G. Southan

发表

Inhibition of experimental gingivitis in beagle dogs with topical mercaptoalkylguanidines.

C. Szabó, S. Offenbacher, D. Paquette, 2006, Journal of periodontology.

C. Szabó, G. Southan, 2003, Current medicinal chemistry.

Crystal structure of nitric oxide synthase bound to nitro indazole reveals a novel inactivation mechanism.

T. Poulos, B. Masters, P. Martásek, 2001, Biochemistry.

Synthesis of (R)-3,4-dihydro-2H-pyran-2-carboxaldehyde: application to the synthesis of potent adenosine A(2A) and A(3) receptor agonist.

K. Klotz, Elizabeth T. Piro, G. Southan, 2009, Tetrahedron letters.

Localizing antithrombotic and vasodilatory activity with a novel, ultrafast nitric oxide donor.

K. M. Davies, W. Hurford, J. Saavedra, 1996, Journal of medicinal chemistry.

Endotoxin-Induced Shock Mechanism and Protects Against Production by a Posttranscriptional Inosine Inhibits Inflammatory Cytokine

C. Szabó, G. Haskó, A. Salzman, 1999 .

Inosine Protects Against the Development of Diabetes in Multiple-Low-Dose Streptozotocin and Nonobese Diabetic Mouse Models of Type 1 Diabetes

C. Szabó, G. Haskó, A. Salzman, 2003, Molecular medicine.

Part II: Beneficial Effects of the Peroxynitrite Decomposition Catalyst FP15 in Murine Models of Arthritis and Colitis

C. Szabó, L. Liaudet, A. Salzman, 2002, Molecular medicine.

The Peroxynitrite Catalyst WW-85 Improves Pulmonary Function in Ovine Septic Shock

D. Herndon, C. Szabó, M. Westphal, 2011, Shock.

Effects of combined selective iNOS inhibition and peroxynitrite blockade during endotoxemia in pigs.

M. Georgieff, P. Radermacher, C. Szabó, 2001, Shock.

Suppression of intestinal polyposis in Apcmin/+ mice by targeting the nitric oxide or poly(ADP-ribose) pathways.

C. Szabó, L. Virág, P. Pacher, 2004, Mutation research.

Mercaptoethylguanidine and Guanidine Inhibitors of Nitric-oxide Synthase React with Peroxynitrite and Protect against Peroxynitrite-induced Oxidative Damage*

B. Zingarelli, C. Szabó, R. Radi, 1997, The Journal of Biological Chemistry.

Inhibition by spermine of the induction of nitric oxide synthase in J774.2 macrophages: requirement of a serum factor

C. Thiemermann, J. Vane, C. Szabó, 1994, British journal of pharmacology.

Isothioureas: potent inhibitors of nitric oxide synthases with variable isoform selectivity

C. Thiemermann, C. Szabó, G. Southan, 1995, British journal of pharmacology.

Effects of S-isopropyl isothiourea, a potent inhibitor of nitric oxide synthase, in severe hemorrhagic shock.

C. Szabó, A. Salzman, G. Southan, 1996, Journal of applied physiology.

Hydroxyguanidines inhibit peroxynitrite-induced oxidation.

C. Szabó, A. Salzman, G. Southan, 1998, Free radical biology & medicine.

Criteria to indicate testosterone administration.

M. Wheeler, G. Southan, D. Cowan, 1990, British journal of sports medicine.

NFkappaB1 (p50)-deficient mice are not susceptible to multiple low-dose streptozotocin-induced diabetes.

C. Szabó, L. Liaudet, G. Haskó, 2002, The Journal of endocrinology.

NF B 1 ( p 50 )-deficient mice are not susceptible to multiple low-dose streptozotocin-induced diabetes

C. Szabó, L. Liaudet, G. Haskó, 2002 .

Local and systemic inflammation: role of poly (ADP-ribose) synthetase activation by reactive nitrogen species

F. Gallyas, É. Szabó, C. Szabó, 2001 .

Conversion of proteins to diazeniumdiolate-based nitric oxide donors.

P. Roller, J. Saavedra, L. Keefer, 1999, Bioconjugate chemistry.

NFκB1 (p50)-deficient mice are not susceptible to multiple low-dose streptozotocin-induced diabetes (Journal of Endocrinology (2000) 173 (457-464))

C. Szabó, L. Liaudet, G. Haskó, 2010 .

THE NOVEL INOSINE ANALOGUE INO-2002 EXERTS AN ANTI-INFLAMMATORY EFFECT IN A MURINE MODEL OF ACUTE LUNG INJURY

K. Murthy, C. Szabó, A. Salzman, 2009, Shock.

The novel inosine analogue, INO-2002, protects against diabetes development in multiple low-dose streptozotocin and non-obese diabetic mouse models of type I diabetes.

