Zhou, S. Sacks, 2004, Clinical and experimental immunology.

DR2 (DRw15, 16): 2-D Gel Patterns

S. Fuggle, D. Charron, S. Sacks, 1989 .

Minireview: functions of the renal tract epithelium in coordinating the innate immune response to infection.

N. Sheerin, P. Chowdhury, S. Sacks, 2004, Kidney international.

Genomics in human renal transplantation.

R. Vaughan, S. Sacks, 2010, Current opinion in immunology.

Complement in organ transplantation

Wuding Zhou, S. Sacks, E. Asgari, 2010, Current opinion in organ transplantation.

The role of complement and Toll‐like receptors in organ transplantation

Wuding Zhou, S. Sacks, Tao Lin, 2007, Transplant international : official journal of the European Society for Organ Transplantation.

Strategies for targeting complement inhibitors in ischaemia/reperfusion injury.

S. Sacks, R. Smith, I. Dodd, 1999, Molecular immunology.

The role of complement in regulating the alloresponse

W. Wong, Wuding Zhou, S. Sacks, 2009, Current opinion in organ transplantation.

Endogenous Ligands for TLR2 and TLR4 Are Not Involved in Renal Injury following Ureteric Obstruction

N. Sheerin, P. Chowdhury, S. Sacks, 2010, Nephron Experimental Nephrology.

Effects of complement inhibition with soluble complement receptor-1 on vascular injury and inflammation during renal allograft rejection in the rat.

S. Sacks, M. Hibbs, R. Smith, 1996, The American journal of pathology.

Accurate intracellular localization of HLA‐DM requires correct spacing of a cytoplasmic YTPL targeting motif relative to the transmembrane domain

J. Neefjes, J. Calafat, H. Janssen, 1999, European journal of immunology.

In vitro erythrophagocytosis by renal tubular cells and tubular toxicity by haemoglobin and iron.

S. Sacks, G. Fogazzi, N. Sheerin, 1999, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Compartmental Localization of Complement Component Transcripts in the Normal Human Kidney

S. Sacks, D. Song, W. Zhou, 1997, Nephron.

Tissue synthesis of complement as an immune regulator.

Wuding Zhou, S. Sacks, P. Andrews, 1995, Molecular medicine today.

Locally produced and activated complement as a mediator of alloreactive T cells.

P. Heeger, Wuding Zhou, S. Sacks, 2009, Frontiers in bioscience.

Interferon‐γ regulation of C4 gene expression in cultured human glomerular epithelial cells

Wuding Zhou, S. Sacks, John Martin, 1993 .

Expression of complement components, receptors and regulators by human dendritic cells

P. Sagoo, G. Lombardi, Wuding Zhou, 2011, Molecular Immunology.

Macrophages from C3-deficient mice have impaired potency to stimulate alloreactive T cells.

Wuding Zhou, S. Sacks, M. Villiers, 2006, Blood.

alloreactive T cells Macrophages from C 3-deficient mice have impaired potency to stimulate

Wuding Zhou, S. Sacks, M. Villiers, 2005 .

The use of eculizumab in renal transplantation

P. Chowdhury, S. Sacks, N. Mamode, 2013, Clinical transplantation.

Common genetic variants in complement genes other than CFH, CD46 and the CFHRs are not associated with aHUS

M. Weale, H. Cordell, N. Sheerin, 2012, Molecular immunology.

Autoimmune Renal Injury in C3- and C4-Deficient Mice: A Histological and Functional Study

S. Sacks, N. Sheerin, J. Marsh, 2004, Nephron Experimental Nephrology.

Graft-derived complement as a mediator of transplant injury.

P. Heeger, Wuding Zhou, S. Sacks, 2007, Current opinion in immunology.

Acute interstitial nephritis associated with Mycoplasma pneumoniae infection.

S. Sacks, C. Lloyd, P. Andrews, 1994, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Unusual presentations of anti-glomerular basement membrane antibody mediated disease are associated with delayed diagnosis and poor outcome.

S. Sacks, J. Hicks, P. Andrews, 1995, Clinical nephrology.

Factor I is required for the development of membranoproliferative glomerulonephritis in factor H-deficient mice.

M. Walport, T. Malik, S. Sacks, 2008, The Journal of clinical investigation.

Localised inhibition of coagulation limits acute complement mediated damage in high risk renal transplantation

R. Smith, C. Horsfield, C. Farrar, 2012 .

Human stem cell-derived retinal epithelial cells activate complement via collectin 11 in response to stress

R. Ali, M. Kloc, A. Gonzalez-Cordero, 2017, Scientific Reports.

Lectin pathway effector enzyme mannan‐binding lectin‐associated serine protease‐2 can activate native complement C3 in absence of C4 and/or C2

P. Andrew, T. Fujita, Robert B Sim, 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Rapamycin at subimmunosuppressive levels inhibits mesangial cell proliferation and extracellular matrix production.

