B. Isakson

发表

Epithelial and Endothelial Pannexin1 Channels Mediate AKI.

Liping Huang, K. Ravichandran, M. Okusa, 2018, Journal of the American Society of Nephrology : JASN.

Endothelial Pannexin 1 Regulates Cardiac Response to Myocardial Infarction.

M. Aronovitz, N. Leitinger, Matthew J. Wolf, 2021, Circulation research.

Polarized Proteins in Endothelium and Their Contribution to Function

B. Isakson, Abigail G. Wolpe, Claire A. Ruddiman, 2021, Journal of Vascular Research.

Pannexin-1 channels on endothelial cells mediate vascular inflammation during lung ischemia-reperfusion injury.

D. Bayliss, K. Ravichandran, E. Charles, 2018, American journal of physiology. Lung cellular and molecular physiology.

Regulation of Cellular Communication by Signaling Microdomains in the Blood Vessel Wall

M. Billaud, B. Isakson, S. Johnstone, 2014, Pharmacological Reviews.

Vascular biomechanical properties in mice with smooth muscle specific deletion of Ndst1

W. Guan, Jennifer L Hall, V. Barocas, 2013, Molecular and Cellular Biochemistry.

Biological and biophysical properties of vascular connexin channels.

B. Isakson, S. Johnstone, D. Locke, 2009, International review of cell and molecular biology.

Pannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis

Michael R. Elliott, D. Bayliss, G. Salvesen, 2010, Nature.

A venous-specific purinergic signaling cascade initiated by Pannexin 1 regulates TNFα-induced increases in endothelial permeability

Michael Koval, B. Isakson, Miranda E. Good, 2021, Science Signaling.

Nitric Oxide–Dependent Feedback Loop Regulates Transient Receptor Potential Vanilloid 4 (TRPV4) Channel Cooperativity and Endothelial Function in Small Pulmonary Arteries

M. Kotlikoff, B. Isakson, Kwangseok Hong, 2017, Journal of the American Heart Association.

Pannexin 1 is required for full activation of insulin-stimulated glucose uptake in adipocytes

D. Bayliss, N. Leitinger, T. Harris, 2015, Molecular metabolism.

Loss of Compliance in Small Arteries, but Not in Conduit Arteries, After 6 Weeks Exposure to High Fat Diet

M. Billaud, B. Isakson, S. Johnstone, 2012, Journal of Cardiovascular Translational Research.

Intercellular Ca2+ signaling in alveolar epithelial cells through gap junctions and by extracellular ATP.

S. Boitano, B. Isakson, W. H. Evans, 2001, American journal of physiology. Lung cellular and molecular physiology.

Consideration of Pannexin 1 channels in COVID-19 pathology and treatment

L. A. Swayne, Michael Koval, C. Ng, 2020, American journal of physiology. Lung cellular and molecular physiology.

The Myoendothelial Junction: Breaking through the Matrix?

B. Isakson, A. Straub, K. Heberlein, 2009, Microcirculation.

The myoendothelial junction: connections that deliver the message.

B. Isakson, A. C. Zeigler, A. Straub, 2014, Physiology.

Smooth Muscle Specific Deletion of Ndst1 Leads to Decreased Vessel Luminal Area and No Change in Blood Pressure in Conscious Mice

W. Pan, Jennifer L Hall, M. Billaud, 2012, Journal of Cardiovascular Translational Research.

MAPK phosphorylation of connexin 43 promotes binding of cyclin E and smooth muscle cell proliferation

C. Lo, B. Kroncke, P. Lampe, 2012, Circulation research.

EXTRACELLULAR MATRIX-DRIVEN ALVEOLAR EPITHELIAL CELL DIFFERENTIATION IN VITRO

S. Boitano, B. Isakson, G. Seedorf, 2005, Experimental lung research.

Endothelial nitric oxide synthase in the microcirculation

L. Columbus, B. Isakson, L. Biwer, 2015, Cellular and Molecular Life Sciences.

A New Method for In Vivo Visualization of Vessel Remodeling Using a Near‐Infrared Dye

Anthony C. Bruce, S. Peirce, M. Billaud, 2011, Microcirculation.

Red blood cell eNOS is cardioprotective in acute myocardial infarction

J. Schmitt, M. Grandoch, M. Kelm, 2022, Redox biology.

Modulation of pulmonary alveolar type II cell phenotype and communication by extracellular matrix and KGF.

