Michael Chan

发表

Enhancement of the Immunostimulatory Activity of a TLR7 Ligand by Conjugation to Polysaccharides.

Shiyin Yao, H. Cottam, D. Carson, 2015, Bioconjugate chemistry.

Synthetic Toll-Like Receptor 4 (TLR4) and TLR7 Ligands as Influenza Virus Vaccine Adjuvants Induce Rapid, Sustained, and Broadly Protective Responses

A. Fernández-Sesma, P. Palese, Shiyin Yao, 2015, Journal of Virology.

Small Molecule Potentiator of Adjuvant Activity Enhancing Survival to Influenza Viral Challenge

Tetsuya Saito, Nikunj M. Shukla, Shiyin Yao, 2021, Frontiers in Immunology.

The antimicrobial activity of liposomal lauric acids against Propionibacterium acnes.

Chun-Ming Huang, Liangfang Zhang, D. Carson, 2009, Biomaterials.

Small Molecule Calcium Channel Activator Potentiates Adjuvant Activity

K. Messer, Tetsuya Saito, Nikunj M. Shukla, 2022, ACS chemical biology.

Mitochondria-dependent synthetic small-molecule vaccine adjuvants for influenza virus infection

A. Molina, Tetsuya Saito, Nikunj M. Shukla, 2021, Proceedings of the National Academy of Sciences.

Hypoestoxide reduces neuroinflammation and α-synuclein accumulation in a mouse model of Parkinson’s disease

E. Masliah, E. Rockenstein, W. Wrasidlo, 2015, Journal of Neuroinflammation.

Structure-Activity Relationship Studies of Pyrimido[5,4-b]indoles as Selective Toll-Like Receptor 4 Ligands.

Masahiro Wakao, Nikunj M. Shukla, Shiyin Yao, 2017, Journal of medicinal chemistry.

Prevention of autoimmune disease by induction of tolerance to Toll-like receptor 7

M. McGargill, D. Carson, Tomoko Hayashi, 2009, Proceedings of the National Academy of Sciences.

Identification of Biologically Active Pyrimido[5,4-b]indoles That Prolong NF-κB Activation without Intrinsic Activity.

Nikunj M. Shukla, Shiyin Yao, Fumi Sato-Kaneko, 2017, ACS combinatorial science.

Additive melanoma suppression with intralesional phospholipid-conjugated TLR7 agonists and systemic IL-2

G. Daniels, Shiyin Yao, H. Cottam, 2011, Melanoma research.

Mast cell-dependent anorexia and hypothermia induced by mucosal activation of Toll-like receptor 7.

K. Messer, H. Cottam, D. Carson, 2008, American journal of physiology. Regulatory, integrative and comparative physiology.

Oral administration of PEGylated TLR7 ligand ameliorates alcohol-associated liver disease via the induction of IL-22

Shelly C. Lu, S. Y. Kim, S. Devkota, 2020, Proceedings of the National Academy of Sciences.

A Novel Doxorubicin Prodrug with Controllable Photolysis Activation for Cancer Chemotherapy

S. Esener, S. Ibsen, Michael Chan, 2010, Pharmaceutical Research.

Discovery of substituted 4-aminoquinazolines as selective Toll-like receptor 4 ligands.

I. Tsigelny, V. Kouznetsova, Shiyin Yao, 2014, Bioorganic & medicinal chemistry letters.

Identification of Substituted Pyrimido[5,4-b]indoles as Selective Toll-Like Receptor 4 Ligands

I. Tsigelny, V. Kouznetsova, Shiyin Yao, 2013, Journal of medicinal chemistry.

Novel Synthetic Toll-Like Receptor 4/MD2 Ligands Attenuate Sterile Inflammation

Shiyin Yao, H. Cottam, D. Carson, 2014, The Journal of Pharmacology and Experimental Therapeutics.

A Dual Adjuvant System for Intranasal Boosting of Local and Systemic Immunity for Influenza Vaccination

J. Jin, Nikunj M. Shukla, Shiyin Yao, 2022, Vaccines.

Synthesis and Immunological Characterization of Toll-Like Receptor 7 Agonistic Conjugates

H. Cottam, D. Carson, Tomoko Hayashi, 2009, Bioconjugate chemistry.

polypnea in mice Central histamine contributed to temperature-induced

I. Homma, M. Izumizaki, M. Iwase, 2015 .

Synthesis and characterization of PEGylated toll like receptor 7 ligands.

