U. Ohto

发表

DNase II-dependent DNA digestion is required for DNA sensing by TLR9

Toshiyuki Shimizu, G. Barber, K. Miyake, 2015, Nature Communications.

Crystal Structure of Human β-Galactosidase

Y. Satow, Toshiyuki Shimizu, K. Usui, 2011, The Journal of Biological Chemistry.

The effect of anesthetics on toll like receptor 9

R. Eckenhoff, Koichi Yuki, S. Koutsogiannaki, 2020, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Saturated fatty acid and TLR signaling link β cell dysfunction and islet inflammation.

T. Kadowaki, K. Tobe, M. Ohsugi, 2012, Cell metabolism.

Emerging roles of the processing of nucleic acids and Toll‐like receptors in innate immune responses to nucleic acids

Toshiyuki Shimizu, K. Miyake, Takuma Shibata, 2017, Journal of leukocyte biology.

Guanosine and its modified derivatives are endogenous ligands for TLR7.

Toshiyuki Shimizu, K. Miyake, Tomoki Ito, 2016, International immunology.

Coagulation Factor X Activates Innate Immunity to Human Species C Adenovirus

James W. MacDonald, P. Stewart, N. D. Di Paolo, 2012, Science.

Mechanisms controlling nucleic acid-sensing Toll-like receptors

Toshiyuki Shimizu, K. Miyake, Y. Murakami, 2018, International immunology.

Homeostatic and pathogenic roles of GM3 ganglioside molecular species in TLR4 signaling in obesity

Kenichi Sato, Toshiyuki Shimizu, A. Cattaneo, 2020, The EMBO journal.

Structural basis for species‐specific activation of mouse Toll‐like receptor 9

Toshiyuki Shimizu, K. Miyake, Takuma Shibata, 2018, FEBS letters.

Structural aspects of nucleic acid-sensing Toll-like receptors

Toshiyuki Shimizu, U. Ohto, 2016, Biophysical Reviews.

Propofol directly binds to and inhibits TLR7

R. Eckenhoff, Koichi Yuki, S. Koutsogiannaki, 2022, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Eritoran inhibits S100A8-mediated TLR4/MD-2 activation and tumor growth by changing the immune microenvironment

A. Kitao, K. Takemura, K. Miyake, 2016, Oncogene.

Structure of SARS-CoV-2 membrane protein essential for virus assembly

M. Ikeguchi, S. Iwata, Takeshi Noda, 2022, Nature Communications.

Activation and regulation mechanisms of NOD-like receptors based on structural biology

U. Ohto, 2022, Frontiers in Immunology.

Structural analysis reveals TLR7 dynamics underlying antagonism

M. Ikeguchi, H. Shigematsu, Masaki Yamamoto, 2020, Nature Communications.

Nucleosides drive histiocytosis in SLC29A3 disorders by activating TLR7

T. Ichinohe, Toshiyuki Shimizu, N. Yoshida, 2019, bioRxiv.

Expression, purification, crystallization and preliminary X-ray crystallographic analysis of human β-galactosidase.

Y. Satow, Toshiyuki Shimizu, K. Usui, 2012, Acta crystallographica. Section F, Structural biology and crystallization communications.

The attenuated inflammation of MPL is due to the lack of CD14-dependent tight dimerization of the TLR4/MD2 complex at the plasma membrane.

Toshiyuki Shimizu, K. Fukase, K. Miyake, 2014, International immunology.

Structural aspects of nucleic acid-sensing Toll-like receptors

Toshiyuki Shimizu, U. Ohto, 2016, Biophysical Reviews.

Structural Analysis Reveals that Toll-like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA.

Toshiyuki Shimizu, M. Taoka, Y. Yamauchi, 2016, Immunity.

Toll-like receptor 8 senses degradation products of single-stranded RNA

Toshiyuki Shimizu, M. Taoka, Y. Yamauchi, 2015, Nature Structural &Molecular Biology.

Determinants of Activity at Human Toll-like Receptors 7 and 8: Quantitative Structure–Activity Relationship (QSAR) of Diverse Heterocyclic Scaffolds

Xiaoqiang Guo, Toshiyuki Shimizu, Toshiyuki Shimizu, 2014, Journal of medicinal chemistry.

