C. Hivroz

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Is there a place and role for endocytic TCR signaling?

L. Saveanu, Irini Evnouchidou, A. Zucchetti, 2019, Immunological reviews.

yc Gene Transfer Into SCID X 1 Patients ' B-Cell Lines Restores Normal High-Affinity Interleukin-2 Receptor Expression and Function

C. Hivroz, By S. Hacein-Bey, Cavazzana‐Calvo, 2002 .

Naturally occurring primary deficiencies of the immune system.

F. Rieux-Laucat, A. Fischer, F. Deist, 1997, Annual review of immunology.

Monocytes But Not of Resting B Cells Pathway After CD40 Triggering of Human Activation of the Janus Kinase 3-STAT5a

A. Fischer, P. Revy, A. Durandy, 1999 .

Activation of the Janus kinase 3-STAT5a pathway after CD40 triggering of human monocytes but not of resting B cells.

A. Fischer, P. Revy, A. Durandy, 1999, Journal of immunology.

ORAI1 deficiency and lack of store-operated Ca2+ entry cause immunodeficiency, myopathy, and ectodermal dysplasia.

A. Fischer, J. Kutok, C. Picard, 2009, The Journal of allergy and clinical immunology.

Differential Requirement of ZAP-70 for CD2-Mediated Activation Pathways of Mature Human T Cells1

E. Meinl, C. Hivroz, N. Blank, 2000, The Journal of Immunology.

Crosstalk between T lymphocytes and dendritic cells.

C. Hivroz, K. Chemin, M. Tourret, 2012, Critical reviews in immunology.

Human immunodeficiency virus gp120 and derived peptides activate protein tyrosine kinase p56Ick in human CD4 T lymphocytes

A. Fischer, R. Sékaly, S. Meloche, 1993, European journal of immunology.

Rab6-dependent retrograde traffic of LAT controls immune synapse formation and T cell activation

L. Johannes, T. Galli, B. Goud, 2018, The Journal of experimental medicine.

Purification of LAT-Containing Membranes from Resting and Activated T Lymphocytes.

M. Jouve, L. Ardouin, C. Hivroz, 2017, Methods in molecular biology.

IFT20 controls LAT recruitment to the immune synapse and T-cell activation in vivo

G. Pazour, C. Baldari, S. Amigorena, 2015, Proceedings of the National Academy of Sciences.

Single-cell immuno-mechanics: rapid viscoelastic changes are a hall-mark of early leukocyte activation

A. Babataheri, A. Barakat, J. Husson, 2019, bioRxiv.

T Cells Signaling in γ Cells Requires IL-12 and IFN-T Cell-Dependent Activation of Dendritic

F. Deist, J. Casanova, F. Miró, 2006 .

immature dendritic cells through dissolution of their podosomes T-cell dendritic cell interactions induce migration of +

F. Miró, S. Amigorena, C. Hivroz, 2008 .

Cognate CD4+ T-cell-dendritic cell interactions induce migration of immature dendritic cells through dissolution of their podosomes.

F. Miró, S. Amigorena, C. Hivroz, 2008, Blood.

Evidence for a CD4‐associated calcium influx independent of the phosphoinositide transduction pathway in human T cells

V. Lafont, T. Fischer, C. Hivroz, 1997, European journal of immunology.

Helper or cytolytic functions can be selectively induced in bifunctional T cell clones

G. Bismuth, A. Bernard, A. Eljaafari, 1990, The Journal of experimental medicine.

T-Cell Artificial Focal Triggering Tools: Linking Surface Interactions with Cell Response

N. Henry, Paolo Pierobon, C. Hivroz, 2009, PloS one.

T-lymphocyte passive deformation is controlled by unfolding of membrane surface reservoirs

A. Babataheri, A. Barakat, J. Husson, 2016, Molecular biology of the cell.

In the immune synapse, ZAP-70 controls T cell polarization and recruitment of signaling proteins but not formation of the synaptic pattern.

