D. Escors

发表

Priming of cytotoxic T lymphocyte responses by dendritic cells: induction of potent anti-tumor immune responses

B. Neyns, K. Thielemans, K. Breckpot, 2013 .

Hyperprogressive Disease: Main Features and Key Controversies

G. Kochan, D. Escors, H. Arasanz, 2021, International journal of molecular sciences.

Distinct Activation Mechanisms of NF-κB Regulator Inhibitor of NF-κB Kinase (IKK) by Isoforms of the Cell Death Regulator Cellular FLICE-like Inhibitory Protein (cFLIP)*

M. Collins, C. Bagnéris, T. Barrett, 2016, The Journal of Biological Chemistry.

CHL1 hypermethylation as a potential biomarker of poor prognosis in breast cancer

M. Esteller, D. Megías, D. Escors, 2017, Oncotarget.

The Membrane M Protein Carboxy Terminus Binds to Transmissible Gastroenteritis Coronavirus Core and Contributes to Core Stability

L. Enjuanes, H. Laude, D. Escors, 2001, Journal of Virology.

Coronavirus derived expression systems. Progress and problems.

J. M. González, C. Sánchez, A. Izeta, 2001, Advances in experimental medicine and biology.

Organization of Two Transmissible Gastroenteritis Coronavirus Membrane Protein Topologies within the Virion and Core

L. Enjuanes, H. Laude, E. Camafeita, 2001, Journal of Virology.

Transmissible Gastroenteritis Coronavirus Packaging Signal Is Located at the 5′ End of the Virus Genome

A. Izeta, L. Enjuanes, D. Escors, 2003, Journal of Virology.

Covariant Space-Time Line Elements in the Friedmann-Lemaitre-Robertson-Walker Geometry

G. Kochan, D. Escors, 2021, Axioms.

PD-L1 in Systemic Immunity: Unraveling Its Contribution to PD-1/PD-L1 Blockade Immunotherapy

G. Kochan, D. Escors, H. Arasanz, 2020, International journal of molecular sciences.

Interference with PD-L1/PD-1 co-stimulation during antigen presentation enhances the multifunctionality of antigen-specific T cells

C. Heirman, K. Thielemans, K. Breckpot, 2013, Gene Therapy.

CAR-T Cells for the Treatment of Lung Cancer

J. Lasarte, G. Kochan, D. Escors, 2022, Life.

Generation of multi-functional antigen-specific human T-cells by lentiviral TCR gene transfer

M. Collins, M. Perro, D. Hart, 2010, Gene Therapy.

Construction of a Severe Acute Respiratory Syndrome Coronavirus Infectious cDNA Clone and a Replicon To Study Coronavirus RNA Synthesis

S. Alonso, I. Sola, L. Enjuanes, 2006, Journal of Virology.

Immunopurification applied to the study of virus protein composition and encapsidation

L. Enjuanes, D. Escors, C. Capiscol, 2004, Journal of Virological Methods.

Nature of the Virus Associated with Endemic Balkan Nephropathy

C. Sánchez, L. Enjuanes, D. Escors, 2002, Emerging infectious diseases.

Coronavirus derived expression systems

J. M. González, C. Sánchez, A. Izeta, 2001, Journal of Biotechnology.

The membrane M protein of the transmissible gastroenteritis coronavirus binds to the internal core through the carboxy-terminus.

L. Enjuanes, D. Escors, J. Ortego, 2001, Advances in experimental medicine and biology.

Profiling of immune responses to COVID-19 and vaccination uncovers potent adjuvant capacities of SARS CoV-2 infection to vaccination leading to memory T cell responses with a Th17 signature in cancer patients

G. Kochan, D. Escors, H. Arasanz, 2022, medRxiv.

EPB41L3, TSP-1 and RASSF2 as new clinically relevant prognostic biomarkers in diffuse gliomas

D. Megías, Agustín F. Fernández, D. Escors, 2015, Oncotarget.

Potent clinical prognostic and systemic adjuvant therapeutic value of plasma fractalkine in PD-L1/PD-1 blockade immunotherapy for lung cancer

J. Lasarte, L. Montuenga, R. Pio, 2022, medRxiv.

Circulating Low Density Neutrophils Are Associated with Resistance to First Line Anti-PD1/PDL1 Immunotherapy in Non-Small Cell Lung Cancer

J. Fernández-Irigoyen, L. Mezquita, G. Kochan, 2022, medRxiv.

[Dendritic cells in cancer immunotherapy].