Yanmei Zhang, Shiyin Yao, Fitzgerald S. Lao, 2011, Bioconjugate chemistry.

Intravesical Toll‐like receptor 7 agonist R‐837: Optimization of its formulation in an orthotopic mouse model of bladder cancer

R. Maj, A. Barberis, H. Cottam, 2010, International journal of urology : official journal of the Japanese Urological Association.

Eradication of drug resistant Staphylococcus aureus by liposomal oleic acids.

Chun-Ming Huang, Liangfang Zhang, Michael Chan, 2011, Biomaterials.

Synthesis and immunostimulatory activity of 8-substituted amino 9-benzyladenines as potent Toll-like receptor 7 agonists.

H. Cottam, D. Carson, Michael Chan, 2006, Bioorganic & medicinal chemistry letters.

Innate Immune Protection against Infectious Diseases by Pulmonary Administration of a Phospholipid-Conjugated TLR7 Ligand

D. Smee, Shiyin Yao, Fitzgerald S. Lao, 2013, Journal of Innate Immunity.

Activation of anti-hepatitis C virus responses via Toll-like receptor 7.

Yu-Tseung Liu, M. Lai, Jongdae Lee, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Structure-Activity Relationship Studies to Identify Affinity Probes in Bis-aryl Sulfonamides that Prolong Immune Stimuli.

Nikunj M. Shukla, Shiyin Yao, Fumi Sato-Kaneko, 2019, Journal of medicinal chemistry.

Synthesis and immunostimulatory activity of sugar-conjugated TLR7 ligands.

Masahiro Wakao, Shiyin Yao, H. Cottam, 2019, Bioorganic & medicinal chemistry letters.

Treatment of Autoimmune Inflammation by a TLR7 Ligand Regulating the Innate Immune System

Linda Vuong, Shiyin Yao, Fitzgerald S. Lao, 2012, PloS one.

A Novel Synthetic Dual Agonistic Liposomal TLR4/7 Adjuvant Promotes Broad Immune Responses in an Influenza Vaccine With Minimal Reactogenicity

Nikunj M. Shukla, Shiyin Yao, Fumi Sato-Kaneko, 2020, Frontiers in Immunology.

Mast Cell-Mediated Inhibition of Abdominal Neutrophil Inflammation by a PEGylated TLR7 Ligand

Shiyin Yao, Fitzgerald S. Lao, H. Cottam, 2011, Mediators of inflammation.

Discovery of a Novel Microtubule Targeting Agent as an Adjuvant for Cancer Immunotherapy

Nikunj M. Shukla, Shiyin Yao, Fumi Sato-Kaneko, 2018, BioMed research international.

Structure-activity relationship studies in substituted sulfamoyl benzamidothiazoles that prolong NF-κB activation.

Tetsuya Saito, Nikunj M. Shukla, Shiyin Yao, 2021, Bioorganic & medicinal chemistry.

Hypoestoxide reduces neuroinflammation and α-synuclein accumulation in a mouse model of Parkinson’s disease

E. Masliah, E. Rockenstein, W. Wrasidlo, 2015, Journal of Neuroinflammation.

A Triple High Throughput Screening for Extracellular Vesicle Inducing Agents With Immunostimulatory Activity

K. Messer, Tetsuya Saito, Nikunj M. Shukla, 2022, Frontiers in Pharmacology.

Identification of a Novel Small Molecule That Enhances the Release of Extracellular Vesicles with Immunostimulatory Potency via Induction of Calcium Influx

K. Messer, Tetsuya Saito, Nikunj M. Shukla, 2023, ACS chemical biology.

Discovery of substituted 4-aminoquinazolines as selective Toll-like receptor 4 ligands.

I. Tsigelny, V. Kouznetsova, Shiyin Yao, 2014, Bioorganic & medicinal chemistry letters.

Recent Advances and Perspectives in Small-molecule TLR Ligands and Their Modulators.

Nikunj M. Shukla, H. Cottam, D. Carson, 2018, ACS medicinal chemistry letters.