S. Boitano, B. Isakson, G. Seedorf, 2001, American journal of physiology. Cell physiology.

Interaction Between Pannexin 1 and Caveolin-1 in Smooth Muscle Can Regulate Blood Pressure

R. Machado, Jiwang Chen, R. Minshall, 2018, Arteriosclerosis, thrombosis, and vascular biology.

Pannexin 1 in the regulation of vascular tone.

M. Billaud, B. Isakson, Joanna K. Sandilos, 2012, Trends in cardiovascular medicine.

RSK2 contributes to myogenic vasoconstriction of resistance arteries by activating smooth muscle myosin and the Na+/H+ exchanger

Z. Derewenda, M. Eto, T. Le, 2018, Science Signaling.

Connexin40 and connexin43 in mouse aortic endothelium: evidence for coordinated regulation.

B. Duling, B. Isakson, D. Damon, 2006, American journal of physiology. Heart and circulatory physiology.

Red Blood Cell and Endothelial eNOS Independently Regulate Circulating Nitric Oxide Metabolites and Blood Pressure

M. Grandoch, M. Kelm, E. Weitzberg, 2021, Circulation.

Anaemia is associated with severe RBC dysfunction and a reduced circulating NO pool: vascular and cardiac eNOS are crucial for the adaptation to anaemia

J. Fischer, U. Flögel, J. Schrader, 2020, Basic Research in Cardiology.

On the Effects of Reactive Oxygen Species and Nitric Oxide on Red Blood Cell Deformability

H. Gohlke, M. Kelm, M. Feelisch, 2018, Front. Physiol..

Plasminogen Activator Inhibitor-1 Regulates Myoendothelial Junction Formation

N. Leitinger, B. Isakson, A. Straub, 2010, Circulation research.

Localized expression of an Ins(1,4,5)P3 receptor at the myoendothelial junction selectively regulates heterocellular Ca2+ communication

B. Isakson, 2008, Journal of Cell Science.

Ca2+ and Inositol 1,4,5-Trisphosphate–Mediated Signaling Across the Myoendothelial Junction

B. Duling, B. Isakson, S. Ramos, 2007, Circulation research.

Vascular gap junctions in hypertension.

B. Duling, B. Isakson, X. Figueroa, 2006, Hypertension.

Enhanced connexin 43 expression delays intra‐mitoitc duration and cell cycle traverse independently of gap junction channel function

R. Errington, B. Isakson, S. Johnstone, 2010, Journal of cellular biochemistry.

Site-Specific Connexin Phosphorylation Is Associated with Reduced Heterocellular Communication between Smooth Muscle and Endothelium

S. Boitano, B. Isakson, S. Johnstone, 2009, Journal of Vascular Research.

Incidence of protein on actin bridges between endothelium and smooth muscle in arterioles demonstrates heterogeneous connexin expression and phosphorylation.

B. Duling, B. Isakson, Angela K. Best, 2008, American journal of physiology. Heart and circulatory physiology.

Oxidized phospholipid species promote in vivo differential cx43 phosphorylation and vascular smooth muscle cell proliferation.

N. Leitinger, P. Lampe, B. Isakson, 2009, The American journal of pathology.

Loss of Endothelial FTO Antagonizes Obesity-Induced Metabolic and Vascular Dysfunction

L. Ragolia, N. Leitinger, T. Harris, 2019, Circulation research.

Hypoxic pulmonary vasoconstriction requires connexin 40-mediated endothelial signal conduction.

W. Kuebler, M. Chanson, I. Fleming, 2012, The Journal of clinical investigation.

Caveolar peroxynitrite formation impairs endothelial TRPV4 channels and elevates pulmonary arterial pressure in pulmonary hypertension

R. Minshall, E. Goncharova, M. Ottolini, 2021, Proceedings of the National Academy of Sciences.

TRPV4 (Transient Receptor Potential Vanilloid 4) Channel–Dependent Negative Feedback Mechanism Regulates Gq Protein–Coupled Receptor–Induced Vasoconstriction

B. Isakson, Kwangseok Hong, Eric L. Cope, 2018, Arteriosclerosis, thrombosis, and vascular biology.

Non–Endoplasmic Reticulum–Based Calr (Calreticulin) Can Coordinate Heterocellular Calcium Signaling and Vascular Function

Neha Agrawal, B. Isakson, Miranda E. Good, 2018, Arteriosclerosis, thrombosis, and vascular biology.

