T. Angata

A. Minami, N. Iwasaki, S. Hatakeyama, 2013, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Molecular Basis and Role of Siglec-7 Ligand Expression on Chronic Lymphocytic Leukemia B Cells

Yu‐Ju Chen, K. Khoo, S. Liang, 2022, Frontiers in Immunology.

The SIGLEC14 null allele is associated with Mycobacterium tuberculosis- and BCG-induced clinical and immunologic outcomes.

Richard D. Wells, H. Mefford, A. Varki, 2017, Tuberculosis.

Sugar nucleotide regeneration system for the synthesis of Bi- and triantennary N-glycans and exploring their activities against siglecs.

Chun‐Cheng Lin, T. Angata, Avijit K. Adak, 2022, European journal of medicinal chemistry.

Influence of SIGLEC 9 polymorphisms on COPD phenotypes including exacerbation 1 frequency 2 3

P. Paré, E. Silverman, A. Gemma, 2016 .

Chemical diversity in the sialic acids and related alpha-keto acids: an evolutionary perspective.

A. Varki, T. Angata, 2002, Chemical reviews.

Discovery, classification, evolution and diversity of Siglecs.

A. Varki, T. Angata, 2022, Molecular aspects of medicine.

Biosynthesis of KDN (2-Keto-3-deoxy-d-glycero-d-galacto-nononic acid)

K. Kitajima, T. Angata, D. Nakata, 1999, The Journal of Biological Chemistry.

Ligand‐assisted imprinting‐probe‐labeling strategy reveals Siglec‐7 ‐ glycoprotein interactions

Chun‐Cheng Lin, T. Angata, Avijit K. Adak, 2022, Journal of the Chinese Chemical Society.

Boronate affinity-based photoactivatable magnetic nanoparticles for the oriented and irreversible conjugation of Fc-fused lectins and antibodies

Chun‐Cheng Lin, K. Hwang, T. Angata, 2019, Chemical science.

Evolution of siglec-11 and siglec-16 genes in hominins.

J. Mullikin, E. Green, T. Hayakawa, 2012, Molecular biology and evolution.

Roles of Siglecs in neurodegenerative diseases.

K. Khoo, Y. Chern, T. Angata, 2022, Molecular aspects of medicine.

Siglec-15 is a potential therapeutic target for postmenopausal osteoporosis.

N. Iwasaki, S. Hatakeyama, M. Kinjo, 2015, Bone.

HLA-B27-mediated activation of TNAP phosphatase promotes pathogenic syndesmophyte formation in ankylosing spondylitis.

S. Hung, I. Tzeng, W. Tsai, 2019, Journal of Clinical Investigation.

Siglec-5 and Siglec-14 are polymorphic paired receptors that modulate neutrophil and amnion signaling responses to group B Streptococcus

V. Nizet, A. Varki, A. Carlin, 2014, The Journal of experimental medicine.

Synthesis of neoglycoconjugates containing deaminated neuraminic acid (KDN) using rat liver alpha2,6-sialyltransferase.

K. Kitajima, T. Matsuda, T. Angata, 1998, Glycobiology.

Deletion polymorphism of SIGLEC14 and its functional implications.

Y. Kato, H. Narimatsu, T. Angata, 2009, Glycobiology.

O-GlcNAcylation is required for B cell homeostasis and antibody responses

P. Hsu, T. Angata, Kuo-I Lin, 2017, Nature Communications.

Preparation of Recombinant Siglecs and Identification of Their Ligands.

T. Angata, D. Sridharan, Lan-Yi Chang, 2020, Methods in molecular biology.

Siglec Siglecs Interactions with Pathogens Pathogens

A. Varki, T. Angata, 2015 .

Bacterial Molecular Mimicry That Targets the Sialic Acid-SAMP Recognition System

A. Varki, T. Angata, 2014 .

Chemical Diversity in the Sialic Acids and Related α-Keto Acids: An Evolutionary Perspective

A. Varki, T. Angata, 2002 .

Chemical Diversity in the Sialic Acids and Related α‐Keto Acids: An Evolutionary Perspective

A. Varki, T. Angata, 2010 .

Identification, characterization, and developmental expression of a novel α2 → 8-KDN-transferase which terminates elongation of α2 → 8-linked oligo-polysialic acid chain synthesis in trout egg polysialoglycoproteins

T. Terada, S. Kitazume, K. Kitajima, 1994, Glycoconjugate Journal.

Multilectin assay for detecting fibrosis-specific glyco-alteration by means of lectin microarray.

A. Kuno, J. Hirabayashi, M. Mizokami, 2011, Clinical chemistry.

CD33/Siglec-3 Binding Specificity, Expression Pattern, and Consequences of Gene Deletion in Mice

A. Varki, S. Hedrick, E. B. D. Brinkman-van der Linden, 2003, Molecular and Cellular Biology.

Glycoproteomic discovery of serological biomarker candidates for HCV/HBV infection-associated liver fibrosis and hepatocellular carcinoma.

