F. Peelman

发表

MAPPIT analysis of TLR adaptor complexes

J. Tavernier, R. Beyaert, Peter Ulrichts, 2007, FEBS letters.

Selection of non-competitive leptin antagonists using a random nanobody-based approach.

J. Tavernier, L. Zabeau, D. Catteeuw, 2012, The Biochemical journal.

Chylomicronemia With Low Postheparin Lipoprotein Lipase Levels in the Setting of GPIHBP1 Defects

S. Young, J. Kastelein, A. Beigneux, 2010, Circulation. Cardiovascular genetics.

Contribution of the hydrophobicity gradient of an amphipathic peptide to its mode of association with lipids.

R. Brasseur, J. Vandekerckhove, M. Goethals, 1998, European journal of biochemistry.

Selective IL-1 activity on CD8+ T cells empowers antitumor immunity and synergizes with neovasculature-targeted TNF for full tumor eradication

J. Tavernier, N. Kley, S. Plaisance, 2021, Journal for immunotherapy of cancer.

Random Mutagenesis MAPPIT Analysis Identifies Binding Sites for Vif and Gag in Both Cytidine Deaminase Domains of Apobec3G

I. Lemmens, J. Tavernier, D. Catteeuw, 2012, PloS one.

Straightforward Protein-Protein Interaction Interface Mapping via Random Mutagenesis and Mammalian Protein Protein Interaction Trap (MAPPIT)

J. Tavernier, Delphine Masschaele, F. Peelman, 2019, International journal of molecular sciences.

The metabolism of triglyceride-rich lipoproteins revisited: new players, new insight.

M. Nieuwdorp, J. Kastelein, G. Dallinga-Thie, 2010, Atherosclerosis.

Safe eradication of large established tumors using neovasculature‐targeted tumor necrosis factor‐based therapies

J. Tavernier, J. Bultinck, N. Kley, 2020, EMBO molecular medicine.

Leptin: linking adipocyte metabolism with cardiovascular and autoimmune diseases.

J. Tavernier, S. Eyckerman, L. Zabeau, 2004, Progress in lipid research.

20 years of leptin: insights into signaling assemblies of the leptin receptor.

J. Tavernier, S. Savvides, L. Zabeau, 2014, The Journal of endocrinology.

A Hydrophobic Cluster at the Surface of the Human Plasma Phospholipid Transfer Protein Is Critical for Activity on High Density Lipoproteins*

J. Tavernier, J. Vandekerckhove, A. Verhee, 2001, The Journal of Biological Chemistry.

Characterization of recombinant wild type and site-directed mutations of apolipoprotein C-III: lipid binding, displacement of ApoE, and inhibition of lipoprotein lipase.

R. Brasseur, P. Talmud, J. Vandekerckhove, 2000, Biochemistry.

The many faces of the SOCS box.

J. Tavernier, F. Peelman, D. Lavens, 2008, Cytokine & growth factor reviews.

Reconstructing the TIR Side of the Myddosome: a Paradigm for TIR-TIR Interactions.

J. Tavernier, Elien Ruyssinck, F. Peelman, 2016, Structure.

Virtual screening for inhibitors of the human TSLP:TSLPR interaction

S. Savvides, K. Verstraete, Dries Van Rompaey, 2017, Scientific Reports.

The Small GTPase Arf6 Is Essential for the Tram/Trif Pathway in TLR4 Signaling*

J. Tavernier, S. Eyckerman, M. Lamkanfi, 2013, The Journal of Biological Chemistry.

Techniques: new pharmacological perspectives for the leptin receptor.

J. Tavernier, L. Zabeau, R. Jockers, 2006, Trends in pharmacological sciences.

Functional Cross-modulation between SOCS Proteins Can Stimulate Cytokine Signaling*

J. Tavernier, J. Vandekerckhove, D. Belsham, 2006, Journal of Biological Chemistry.

Headgroup specificity of lecithin cholesterol acyltransferase for monomeric and vesicular phospholipids.

J. Tavernier, J. Vandekerckhove, A. Verhee, 2000, Biochimica et biophysica acta.

Relationship between structure and biochemical phenotype of lecithin:cholesterol acyltransferase (LCAT) mutants causing fish-eye disease.

J. Tavernier, J. Vandekerckhove, A. Verhee, 2000, Journal of lipid research.

Characterization of the ABCA transporter subfamily: identification of prokaryotic and eukaryotic members, phylogeny and topology.

J. Vandekerckhove, P. Denéfle, M. Rosseneu, 2003, Journal of molecular biology.

Structural basis of the proinflammatory signaling complex mediated by TSLP

J. Tavernier, S. Savvides, Y. Bloch, 2014, Nature Structural &Molecular Biology.

NR5A1 is a novel disease gene for 46,XX testicular and ovotesticular disorders of sex development

R. Veitia, L. Looijenga, H. Stoop, 2016, Genetics in Medicine.

Leptin: From structural insights to the design of antagonists.

