Takuma Shibata

发表

DNase II-dependent DNA digestion is required for DNA sensing by TLR9

Toshiyuki Shimizu, G. Barber, K. Miyake, 2015, Nature Communications.

This information is current as Double-Strand RNA Sensing Fragment and Cell Surface TLR 3 in Roles of the Cleaved N-Terminal TLR 3 Saitoh and

K. Miyake, Y. Murakami, S. Saitoh, 2014 .

Emerging roles of the processing of nucleic acids and Toll‐like receptors in innate immune responses to nucleic acids

Toshiyuki Shimizu, K. Miyake, Takuma Shibata, 2017, Journal of leukocyte biology.

Guanosine and its modified derivatives are endogenous ligands for TLR7.

Toshiyuki Shimizu, K. Miyake, Tomoki Ito, 2016, International immunology.

Combating herpesvirus encephalitis by potentiating a TLR3–mTORC2 axis

T. Manabe, G. Barber, T. Ikenoue, 2018, Nature Immunology.

Mechanisms controlling nucleic acid-sensing Toll-like receptors

Toshiyuki Shimizu, K. Miyake, Y. Murakami, 2018, International immunology.

Requirement of glycosylation machinery in TLR responses revealed by CRISPR/Cas9 screening

Y. Furukawa, S. Miyano, S. Imoto, 2017, International immunology.

The protective effect of the anti-Toll-like receptor 9 antibody against acute cytokine storm caused by immunostimulatory DNA

K. Miyake, Y. Murakami, S. Saitoh, 2017, Scientific Reports.

PRAT4A-dependent expression of cell surface TLR5 on neutrophils, classical monocytes and dendritic cells.

S. Akira, H. Kiyono, T. Kitamura, 2012, International immunology.

PRAT 4 A-dependent expression of cell surface TLR 5 on neutrophils , classical monocytes and dendritic cells

S. Akira, H. Kiyono, T. Kitamura, 2012 .

Establishment and analysis of a novel mouse line carrying a conditional knockin allele of a cancer-specific FBXW7 mutation

Y. Furukawa, Y. Iwakura, T. Ikenoue, 2018, Scientific Reports.

Nucleic Acid Sensing by Toll-Like Receptors in the Endosomal Compartment

K. Miyake, Y. Murakami, S. Saitoh, 2022, Frontiers in Immunology.

Epithelial membrane protein 3 (Emp3) downregulates induction and function of cytotoxic T lymphocytes by macrophages via TNF-α production.

T. Ishii, K. Miyake, S. Saitoh, 2017, Cellular immunology.

Structural basis for species‐specific activation of mouse Toll‐like receptor 9

Toshiyuki Shimizu, K. Miyake, Takuma Shibata, 2018, FEBS letters.

Essential role for Toll-like receptor 7 (TLR7)-unique cysteines in an intramolecular disulfide bond, proteolytic cleavage and RNA sensing.

K. Miyake, S. Saitoh, M. Onji, 2013, International immunology.

C4b binding protein negatively regulates TLR1/2 response

K. Miyake, Takuma Shibata, Toshihiko Kobayashi, 2017, Innate immunity.

Role of the Orphan Transporter SLC35E1 in the Nuclear Egress of Herpes Simplex Virus 1

M. Oyama, S. Miyano, S. Imoto, 2022, Journal of virology.

A single base mutation in the PRAT4A gene reveals differential interaction of PRAT4A with Toll-like receptors.

Y. Seto, K. Miyake, C. Nishitani, 2008, International immunology.

Structural analysis reveals TLR7 dynamics underlying antagonism

M. Ikeguchi, H. Shigematsu, Masaki Yamamoto, 2020, Nature Communications.

Nucleosides drive histiocytosis in SLC29A3 disorders by activating TLR7

T. Ichinohe, Toshiyuki Shimizu, N. Yoshida, 2019, bioRxiv.

Unc93 homolog B1 restricts systemic lethal inflammation by orchestrating TLR7 and TLR9 response

S. Akira, M. Matsumoto, N. Yoshida, 2012, Arthritis Research & Therapy.

Dynamic control of nucleic-acid-sensing Toll-like receptors by the endosomal compartment.