G. Kochan, D. Escors, I. Blanco-Luquin, 2015, Anales del sistema sanitario de Navarra.

Ex vivo generation of myeloid-derived suppressor cells that model the tumor immunosuppressive environment in colorectal cancer

M. de Ridder, K. Breckpot, D. Escors, 2015, Oncotarget.

A highly efficient tumor-infiltrating MDSC differentiation system for discovery of anti-neoplastic targets, which circumvents the need for tumor establishment in mice

K. Breckpot, J. Fernández-Irigoyen, E. Santamaría, 2014, Oncotarget.

Lentiviral Vectors for Cancer Immunotherapy and Clinical Applications

D. Escors, N. Pérez-Janices, T. Liechtenstein, 2013, Cancers.

Immune modulation by genetic modification of dendritic cells with lentiviral vectors.

C. Goyvaerts, K. Breckpot, C. Bricogne, 2013, Virus research.

Myeloid-Derived Suppressor Cells in the Tumor Microenvironment: Current Knowledge and Future Perspectives

G. Kochan, D. Escors, H. Arasanz, 2018, Archivum Immunologiae et Therapiae Experimentalis.

Cancer Immunotherapy of TLR4 Agonist-Antigen Constructs Enhanced with Pathogen-Mimicking Magnetite Nanoparticles and Checkpoint Blockade of PD-L1.

J. Blanco-Canosa, A. Molinaro, Alba Silipo, 2019, Small.

Effective cancer immunotherapy in mice by polyIC-imiquimod complexes and engineered magnetic nanoparticles.

J. Llop, A. Zabaleta, J. Mareque-Rivas, 2018, Biomaterials.

Molecular mechanisms of programmed cell death-1 dependent T cell suppression: relevance for immunotherapy.

G. Kochan, D. Escors, H. Arasanz, 2017, Annals of translational medicine.

Assessing T-cell responses in anticancer immunotherapy

C. Goyvaerts, K. Breckpot, A. Lanna, 2013, Oncoimmunology.

MODULATING CO-STIMULATION DURING ANTIGEN PRESENTATION TO ENHANCE CANCER IMMUNOTHERAPY.

K. Breckpot, A. Lanna, D. Escors, 2012, Immunology, endocrine & metabolic agents in medicinal chemistry.

Radiopotentiation of Enzalutamide Over Human Prostate Cancer Cells as Assessed by Real-Time Cell Monitoring

G. Kochan, D. Escors, F. Arias, 2018, bioRxiv.

Lentiviral Vectors in Immunotherapy

K. Breckpot, C. Bricogne, A. Lanna, 2013 .

Retroviral and Lentiviral Vectors for the Induction of Immunological Tolerance

K. Breckpot, C. Bricogne, A. Lanna, 2012, Scientifica.

PD-L1 co-stimulation contributes to ligand-induced T cell receptor down-modulation on CD8+ T cells

Clare L. Bennett, K. Karwacz, M. Collins, 2011, EMBO molecular medicine.

Characterization of Macrophage Endogenous S-Nitrosoproteome Using a Cysteine-Specific Phosphonate Adaptable Tag in Combination with TiO2 Chromatography.

M. Larsen, J. Fernández-Irigoyen, E. Santamaría, 2018, Journal of proteome research.

Understanding LAG-3 Signaling

G. Kochan, D. Escors, H. Arasanz, 2021, International journal of molecular sciences.

The multi-specific VH-based Humabody CB213 co-targets PD1 and LAG3 on T cells to promote anti-tumour activity

Isabelle H. Osuch, Phillipa Bartlett, G. Kochan, 2021, British Journal of Cancer.

Lentiviral Vectors for TCR Gene Transfer: Improved Function of TCR-Transduced T Cells After Non-Activating Cytokine-Mediated Transduction

Emma Morris, Daniel P. Hart, Hans J. Stauss, 2010 .