A. Kuno, J. Hirabayashi, M. Mizokami, 2013, Journal of proteome research.

Immunomodulatory activity of extracellular Hsp70 mediated via paired receptors Siglec‐5 and Siglec‐14

V. Nizet, A. Varki, Qinglian Liu, 2015, The EMBO journal.

Glycoconjugate microarray based on an evanescent-field fluorescence-assisted detection principle for investigation of glycan-binding proteins.

J. Hirabayashi, H. Narimatsu, T. Angata, 2008, Glycobiology.

Detection of anti–Siglec‐14 alloantibodies in blood components implicated in nonhaemolytic transfusion reactions

F. Hirayama, Takafumi Kimura, H. Narimatsu, 2011, British journal of haematology.

Siglecs--the major subfamily of I-type lectins.

A. Varki, T. Angata, 2006, Glycobiology.

Loss of Siglec-14 reduces the risk of chronic obstructive pulmonary disease exacerbation

V. Nizet, A. Gemma, K. Ohtsubo, 2013, Cellular and Molecular Life Sciences.

Discovery of Siglec‐14, a novel sialic acid receptor undergoing concerted evolution with Siglec‐5 in primates

T. Hayakawa, A. Varki, Mitsuru Nakamura, 2006, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Coevolution of Siglec-11 and Siglec-16 via gene conversion in primates

T. Hayakawa, A. Varki, S. Liang, 2017, BMC Evolutionary Biology.

A Guillain-Barré syndrome-associated SIGLEC10 rare variant impairs its recognition of gangliosides.

H. Takematsu, N. Ito, T. Tsubata, 2020, Journal of autoimmunity.

Glycans in Infection and Immunity

K. Takegawa, H. Kiyono, T. Kinoshita, 2019, Glycoscience: Basic Science to Applications.

Streamlined single-cell proteomics by an integrated microfluidic chip and data-independent acquisition mass spectrometry

Reta Birhanu Kitata, Asad Ali Siyal, Hsiung-Lin Tu, 2022, Nature communications.

SIGLEC12, a Human-specific Segregating (Pseudo)gene, Encodes a Signaling Molecule Expressed in Prostate Carcinomas*

T. K. Altheide, A. Varki, J. Beuten, 2011, The Journal of Biological Chemistry.

Cloning and Characterization of Human Siglec-11

A. Varki, D. Greaves, P. Crocker, 2002, The Journal of Biological Chemistry.

Cloning and Characterization of a Novel Mouse Siglec, mSiglec-F DIFFERENTIAL EVOLUTION OF THE MOUSE AND HUMAN (CD33) Siglec-3-RELATED GENE CLUSTERS* □ S

A. Varki, T. Angata, N. Varki, 2001 .

I-type lectins.

E. B. D. Brinkman-van der Linden, T. Angata, 2002, Biochimica et biophysica acta.

Soluble Siglec-14 glycan-recognition protein is generated by alternative splicing and suppresses myeloid inflammatory responses

S. Hsu, T. Angata, Po-Chun Huang, 2018, The Journal of Biological Chemistry.

Integrated approach toward the discovery of glyco‐biomarkers of inflammation‐related diseases

K. Ohtsubo, N. Taniguchi, S. Kitazume, 2012, Annals of the New York Academy of Sciences.

Molecular diversity and evolution of the Siglec family of cell-surface lectins

T. Angata, 2006, Molecular Diversity.

A Human-Specific Gene in Microglia

T. Mikkelsen, T. Hayakawa, A. Varki, 2005, Science.

Large-scale sequencing of the CD33-related Siglec gene cluster in five mammalian species reveals rapid evolution by multiple mechanisms.

Ajit Varki, Eric D Green, Takashi Angata, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Siglecs that Associate with DAP12.

T. Angata, 2020, Advances in experimental medicine and biology.

Siglec-15: an immune system Siglec conserved throughout vertebrate evolution.

Mitsuru Nakamura, Kazunori Nakamura, T. Angata, 2007, Glycobiology.

Loss of Siglec-14 reduces the risk of chronic obstructive pulmonary disease exacerbation

V. Nizet, A. Gemma, A. Varki, 2013, Cellular and Molecular Life Sciences.

Siglec-15: a potential regulator of osteoporosis, cancer, and infectious diseases

T. Angata, 2020, Journal of Biomedical Science.

Association of serum interleukin‐27 with the exacerbation of chronic obstructive pulmonary disease

A. Gemma, K. Ohtsubo, N. Taniguchi, 2014, Physiological reports.

Identification and functional characterization of a Siglec-7 counter-receptor on K562 cells

C. Sato, K. Kitajima, T. Angata, 2021, The Journal of biological chemistry.

Identification and functional characterization of a Siglec-7 counter-receptor on K562cells

C. Sato, K. Kitajima, T. Angata, 2021 .

Hypoxic regulation of glycosylation via the N-acetylglucosamine cycle

K. Ohtsubo, N. Taniguchi, K. Shirato, 2010, Journal of clinical biochemistry and nutrition.

Cloning, Characterization, and Phylogenetic Analysis of Siglec-9, a New Member of the CD33-related Group of Siglecs

A. Varki, T. Angata, 2000, The Journal of Biological Chemistry.

Siglec-7: a sialic acid-binding lectin of the immunoglobulin superfamily.