K. Miyake, Y. Murakami, S. Saitoh, 2021, International immunology.

Tonic B cell activation by Radioprotective105/MD-1 promotes disease progression in MRL/lpr mice.

S. Akira, H. Kiyono, Y. Nagai, 2008, International immunology.

Toll-like receptor 7 cooperates with IL-4 in activated B cells through antigen receptor or CD38 and induces class switch recombination and IgG1 production.

S. Akira, T. Kaisho, K. Takatsu, 2009, Molecular immunology.

Intracellular TLR4/MD-2 in macrophages senses Gram-negative bacteria and induces a unique set of LPS-dependent genes.

K. Miyake, S. Akashi-Takamura, Takuma Shibata, 2011, International immunology.

Cleavage of Toll-Like Receptor 9 Ectodomain Is Required for In Vivo Responses to Single Strand DNA

N. Yoshida, K. Miyake, Y. Murakami, 2018, Front. Immunol..

TLR7 mediated viral recognition results in focal type I interferon secretion by dendritic cells

Katsuaki Sato, M. Oyama, T. Katada, 2017, Nature Communications.

Cytidine deaminase enables Toll-like receptor 8 activation by cytidine or its analogs

T. Ichinohe, K. Miyake, M. Moriyama, 2018, International immunology.

Lipopeptides are signaled by Toll-like receptor 1, 2 and 6 in endolysosomes.

K. Miyake, Y. Murakami, T. Kasahara, 2014, International immunology.

Biallelic Variants in CNPY3, Encoding an Endoplasmic Reticulum Chaperone, Cause Early-Onset Epileptic Encephalopathy.

H. Kitaura, A. Kakita, H. Mutoh, 2018, American journal of human genetics.

Mucolipin 1 positively regulates TLR7 responses in dendritic cells by facilitating RNA transportation to lysosomes.

K. Miyake, S. Saitoh, Ryutaro Fukui, 2015, International immunology.

IMPDH inhibition activates TLR‐VCAM1 pathway and suppresses the development of MLL‐fusion leukemia

T. Shibata, S. Yamasaki, A. Sasaki, 2022, EMBO molecular medicine.

Structural Analysis Reveals that Toll-like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA.

Toshiyuki Shimizu, M. Taoka, Y. Yamauchi, 2016, Immunity.

Toll-like receptor 8 senses degradation products of single-stranded RNA

Toshiyuki Shimizu, M. Taoka, Y. Yamauchi, 2015, Nature Structural &Molecular Biology.

Core fucose is critical for CD14-dependent Toll-like receptor 4 signaling

N. Taniguchi, Yasuhiko Kizuka, S. Kitazume, 2017, Glycobiology.

UNC93B1 is essential for the plasma membrane localization and signaling of Toll-like receptor 5

K. Miyake, You-Me Kim, Ryutaro Fukui, 2014, Proceedings of the National Academy of Sciences.

Endolysosomal compartments as platforms for orchestrating innate immune and metabolic sensors

K. Miyake, Y. Murakami, S. Saitoh, 2019, Journal of leukocyte biology.

Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9

Toshiyuki Shimizu, S. Uchiyama, Elena Krayukhina, 2015, Nature.

Structural Reorganization of the Toll-Like Receptor 8 Dimer Induced by Agonistic Ligands

Takuma Shibata, Toshiyuki Shimizu, Toshiyuki Shimizu, 2013, Science.

Human TLR4 polymorphism D299G/T399I alters TLR4/MD-2 conformation and response to a weak ligand monophosphoryl lipid A.

Toshiyuki Shimizu, K. Miyake, T. Suganami, 2013, International immunology.