PD1 signal transduction pathways in T cells

K. Breckpot, G. Kochan, D. Escors, 2017, Oncotarget.

Chapter 13 Lentiviral Vectors in Immunotherapy

K. Breckpot, C. Bricogne, A. Lanna, 2018 .

Modulation of Regulatory T Cell Function by Monocyte-Derived Dendritic Cells Matured through Electroporation with mRNA Encoding CD40 Ligand, Constitutively Active TLR4, and CD70

J. Aerts, C. Heirman, K. Thielemans, 2013, The Journal of Immunology.

Immunomodulation by Genetic Modification Using Lentiviral Vectors

K. Breckpot, G. Kochan, D. Escors, 2012 .

immunization Targeting dendritic cell signaling to regulate the response to

S. Akira, J. Hiscott, R. Lin, 2008 .

Ex Vivo MDSC Differentiation Models

G. Kochan, D. Escors, 2016 .

Cutting-Edge: Preclinical and Clinical Development of the First Approved Lag-3 Inhibitor

G. Kochan, D. Escors, H. Arasanz, 2022, Cells.

How Can We Improve the Vaccination Response in Older People? Part II: Targeting Immunosenescence of Adaptive Immunity Cells

C. Caruso, F. Farzaneh, G. Kochan, 2022, International journal of molecular sciences.

DNA fusion vaccine designs to induce tumor‐lytic CD8+ T‐cell attack via the immunodominant cysteine‐containing epitope of NY‐ESO 1

M. Collins, J. Rice, F. Stevenson, 2013, International journal of cancer.

Systemic immunological biomarkers of clinical responses in immune checkpoint blockade therapies

G. Kochan, D. Escors, H. Arasanz, 2018, Lung cancer management.

HIV-1 Lentiviral Vector Immunogenicity Is Mediated by Toll-Like Receptor 3 (TLR3) and TLR7

K. Karwacz, M. Collins, K. Breckpot, 2010, Journal of Virology.

TNF-α-Secreting Lung Tumor-Infiltrated Monocytes Play a Pivotal Role During Anti-PD-L1 Immunotherapy

J. Timmermans, Y. De Vlaeminck, Q. Lecocq, 2022, Frontiers in Immunology.

Kaposi's Sarcoma-Associated Herpesvirus vFLIP and Human T Cell Lymphotropic Virus Type 1 Tax Oncogenic Proteins Activate IκB Kinase Subunit γ by Different Mechanisms Independent of the Physiological Cytokine-Induced Pathways

Y. Takeuchi, M. Noursadeghi, M. Collins, 2011, Journal of Virology.

Short-Term Local Expression of a PD-L1 Blocking Antibody from a Self-Replicating RNA Vector Induces Potent Antitumor Responses.

J. Prieto, I. Melero, M. Buñuales, 2019, Molecular therapy : the journal of the American Society of Gene Therapy.

Selective ERK Activation Differentiates Mouse and Human Tolerogenic Dendritic Cells, Expands Antigen-Specific Regulatory T Cells, and Suppresses Experimental Inflammatory Arthritis

K. Karwacz, M. Collins, K. Breckpot, 2011, Arthritis and rheumatism.

Circulating Low Density Neutrophils Are Associated with Resistance to First Line Anti-PD1/PDL1 Immunotherapy in Non-Small Cell Lung Cancer

J. Fernández-Irigoyen, L. Mezquita, G. Kochan, 2022, Cancers.

Intratumoral administration of mRNA encoding a fusokine consisting of IFN-β and the ectodomain of the TGF-β receptor II potentiates antitumor immunity

C. Heirman, K. Thielemans, K. Breckpot, 2014, Oncotarget.

Immune Profiling Uncovers Memory T-Cell Responses with a Th17 Signature in Cancer Patients with Previous SARS-CoV-2 Infection Followed by mRNA Vaccination

M. Alsina, G. Kochan, D. Escors, 2022, Cancers.

Conventional Dendritic Cells Are Required for the Activation of Helper-Dependent CD8 T Cell Responses to a Model Antigen After Cutaneous Vaccination with Lentiviral Vectors

Clare L. Bennett, Hugh D. Goold, D. Escors, 2011, The Journal of Immunology.