A. Varki, T. Angata, A. Varki, 2000, Glycobiology.

A single dose of lipopolysaccharide into mice with emphysema mimics human chronic obstructive pulmonary disease exacerbation as assessed by micro-computed tomography.

Naoyuki Taniguchi, Tomoko Betsuyaku, Manabu Ueno, 2013, American journal of respiratory cell and molecular biology.

Mass Isotopomer Analysis of Metabolically Labeled Nucleotide Sugars and N- and O-Glycans for Tracing Nucleotide Sugar Metabolisms*

K. Ohtsubo, N. Taniguchi, S. Kitazume, 2013, Molecular & Cellular Proteomics.

Therapeutic Targeting of Siglecs using Antibody- and Glycan-Based Approaches.

Corwin M. Nycholat, Matthew S Macauley, T. Angata, 2015, Trends in pharmacological sciences.

A Second Uniquely Human Mutation Affecting Sialic Acid Biology* 210

T. Angata, N. Varki, A. Varki, 2001, The Journal of Biological Chemistry.

Possible Influences of Endogenous and Exogenous Ligands on the Evolution of Human Siglecs

T. Angata, 2018, Front. Immunol..

Role of activating-type Siglecs on myeloid cell function

T. Angata, 2014 .

Associations of genetic polymorphisms of Siglecs with human diseases.

T. Angata, 2014, Glycobiology.

Cloning and Characterization of a Novel Mouse Siglec, mSiglec-F

T. Angata, N. Varki, R. Hingorani, 2001, The Journal of Biological Chemistry.

Siglec-15: An immune system Siglec that is conserved throughout vertebrate

Mitsuru Nakamura, Kazunori Nakamura, T. Angata, 2007 .

Identification, developmental expression and tissue distribution of deaminoneuraminate hydrolase (KDNase) activity in rainbow trout.

K. Kitajima, S. Inoue, Y. Inoue, 1994, Glycobiology.

Simultaneous determination of nucleotide sugars with ion-pair reversed-phase HPLC.

K. Ohtsubo, N. Taniguchi, S. Kitazume, 2010, Glycobiology.

O-GlcNAcylation is required for B cell homeostasis and antibody responses

P. Hsu, T. Angata, Kuo-I Lin, 2017, Nature Communications.

Elevated expression of free deaminoneuraminic acid in mammalian cells cultured in mannose-rich media.

K. Kitajima, T. Matsuda, T. Angata, 1999, Biochemical and Biophysical Research Communications - BBRC.

Rapid evolution of binding specificities and expression patterns of inhibitory CD33‐related Siglecs in primates

X. Chen, V. Nizet, A. Varki, 2014, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

α1,6-Fucosyltransferase (Fut8) is implicated in vulnerability to elastase-induced emphysema in mice and a possible non-invasive predictive marker for disease progression and exacerbations in chronic obstructive pulmonary disease (COPD).

T. Betsuyaku, M. Nishimura, A. Gemma, 2012, Biochemical and biophysical research communications.

Siglec-E retards atherosclerosis by inhibiting CD36-mediated foam cell formation

P. Crocker, F. Hsu, L. Chau, 2020, Journal of Biomedical Science.

High Density of N- and O-Glycosylation Shields and Defines the Structural Dynamics of the Intrinsically Disordered Ectodomain of Receptor-type Protein Tyrosine Phosphatase Alpha

Chu-Wei Kuo, K. Khoo, S. Hsu, 2023, JACS Au.

Siglec-15: a potential regulator of osteoporosis, cancer, and infectious diseases

T. Angata, 2020, Journal of Biomedical Science.

Ultra-streamlined single cell proteomics by all-in-one chip and data-independent-acquisition mass spectrometry

Reta Birhanu Kitata, Yu-Ju Chen, Asad Ali Siyal, 2021 .

The SIGLEC14 null allele is associated with Mycobacterium tuberculosis- and BCG-induced clinical and immunologic outcomes.

Richard D. Wells, H. Mefford, A. Varki, 2017, Tuberculosis.

Defining the in vivo function of Siglec-F, a CD33-related Siglec expressed on mouse eosinophils.

A. Varki, D. Broide, Marina Miller, 2007, Blood.

Siglec‐15 Regulates Osteoclast Differentiation by Modulating RANKL‐Induced Phosphatidylinositol 3‐Kinase/Akt and Erk Pathways in Association With Signaling Adaptor DAP12

A. Minami, N. Iwasaki, S. Hatakeyama, 2013, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Simultaneous determination of nucleotide sugars with ion-pair reversed-phase HPLC.

K. Ohtsubo, N. Taniguchi, S. Kitazume, 2010, Glycobiology.

Siglec-E retards atherosclerosis by inhibiting CD36-mediated foam cell formation

P. Crocker, L. Chau, T. Angata, 2021, Journal of Biomedical Science.

Identification and characterization of sulfated glycoproteins from small cell lung carcinoma cells assisted by management of molecular charges

H. Narimatsu, H. Kaji, A. Togayachi, 2016, Glycoconjugate Journal.