C. Hivroz, V. Di Bartolo, N. Blanchard, 2002, Immunity.

The immunological synapse: the more you look the less you know…

C. Hivroz, N. Blanchard, 2002, Biology of the cell.

Inherited and somatic CD3zeta mutations in a patient with T-cell deficiency.

F. Rieux-Laucat, A. Fischer, A. Lim, 2006, The New England journal of medicine.

HLA-independent T cell receptors for targeting tumors with low antigen density

M. Sadelain, A. Iyer, M. Huse, 2022, Nature Medicine.

T Cell-Dependent Activation of Dendritic Cells Requires IL-12 and IFN-γ Signaling in T Cells1

J. Casanova, F. Miró, A. Chapgier, 2006, The Journal of Immunology.

Ligation of CD4 surface antigen induces rapid tyrosine phosphorylation of the cytoskeletal protein ezrin.

P. Mangeat, R. Fagard, C. Hivroz, 1994, Cellular immunology.

Restoring the association of the T cell receptor with CD8 reverses anergy in human tumor-infiltrating lymphocytes.

P. Courtoy, T. Boon, P. van der Smissen, 2008, Immunity.

Biomimetic droplets for artificial engagement of living cell surface receptors: the specific case of the T-cell.

J. Husson, N. Henry, C. Hivroz, 2012, Langmuir : the ACS journal of surfaces and colloids.

Primary T-cell immunodeficiency with immunodysregulation caused by autosomal recessive LCK deficiency.

F. Rieux-Laucat, A. Fischer, J. Soulier, 2012, The Journal of allergy and clinical immunology.

PD-1 mediates functional exhaustion of activated NK cells in patients with Kaposi sarcoma

D. Olive, C. Lebbé, D. Sène, 2016, Oncotarget.

Mammalian Amoeboid Swimming is propelled by molecular and not protrusion-based paddling in Lymphocytes

J. Sibarita, R. Galland, C. Misbah, 2019, bioRxiv.

X-linked primary immunodeficiency associated with hemizygous mutations in the moesin (MSN) gene.

F. Rieux-Laucat, A. Fischer, C. Picard, 2016, The Journal of allergy and clinical immunology.

Hypomorphic mutation of ZAP70 in human results in a late onset immunodeficiency and no autoimmunity

F. Rieux-Laucat, A. Fischer, C. Picard, 2009, European journal of immunology.

MAIT Cells Detect and Efficiently Lyse Bacterially-Infected Epithelial Cells

P. Sansonetti, O. Lantz, C. Hivroz, 2013, PLoS pathogens.

Upholding the T cell immune-regulatory function of CD31 inhibits the formation of T/B immunological synapses in vitro and attenuates the development of experimental autoimmune arthritis in vivo.

G. Bismuth, M. Clément, G. Caligiuri, 2015, Journal of autoimmunity.

Ligands of CD4 inhibit the association of phospholipase Cγ1 with phosphoinositide 3 kinase in T cells: regulation of this association by the phosphoinositide 3 kinase activity

A. Fischer, N. Jabado, A. Pallier, 1998, European journal of immunology.

ExpressionCells Is Dependent on CD4 Molecule T + Sam68 Association with p120GAP in CD4

N. Jabado, A. Bernard, A. Pallier, 1998 .

gp160 of HIV or anti‐CD4 monoclonal antibody ligation of CD4 induces inhibition of JNK and ERK‐2 activities in human peripheral CD4+ T lymphocytes

N. Jabado, A. Pallier, C. Hivroz, 1997, European journal of immunology.

JEM career launchpad

S. Tangye, J. Kipnis, A. Bigas, 2021, The Journal of experimental medicine.

Antigen‐independent adhesion of CD4 CD45RA T cells from cord blood

C. Hivroz, C. Barbat, F. Mazerolles, 1993, European journal of immunology.

Regulation of Antigen-Independent Adhesion of CD4 T Cells

R. Sékaly, S. Meloche, F. Amblard, 1993 .

Herpesvirus saimiri Replaces ZAP-70 for CD3- and CD2-mediated T Cell Activation*

T. Derfuss, E. Meinl, B. Fleckenstein, 2001, The Journal of Biological Chemistry.

Dendritic Cells Can Turn CD4+ T Lymphocytes into Vascular Endothelial Growth Factor-Carrying Cells by Intercellular Neuropilin-1 Transfer1