the Message The Myoendothelial Junction: Connections That Deliver

B. Isakson, A. C. Zeigler, Angela C. Zeigler, 2016 .

The MEJ : Hubs for Microdomain Organization and Localization in the Resistance Vasculature

B. Isakson, A. C. Zeigler, A. Straub, 2014 .

Ca 2 (cid:1) and 1,4,5-Trisphosphate–Mediated Signaling Across the Myoendothelial Junction

B. Duling, B. Isakson, S. Ramos, 2007 .

Cardiovascular magnetic resonance detects the progression of impaired myocardial perfusion reserve and increased left-ventricular mass in mice fed a high-fat diet

F. Epstein, C. Kramer, L. Gan, 2016, Journal of Cardiovascular Magnetic Resonance.

Compartmentalized Connexin 43 S-Nitrosylation/Denitrosylation Regulates Heterocellular Communication in the Vessel Wall

B. Gaston, M. Billaud, B. Isakson, 2011, Arteriosclerosis, thrombosis, and vascular biology.

Pannexin 1 as a driver of inflammation and ischemia–reperfusion injury

B. Isakson, Miranda E. Good, Thomas Carr, 2021, Purinergic Signalling.

Redox-Regulation of α-Globin in Vascular Physiology

Alfonso G. Fernandez, M. Weiss, L. Kiger, 2022, Antioxidants.

Endothelial cell &agr;-globin and its molecular chaperone &agr;-hemoglobin–stabilizing protein regulate arteriolar contractility

M. Weiss, L. Kiger, Christophe Lechauve, 2018, The Journal of clinical investigation.

Pannexin 1 Channels as an Unexpected New Target of the Anti-Hypertensive Drug Spironolactone

D. Bayliss, K. Ravichandran, N. Leitinger, 2017, Circulation research.

Myoendothelial Junctions of Mature Coronary Vessels Express Notch Signaling Proteins

Patricia E. Mccallinhart, B. Lilly, B. Isakson, 2020, Frontiers in Physiology.

Mechanisms of Connexin Regulating Peptides

Samy Lamouille, B. Isakson, S. Johnstone, 2021, International journal of molecular sciences.

‘Gaps’ in targeted ischaemic injury therapies in ST-elevation myocardial infarction

B. Isakson, S. Johnstone, 2018, Heart.

Assessment of tissue perfusion and vascular function in mice by scanning laser Doppler perfusion imaging.

M. Kelm, B. Isakson, C. Heiss, 2020, Biochemical pharmacology.

Polarized localization of phosphatidylserine in the endothelium regulates Kir2.1

Bruce A. Corliss, Chien-Jung Lin, R. Mecham, 2022, bioRxiv.

Spontaneous lung dysfunction and fibrosis in mice lacking connexin 40 and endothelial cell connexin 43.

A. Zarbock, B. Duling, M. Billaud, 2011, The American journal of pathology.

Two functionally distinct pools of eNOS in endothelium are facilitated by myoendothelial junction lipid composition.

K. Hoehn, E. Taddeo, B. Isakson, 2016, Biochimica et biophysica acta.

S-Nitrosylation Inhibits Pannexin 1 Channel Function*

D. Bayliss, N. Leitinger, D. Laird, 2012, The Journal of Biological Chemistry.

Interaction between nitric oxide signaling and gap junctions: effects on vascular function.

M. Billaud, B. Isakson, S. Johnstone, 2012, Biochimica et biophysica acta.

Characterization of the Thoracodorsal Artery: Morphology and Reactivity

M. Billaud, B. Isakson, S. Johnstone, 2012, Microcirculation.

Pannexin1 Regulates &agr;1-Adrenergic Receptor– Mediated Vasoconstriction

K. Ravichandran, D. Laird, M. Billaud, 2011, Circulation research.

Pannexin1 Regulates (cid:1) 1-Adrenergic Receptor– Mediated Vasoconstriction Short Communication

K. Ravichandran, D. Laird, M. Billaud, 2011 .

Heterocellular Contact at the Myoendothelial Junction Influences Gap Junction Organization

B. Duling, B. Isakson, 2005, Circulation research.

Pannexin 1-a novel regulator of acute hypoxic pulmonary vasoconstriction.

W. Kuebler, K. Connelly, J. Grune, 2021, Cardiovascular research.

Constitutive SRC-mediated phosphorylation of pannexin 1 at tyrosine 198 occurs at the plasma membrane

Roger J. Thompson, M. Yeager, L. A. Swayne, 2019, The Journal of Biological Chemistry.