Funiculosin variants and phosphorylated derivatives promote innate immune responses via the Toll-like receptor 4/myeloid differentiation factor-2 complex

T. Hirokawa, Toshiyuki Shimizu, K. Takatsu, 2017, The Journal of Biological Chemistry.

Structure-Based Design of Human TLR8-Specific Agonists with Augmented Potency and Adjuvanticity

Toshiyuki Shimizu, Giuseppe Caruso, Diptesh Sil, 2015, Journal of medicinal chemistry.

Structural basis for the oligomerization-mediated regulation of NLRP3 inflammasome activation

Toshiyuki Shimizu, C. Hirama, U. Ohto, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Small-molecule inhibition of TLR8 through stabilization of its resting state

Toshiyuki Shimizu, H. Yin, Shuangshuang Jiang, 2017, Nature chemical biology.

Identification of a Human Toll-Like Receptor (TLR) 8-Specific Agonist and a Functional Pan-TLR Inhibitor in 2-Aminoimidazoles.

Toshiyuki Shimizu, Giuseppe Caruso, U. Ohto, 2016, Journal of medicinal chemistry.

Structure‐Based Design of Novel Human Toll‐like Receptor 8 Agonists

Diptesh Sil, U. Ohto, Diptesh Sil, 2014, ChemMedChem.

Volatile anesthetics isoflurane and sevoflurane directly target and attenuate Toll‐like receptor 4 system

R. Eckenhoff, Koichi Yuki, S. Koutsogiannaki, 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9

Toshiyuki Shimizu, S. Uchiyama, Elena Krayukhina, 2015, Nature.

Structure and function of toll-like receptor 8.

Toshiyuki Shimizu, U. Ohto, H. Tanji, 2014, Microbes and infection.

Serum Amyloid A3 Binds MD-2 To Activate p38 and NF-κB Pathways in a MyD88-Dependent Manner

K. Miyake, Satoshi Takahashi, S. Akashi-Takamura, 2013, The Journal of Immunology.

Structural Reorganization of the Toll-Like Receptor 8 Dimer Induced by Agonistic Ligands

Takuma Shibata, Toshiyuki Shimizu, Toshiyuki Shimizu, 2013, Science.

Human TLR4 polymorphism D299G/T399I alters TLR4/MD-2 conformation and response to a weak ligand monophosphoryl lipid A.

Toshiyuki Shimizu, K. Miyake, T. Suganami, 2013, International immunology.

MyD 88-Dependent Manner B Pathways in a κ p 38 and NF-Serum Amyloid A 3 Binds MD2 To Activate

K. Miyake, Satoshi Takahashi, S. Akashi-Takamura, 2013 .

Structural Analyses of Human Toll-like Receptor 4 Polymorphisms D299G and T399I*

Toshiyuki Shimizu, K. Miyake, S. Akashi-Takamura, 2012, The Journal of Biological Chemistry.

Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2

Koichi Fukase, Toshiyuki Shimizu, Toshiyuki Shimizu, 2012, Proceedings of the National Academy of Sciences.

Crystal structures of mouse and human RP105/MD-1 complexes reveal unique dimer organization of the toll-like receptor family.

Toshiyuki Shimizu, K. Miyake, U. Ohto, 2011, Journal of molecular biology.

Crystal structure of mouse MD-1 with endogenous phospholipid bound in its cavity.

Y. Satow, U. Ohto, Hitomi Harada, 2010, Journal of molecular biology.

Crystal Structures of Human MD-2 and Its Complex with Antiendotoxic Lipid IVa

Y. Satow, K. Fukase, K. Miyake, 2007, Science.

Structure of IZUMO1–JUNO reveals sperm–oocyte recognition during mammalian fertilization

Toshiyuki Shimizu, S. Uchiyama, Elena Krayukhina, 2016, Nature.

Structure of the bile acid transporter and HBV receptor NTCP

S. Iwata, H. Shigematsu, Takeshi Noda, 2022, Nature.

Structural Analyses of Toll-like Receptor 7 Reveal Detailed RNA Sequence Specificity and Recognition Mechanism of Agonistic Ligands.