J. Tavernier, L. Zabeau, F. Peelman, 2015, Life sciences.

Leptin Receptor Activation Depends on Critical Cysteine Residues in Its Fibronectin Type III Subdomains*

J. Tavernier, J. Vandekerckhove, L. Zabeau, 2005, Journal of Biological Chemistry.

The ins and outs of leptin receptor activation

J. Tavernier, J. Vandekerckhove, S. Eyckerman, 2003, FEBS letters.

Antagonizing leptin: current status and future directions

J. Tavernier, L. Zabeau, F. Peelman, 2014, Biological chemistry.

Germline gain-of-function myeloid differentiation primary response gene-88 (MYD88) mutation in a child with severe arthritis.

L. Staudt, J. Tavernier, M. Gadina, 2018, The Journal of allergy and clinical immunology.

Chemical inhibition of a subset of Arabidopsis thaliana GSK3-like kinases activates brassinosteroid signaling.

D. Inzé, J. Chory, G. Vert, 2009, Chemistry & biology.

Isolated and Syndromic Retinal Dystrophy Caused by Biallelic Mutations in RCBTB1, a Gene Implicated in Ubiquitination

C. Rivolta, T. Langmann, P. Farinelli, 2016, American journal of human genetics.

Biallelic sequence and structural variants in RAX2 are a novel cause for autosomal recessive inherited retinal disease

J. van den Ende, M. McKibbin, C. Inglehearn, 2018, Genetics in Medicine.

Functional characterization of naturally occurring pathogenic mutations in the human leptin receptor.

S. O’Rahilly, J. Tavernier, I. Farooqi, 2008, Endocrinology.

TYK2-induced phosphorylation of Y640 suppresses STAT3 transcriptional activity

J. Tavernier, K. De Bosscher, F. Peelman, 2017, Scientific Reports.

Definition of the interacting interfaces of Apobec3G and HIV-1 Vif using MAPPIT mutagenesis analysis

J. Tavernier, R. Clayton, D. Catteeuw, 2010, Retrovirology.

Definition of the interacting interfaces of Apobec3G and HIV-1 Vif using MAPPIT mutagenesis analysis

J. Tavernier, R. Clayton, D. Catteeuw, 2009, Nucleic acids research.

HyperISGylation of Old World Monkey ISG15 in Human Cells

J. Tavernier, J. Vandekerckhove, K. Gevaert, 2008, PloS one.

MAPPIT: a protein interaction toolbox built on insights in cytokine receptor signaling.

Jan Tavernier, Irma Lemmens, Sam Lievens, 2011, Cytokine & growth factor reviews.

Biallelic and monoallelic ESR2 variants associated with 46,XY disorders of sex development

L. Looijenga, H. Stoop, K. De Bosscher, 2017, Genetics in Medicine.

Caspase-1 targets the TLR adaptor Mal at a crucial TIR-domain interaction site

J. Tavernier, S. Lievens, R. Beyaert, 2010, Journal of Cell Science.

The Small GTPase Arf6: An Overview of Its Mechanisms of Action and of Its Role in Host–Pathogen Interactions and Innate Immunity

J. Tavernier, F. Peelman, T. Van Acker, 2019, International journal of molecular sciences.

Identification of Binding Sites for Myeloid Differentiation Primary Response Gene 88 (MyD88) and Toll-like Receptor 4 in MyD88 Adapter-like (Mal)*

J. Tavernier, F. Peelman, T. Van Acker, 2013, The Journal of Biological Chemistry.

TYK 2-induced phosphorylation of Y 640 suppresses STAT 3 transcriptional activity

J. Tavernier, J. V. D. Heyden, F. Peelman, 2018 .

Specific targeting of IL-1β activity to CD8+ T cells allows for safe use as a vaccine adjuvant

J. Tavernier, N. Kley, X. Saelens, 2020, npj Vaccines.

Identification of Interaction Sites for Dimerization and Adapter Recruitment in Toll/Interleukin-1 Receptor (TIR) Domain of Toll-like Receptor 4*

Anne-Sophie de Smet, J. Tavernier, D. Catteeuw, 2011, The Journal of Biological Chemistry.

Three arginine residues in apolipoprotein A-I are critical for activation of lecithin:cholesterol acyltransferase.

Hetal N. Patel, J. Vandekerckhove, C. Shoulders, 2001, Journal of lipid research.

Effects of natural mutations in lecithin:cholesterol acyltransferase on the enzyme structure and activity.

J. Tavernier, J. Vandekerckhove, C. Ampe, 1999, Journal of lipid research.

Functional characterization of the first missense variant in CEP78, a founder allele associated with cone‐rod dystrophy, hearing loss, and reduced male fertility

C. Bachert, C. Rivolta, P. Farinelli, 2020, Human mutation.

Structure and function of lecithin cholesterol acyl transferase: new insights from structural predictions and animal models

J. Vandekerckhove, M. Rosseneu, F. Peelman, 2000, Current opinion in lipidology.

A proposed architecture for lecithin cholesterol acyl transferase (LCAT): Identification of the catalytic triad and molecular modeling

J. Tavernier, A. Verhee, M. Rosseneu, 1998, Protein science : a publication of the Protein Society.

Elongin B/C Recruitment Regulates Substrate Binding by CIS*

J. Tavernier, D. Catteeuw, F. Peelman, 2008, Journal of Biological Chemistry.

Mammalian protein-protein interaction trap (MAPPIT) analysis of STAT5, CIS, and SOCS2 interactions with the growth hormone receptor.