P. Romeo, C. Hivroz, N. Blanchard, 2006, The Journal of Immunology.

Intercellular Neuropilin-1 Transfer Growth Factor-Carrying Cells by Lymphocytes into Vascular Endothelial T + Dendritic Cells Can Turn CD4 Dendritic Cells Can Turn CD4 (cid:1) T Lymphocytes into Vascular Endothelial Growth Factor-Carrying Cells by Intercellular Neuropilin-1 Transfer 1

P. Romeo, C. Hivroz, N. Blanchard, 2006 .

Correction: T-Cell Artificial Focal Triggering Tools: Linking Surface Interactions with Cell Response

N. Henry, Paolo Pierobon, C. Hivroz, 2009, PLoS ONE.

LymphocytesDuration of the Interactions with Naive T Adhesion, Synapse Formation, and the Dendritic Cell Maturation Controls

A. Trautmann, O. Lantz, S. Amigorena, 2003 .

Human immunodeficiency virus gp120 and derived peptides activate protein tyrosine kinase p56lck in human CD4 T lymphocytes.

A. Fischer, R. Sékaly, S. Meloche, 1993, European journal of immunology.

LFA-1-mediated antigen-independent T cell adhesion is regulated by CD4 and p56lck tyrosine kinase.

R. Sékaly, J. Bernier, S. Meloche, 1994, Journal of immunology.

Phosphoinositide 3-Kinase Activation by Igβ Controls de Novo Formation of an Antigen-processing Compartment*

G. Raposo, C. Hivroz, C. Bonnerot, 2003, The Journal of Biological Chemistry.

Immunodeficiency Diseases: Multiple roles for ZAP-70

A. Fischer, C. Hivroz, 1994, Current Biology.

Altered signal transduction secondary to surface IgM cross-linking on B-chronic lymphocytic leukemia cells. Differential activation of the phosphatidylinositol-specific phospholipase C.

C. Hivroz, J. Brouet, C. Grillot‐Courvalin, 1990, Journal of immunology.

SIGNAL TRANSDUCTION VIA MHC CLASS II ANTIGENS ON B LYMPHOCYTES

D. Charron, C. Hivroz, C. Grillot‐Courvalin, 1989, Journal of immunogenetics.

A role for MHC class II antigens in B-cell activation.

D. Charron, C. Hivroz, C. Grillot‐Courvalin, 1989, Journal of autoimmunity.

Tissue-specific Activity of the γc Chain Gene Promoter Depends upon an Ets Binding Site and Is Regulated by GA-binding Protein*

A. Fischer, F. Deist, J. Ghysdael, 1996, The Journal of Biological Chemistry.

T cell activation deficiencies.

F. Rieux-Laucat, D. Choquet, C. Hivroz, 1995, Clinical immunology and immunopathology.

The lectin jacalin specifically triggers cell signaling in CD4+ T lymphocytes.

V. Lafont, C. Hivroz, P. Carayon, 1997, Cellular immunology.

The protein tyrosine kinase p60c-Src is not implicated in the pathogenesis of the human autosomal recessive form of osteopetrosis: a study of 13 children.

A. Fischer, J. Casanova, N. Jabado, 1998, The Journal of pediatrics.

Functional Implication of Cellular Prion Protein in Antigen-Driven Interactions between T Cells and Dendritic Cells1

C. Hivroz, C. Carnaud, P. Aucouturier, 2006, The Journal of Immunology.

Regulation by interleukin 2 of CD23 expression of leukemic and normal B cells: comparison with interleukin 4

J. Banchereau, C. Hivroz, J. Brouet, 1989, European journal of immunology.

CD4 ligands inhibit the formation of multifunctional transduction complexes involved in T cell activation.