Macrophage metabolic adaptation to heme detoxification involves CO-dependent activation of the pentose phosphate pathway.

N. Leitinger, T. Fox, B. Isakson, 2020, Blood.

Oxidized Phospholipids Alter Vascular Connexin Expression, Phosphorylation, and Heterocellular Communication

N. Leitinger, B. Duling, B. Isakson, 2006, Arteriosclerosis, thrombosis, and vascular biology.

AXL-Mediated Productive Infection of Human Endothelial Cells by Zika Virus.

B. Isakson, Shufeng Liu, Leon J. DeLalio, 2016, Circulation research.

Endothelial Pannexin 1 Channels Control Inflammation by Regulating Intracellular Calcium

Ashley M. Miller, M. McBride, Michael Koval, 2019, The Journal of Immunology.

Heterocellular contact can dictate arterial function

L. Columbus, B. Isakson, Miranda E. Good, 2019, Circulation research.

Mechanisms of Connexin Mimetic Peptides

Samy Lamouille, B. Isakson, S. Johnstone, 2021 .

Laminin-332 alters connexin profile, dye coupling and intercellular Ca2+ waves in ciliated tracheal epithelial cells

S. Boitano, B. Isakson, Colin E. Olsen, 2006, Respiratory research.

Signaling Pathways Linked to Serotonin-Induced Superoxide Anion Production: A Physiological Role for Mitochondria in Pulmonary Arteries

R. Marthan, R. Rossignol, M. Billaud, 2017, Front. Physiol..

Endothelial cell expression of hemoglobin a regulates nitric oxide signaling

B. Gaston, B. Isakson, A. Straub, 2012 .

Probenecid Inhibits &agr;-Adrenergic Receptor–Mediated Vasoconstriction in the Human Leg Vasculature

M. Nyberg, Y. Hellsten, T. S. Jørgensen, 2018, Hypertension.

Pannexin 1 channels regulate leukocyte emigration through the venous endothelium during acute inflammation

K. Stokes, K. Ravichandran, N. Leitinger, 2015, Nature Communications.

Loss of Collectrin, an ACE2 Homologue, Uncouples Endothelial Nitric Oxide Synthase and Causes Hypertension and Vascular Dysfunction Running title: Cechova et al.; Role of collectrin in blood pressure homeostasis

R. Carey, R. Griffiths, M. Billaud, 2013 .

Ablation of both Cx40 and Panx1 results in similar cardiovascular phenotypes exhibited in Cx40 knockout mice

Q. Feng, D. Laird, B. Isakson, 2019, Bioscience reports.

Endothelial cell expression of hemoglobin α regulates nitric oxide signaling

B. Gaston, L. Columbus, M. Billaud, 2012, Nature.

Secreting von Willebrand factor in a Gα-SNAP.

B. Isakson, 2014, Blood.

Endothelial cell transfection of ex vivo arteries

B. Isakson, A. Straub, A. Lohman, 2012 .

Endothelial calreticulin deletion impairs endothelial function in aged mice.

B. Isakson, Miranda E. Good, S. Johnstone, 2020, American journal of physiology. Heart and circulatory physiology.

Cell-cell communication in heterocellular cultures of alveolar epithelial cells.

S. Boitano, B. Isakson, G. Seedorf, 2003, American journal of respiratory cell and molecular biology.

The Evolving Role of Diverse Gaseous Transmitters Mediating Heterocellular Communication Within the Vasculature.

B. Isakson, Alexander S. Keller, 2017, Antioxidants & redox signaling.

ZP1609/danegaptide and mitochondrial connexin hemichannels: a harbinger for peptide drug design

B. Isakson, Leon J. DeLalio, 2017, British journal of pharmacology.

CCR7 and IRF4-dependent dendritic cells regulate lymphatic collecting vessel permeability.

M. Colonna, B. Zinselmeyer, R. Förster, 2016, The Journal of clinical investigation.

Emerging concepts regarding pannexin 1 in the vasculature.

M. Billaud, B. Isakson, Miranda E. Good, 2015, Biochemical Society transactions.

Loss of reticulocalbin 2 lowers blood pressure and restrains ANG II-induced hypertension in vivo.

Weibin Shi, Jing Li, T. Le, 2019, American journal of physiology. Renal physiology.