Establishment and analysis of a novel mouse line carrying a conditional knockin allele of a cancer-specific FBXW7 mutation

Y. Furukawa, Y. Iwakura, T. Ikenoue, 2018, Scientific Reports.

Structural Analyses of Toll-like Receptor 7 Reveal Detailed RNA Sequence Specificity and Recognition Mechanism of Agonistic Ligands.

Toshiyuki Shimizu, M. Taoka, Y. Yamauchi, 2018, Cell reports.

Toll‐like Receptor 9 Contains Two DNA Binding Sites that Function Cooperatively to Promote Receptor Dimerization and Activation

Toshiyuki Shimizu, K. Miyake, Takuma Shibata, 2018, Immunity.

The impact of cell maturation and tissue microenvironments on the expression of endosomal Toll-like receptors in monocytes and macrophages.

E. Latz, S. Yamazaki, H. Tsukamoto, 2020, International immunology.

Activated M2 Macrophages Contribute to the Pathogenesis of IgG4‐Related Disease via Toll‐like Receptor 7/Interleukin‐33 Signaling

Hidetaka Yamamoto, K. Miyake, Y. Murakami, 2019, Arthritis & rheumatology.

Unc93B1 restricts systemic lethal inflammation by orchestrating Toll-like receptor 7 and 9 trafficking.

S. Akira, M. Matsumoto, N. Yoshida, 2011, Immunity.

TLR3 forms a laterally aligned multimeric complex along double-stranded RNA for efficient signal transduction

M. Ikeguchi, H. Shigematsu, Toshiyuki Shimizu, 2023, Nature Communications.

Nucleic acid‐sensing TLRs and autoimmunity: novel insights from structural and cell biology

E. Latz, K. Miyake, K. Pelka, 2016, Immunological reviews.

A protein associated with Toll-like receptor (TLR) 4 (PRAT4A) is required for TLR-dependent immune responses

K. Takatsu, Y. Nagai, K. Miyake, 2007, The Journal of experimental medicine.

Crystal structure of NOD2 and its implications in human disease

Toshiyuki Shimizu, K. Miyake, Takuma Shibata, 2016, Nature Communications.

Targeting cell surface TLR7 for therapeutic intervention in autoimmune diseases

Toshiyuki Shimizu, Kazuhide Yamamoto, K. Miyake, 2015, Nature Communications.

An essential role for the N-terminal fragment of Toll-like receptor 9 in DNA sensing

H. Kiyono, Shintaro Sato, Kazuhide Yamamoto, 2013, Nature Communications.

Autoinhibition and relief mechanism by the proteolytic processing of Toll-like receptor 8

Takuma Shibata, Toshiyuki Shimizu, Toshiyuki Shimizu, 2016, Proceedings of the National Academy of Sciences.

TLR7 mediated viral recognition results in focal type I interferon secretion by dendritic cells

Katsuaki Sato, M. Oyama, T. Katada, 2017, Nature Communications.

TLR7/8 stress response drives histiocytosis in SLC29A3 disorders

Y. Furukawa, T. Ichinohe, E. Latz, 2022, bioRxiv.

Microbiome ssRNA as an environmental cue to activate TLR13-dependent tissue-protective programs in CD5Lhi hepatic macrophages

Y. Furukawa, T. Kaisho, E. Latz, 2023, bioRxiv.

Roles of the Cleaved N-Terminal TLR3 Fragment and Cell Surface TLR3 in Double-Stranded RNA Sensing

K. Miyake, Y. Murakami, S. Saitoh, 2014, The Journal of Immunology.

Structural basis for thioredoxin-mediated suppression of NLRP1 inflammasome

Takuma Shibata, U. Ohto, J. Kitaura, 2023, Nature.

Intracellular TLR4/MD-2 in macrophages senses Gram-negative bacteria and induces a unique set of LPS-dependent genes.

K. Miyake, Takuma Shibata, Y. Motoi, 2011, International immunology.

Skewed endosomal RNA responses from TLR7 to TLR3 in RNase T2-deficient macrophages.

T. Ichinohe, E. Latz, N. Yoshida, 2021, International immunology.