VectorsCutaneous Vaccination with Lentiviral T Cell Responses to a Model Antigen After for the Activation of Helper-Dependent CD8 Conventional Dendritic Cells Are Required

Clare L. Bennett, D. Escors, R. Chakraverty, 2011 .

PD-L1 co-stimulation, ligand-induced TCR down-modulation and anti-tumor immunotherapy

K. Karwacz, C. Bricogne, G. Kochan, 2012, Oncoimmunology.

On the Mechanism of T cell receptor down-modulation and its physiological significance.

K. Karwacz, C. Bricogne, G. Kochan, 2011, The journal of bioscience and medicine.

Pseudaminic Acid on Campylobacter jejuni Flagella Modulates Dendritic Cell IL-10 Expression via Siglec-10 Receptor: A Novel Flagellin-Host Interaction

B. Wren, P. Crocker, N. Dorrell, 2014, The Journal of infectious diseases.

A Proteomic Atlas of Lineage and Cancer-Polarized Expression Modules in Myeloid Cells Modeling Immunosuppressive Tumor-Infiltrating Subsets

M. Larsen, J. Fernández-Irigoyen, E. Santamaría, 2021, Journal of personalized medicine.

Clinical landscape of LAG-3-targeted therapy

G. Kochan, D. Escors, H. Arasanz, 2022, Immuno-oncology technology.

How Can We Improve Vaccination Response in Old People? Part I: Targeting Immunosenescence of Innate Immunity Cells

C. Caruso, F. Farzaneh, G. Kochan, 2022, International journal of molecular sciences.

Editorial on “ PD-1 is a haploinsufficient suppressor of T cell lymphomagenesis ”

G. Kochan, D. Escors, 2018 .

Anti-melanoma vaccines engineered to simultaneously modulate cytokine priming and silence PD-L1 characterized using ex vivo myeloid-derived suppressor cells as a readout of therapeutic efficacy

M. Ridder, C. Goyvaerts, K. Breckpot, 2014, Oncoimmunology.

Dendritic Cells Cross-Present Immunogenic Lentivector-Encoded Antigen from Transduced Cells to Prime Functional T Cell Immunity

Clare L. Bennett, D. Escors, R. Chakraverty, 2017, Molecular therapy : the journal of the American Society of Gene Therapy.

PD1 signal transduction pathways in T cells

K. Breckpot, G. Kochan, D. Escors, 2017, Oncotarget.

The transduction pattern of IL‐12‐encoding lentiviral vectors shapes the immunological outcome

C. Heirman, K. Thielemans, C. Goyvaerts, 2015, European journal of immunology.

A sestrin-dependent Erk/Jnk/p38 MAPK activation complex inhibits immunity during ageing

M. Karin, D. Gilroy, J. H. Lee, 2016, Nature Immunology.

Perforin and Granzyme B Expressed by Murine Myeloid-Derived Suppressor Cells: A Study on Their Role in Outgrowth of Cancer Cells

M. de Ridder, Y. De Vlaeminck, K. Breckpot, 2019, Cancers.

Differential role of gene hypermethylation in adenocarcinomas, squamous cell carcinomas and cervical intraepithelial lesions of the uterine cervix

R. Guarch, D. Escors, E. Martín-Sánchez, 2015, Pathology international.

Systemic CD4 immunity: A powerful clinical biomarker for PD‐L1/PD‐1 immunotherapy

G. Kochan, H. Kagamu, D. Escors, 2020, EMBO molecular medicine.

A Novel Sorting Signal for Intracellular Localization Is Present in the S Protein of a Porcine Coronavirus but Absent from Severe Acute Respiratory Syndrome-associated Coronavirus

L. Enjuanes, C. Schwegmann-Wessels, G. Herrler, 2004, Journal of Biological Chemistry.

Cutting-Edge CAR Engineering: Beyond T Cells

G. Kochan, D. Escors, H. Arasanz, 2022, Biomedicines.

Harnessing alveolar macrophages for sustained mucosal T-cell recall confers long-term protection to mice against lethal influenza challenge without clinical disease