Toshiyuki Shimizu, M. Taoka, Y. Yamauchi, 2018, Cell reports.

The crystal structure of human DEAH-box RNA helicase 15 reveals a domain organization of the mammalian DEAH/RHA family.

K. Nakano, Toshiyuki Shimizu, U. Ohto, 2017, Acta crystallographica. Section F, Structural biology communications.

Crystal structure of human TLR4 polymorphic variant D299G and T399I in complex with MD-2 and LPS

U. Ohto, T. Shimizu, 2012 .

Toll‐like Receptor 9 Contains Two DNA Binding Sites that Function Cooperatively to Promote Receptor Dimerization and Activation

Toshiyuki Shimizu, K. Miyake, Takuma Shibata, 2018, Immunity.

The crystal structure of the AhRR–ARNT heterodimer reveals the structural basis of the repression of AhR-mediated transcription

Toshiyuki Shimizu, S. Sakurai, U. Ohto, 2017, The Journal of Biological Chemistry.

Small-Molecule TLR8 Antagonists via Structure-Based Rational Design.

Toshiyuki Shimizu, H. Yin, Shuangshuang Jiang, 2018, Cell chemical biology.

The structure of NLRP9 reveals a unique C‐terminal region with putative regulatory function

K. Nakano, K. Hirata, Masaki Yamamoto, 2022, FEBS letters.

TLR3 forms a laterally aligned multimeric complex along double-stranded RNA for efficient signal transduction

M. Ikeguchi, H. Shigematsu, Toshiyuki Shimizu, 2023, Nature Communications.

Rationally designed small-molecule inhibitors targeting an unconventional pocket on the TLR8 protein-protein interface.

Toshiyuki Shimizu, H. Yin, Shuangshuang Jiang, 2020, Journal of medicinal chemistry.

Toward a structural understanding of nucleic acid‐sensing Toll‐like receptors in the innate immune system

Toshiyuki Shimizu, U. Ohto, Zhikuan Zhang, 2017, FEBS letters.

Crystal structure of NOD2 and its implications in human disease

Toshiyuki Shimizu, K. Miyake, Takuma Shibata, 2016, Nature Communications.

Targeting cell surface TLR7 for therapeutic intervention in autoimmune diseases

Toshiyuki Shimizu, Kazuhide Yamamoto, K. Miyake, 2015, Nature Communications.

Crystal structure of the FYCO1 RUN domain suggests possible interfaces with small GTPases.

Toshiyuki Shimizu, S. Sakurai, U. Ohto, 2020, Acta crystallographica. Section F, Structural biology communications.

Crystal structure of a humanized Fab fragment of anti-tissue-factor antibody in complex with tissue factor.

Y. Satow, U. Ohto, R. Mizutani, 2004, Journal of synchrotron radiation.

Structure of human Roquin-2 and its complex with constitutive-decay element RNA.

Toshiyuki Shimizu, S. Sakurai, U. Ohto, 2015, Acta crystallographica. Section F, Structural biology communications.

TLR4–MD-2 complex is negatively regulated by an endogenous ligand, globotetraosylceramide

Kazuro Furukawa, K. Ikeda, R. Taguchi, 2013, Proceedings of the National Academy of Sciences.

Impaired α-TTP-PIPs Interaction Underlies Familial Vitamin E Deficiency

Y. Satow, H. Arai, N. Kono, 2013, Science.

The Imidazoquinoline Toll-Like Receptor-7/8 Agonist Hybrid-2 Potently Induces Cytokine Production by Human Newborn and Adult Leukocytes

O. Levy, Toshiyuki Shimizu, Nikunj M. Shukla, 2015, PloS one.

Crystal structure of human beta-galactosidase: structural basis of Gm1 gangliosidosis and morquio B diseases

Y. Satow, Toshiyuki Shimizu, K. Usui, 2011 .

Structural analysis of HTL and D14 proteins reveals the basis for ligand selectivity in Striga

M. Tanokura, Toshiyuki Shimizu, T. Asami, 2018, Nature Communications.

Structure of the bile acid transporter and HBV receptor NTCP

S. Iwata, H. Shigematsu, Takeshi Noda, 2022, Nature.

The crystal structure of mouse LC3B in complex with the FYCO1 LIR reveals the importance of the flanking region of the LIR motif.