K. Murthy, C. Szabó, A. Salzman, 2008, The Journal of endocrinology.

The mechanism of the inhibitory effect of polyamines on the induction of nitric oxide synthase: role of aldehyde metabolites

C. Thiemermann, J. Vane, C. Szabó, 1994, British journal of pharmacology.

Discovery of potent poly(ADP-ribose) polymerase-1 inhibitors from the modification of indeno[1,2-c]isoquinolinone.

E. Baloglu, C. Szabó, A. Salzman, 2005, Journal of medicinal chemistry.

Inhibition of nitric oxide synthase ameliorates cellular injury in sickle cell mouse kidneys.

C. Szabó, P. Singhal, N. Bank, 2000, Kidney international.

Possible indices for the detection of the administration of dihydrotestosterone to athletes

G. Southan, D. Cowan, A. Kicman, 1992, The Journal of Steroid Biochemistry and Molecular Biology.

Tamás Transplantation Poly ( ADP-Ribose ) Polymerase Inhibition Reduces Reperfusion Injury After Heart

S. Hagl, C. Vahl, T. Csont, 2001 .

Effect of mercaptoethylguanidine scavengers of peroxynitrite on the development of experimental allergic encephalomyelitis in PLSJL mice

C. Szabó, R. Kean, D. Hooper, 2001, Neuroscience Letters.

Nitrogen oxides and hydroxyguanidines: formation of donors of nitric and nitrous oxides and possible relevance to nitrous oxide formation by nitric oxide synthase.

G. Southan, A. Srinivasan, 1998, Nitric oxide : biology and chemistry.

Comparison of the inhibitory effect of isothiourea and mercapto-alkylguanidine derivatives on the alternative pathways of arginine metabolism in macrophages.

C. Szabó, A. Salzman, G. Southan, 1997, Life sciences.

Potent inhibition of the inducible isoform of nitric oxide synthase by aminoethylisoselenourea and related compounds.

C. Szabó, A. Salzman, G. Southan, 1996, Life sciences.

Amidines are potent inhibitors of nitric oxide synthases: preferential inhibition of the inducible isoform.

C. Thiemermann, C. Szabó, A. Salzman, 1995, European journal of pharmacology.

The Combined Inducible Nitric Oxide Synthase Inhibitor and Free Radical Scavenger Guanidinoethyldisulfide Prevents Multiple Low-Dose Streptozotocin-Induced Diabetes In Vivo and Interleukin-1&bgr;-Induced Suppression of Islet Insulin Secretion In Vitro

C. Szabó, A. Salzman, G. Southan, 2004, Pancreas.

Beneficial effects and improved survival in rodent models of septic shock with S-methylisothiourea sulfate, a potent and selective inhibitor of inducible nitric oxide synthase.

C. Thiemermann, C. Szabó, G. Southan, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Inactivation of Thioredoxin-1 and Its Role in Postischemic Myocardial Apoptosis

W. Lau, B. Lopez, T. Christopher, 2006 .

Novel phenanthridinone inhibitors of poly(adenosine 5′-diphosphate-ribose) synthetase: Potent cytoprotective and antishock agents*

F. Gallyas, E. Baloglu, É. Szabó, 2002, Critical care medicine.

Facile and convenient syntheses of 6,11-dihydro-5H-indeno[1,2-c]isoquinolin- 5-ones and 6,11-dihydro-5H-indolo[3,2-c]isoquinolin-5-one.

E. Baloglu, C. Szabó, A. Salzman, 2005, Organic letters.

The discovery and synthesis of novel adenosine substituted 2,3-dihydro-1H-isoindol-1-ones: potent inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1).

Csaba Szabó, E. Baloglu, C. Szabó, 2004, Bioorganic & medicinal chemistry letters.

Inhibition of nitric oxide synthase with pyrazole-1-carboxamidine and related compounds.

D. J. Wolff, S. Cuzzocrea, B. Zingarelli, 1997, Biochemical pharmacology.

Spontaneous rearrangement of aminoalkylisothioureas into mercaptoalkylguanidines, a novel class of nitric oxide synthase inhibitors with selectivity towards the inducible isoform

M. O’connor, B. Zingarelli, C. Szabó, 1996, British journal of pharmacology.

Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation

K. Murthy, É. Szabó, C. Szabó, 2001, Nature Medicine.

Selective pharmacological inhibition of distinct nitric oxide synthase isoforms.

C. Szabó, Csaba Szabó, G. Southan, 1996, Biochemical pharmacology.

Inosine Inhibits Inflammatory Cytokine Production by a Posttranscriptional Mechanism and Protects Against Endotoxin-Induced Shock1

C. Szabó, G. Haskó, A. Salzman, 2000, The Journal of Immunology.

Mercaptoethylguanidine inhibits the inflammatory response in a murine model of chronic infection with Pseudomonas aeruginosa.