W. Barclay, M. Collins, M. Maini, 2013, Mucosal Immunology.

Introduction to Gene Therapy

K. Breckpot, D. Escors, 2012 .

Lentiviral Vectors in Gene Therapy: Their Current Status and Future Potential

K. Breckpot, D. Escors, 2010, Archivum Immunologiae et Therapiae Experimentalis.

Lentiviral Vectors and Gene Therapy

K. Breckpot, G. Kochan, D. Escors, 2012, SpringerBriefs in Biochemistry and Molecular Biology.

Cell and Tissue Gene Targeting with Lentiviral Vectors

K. Breckpot, G. Kochan, D. Escors, 2012, Lentiviral Vectors and Gene Therapy.

Human Gene Therapy with Retrovirus and Lentivirus Vectors

K. Breckpot, G. Kochan, D. Escors, 2012 .

Clinical Grade Lentiviral Vectors

K. Breckpot, G. Kochan, D. Escors, 2012 .

Impact of T cell selection methods in the success of clinical adoptive immunotherapy

E. Bandrés, D. Escors, M. Rodríguez-Calvillo, 2013, Cellular and Molecular Life Sciences.

Targeted Lentiviral Vectors: Current Applications and Future Potential

C. Goyvaerts, K. Breckpot, C. Bricogne, 2013 .

PD-L1/PD-1 Co-Stimulation, a Brake for T cell Activation and a T cell Differentiation Signal.

K. Breckpot, C. Bricogne, A. Lanna, 2012, Journal of clinical & cellular immunology.

Metabolic dyshomeostasis induced by SARS-CoV-2 structural proteins reveals immunological insights into viral olfactory interactions

J. Fernández-Irigoyen, E. Santamaría, G. Kochan, 2022, bioRxiv.

Tumour immunogenicity, antigen presentation and immunological barriers in cancer immunotherapy.

David Escors, D. Escors, 2014, New journal of science.

PDL1 Signals through Conserved Sequence Motifs to Overcome Interferon-Mediated Cytotoxicity.

C. Wellbrock, I. Arozarena, K. Breckpot, 2017, Cell reports.

Molecular Recalibration of PD-1+ Antigen-Specific T Cells from Blood and Liver

A. Bertoletti, B. Davidson, M. Maini, 2018, Molecular therapy : the journal of the American Society of Gene Therapy.

Phosphorylation and subcellular localization of transmissible gastroenteritis virus nucleocapsid protein in infected cells.

J. M. González, E. Calvo, L. Enjuanes, 2005, The Journal of general virology.

Novel function for the p38-MK2 signaling pathway in circulating CD1c+ (BDCA-1+) myeloid dendritic cells from healthy donors and advanced cancer patients; inhibition of p38 enhances IL-12 whilst suppressing IL-10

M. Collins, P. Patel, A. Jackson, 2013, International journal of cancer.

HUMAN PANCREATIC CANCER CELLS UNDERGO PROFOUND METABOLIC REPROGRAMMING TOWARDS CELLULAR STEMNESS AS ADAPTATION TO INHIBITION OF THE AKT PATHWAY

J. Fernández-Irigoyen, E. Santamaría, G. Kochan, 2020, bioRxiv.

Dendritic Cells and Lentiviral Vectors: Mapping the Way to Successful Immunotherapy

C. Goyvaerts, K. Breckpot, G. Kochan, 2012 .

Selective activation of intracellular signalling pathways in dendritic cells for cancer immunotherapy.

K. Breckpot, G. Kochan, D. Escors, 2012, Anti-cancer agents in medicinal chemistry.

Targeting lentiviral vectors for cancer immunotherapy.

M. Collins, K. Breckpot, D. Escors, 2011, Current cancer therapy reviews.

Dendritic Cells and Lentiviral Vectors: Mapping the Way to Successful Immuno Gene Therapy

C. Goyvaerts, K. Breckpot, G. Kochan, 2011 .

Dendritic cells for active anti-cancer immunotherapy: targeting activation pathways through genetic modification.

K. Breckpot, D. Escors, 2009, Endocrine, metabolic & immune disorders drug targets.

Novel immunotherapies for the treatment of melanoma.