Red Blood Cell Function and Dysfunction: Redox Regulation, Nitric Oxide Metabolism, Anemia

M. Kelm, B. Isakson, M. Cortese-Krott, 2017, Antioxidants & redox signaling.

KLF4 Dependent Phenotypic Modulation of SMCs Plays a Key Role in Atherosclerotic Plaque Pathogenesis

Laura S. Shankman, G. Owens, G. Randolph, 2015, Nature Medicine.

Guidelines for the measurement of vascular function and structure in isolated arteries and veins.

J. Filosa, D. Gutterman, B. Isakson, 2021, American journal of physiology. Heart and circulatory physiology.

Possible roles for ATP release from RBCs exclude the cAMP-mediated Panx1 pathway.

Joshua C. Drake, Zhen Yan, M. Kelm, 2017, American journal of physiology. Cell physiology.

The role of globins in cardiovascular physiology.

M. Weiss, L. Columbus, Christophe Lechauve, 2021, Physiological reviews.

Marked oestrous cycle‐dependent regulation of rat arterial KV7.4 channels driven by GPER1

R. Andrew, B. Isakson, N. Homer, 2022, British journal of pharmacology.

Capillary-associated microglia regulate vascular structure and function through PANX1-P2RY12 coupling in mice

Bruce A. Corliss, Ukpong B. Eyo, William A Mills, 2021, Nature Communications.

Connexins: gaps in our knowledge of vascular function.

B. Duling, B. Isakson, X. Figueroa, 2004, Physiology.

Phosphatidylserine on viable sperm and phagocytic machinery in oocytes regulate mammalian fertilization

Laura S. Shankman, K. Ravichandran, S. Arandjelovic, 2019, Nature Communications.

Heterocellular cultures of pulmonary alveolar epithelial cells grown on laminin-5 supplemented matrix

S. Boitano, B. Isakson, G. Seedorf, 2002, In Vitro Cellular & Developmental Biology - Animal.

Extracellular vesicles and insulin‐mediated vascular function in metabolic syndrome

Nathan R. Stewart, S. Malin, U. Erdbrügger, 2023, Physiological reports.

Circulating Extracellular Vesicles in Normotension Restrain Vasodilation in Resistance Arteries.

R. Carey, T. Le, U. Erdbrügger, 2019, Hypertension.

Connexins in vascular physiology and pathology.

B. Kwak, B. Isakson, A. Brisset, 2009, Antioxidants & redox signaling.

Small Interfering RNA-Mediated Connexin Gene Knockdown in Vascular Endothelial and Smooth Muscle Cells.

B. Isakson, Miranda E. Good, S. Johnstone, 2016, Methods in molecular biology.

Klf4 has an unexpected protective role in perivascular cells within the microvasculature.

B. A. French, S. Peirce, G. Owens, 2018, American journal of physiology. Heart and circulatory physiology.

Mechanisms of ATP release and signalling in the blood vessel wall.

M. Billaud, B. Isakson, A. Lohman, 2012, Cardiovascular research.

Pannexin-1 as a potentiator of ligand-gated receptor signaling

Roger J. Thompson, B. Isakson, 2014, Channels.

Posttranslational Modifications in Connexins and Pannexins

E. Taddeo, M. Billaud, B. Isakson, 2012, The Journal of Membrane Biology.

Expression of Pannexin Isoforms in the Systemic Murine Arterial Network

D. Laird, M. Billaud, B. Isakson, 2012, Journal of Vascular Research.

Correction: Corrigendum: KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis

Laura S. Shankman, G. Owens, G. Randolph, 2015, Nature Medicine.

The importance of serine 161 in the sodium channel β3 subunit for modulation of NaV1.2 gating

Ellen C. Merrick, C. Kalmar, B. Isakson, 2010, Pflügers Archiv - European Journal of Physiology.

Smooth muscle cell-specific deletion of Col 15 a 1 unexpectedly leads to impaired 1 development of advanced atherosclerotic lesions 2 3

J. Connelly, G. Owens, Yu-Qing Zhou, 2017 .

Vascular Expression of Hemoglobin Alpha in Antarctic Icefish Supports Iron Limitation as Novel Evolutionary Driver

Bruce A. Corliss, S. Peirce, J. Beers, 2019, bioRxiv.

Endothelial alpha globin is a nitrite reductase

G. Christ, M. Weiss, T. Bender, 2021, bioRxiv.

Cellular microdomains for nitric oxide signaling in endothelium and red blood cells.