C. Szabó, A. Salzman, R. Wilmott, 2000, The Journal of pharmacology and experimental therapeutics.

Aerosolized linear polyethylenimine-nitric oxide/nucleophile adduct attenuates endotoxin-induced lung injury in sheep.

O. V. Evgenov, C. Szabó, A. Salzman, 2002, American journal of respiratory and critical care medicine.

Attenuation of endotoxin‐induced multiple organ dysfunction by 1‐amino‐2‐hydroxy‐guanidine, a potent inhibitor of inducible nitric oxide synthase

C. Thiemermann, H. Ruetten, G. Southan, 1996, British journal of pharmacology.

Characterization of Serine Protease‐Derived Metabolites of Big Endothelin in the Cytosolic Fraction from Human Polymorphonuclear Leukocytes

J. Vane, M. Hecker, T. Warner, 1992, Journal of cardiovascular pharmacology.

Nicotine reduces the incidence of type I diabetes in mice.

C. Szabó, A. Salzman, P. Pacher, 2002, The Journal of pharmacology and experimental therapeutics.

Inactivation of nitric oxide synthase by substituted aminoguanidines and aminoisothioureas.

D. J. Wolff, M. Neulander, G. Southan, 1997, The Journal of pharmacology and experimental therapeutics.

Peroxynitrite: The Dark Side of Nitric Oxide-Effects of Mercaptoethylguanidine, a Combined Inhibitor of Inducible Nitric Oxide Synthase and Scavenger of Peroxynitrite, in Shock, Inflammation, and Ischemia-Reperfusion Injury

S. Cuzzocrea, T. Csont, B. Zingarelli, 1999 .

Modulation of oxidative and nitrosative stress attenuates microvascular hyperpermeability in ovine model of Pseudomonas aeruginosa sepsis

D. Prough, A. Salzman, C. Garner, 2021, Scientific Reports.

Pharmacological inhibition of poly(ADP-ribose) polymerase (PARP)

C. Szabó, G. Southan, 2003 .

INO-8875, An Adenosine A1 Agonist, in Development for Open-Angle Glaucoma Reduces IOP in Three Rabbit Models

C. Supuran, T. McCauley, G. Southan, 2009 .

Poly(ADP-Ribose) Polymerase Inhibition Reduces Reperfusion Injury After Heart Transplantation

S. Hagl, C. Vahl, T. Csont, 2002, Circulation research.

Mitogen-activated protein kinase phosphorylation in kidneys of beta(s) sickle cell mice.

C. Szabó, N. Bank, G. Southan, 2000, Journal of the American Society of Nephrology : JASN.

Chlorosulfonic acid-mediated cyclization of 4-phenyl-3-isocoumarincarboxylic acids and 4-phenyl-3-isoquinolinonecarboxylic acids: an efficient synthesis of 3-oxoindeno[2,1-c]isocoumarins and 3-oxoindeno[2,1-c]isoquinolinones

G. Southan, P. Jagtap, Zhiyu Chen, 2009 .

The inhibitory effects of mercaptoalkylguanidines on cyclo‐oxygenase activity

M. O’connor, B. Zingarelli, E. Gilad, 1997, British journal of pharmacology.

Poly(ADP-ribose) polymerase inhibition protect neurons and the white matter and regulates the translocation of apoptosis-inducing factor in stroke.

C. Szabó, A. Salzman, L. Virág, 2004, International journal of molecular medicine.

Inhibition of the induction of nitric oxide synthase by spermine is modulated by aldehyde dehydrogenase.

C. Thiemermann, C. Szabó, G. Southan, 1994, Biochemical and biophysical research communications.

N-Nitrosated N-hydroxyguanidines are nitric oxide-releasing diazeniumdiolates

C. George, L. Keefer, H. Fales, 1998 .

Pharmacological characterization of guanidinoethyldisulphide (GED), a novel inhibitor of nitric oxide synthase with selectivity towards the inducible isoform

D. J. Wolff, B. Zingarelli, C. Szabó, 1996, British journal of pharmacology.

Potentiation of the vasorelaxant activity of nitric oxide by hydroxyguanidine: implications for the nature of endothelium‐derived relaxing factor

J. Vane, M. Hecker, G. Southan, 1992, British journal of pharmacology.

Poly(ADP-Ribose) Polymerase Inhibition Reduces Reperfusion Injury After Heart Transplantation

S. Hagl, C. Vahl, T. Csont, 2002, Circulation research.

Nitrative Inactivation of Thioredoxin-1 and Its Role in Postischemic Myocardial Apoptosis

W. Lau, B. Lopez, T. Christopher, 2006, Circulation.

Mechanisms of the Endothelium‐Dependent Relaxation Induced by NG‐Hydroxy‐L‐Arginine

J. Vane, M. Hecker, G. Southan, 1992, Journal of cardiovascular pharmacology.