G. Kochan, D. Escors, H. Arasanz, 2016, Immunotherapy.

Systemic CD4 Immunity and PD-L1/PD-1 Blockade Immunotherapy

G. Kochan, D. Escors, H. Arasanz, 2022, International journal of molecular sciences.

Systemic CD4 Immunity as a Key Contributor to PD-L1/PD-1 Blockade Immunotherapy Efficacy

G. Kochan, D. Escors, H. Arasanz, 2020, Frontiers in Immunology.

Functional systemic CD4 immunity is required for clinical responses to PD‐L1/PD‐1 blockade therapy

G. Kochan, D. Escors, H. Arasanz, 2019, EMBO molecular medicine.

Functional systemic CD4 immunity is a differential factor for clinical responses to PD-L1/PD-1 blockade therapy in lung cancer

G. Kochan, D. Escors, H. Arasanz, 2018, bioRxiv.

Resistance to PD-L1/PD-1 Blockade Immunotherapy. A Tumor-Intrinsic or Tumor-Extrinsic Phenomenon?

G. Kochan, D. Escors, H. Arasanz, 2020, Frontiers in Pharmacology.

Early Detection of Hyperprogressive Disease in Non-Small Cell Lung Cancer by Monitoring of Systemic T Cell Dynamics

G. Kochan, D. Escors, H. Arasanz, 2020, Cancers.

Systemic Blood Immune Cell Populations as Biomarkers for the Outcome of Immune Checkpoint Inhibitor Therapies

G. Kochan, D. Escors, H. Arasanz, 2020, International journal of molecular sciences.

The intracellular signalosome of PD-L1 in cancer cells

G. Kochan, D. Escors, H. Arasanz, 2018, Signal Transduction and Targeted Therapy.

Gene promoter hypermethylation is found in sentinel lymph nodes of breast cancer patients, in samples identified as positive by one-step nucleic acid amplification of cytokeratin 19 mRNA

D. Escors, A. Córdoba, E. Martín-Sánchez, 2016, Virchows Archiv.

Generation of a Replication-Competent, Propagation-Deficient Virus Vector Based on the Transmissible Gastroenteritis Coronavirus Genome

Javier Ortego, David Escors, L. Enjuanes, 2002, Journal of Virology.

Differential involvement of RASSF2 hypermethylation in breast cancer subtypes and their prognosis

M. Berdasco, G. Kochan, D. Escors, 2015, Oncotarget.

Development of Retroviral and Lentiviral Vectors

K. Breckpot, G. Kochan, D. Escors, 2012 .

Growth factors improve gene expression after lentiviral transduction in human adult and fetal hepatocytes

M. Collins, C. Selden, D. Escors, 2007, The journal of gene medicine.

AMPK-TAB1 activated p38 drives human T cell senescence

A. Lanna, S. Henson, A. Akbar, 2014, Nature immunology.

The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells

A. Lanna, S. Henson, A. Akbar, 2014, Nature Immunology.

Role of non-classical MHC class I molecules in cancer immunosuppression

Grazyna Kochan, David Escors, Karine Breckpot, 2013, Oncoimmunology.

Construction of stable packaging cell lines for clinical lentiviral vector production

J. Minshull, Y. Takeuchi, A. Thrasher, 2015, Scientific Reports.

Non-invasive assessment of murine PD-L1 levels in syngeneic tumor models by nuclear imaging with nanobody tracers

Marleen Keyaerts, Nick Devoogdt, David Escors, 2017, Oncotarget.

Signal transducer and activator of transcription 3 in myeloid-derived suppressor cells: an opportunity for cancer therapy

M. de Ridder, K. Breckpot, D. Escors, 2016, Oncotarget.

Myeloid-Derived Suppressor Cells and Cancer

J. Talmadge, K. Breckpot, G. Kochan, 2016, SpringerBriefs in Immunology.

Immunotherapy in malignant melanoma: recent approaches and new perspectives.

