A. Bonehill

发表

Priming of cytotoxic T lymphocyte responses by dendritic cells: induction of potent anti-tumor immune responses

B. Neyns, K. Thielemans, K. Breckpot, 2013 .

Messenger RNA-Electroporated Dendritic Cells Presenting MAGE-A3 Simultaneously in HLA Class I and Class II Molecules1

F. Brasseur, C. Heirman, K. Thielemans, 2004, The Journal of Immunology.

Preclinical evaluation of TriMix and antigen mRNA-based antitumor therapy.

C. Heirman, K. Thielemans, C. Goyvaerts, 2012, Cancer research.

Immunotherapy of cancer with dendritic cells loaded with tumor antigens and activated through mRNA electroporation.

B. Neyns, C. Heirman, K. Thielemans, 2010, Methods in molecular biology.

Single-step antigen loading and maturation of dendritic cells through mRNA electroporation of a tumor-associated antigen and a TriMix of costimulatory molecules.

S. Wilgenhof, D. Benteyn, A. Bonehill, 2014, Methods in molecular biology.

Activation of monocytes via the CD14 receptor leads to the enhanced lentiviral transduction of immature dendritic cells.

C. Heirman, K. Thielemans, K. Breckpot, 2004, Human gene therapy.

Lentivirally transduced dendritic cells as a tool for cancer immunotherapy

M. Dullaers, C. Heirman, K. Thielemans, 2003, The journal of gene medicine.

Inefficient exogenous loading of a tapasin‐dependent peptide onto HLA‐B*44:02 can be improved by acid treatment or fixation of target cells

P. Cresswell, A. Bonehill, P. van der Bruggen, 2012, European journal of immunology.

Enhancing the T-cell stimulatory capacity of human dendritic cells by co-electroporation with CD40L, CD70 and constitutively active TLR4 encoding mRNA.

B. Neyns, C. Heirman, K. Thielemans, 2008, Molecular therapy : the journal of the American Society of Gene Therapy.

Optimized dendritic cell-based immunotherapy for melanoma: the TriMix-formula

B. Neyns, C. Heirman, K. Thielemans, 2014, Cancer Immunology, Immunotherapy.

Genetic approaches for the induction of a CD4+ T cell response in cancer immunotherapy

C. Heirman, K. Thielemans, A. Bonehill, 2005, The journal of gene medicine.

Dendritic cells differentiated in the presence of IFN‐β and IL‐3 are potent inducers of an antigen‐specific CD8+ T cell response

C. Heirman, K. Thielemans, K. Breckpot, 2005, Journal of leukocyte biology.

Expression of human GITRL on myeloid dendritic cells enhances their immunostimulatory function but does not abrogate the suppressive effect of CD4+CD25+ regulatory T cells

J. Aerts, H. Waldmann, C. Heirman, 2007, Journal of leukocyte biology.

Modulation of Regulatory T Cell Function by Monocyte-Derived Dendritic Cells Matured through Electroporation with mRNA Encoding CD40 Ligand, Constitutively Active TLR4, and CD70

J. Aerts, C. Heirman, K. Thielemans, 2013, The Journal of Immunology.

A phase IB study on intravenous synthetic mRNA electroporated dendritic cell immunotherapy in pretreated advancedmelanoma patients

B. Neyns, C. Heirman, K. Thielemans, 2013 .

Hemorrhagic regression of melanoma metastases during therapeutic vaccination: a report of three cases.

B. Neyns, C. Heirman, K. Thielemans, 2009, Melanoma research.

Induction of effective therapeutic antitumor immunity by direct in vivo administration of lentiviral vectors

J. Aerts, M. Dullaers, C. Heirman, 2006, Gene Therapy.

Electroporation of immature and mature dendritic cells: implications for dendritic cell-based vaccines

F. Brasseur, P. Bruggen, M. Dullaers, 2005, Gene Therapy.

Induction of Influenza Matrix Protein 1 and MelanA-specific T lymphocytes in vitro using mRNA-electroporated dendritic cells

C. Heirman, K. Thielemans, A. Bonehill, 2003, Cancer Gene Therapy.

Design of an Optimized Wilms' Tumor 1 (WT1) mRNA Construct for Enhanced WT1 Expression and Improved Immunogenicity In Vitro and In Vivo

C. Heirman, K. Thielemans, K. Breckpot, 2013, Molecular therapy. Nucleic acids.

A phase I clinical trial on the combined intravenous (IV) and intradermal (ID) administration of autologous TriMix-DC cellular therapy in patients with pretreated melanoma (TriMixIDIV).

B. Neyns, C. Heirman, K. Thielemans, 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Loading of dendritic cells for immunotherapy

B. Neyns, C. Heirman, K. Thielemans, 2013 .

CD83 expression on dendritic cells and T cells: Correlation with effective immune responses

J. Aerts, C. Heirman, K. Thielemans, 2007, European journal of immunology.

Efficient presentation of known HLA class II-restricted MAGE-A3 epitopes by dendritic cells electroporated with messenger RNA encoding an invariant chain with genetic exchange of class II-associated invariant chain peptide.