Toshiyuki Shimizu, S. Sakurai, T. Tomita, 2017, Acta crystallographica. Section F, Structural biology communications.

Tetrasubstituted imidazoles as incognito Toll-like receptor 8 a(nta)gonists

Toshiyuki Shimizu, H. Yin, Shuangshuang Jiang, 2021, Nature Communications.

Improving particle quality in cryo-EM analysis using a PEGylation method.

H. Shigematsu, Toshiyuki Shimizu, U. Ohto, 2021, Structure.

Cryo-EM structures of Toll-like receptors in complex with UNC93B1

H. Shigematsu, T. Nishizawa, Toshiyuki Shimizu, 2021, Nature Structural & Molecular Biology.

Autoinhibition and relief mechanism by the proteolytic processing of Toll-like receptor 8

Takuma Shibata, Toshiyuki Shimizu, Toshiyuki Shimizu, 2016, Proceedings of the National Academy of Sciences.

Novel multivalent S100A8 inhibitory peptides attenuate tumor progression and metastasis by inhibiting the TLR4-dependent pathway

Nobuto Arashiki, K. Nishikawa, U. Ohto, 2023, Cancer Gene Therapy.

Crystal structure of human MD-2 in complex with lipid IVa

Y. Satow, K. Fukase, K. Miyake, 2007 .

Crystal twinning of human MD-2 recognizing endotoxin cores of lipopolysaccharide

Y. Satow, U. Ohto, 2008, Journal of synchrotron radiation.

Crystal structure of TEX101, a glycoprotein essential for male fertility, reveals the presence of tandemly arranged Ly6/uPAR domains

Toshiyuki Shimizu, M. Masutani, S. Sakurai, 2020, FEBS letters.

TLR7/8 stress response drives histiocytosis in SLC29A3 disorders

Y. Furukawa, T. Ichinohe, E. Latz, 2022, bioRxiv.

Structural basis for thioredoxin-mediated suppression of NLRP1 inflammasome

Takuma Shibata, U. Ohto, J. Kitaura, 2023, Nature.

Structural analysis of HTL and D14 proteins reveals the basis for ligand selectivity in Striga

M. Tanokura, Toshiyuki Shimizu, T. Asami, 2018, Nature Communications.

The crystal structure of human DEAH-box RNA helicase 15 reveals a domain organization of the mammalian DEAH/RHA family.

K. Nakano, Toshiyuki Shimizu, U. Ohto, 2017, Acta crystallographica. Section F, Structural biology communications.

Emerging roles of the processing of nucleic acids and Toll‐like receptors in innate immune responses to nucleic acids

Toshiyuki Shimizu, K. Miyake, Takuma Shibata, 2017, Journal of leukocyte biology.

Guanosine and its modified derivatives are endogenous ligands for TLR7.

Toshiyuki Shimizu, K. Miyake, Tomoki Ito, 2016, International immunology.

Crystal Structure of Human (cid:1) -Galactosidase STRUCTURAL BASIS OF G M1 GANGLIOSIDOSIS AND MORQUIO B DISEASES * □ S

K. Usui, U. Ohto, T. Ochi, 2020 .

Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9

Toshiyuki Shimizu, S. Uchiyama, Elena Krayukhina, 2015, Nature.

Cryo-EM analysis reveals human SID1 transmembrane family member 1 dynamics underlying lipid hydrolytic activity

U. Ohto, Ryota Sato, Kensuke Miyake, 2022 .

Conservation and Divergence of Ligand Recognition and Signal Transduction Mechanisms in Toll-Like Receptors.

U. Ohto, 2017, Chemical & pharmaceutical bulletin.

Dexmedetomidine directly binds to and inhibits Toll-like receptor 4.

R. Eckenhoff, S. Koutsogiannaki, U. Ohto, 2024, International immunopharmacology.