G. Kochan, D. Escors, H. Arasanz, 2017, Melanoma management.

PD-L1 Expression in Systemic Immune Cell Populations as a Potential Predictive Biomarker of Responses to PD-L1/PD-1 Blockade Therapy in Lung Cancer

G. Kochan, D. Escors, H. Arasanz, 2019, International journal of molecular sciences.

Leading Edge: Intratumor Delivery of Monoclonal Antibodies for the Treatment of Solid Tumors

G. Kochan, D. Escors, H. Arasanz, 2023, International journal of molecular sciences.

Coronavirus Reverse Genetics and Development of Vectors for Gene Expression

S. Alonso, I. Sola, L. Enjuanes, 2005, Current topics in microbiology and immunology.

Targeting dendritic cell signaling to regulate the response to immunization.

S. Akira, J. Hiscott, M. Collins, 2008, Blood.

Predictive Biomarkers for Checkpoint Inhibitor Immune-Related Adverse Events

G. Kochan, V. Arrazubi, D. Escors, 2023, Cancers.

Manipulating Immune Regulatory Pathways to Enhance T Cell Stimulation

J. Aerts, K. Breckpot, J. Pen, 2014 .

Chapter 2 Differentiation of Murine Myeloid-Derived Suppressor Cells

D. Escors, 2018 .

Drafting the proteome landscape of myeloid‐derived suppressor cells

J. Fernández-Irigoyen, E. Santamaría, G. Kochan, 2016, Proteomics.

Differentiation of Murine Myeloid-Derived Suppressor Cells

D. Escors, 2016 .

Profound Reprogramming towards Stemness in Pancreatic Cancer Cells as Adaptation to AKT Inhibition

J. Fernández-Irigoyen, E. Santamaría, G. Kochan, 2020, Cancers.

PD-1/LAG-3 DYSFUNCTIONALITY SIGNATURES IN HUMAN CANCERS

C. Johnston, J. Fernández-Irigoyen, G. Kochan, 2023, medRxiv.

Interference with virus and bacteria replication by the tissue specific expression of antibodies and interfering molecules.

J. M. González, C. Sánchez, A. Izeta, 1999, Advances in experimental medicine and biology.

mRNA Vaccines against SARS-CoV-2: Advantages and Caveats

G. Kochan, D. Escors, A. Bocanegra, 2023, International journal of molecular sciences.

A core of kinase-regulated interactomes defines the neoplastic MDSC lineage

S. Knapp, A. Chaikuad, J. Fernández-Irigoyen, 2015, Oncotarget.

Functional systemic CD4 immunity is required for clinical responses to PD-L1/PD-1 blockade therapy

G. Kochan, D. Escors, H. Arasanz, 2019, Annals of Oncology.

Complement C5a induces the formation of neutrophil extracellular traps by myeloid-derived suppressor cells to promote metastasis.

John D Lambris, C. Ortiz de Solórzano, S. Vicent, 2021, Cancer letters.

Lentiviral expression of GAD67 and CCK promoter‐driven opsins to target interneurons in vitro and in vivo

D. Kullmann, S. Schorge, M. Collins, 2016, The journal of gene medicine.

Highly differentiated CD4 T cells Unequivocally Identify Primary Resistance and Risk of Hyperprogression to PD-L1/PD-1 Immune Checkpoint Blockade in Lung Cancer

G. Kochan, D. Escors, H. Arasanz, 2018, bioRxiv.

Functional systemic CD4 immunity is required for clinical responses to PD‐L1/PD‐1 blockade therapy

G. Kochan, D. Escors, H. Arasanz, 2019, EMBO molecular medicine.

Nonintegrating Lentivector Vaccines Stimulate Prolonged T-Cell and Antibody Responses and Are Effective in Tumor Therapy

K. Karwacz, A. Thrasher, M. Collins, 2009, Journal of Virology.

Current Indications and Future Landscape of Bispecific Antibodies for the Treatment of Lung Cancer

G. Kochan, D. Escors, H. Arasanz, 2023, International journal of molecular sciences.

Impact of T cell selection methods in the success of clinical adoptive immunotherapy

E. Bandrés, D. Escors, M. Rodríguez-Calvillo, 2014, Cellular and Molecular Life Sciences.

Membrane cell fusion activity of the vaccinia virus A17–A27 protein complex

M. Esteban, J. Casasnovas, G. Kochan, 2007, Cellular microbiology.

Antigen-presenting cell-targeted lentiviral vectors do not support the development of productive T-cell effector responses: implications for in vivo targeted vaccine delivery

C. Goyvaerts, K. Breckpot, M. Keyaerts, 2017, Gene Therapy.

Plasma fractalkine contributes to systemic myeloid diversity and PD‐L1/PD‐1 blockade in lung cancer

J. Lasarte, L. Montuenga, R. Pio, 2023, EMBO reports.

Metabolic rewiring induced by ranolazine improves melanoma responses to targeted therapy and immunotherapy

Camille Stephan-Otto Attolini, H. Heyn, C. Wellbrock, 2023, Nature Metabolism.

