W. M. Seganish

发表

Small molecule agonists of toll-like receptors 7 and 8: a patent review 2014 – 2020

S. Hollingsworth, M. Kieffer, A. Patel, 2020, Expert opinion on therapeutic patents.

Modulation of myosin by cardiac myosin binding protein-C peptides improves cardiac contractility in ex-vivo experimental heart failure models

Luqia Hou, S. Sadayappan, Yinhong Chen, 2022, Scientific reports.

Preparation and palladium-catalyzed cross-coupling of aryl triethylammonium bis(catechol) silicates with aryl triflates.

W. M. Seganish, P. DeShong, 2004, The Journal of organic chemistry.

Optimization and Mechanistic Investigations of Novel Allosteric Activators of PKG1α.

P. McEwan, Yeon-Hee Lim, A. Cheng, 2022, Journal of medicinal chemistry.

DEVELOPMENT OF ARYL SILOXANE CROSS-COUPLING TECHNOLOGY AND ITS APPLICATION TO THE SYNTHESIS OF COLCHICINE AND ALLOCOLCHICINE DERIVATIVES

W. M. Seganish, 2005 .

Mechanistic insights on novel small molecule allosteric activators of cGMP-dependent protein kinase PKG1α

P. Tawa, Rumin Zhang, W. M. Seganish, 2022, The Journal of biological chemistry.

Palladium-catalyzed cross-coupling of aryl triethylammonium bis(catechol) silicates with aryl bromides using microwave irradiation.

W. M. Seganish, P. DeShong, 2004, Organic letters.

Palladium-catalyzed homocoupling of aryl halides in the presence of fluoride

W. M. Seganish, P. DeShong, M. E. Mowery, 2005 .

Application of aryl siloxane cross-coupling to the synthesis of allocolchicinoids.

W. M. Seganish, P. DeShong, Seganish Wm, 2006, Organic letters.

Total synthesis of laulimalide: synthesis of the northern and southern fragments.

B. Trost, W. M. Seganish, Cheol K. Chung, 2012, Chemistry.

Recent advances in siloxane-based aryl-aryl coupling reactions : focus on heteroaromatic systems

W. M. Seganish, P. DeShong, W. McElroy, 2005 .

Improved synthesis of aryltrialkoxysilanes via treatment of aryl Grignard or lithium reagents with tetraalkyl orthosilicates.

W. M. Seganish, P. DeShong, C. Ahn, 2004, The Journal of organic chemistry.

Application of directed orthometalation toward the synthesis of aryl siloxanes.

W. M. Seganish, P. DeShong, 2004, The Journal of organic chemistry.

Facile access to enantiomerically pure bis(sulfoxide) chelates of late transition metals

J. Fettinger, Mingsheng Huang, Tracie L. Williams, 2003 .

Total synthesis of laulimalide: assembly of the fragments and completion of the synthesis of the natural product and a potent analogue.

B. Trost, W. M. Seganish, Cheol K. Chung, 2012, Chemistry.

Evaluating transition-metal-catalyzed transformations for the synthesis of laulimalide.

B. Trost, W. M. Seganish, Cheol K. Chung, 2009, Journal of the American Chemical Society.

Application of Aryl Siloxane Cross‐Coupling to the Synthesis of Allocolchicinoids.

W. M. Seganish, P. DeShong, 2007 .

Efforts directed toward the synthesis of colchicine: application of palladium-catalyzed siloxane cross-coupling methodology.

W. M. Seganish, P. DeShong, C. Handy, 2005, The Journal of organic chemistry.

Inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4): a patent review (2012-2015)

W. M. Seganish, 2016, Expert opinion on therapeutic patents.

Treatments for Heart Failure

J. Lynch, W. M. Seganish, S. Sorota, 2017 .

Potent and Selective Amidopyrazole Inhibitors of IRAK4 That Are Efficacious in a Rodent Model of Inflammation.

D. Tulshian, T. Fischmann, C. Garlisi, 2015, ACS medicinal chemistry letters.

Discovery of the First Non-cGMP Mimetic Small Molecule Activators of cGMP-Dependent Protein Kinase 1 α (PKG1α).

Gregory T O'Donnell, Lei Zhang, P. Tawa, 2021, ACS medicinal chemistry letters.

Modulation of myosin by cardiac myosin binding protein-C peptides improves cardiac contractility in ex-vivo experimental heart failure models

Luqia Hou, S. Sadayappan, Yinhong Chen, 2021, Scientific Reports.

Discovery and Structure Enabled Synthesis of 2,6-Diaminopyrimidin-4-one IRAK4 Inhibitors.

D. Tulshian, T. Fischmann, C. Garlisi, 2015, ACS medicinal chemistry letters.

Efforts towards the optimization of a bi-aryl class of potent IRAK4 inhibitors.

D. Tulshian, C. Garlisi, W. M. Seganish, 2016, Bioorganic & medicinal chemistry letters.

Total synthesis of laulimalide: synthesis of the northern and southern fragments.

B. Trost, W. M. Seganish, Cheol K. Chung, 2012, Chemistry.

Total synthesis of laulimalide: assembly of the fragments and completion of the synthesis of the natural product and a potent analogue.

B. Trost, W. M. Seganish, Cheol K. Chung, 2012, Chemistry.

Initial optimization and series evolution of diaminopyrimidine inhibitors of interleukin-1 receptor associated kinase 4.

W. Greenlee, D. Tulshian, Jinhai Yang, 2015, Bioorganic & medicinal chemistry letters.

Inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4): a patent review (2012-2015)

W. M. Seganish, 2016, Expert opinion on therapeutic patents.

Development and application of an in vitro assay to assess target-independent B-cell activation by targeted TLR7 immune agonists.

A. Willingham, W. M. Seganish, Bhagyashree Bhagwat, 2023, Journal of immunological methods.

Discovery and Evaluation of TLR-Targeted Immune Agonists.

A. Willingham, W. M. Seganish, Saraswathi Naravula, 2024, Journal of medicinal chemistry.

Design and Optimization of Selectivity-Tunable Toll-like Receptor 7/8 Agonists as Novel Antibody-Drug Conjugate Payloads.

A. Willingham, W. M. Seganish, Saraswathi Naravula, 2024, Journal of medicinal chemistry.