B. Isakson, Claire A. Ruddiman, M. Cortese-Krott, 2020, Nitric oxide : biology and chemistry.

Vascular Smooth Muscle Remodeling in Conductive and Resistance Arteries in Hypertension.

T. Le, B. Isakson, Miranda E. Good, 2018, Arteriosclerosis, thrombosis, and vascular biology.

Hemoglobin α/eNOS coupling at myoendothelial junctions is required for nitric oxide scavenging during vasoconstriction

B. Isakson, A. Nguyen, A. Straub, 2014 .

Hemoglobin α in the blood vessel wall.

J. Beers, L. Columbus, B. Isakson, 2014, Free radical biology & medicine.

Hemoglobin Interacts with Endothelial Nitric Oxide Synthase to Regulate Vasodilation in Human Resistance Arteries

J. Kabat, O. Kamenyeva, S. Ganesan, 2021, medRxiv.

Modulating Vascular Hemodynamics With an Alpha Globin Mimetic Peptide (Hb&agr;X)

S. Peirce, Bo Ning, L. Columbus, 2016, Hypertension.

Hemoglobin &agr;/eNOS Coupling at Myoendothelial Junctions Is Required for Nitric Oxide Scavenging During Vasoconstriction

Megan P. Miller, L. Columbus, M. Billaud, 2014, Arteriosclerosis, thrombosis, and vascular biology.

Differentiating connexin hemichannels and pannexin channels in cellular ATP release

B. Isakson, A. Lohman, Alexander W. Lohman, 2014, FEBS letters.

Loss of Collectrin, an Angiotensin-Converting Enzyme 2 Homolog, Uncouples Endothelial Nitric Oxide Synthase and Causes Hypertension and Vascular Dysfunction

R. Carey, R. Griffiths, M. Billaud, 2013, Circulation.

Brain endothelial cell TRPA1 channels initiate neurovascular coupling

C. Tran, Michael G. Alvarado, B. Isakson, 2020, bioRxiv.

Identification of a Novel Macrophage Phenotype That Develops in Response to Atherogenic Phospholipids via Nrf2

Michael R. Elliott, Jenny Han, Florian Gruber, 2010, Circulation research.

Cellular and Functional Effects of Insulin Based Therapies and Exercise on Endothelium.

S. Malin, B. Isakson, E. Heiston, 2020, Current pharmaceutical design.

Endoplasmic reticulum‐mediated signalling in cellular microdomains

B. Isakson, L. Biwer, 2017, Acta physiologica.

Endothelial Cell Pannexin1 Modulates Severity of Ischemic Stroke by Regulating Cerebral Inflammation and Myogenic Tone

S. Eucker, B. Isakson, Miranda E. Good, 2018, JCI insight.

A molecular signature in the pannexin1 intracellular loop confers channel activation by the α1 adrenoreceptor in smooth muscle cells

Roger J. Thompson, D. Bayliss, K. Ravichandran, 2015, Science Signaling.

Engineering Particle-based Materials for Vasculogenesis

B. Isakson, Melissa A. Luse, Natasha L. Claxton, 2023, bioRxiv.

Connexins and Pannexins in Vascular Function and Disease

B. Kwak, B. Isakson, J. Gibbins, 2018, International journal of molecular sciences.

The effect of oxidative stress on connexins in the vasculature

M. Billaud, B. Isakson, A. Straub, 2013 .

Endothelial nitric oxide synthase in the microcirculation

L. Columbus, B. Isakson, L. Biwer, 2015, Cellular and Molecular Life Sciences.

Local Peroxynitrite Impairs Endothelial Transient Receptor Potential Vanilloid 4 Channels and Elevates Blood Pressure in Obesity

Min S. Park, Matteo Ottolini, M. Kalani, 2020, Circulation.

Pannexin channel and connexin hemichannel expression in vascular function and inflammation

B. Isakson, Miranda E. Good, X. Figueroa, 2017, BMC Cell Biology.

The connexin 43/ZO-1 complex regulates cerebral endothelial F-actin architecture and migration.

B. Isakson, S. Johnstone, R. Gourdie, 2015, American journal of physiology. Cell physiology.

Endothelial pannexin-1 channels modulate macrophage and smooth muscle cell activation in abdominal aortic aneurysm formation

Craig T. Elder, K. Ravichandran, J. Mehaffey, 2022, Nature Communications.