Abstract 930: CB213: A half-life extended bispecific Humabody VHdelivering dual checkpoint blockade to reverse the dysfunction of LAG3+PD-1+double-positive T cells

G. Kochan, D. Escors, H. Arasanz, 2020 .

Role of the next-generation immune checkpoint LAG-3 in response and resistance to cancer immunotherapy

G. Kochan, D. Escors, H. Arasanz, 2022, Proceedings of MOL2NET'22, Conference on Molecular, Biomedical & Computational Sciences and Engineering, 8th ed. - MOL2NET: FROM MOLECULES TO NETWORKS.

LAG-3 Role in Neurological Diseases

G. Kochan, D. Escors, H. Arasanz, 2022, Proceedings of MOL2NET'22, Conference on Molecular, Biomedical & Computational Sciences and Engineering, 8th ed. - MOL2NET: FROM MOLECULES TO NETWORKS.

LAG-3 Role in Cardiovascular Diseases

G. Kochan, D. Escors, H. Arasanz, 2022, Proceedings of MOL2NET'22, Conference on Molecular, Biomedical & Computational Sciences and Engineering, 8th ed. - MOL2NET: FROM MOLECULES TO NETWORKS.

LAG-3 Role in Infection

G. Kochan, D. Escors, H. Arasanz, 2021, The 1st International Electronic Conference on Molecular Sciences: Druggable Targets of Emerging Infectious Diseases.

55P Clinical landscape of LAG-3-targeted therapy

G. Kochan, D. Escors, H. Arasanz, 2021, Annals of Oncology.

Modulation of Regulatory T Cell Function by Monocyte-Derived Dendritic Cells Matured through Electroporation with mRNA Encoding CD40 Ligand, Constitutively Active TLR4, and CD70

J. Aerts, C. Heirman, K. Thielemans, 2013, Journal of Immunology.

Cancer Immunotherapy of TLR 4 Agonist – Antigen Constructs Enhanced with Pathogen-Mimicking Magnetite Nanoparticles and Checkpoint Blockade of PD-L 1

A. Molinaro, D. Escors, Kepa Zamacola Bascarán, 2019 .

A sestrin-dependent Erk/Jnk/p38 MAPK activation complex inhibits immunity during ageing

M. Karin, D. Gilroy, J. H. Lee, 2016, Nature Immunology.

Constraints on General Relativity Geodesics by a Covariant Geometric Uncertainty Principle

G. Kochan, D. Escors, 2021, Physics.

Nonintegrating Lentivector Vaccines Stimulate Prolonged T-Cell and Antibody Responses and Are Effective in Tumor Therapy

K. Karwacz, A. Thrasher, M. Collins, 2009, Journal of Virology.

Immunopurification applied to the study of virus protein composition and encapsidation

L. Enjuanes, D. Escors, C. Capiscol, 2004, Journal of Virological Methods.

Oleuropein-driven reprogramming of the myeloid cell compartment to sensitise tumours to PD-1/PD-L1 blockade strategies

N. Razquin, J. Fernández-Irigoyen, G. Kochan, 2024, British journal of cancer.

Evaluation of the disinfecting capacity of ozone in emergency vehicles.

G. Kochan, J. Biurrun, D. Escors, 2020, medRxiv.

Circulating low density neutrophils are associated with resistance to anti‐PD1 immunotherapy in squamous head and neck cancer

G. Kochan, D. Escors, H. Arasanz, 2023, Head & neck.

Fractalkine in Health and Disease

G. Kochan, D. Escors, L. Chocarro, 2024, International journal of molecular sciences.