I. Lemmens, Anne-Sophie de Smet, J. Tavernier, 2007, Molecular Endocrinology.

The C-terminus of CIS defines its interaction pattern.

J. Tavernier, J. Vandekerckhove, K. Gevaert, 2007, The Biochemical journal.

RNF41 interacts with the VPS52 subunit of the GARP and EARP complexes

J. Tavernier, S. Lievens, Delphine Masschaele, 2017, PloS one.

Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma

H. Hammad, B. Lambrecht, J. Tavernier, 2017, Nature Communications.

Mapping of the Leptin Binding Sites and Design of a Leptin Antagonist*

J. Tavernier, L. Zabeau, D. Catteeuw, 2004, Journal of Biological Chemistry.

Caenorhabditis elegans expresses three functional profilins in a tissue-specific manner.

J. Vandekerckhove, D. Baillie, C. Ampe, 2006, Cell motility and the cytoskeleton.

Mapping of Binding Site III in the Leptin Receptor and Modeling of a Hexameric Leptin·Leptin Receptor Complex*

Anne-Sophie de Smet, J. Tavernier, J. Vandekerckhove, 2006, Journal of Biological Chemistry.

Mapping of the interface between leptin and the leptin receptor CRH2 domain

J. Tavernier, J. Vandekerckhove, L. Zabeau, 2005, Journal of Cell Science.

High prevalence of mutations in LCAT in patients with low HDL cholesterol levels in the Netherlands: Identification and characterization of eight novel mutations

J. Kastelein, E. Stroes, M. Motazacker, 2011, Human mutation.

Characterization of functional residues in the interfacial recognition domain of lecithin cholesterol acyltransferase (LCAT).

R. Brasseur, J. Tavernier, J. Vandekerckhove, 1999, Protein Engineering.

Phosphorylation by Protein Kinase CK2 Modulates the Activity of the ATP Binding Cassette A1 Transporter*

J. Tavernier, J. Vandekerckhove, M. Lensink, 2004, Journal of Biological Chemistry.

Expression and activity of the nucleotide-binding domains of the human ABCA1 transporter.

J. Vandekerckhove, B. Christiaens, M. Rosseneu, 2004, Protein expression and purification.

Modulation of the ABCA1 transporter activity by protein kinase CK2

J. Tavernier, J. Vandekerckhove, M. Lensink, 2004 .

Effect of mutations of N- and C-terminal charged residues on the activity of LCAT.

J. Tavernier, J. Vandekerckhove, A. Verhee, 2001, Journal of lipid research.

Structural and functional properties of the 154-171 wild-type and variant peptides of human lecithin-cholesterol acyltransferase.

R. Brasseur, J. Vandekerckhove, M. Goethals, 1997, European journal of biochemistry.

Leptin’s metabolic and immune functions can be uncoupled at the ligand/receptor interaction level

J. Tavernier, K. Venken, H. Chen, 2014, Cellular and Molecular Life Sciences.

Structural and mechanistic paradigm of leptin receptor activation revealed by complexes with wild-type and antagonist leptins.

Jan Tavernier, Philippe Ringler, Henning Stahlberg, 2014, Structure.

Reciprocal cross-regulation between RNF41 and USP8 controls cytokine receptor sorting and processing

J. Tavernier, Delphine Masschaele, F. Peelman, 2013, Journal of Cell Science.

An affinity-enhanced, broadly neutralizing heavy chain–only antibody protects against SARS-CoV-2 infection in animal models

P. Maes, N. Callewaert, B. Weynand, 2021, Science Translational Medicine.

Drug development of an affinity enhanced, broadly neutralizing heavy chain-only antibody that restricts SARS-CoV-2 in rodents

P. Maes, N. Callewaert, B. Weynand, 2021, bioRxiv.

Biallelic sequence and structural variants in RAX2 are a novel cause for autosomal recessive inherited retinal disease

J. van den Ende, M. McKibbin, C. Inglehearn, 2018, Genetics in Medicine.

The N‐terminal p.(Ser38Cys) TIMP3 mutation underlying Sorsby fundus dystrophy is a founder mutation disrupting an intramolecular disulfide bond

R. Vandenbroucke, F. Coppieters, J. de Zaeytijd, 2019, Human mutation.

The Biologist’s Guide to the Glucocorticoid Receptor’s Structure

I. Rogatsky, K. De Bosscher, F. Peelman, 2023, Cells.

Leptin’s metabolic and immune functions can be uncoupled at the ligand/receptor interaction level

J. Tavernier, K. Venken, J. Rubio, 2014, Cellular and Molecular Life Sciences.

Biallelic and monoallelic ESR2 variants associated with 46,XY disorders of sex development

L. Looijenga, H. Stoop, K. De Bosscher, 2018, Genetics in Medicine.

Chemical inhibition of a subset of Arabidopsis thaliana GSK3-like kinases activates brassinosteroid signaling.

D. Inzé, J. Chory, G. Vert, 2009, Chemistry & biology.