A Novel mRNA Binding Protein Complex Promotes Localized Plasminogen Activator Inhibitor-1 Accumulation at the Myoendothelial Junction

J. Wojta, C. Kaun, B. Isakson, 2012, Arteriosclerosis, thrombosis, and vascular biology.

Endothelial pannexin 1–TRPV4 channel signaling lowers pulmonary arterial pressure in mice

R. Minshall, V. Laubach, B. Isakson, 2021, eLife.

Induction of microvascular network growth in the mouse mesentery

S. Peirce, B. Isakson, J. Wang, 2018, Microcirculation.

Reply to Boedtkjer and Aalkjaer.

J. Filosa, D. Gutterman, B. Isakson, 2022, American journal of physiology. Heart and circulatory physiology.

Reply to De Mey et al.

J. Filosa, D. Gutterman, B. Isakson, 2022, American journal of physiology. Heart and circulatory physiology.

PANNEXIN 1 CHANNELS IN RENIN-EXPRESSING CELLS INFLUENCE RENIN SECRETION AND BLOOD PRESSURE HOMEOSTASIS.

D. Bayliss, P. Barrett, K. Ravichandran, 2020, Kidney international.

Posttranslational Modifications in Connexins and Pannexins

E. Taddeo, M. Billaud, B. Isakson, 2012, The Journal of Membrane Biology.

Response by Good et al to Letter Regarding Article, "Pannexin-1 Channels as an Unexpected New Target of the Antihypertensive Drug Spironolactone".

D. Bayliss, K. Ravichandran, I. Jaffe, 2018, Circulation research.

Endothelial Pannexin 1–TRPV4 channel signaling lowers pulmonary arterial pressure

R. Minshall, V. Laubach, B. Isakson, 2021, bioRxiv.

Central Role of P2Y6 UDP Receptor in Arteriolar Myogenic Tone

H. Monyer, P. Abraham, P. Rousseau, 2016, Arteriosclerosis, thrombosis, and vascular biology.

Pannexin channel and connexin hemichannel expression in vascular function and inflammation

B. Isakson, Miranda E. Good, X. Figueroa, 2017, BMC Cell Biology.

Recombinant PAI‐1 therapy restores myoendothelial junctions and erectile function in PAI‐1‐deficient mice

W. Steers, J. Lysiak, B. Annex, 2015, Andrologia.

Pharmacology of pannexin channels.

Michael Koval, B. Isakson, Wyatt J Schug, 2023, Current opinion in pharmacology.

Nitric Oxide Synthase and Causes Hypertension and Vascular Dysfunction Loss of Collectrin, an Angiotensin-Converting Enzyme 2 Homolog, Uncouples Endothelial

J. Pankow, A. Kraja, D. Arnett, 2015 .

Vascular Endothelial Barrier Protection Prevents Atrial Fibrillation by Preserving Cardiac Nanostructure

B. Isakson, S. Johnstone, R. Veeraraghavan, 2023, bioRxiv.

Amount of Pannexin 1 in smooth muscle cells regulates sympathetic nerve induced vasoconstriction

K. Ravichandran, M. Billaud, Michael Koval, 2022, bioRxiv.

Diverse post-translational modifications of the pannexin family of channel-forming proteins

D. Litchfield, D. Laird, B. Isakson, 2014, Channels.

Connexins, pannexins and innexins: Protein cousins with overlapping functions

Michael Koval, B. Isakson, R. Gourdie, 2014, FEBS letters.

Unbiased proteomics identifies plasminogen activator inhibitor-1 as a negative regulator of endothelial nitric oxide synthase

W. Sessa, D. Stuehr, B. Isakson, 2020, Proceedings of the National Academy of Sciences.

Culturing alveolar type I, alveolar type II, and mixed cell populations by altering the extracellular matrix promotes changes in intercellular signaling mechanisms.

S. Boitano, B. Isakson, R. Lubman, 2002, Chest.

Physiological functions of caveolae in endothelium.

B. Isakson, Madeline Jackson, Melissa A. Luse, 2023, Current opinion in physiology.

Organization of IP3‐R1 and TRPC3 at the Myoendothelial Junction May Influence Polarized Calcium Signaling

B. Duling, B. Isakson, 2006 .

Loss of endothelial cell heterogeneity in arteries after obesogenic diet

K. Hirschi, B. Isakson, M. Cortese-Krott, 2023, bioRxiv.

Polarized localization of phosphatidylserine in the endothelium regulates Kir2.1

Bruce A. Corliss, R. Berne, Chien-Jung Lin, 2023 .