A. Fischer, N. Jabado, A. Pallier, 1997, Journal of immunology.

TCR/CD3 Down-Modulation and ζ Degradation Are Regulated by ZAP-701

C. Hivroz, V. Di Bartolo, C. Dumont, 2002, The Journal of Immunology.

IRAP-dependent endosomal T cell receptor signalling is essential for T cell responses

P. van Endert, J. Davoust, S. Lotersztajn, 2020, Nature Communications.

Label-free single-cell live imaging reveals fast metabolic switch in T lymphocytes

C. Stringari, C. Hivroz, Stéphanie Dogniaux, 2023, bioRxiv.

STIM1 mutation associated with a syndrome of immunodeficiency and autoimmunity.

F. Rieux-Laucat, A. Fischer, C. Picard, 2009, The New England journal of medicine.

A primary T-cell immunodeficiency associated with defective transmembrane calcium influx.

A. Fischer, D. Choquet, C. Hivroz, 1995, Blood.

The calcium current activated by T cell receptor and store depletion in human lymphocytes is absent in a primary immunodeficiency.

H. Korn, D. Choquet, C. Hivroz, 1994, The Journal of biological chemistry.

T cell-dependent activation of dendritic cells requires IL-12 and IFN-gamma signaling in T cells.

J. Casanova, F. Miró, A. Chapgier, 2006, Journal of immunology.

Cytotoxic T Cells Use Mechanical Force to Potentiate Target Cell Killing

Weiyang Jin, Morgan Huse, Judy Lieberman, 2016, Cell.

ZAP70: a master regulator of adaptive immunity

Capucine Picard, Claire Hivroz, A. Fischer, 2010, Seminars in Immunopathology.

Mutations in Fas associated with human lymphoproliferative syndrome and autoimmunity.

F. Rieux-Laucat, F. Deist, K. Debatin, 1995, Science.

Human Primary Immune Cells Exhibit Distinct Mechanical Properties that Are Modified by Inflammation.

Alain Richert, Atef Asnacios, Claire Hivroz, 2015, Biophysical journal.

Mechanobiology of antigen‐induced T cell arrest

K. Gaus, C. Hivroz, M. Chabaud, 2020, Biology of the cell.

Different TCR-induced T lymphocyte responses are potentiated by stiffness with variable sensitivity

C. Goudot, C. Hivroz, A. Asnacios, 2017, eLife.

Cells Is Dependent on CD4 Molecule Sam68 Association with p120GAP in CD4+ T

A. Fischer, N. Jabado, C. Hivroz, 2013 .

Sam68 association with p120GAP in CD4+ T cells is dependent on CD4 molecule expression.

A. Fischer, N. Jabado, A. Pallier, 1998, Journal of immunology.

Combined immunodeficiency associated with increased apoptosis of lymphocytes and radiosensitivity fibroblasts.

P. Jeggo, F. Rieux-Laucat, A. Fischer, 1999, Cancer research.

gamma-c gene transfer into SCID X1 patients' B-cell lines restores normal high-affinity interleukin-2 receptor expression and function.

K. Sugamura, M. Cavazzana‐Calvo, A. Dautry‐Varsat, 1996, Blood.

TCR Activation of Human T Cells Induces the Production of Exosomes Bearing the TCR/CD3/ζ Complex1

A. Régnault, G. Raposo, F. Faure, 2002, The Journal of Immunology.

Partial interferon-gamma receptor 1 deficiency in a child with tuberculoid bacillus Calmette-Guérin infection and a sibling with clinical tuberculosis.

J. Casanova, R. Schreiber, M. Levin, 1997, The Journal of clinical investigation.

Differential CD4-dependent inhibition of JNK but not Erk-2 activities in human naive and memory CD4+ T cell populations.

A. Fischer, N. Jabado, A. Pallier, 1998, International immunology.

ZAP‐70 kinase regulates HIV cell‐to‐cell spread and virological synapse formation

Claire Hivroz, N. Taylor, A. Alcover, 2007, The EMBO journal.