S. Sacks, M. Robson, H. Lock, 2007, American journal of physiology. Renal physiology.

Complement in ischaemia–reperfusion injury and transplantation

C. Farrar, S. Sacks, M. Howard, 2021, Seminars in Immunopathology.

Visceral leishmaniasis: a rare imported disease.

D. Rubenstein, S. Sacks, T. Wheatley, 1983, The Journal of infection.

Role of the complement system in rejection.

P. Chowdhury, Wuding Zhou, S. Sacks, 2003, Current opinion in immunology.

Cyclic AMP plays a critical role in C3a-receptor-mediated regulation of dendritic cells in antigen uptake and T-cell stimulation.

A. Kelly, Wuding Zhou, S. Sacks, 2008, Blood.

Targeting complement at the time of transplantation.

R. Smith, Wuding Zhou, C. Farrar, 2013, Advances in experimental medicine and biology.

Independent pathways of P-selectin and complement-mediated renal ischemia/reperfusion injury.

Wuding Zhou, C. Farrar, S. Sacks, 2004, The American journal of pathology.

Deficiency of C4 from donor or recipient mouse fails to prevent renal allograft rejection.

N. Sheerin, R. Hargreaves, Wuding Zhou, 2006, The American journal of pathology.

Complement activation regulates the capacity of proximal tubular epithelial cell to stimulate alloreactive T cell response.

R. Hargreaves, Wuding Zhou, C. Farrar, 2004, Journal of the American Society of Nephrology : JASN.

Controlling the Generation and Function of Human CD8+ Memory T Cells In Vitro with Immunosuppressants

W. Wong, S. Sacks, Danielle L. Jones, 2006, Transplantation.

Recombinant Complement Receptor 2 Radiolabeled with [99mTc(CO)3]+ : A Potential New Radiopharmaceutical for Imaging Activated Complement

R. Razavi, A. Badar, G. Mullen, 2011, PloS one.

Deconstructing the Lectin Pathway in the Pathogenesis of Experimental Inflammatory Arthritis: Essential Role of the Lectin Ficolin B and Mannose-Binding Protein–Associated Serine Protease 2

T. Fujita, Y. Endo, H. Sekine, 2017, The Journal of Immunology.

Dendritic Cell Function in Allostimulation Is Modulated by C5aR Signaling1

T. Woodruff, Qijun Li, Wuding Zhou, 2009, The Journal of Immunology.

Late Low‐Dose Steroid Withdrawal in Renal Transplant Recipients Increases Bone Formation and Bone Mineral Density

I. Fogelman, R. Hilton, S. Sacks, 2006, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Footprints of humoral rejection.

P. Chowdhury, S. Sacks, 2002, Current opinion in nephrology and hypertension.

MOLECULAR ANALYSIS OF C3 ALLOTYPES RELATED TO TRANSPLANT OUTCOME IN HUMAN RENAL ALLOGRAFTS

P. Mathieson, S. Sacks, P. Andrews, 1995, Transplantation.

Expression of complement components, receptors and regulators by human dendritic cells and the role of C3a and C5a in modulation of dendritic cell function

P. Sagoo, G. Lombardi, Wuding Zhou, 2010 .

Deficiency of C 5 aR Prolongs Renal Allograft Survival

Qijun Li, Wuding Zhou, C. Farrar, 2010 .

An Antibody Combination That Targets Activated T Cells Extends Graft Survival in Sensitized Recipients

E. Simpson, N. Gardner, H. Yagita, 2008, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Innate networking: Thrombotic microangiopathy, the activation of coagulation and complement in the sensitized kidney transplant recipient.

S. Knechtle, S. Sacks, J. Kwun, 2018, Transplantation reviews.

Sparing of first dose effect of monovalent anti-CD3 antibody used in allograft rejection is associated with diminished release of pro-inflammatory cytokines.

L. Chatenoud, H. Waldmann, S. Sacks, 1994, Therapeutic immunology.

Soluble Collectin 11 (CL-11) Acts as an Immunosuppressive Molecule Potentially Used by Stem Cell-Derived Retinal Epithelial Cells to Modulate T Cell Response

G. Lombardi, S. Sacks, Marco Romano, 2023, Cells.

RAPID REJECTION OF HLA-A2 TRANSGENIC SKIN GRAFT DUE TO INDIRECT ALLORECOGNITION1

E. Simpson, S. Jurcevic, P. Chandler, 2001, Transplantation.

Factor I is required for the development of membranoproliferative glomerulonephritis in factor H-deficient mice

M. Walport, T. Malik, S. Sacks, 2007 .

Modulated by C 5 aR Signaling Dendritic Cell Function in Allostimulation

T. Woodruff, Qijun Li, Wuding Zhou, 2009 .