Obesity-Induced Coronary Microvascular Disease Is Prevented by iNOS Deletion and Reversed by iNOS Inhibition

F. Epstein, B. A. French, Matthew J. Wolf, 2023, JACC. Basic to translational science.

Connexins: gaps in our knowledge of vascular function.

B. Duling, B. Isakson, X. Figueroa, 2004, Physiology.

Connexins : Gaps in Our Knowledge of Vascular Function

B. Duling, B. Isakson, X. Figueroa, 2022 .

A Cell Culture Model of Resistance Arteries.

M. Weiss, Christophe Lechauve, B. Isakson, 2017, Journal of visualized experiments : JoVE.

Differentiating connexin hemichannels and pannexin channels in cellular ATP release

B. Isakson, Alexander W. Lohman, 2014, FEBS letters.

Regulation of Cellular Communication by Signaling Microdomains in the Blood Vessel Wall

M. Billaud, B. Isakson, S. Johnstone, 2014, Pharmacological Reviews.

Identification of a Novel Macrophage Phenotype That Develops in Response to Atherogenic Phospholipids via Nrf2

Michael R. Elliott, F. Gruber, K. Ravichandran, 2010, Circulation research.

Hypoxic pulmonary vasoconstriction requires endothelial signal conduction via connexin 40

W. Kuebler, I. Fleming, Eduardo Barbosa-Sicard, 2012 .

Biological and biophysical properties of vascular connexin channels.

B. Isakson, S. Johnstone, Darren Locke, 2009, International review of cell and molecular biology.

Connexins: gaps in our knowledge of vascular function.

B. Duling, B. Isakson, X. Figueroa, 2004, Physiology.

Enhanced connexin 43 expression delays intra‐mitoitc duration and cell cycle traverse independently of gap junction channel function

R. Errington, B. Isakson, S. Johnstone, 2010, Journal of cellular biochemistry.

Spontaneous lung dysfunction and fibrosis in mice lacking connexin 40 and endothelial cell connexin 43.

A. Zarbock, B. Duling, M. Billaud, 2011, The American journal of pathology.

Vascular Expression of Hemoglobin Alpha in Antarctic Icefish Vascular Expression of Hemoglobin Alpha in Antarctic Icefish Supports Iron Limitation as Novel Evolutionary Driver Supports Iron Limitation as Novel Evolutionary Driver

Bruce A. Corliss, S. Peirce, J. Beers, 2023 .

Pannexin1 Regulates &agr;1-Adrenergic Receptor– Mediated Vasoconstriction

K. Ravichandran, D. Laird, M. Billaud, 2011, Circulation research.

Expression of Pannexin Isoforms in the Systemic Murine Arterial Network

D. Laird, M. Billaud, B. Isakson, 2012, Journal of Vascular Research.

Vascular Endothelial Barrier Protection Prevents Atrial Fibrillation by Preserving Cardiac Nanostructure

B. Isakson, S. Johnstone, R. Veeraraghavan, 2023, bioRxiv.

Quantitative Morphological Analysis of Super-resolution Images Provides Validation of Novel Therapies to Prevent Atrial Fibrillation

B. Isakson, S. Johnstone, R. Veeraraghavan, 2022, Microscopy and Microanalysis.

Two functionally distinct pools of eNOS in endothelium are facilitated by myoendothelial junction lipid composition.

B. Isakson, A. Straub, L. Biwer, 2016, Biochimica et biophysica acta.

Incidence of protein on actin bridges between endothelium and smooth muscle in arterioles demonstrates heterogeneous connexin expression and phosphorylation.

B. Duling, B. Isakson, Angela K. Best, 2008, American journal of physiology. Heart and circulatory physiology.

Heme metabolism in nonerythroid cells

E. Tolosano, B. Isakson, Luke S. Dunaway, 2024, The Journal of biological chemistry.

Pannexin 1 Channels Control Cardiomyocyte Metabolism and Neutrophil Recruitment During Non-Ischemic Heart Failure

M. Okusa, B. Isakson, Abigail G. Wolpe, 2023, bioRxiv.

Smooth muscle cell-specific deletion of Col15a1 unexpectedly leads to impaired development of advanced atherosclerotic lesions.

J. Connelly, G. Owens, Yu-Qing Zhou, 2017, American journal of physiology. Heart and circulatory physiology.

"Yin and Yang" for Notch signaling in the mature vasculature.

B. Isakson, Miranda E. Good, 2018, American journal of physiology. Heart and circulatory physiology.