C. Heirman, K. Thielemans, A. Bonehill, 2003, Cancer research.

Enhancement of the antigen-specific cytotoxic T lymphocyte-inducing ability in the PMDC11 leukemic plasmacytoid dendritic cell line via lentiviral vector-mediated transduction of the caTLR4 gene

N. Kasahara, A. Bonehill, J. Takizawa, 2015, Molecular medicine reports.

Overcoming HLA restriction in clinical trials

K. Thielemans, S. Wilgenhof, A. Bonehill, 2012, Oncoimmunology.

Engineering dendritic cells to enhance cancer immunotherapy.

J. Boudreau, K. Thielemans, A. Bonehill, 2011, Molecular therapy : the journal of the American Society of Gene Therapy.

A phase IB study on intravenous synthetic mRNA electroporated dendritic cell immunotherapy in pretreated advanced melanoma patients.

B. Neyns, C. Heirman, K. Thielemans, 2013, Annals of oncology : official journal of the European Society for Medical Oncology.

Intravenous and intradermal TriMix-dendritic cell therapy results in a broad T-cell response and durable tumor response in a chemorefractory stage IV-M1c melanoma patient

B. Neyns, C. Heirman, K. Thielemans, 2012, Cancer Immunology, Immunotherapy.

Restoration of tumor equilibrium after immunotherapy for advanced melanoma: three illustrative cases.

B. Neyns, C. Heirman, K. Thielemans, 2011, Melanoma research.

Long-term clinical outcome of melanoma patients treated with messenger RNA-electroporated dendritic cell therapy following complete resection of metastases

B. Neyns, C. Heirman, K. Thielemans, 2015, Cancer Immunology, Immunotherapy.

Human GITRL expression on myeloid dendritic cells enhances their immuno-stimulatory function but does not abrogate the suppressive effect by regulatory T cells

J. Aerts, C. Heirman, K. Thielemans, 2006 .

Current approaches in dendritic cell generation and future implications for cancer immunotherapy

B. Neyns, J. Aerts, C. Heirman, 2007, Cancer Immunology, Immunotherapy.

Induction of antigen-specific CD8+ cytotoxic T cells by dendritic cells co-electroporated with a dsRNA analogue and tumor antigen mRNA

J. Aerts, C. Heirman, K. Thielemans, 2006, Gene Therapy.

Side-by-side comparison of lentivirally transduced and mRNA-electroporated dendritic cells: implications for cancer immunotherapy protocols.

M. Dullaers, C. Heirman, K. Thielemans, 2004, Molecular therapy : the journal of the American Society of Gene Therapy.

mRNA-based dendritic cell vaccines

C. Heirman, K. Thielemans, K. Breckpot, 2015, Expert review of vaccines.

Single-Step Antigen Loading and Activation of Dendritic Cells by mRNA Electroporation for the Purpose of Therapeutic Vaccination in Melanoma Patients

B. Neyns, C. Heirman, K. Thielemans, 2009, Clinical Cancer Research.

Therapeutic Vaccination With an Autologous mRNA Electroporated Dendritic Cell Vaccine in Patients With Advanced Melanoma

B. Neyns, C. Heirman, K. Thielemans, 2011, Journal of immunotherapy.

in HLA Class I and Class II Molecules Cells Presenting MAGE-A3 Simultaneously Messenger RNA-Electroporated Dendritic

Kris Thielemans, Sandra Tuyaerts, Pierre van der Bruggen, 2013 .

Delivery of tumor-antigen-encoding mRNA into dendritic cells for vaccination.

C. Heirman, K. Thielemans, A. Bonehill, 2008, Methods in molecular biology.

Dendritic cells loaded with mRNA encoding full-length tumor antigens prime CD4+ and CD8+ T cells in melanoma patients.

B. Neyns, P. Coulie, C. Heirman, 2012, Molecular therapy : the journal of the American Society of Gene Therapy.

Characterization of CD8+ T-Cell Responses in the Peripheral Blood and Skin Injection Sites of Melanoma Patients Treated with mRNA Electroporated Autologous Dendritic Cells (TriMixDC-MEL)

Kris Thielemans, Bart Neyns, Aude Bonehill, 2013, BioMed research international.

Epitope and HLA-type independent monitoring of antigen-specific T-cells after treatment with dendritic cells presenting full-length tumor antigens.

B. Neyns, C. Heirman, K. Thielemans, 2012, Journal of immunological methods.

Engineering WT1-Encoding mRNA to Increase Translational Efficiency in Dendritic Cells.

C. Heirman, K. Thielemans, D. Benteyn, 2016, Methods in molecular biology.

Lumenal part of the DC-LAMP protein is not required for induction of antigen-specific T cell responses by means of antigen-DC-LAMP messenger RNA-electroporated dendritic cells.

J. Aerts, C. Heirman, K. Thielemans, 2010, Human gene therapy.

Functional T-cell responses generated by dendritic cells expressing the early HIV-1 proteins Tat, Rev and Nef.

A. Osterhaus, J. Aerts, P. Lacor, 2008, Vaccine.