Influence of external forces on actin‐dependent T cell protrusions during immune synapse formation

J. Husson, Olga Markova, A. Zucchetti, 2021, Biology of the cell.

Cytokine Secretion by CD4+ T Cells at the Immunological Synapse Requires Cdc42-Dependent Local Actin Remodeling but Not Microtubule Organizing Center Polarity

F. Miró, C. Hivroz, K. Chemin, 2012, The Journal of Immunology.

Critical role for TRIM28 and HP1β/γ in the epigenetic control of T cell metabolic reprograming and effector differentiation

G. Kroemer, V. Adoue, U. Gehrmann, 2019, Proceedings of the National Academy of Sciences.

Characterization of endogenous Kv1.3 channel isoforms in T cells

P. Cidad, C. Hivroz, J. J. Sáez, 2022, Journal of cellular physiology.

T Cell Polarity at the Immunological Synapse Is Required for CD154-Dependent IL-12 Secretion by Dendritic Cells

F. Miró, C. Hivroz, K. Chemin, 2010, The Journal of Immunology.

Cross‐linking of membrane IgM on B CLL cells: dissociation between intracellular free Ca2+ mobilization and cell proliferation

C. Hivroz, J. Brouet, C. Grillot‐Courvalin, 1988, European journal of immunology.

Heterogeneity of responsiveness of chronic lymphocytic leukemic B cells to B cell growth factor or interleukin 2

C. Hivroz, J. Brouet, C. Grillot‐Courvalin, 1986, European journal of immunology.

Dendritic Cell Maturation Controls Adhesion, Synapse Formation, and the Duration of the Interactions with Naive T Lymphocytes

Olivier Lantz, Sebastian Amigorena, Federica Benvenuti, 2004, The Journal of Immunology.

Mature Human T Cells CD2-Mediated Activation Pathways of Differential Requirement of ZAP-70 for

Norbert Blank, Luis Barata, Claire Hivroz, 2013 .

the Production of Exosomes Bearing the TCR Activation of Human T Cells Induces

G. Raposo, F. Faure, C. Hivroz, 2013 .

Early T‐cell activation biophysics

N. Henry, C. Hivroz, 2009, HFSP journal.

Strong and Durable TCR Clustering at the T/Dendritic Cell Immune Synapse Is Not Required for NFAT Activation and IFN-γ Production in Human CD4+ T Cells12

S. Amigorena, F. Miró-Mur, C. Hivroz, 2004, The Journal of Immunology.

transmembrane calcium influx A primary T-cell immunodeficiency associated with defective

F. Deist, D. Choquet, C. Hivroz, 2011 .

between T Cells and Dendritic Cells Protein in Antigen-Driven Interactions Functional Implication of Cellular Prion

C. Hivroz, P. Aucouturier, V. Bachy, 2006 .

Biophysical Aspects of T Lymphocyte Activation at the Immune Synapse

C. Hivroz, M. Saitakis, 2016, Front. Immunol..

Early biochemical events after MHC class II-mediated signaling on human B lymphocytes.

D. Charron, C. Hivroz, C. Grillot‐Courvalin, 1990, Journal of immunology.

GF109203X, a specific PKC inhibitor, abrogates anti-CD3 antibody-induced upregulation of CD4+ T cell adhesion to B cells.

C. Hivroz, A. Fischer, C. Barbat, 1993, Cellular immunology.

Rapid viscoelastic changes are a hallmark of early leukocyte activation.

A. Babataheri, A. Barakat, J. Husson, 2021, Biophysical journal.

Dynamic palmitoylation events following T-cell receptor signaling

S. Kliche, E. Krause, C. Freund, 2019, bioRxiv.

Differential effects of the stimulation of complement receptors CR1 (CD35) and CR2 (CD21) on cell proliferation and intracellular Ca2+ mobilization of chronic lymphocytic leukemia B cells.

M. Kazatchkine, C. Hivroz, C. Grillot‐Courvalin, 1991, Journal of immunology.

HIV-1 Nef Inhibits Ruffles, Induces Filopodia, and Modulates Migration of Infected Lymphocytes

Christophe Machu, Claire Hivroz, Nathalie Aulner, 2009, Journal of Virology.

Tethering of vesicles to the Golgi by GMAP210 controls LAT delivery to the immune synapse

G. Pazour, C. Baldari, R. Rios, 2019, Nature Communications.

Interaction of HIV gp120 and anti‐CD4 antibodies with the CD4 molecule on human CD4+ T cells inhibits the binding activity of NF‐AT, NF‐χB and AP‐1, three nuclear factors regulating interleukin‐2 gene enhancer activity

Nada Jabado, Claire Hivroz, A. Fischer, 1994, European journal of immunology.

[Primary immunodeficiency secondary to ZAP-70 deficiency].

A. Fischer, E. Jouanguy, C. Hivroz, 2001, Acta medica portuguesa.

Phosphatidylinositol 3-kinase participates in p56(lck)/CD4-dependent down-regulation of LFA-1-mediated T cell adhesion.

C. Hivroz, A. Fischer, C. Barbat, 1996, Journal of immunology.

Abnormal CD40-mediated activation pathway in B lymphocytes from patients with hyper-IgM syndrome and normal CD40 ligand expression.

A. Fischer, J. Casanova, C. Schiff, 1997, Journal of immunology.

Dynamic recruitment of the adaptor protein LAT: LAT exists in two distinct intracellular pools and controls its own recruitment

D. Olive, F. Sánchez‐Madrid, C. Langlet, 2004, Journal of Cell Science.

Amoeboid Swimming Is Propelled by Molecular Paddling in Lymphocytes.

J. Sibarita, R. Galland, C. Misbah, 2020, Biophysical journal.

CTLA4 prohibits T cells from cross-dressing.

C. Hivroz, Noémie Paillon, 2023, Journal of Experimental Medicine.

Retrograde and Anterograde Transport of Lat-Vesicles during the Immunological Synapse Formation: Defining the Finely-Tuned Mechanism

L. Johannes, A. Zucchetti, C. Hivroz, 2020, bioRxiv.

VAMP7 controls T cell activation by regulating the recruitment and phosphorylation of vesicular Lat at TCR-activation sites

Katharina Gaus, Lydia Danglot, David J. Williamson, 2013, Nature Immunology.

Micropipette force probe to quantify single-cell force generation: application to T-cell activation

A. Babataheri, A. Barakat, J. Husson, 2017, Molecular biology of the cell.

Force Generation upon T Cell Receptor Engagement

J. Husson, N. Henry, C. Hivroz, 2011, PloS one.

IRAP-dependent endosomal T cell receptor signalling is essential for T cell responses

P. van Endert, J. Davoust, S. Lotersztajn, 2020, Nature Communications.

Dynamic palmitoylation events following T-cell receptor signaling

S. Kliche, B. Brügger, E. Krause, 2020, Communications Biology.

TCR/CD3 down-modulation and zeta degradation are regulated by ZAP-70.

C. Hivroz, V. Di Bartolo, C. Dumont, 2002, Journal of immunology.

Severe Combined Immunodeficiencies in Humans

F. Rieux-Laucat, F. Deist, M. Cavazzana‐Calvo, 1993 .

Dual ligand engagement for noncanonical inflammasome activation

C. Hivroz, Zhang-Hua Yang, Jiahuai Han, 2022, Nature Immunology.

Cognate CD4+ T-cell-dendritic cell interactions induce migration of immature dendritic cells through dissolution of their podosomes.

F. Miró, S. Amigorena, C. Hivroz, 2008, Blood.

PD-1 inhibits T cell actin remodeling at the immunological synapse independently of its signaling motifs

A. Zucchetti, C. Hivroz, Laurence Bataille, 2023, Science Signaling.

Defective transmembrane calcium influx demonstrated in a primary immunodeficiency by video-imaging.

H. Korn, D. Choquet, C. Hivroz, 1994, Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie.