D. Vučić

发表

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

S. Lipton, A. Ciechanover, T. Luedde, 2018, Cell Death & Differentiation.

The Balance of TNF Mediated Pathways Regulates Inflammatory Cell Death Signaling in Healthy and Diseased Tissues

J. Webster, D. Vučić, 2020, Frontiers in Cell and Developmental Biology.

Intracellular regulation of TNF activity in health and disease.

D. Vučić, E. Varfolomeev, 2018, Cytokine.

Diverse ubiquitin linkages regulate RIP kinases-mediated inflammatory and cell death signaling

D. Vučić, Domagoj Vucic, A. Witt, 2017, Cell Death and Differentiation.

RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury

N. van Bruggen, M. Hedehus, J. DeVoss, 2016, Cell Death and Differentiation.

Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death

Vishva M. Dixit, V. Dixit, I. Wertz, 2011, Nature Reviews Molecular Cell Biology.

(Un)expected roles of c-IAPs in apoptotic and NFκB signaling pathways

D. Vučić, Domagoj Vucic, Eugene Varfolomeev, 2008 .

Targeting Cell Death Pathways for Therapeutic Intervention in Kidney Diseases.

D. Vučić, J. Garg, 2016, Seminars in nephrology.

Cellular Inhibitors of Apoptosis Are Global Regulators of NF-κB and MAPK Activation by Members of the TNF Family of Receptors

H. Maecker, K. Deshayes, K. Zobel, 2012, Science Signaling.

MAPK Activation by Members of the TNF Family of Receptors Cellular Inhibitors of Apoptosis Are Global Regulators

H. Maecker, K. Deshayes, K. Zobel, 2012 .

Workshop summary: novel aspects of the functions of the TRAFs and cIAPs.

J. Silke, D. Vučić, 2011, Advances in experimental medicine and biology.

Inhibitor of apoptosis proteins: fascinating biology leads to attractive tumor therapeutic targets.

D. Vučić, E. Varfolomeev, 2011, Future oncology.

IAP Antagonists Induce Autoubiquitination of c-IAPs, NF-κB Activation, and TNFα-Dependent Apoptosis

Vishva M. Dixit, V. Dixit, J. Blankenship, 2007, Cell.

Molecular Determinants of Kinase Pathway Activation by Apo2 Ligand/Tumor Necrosis Factor-related Apoptosis-inducing Ligand*

D. Lawrence, H. Maecker, A. Ashkenazi, 2005, Journal of Biological Chemistry.

Necroptosis: Pathway diversity and characteristics.

D. Vučić, M. C. de Almagro, M. de Almagro, 2015, Seminars in cell & developmental biology.

Ubiquitination in disease pathogenesis and treatment

Ivan Dikic, I. Dikic, Doris Popovic, 2014, Nature Medicine.

The Inhibitor of Apoptosis Proteins as Therapeutic Targets in Cancer

W. Fairbrother, D. Vučić, Domagoj Vucic, 2007, Clinical Cancer Research.

c-IAP1 and c-IAP2 Are Critical Mediators of Tumor Necrosis Factor α (TNFα)-induced NF-κB Activation*

W. Fairbrother, K. Deshayes, K. Zobel, 2008, Journal of Biological Chemistry.

OTUB1 modulates c‐IAP1 stability to regulate signalling pathways

D. Arnott, K. Deshayes, D. Kirkpatrick, 2013, The EMBO journal.

TRAF2 and cellular IAPs: a critical link in TNFR family signaling.

D. Vučić, 2011, Advances in experimental medicine and biology.

X Chromosome-linked Inhibitor of Apoptosis Regulates Cell Death Induction by Proapoptotic Receptor Agonists

A. Ashkenazi, W. Fairbrother, H. Wong, 2009, The Journal of Biological Chemistry.

Targeting inhibitor of apoptosis proteins for therapeutic intervention.

D. Vučić, E. Varfolomeev, Chudi O. Ndubaku, 2009, Future medicinal chemistry.

The Inhibitor of Apoptosis Protein Fusion c-IAP2·MALT1 Stimulates NF-κB Activation Independently of TRAF1 AND TRAF2*

V. Dixit, W. Fairbrother, S. Wayson, 2006, Journal of Biological Chemistry.

Inhibition of reaper-induced apoptosis by interaction with inhibitor of apoptosis proteins (IAPs).

A. Harvey, W. Kaiser, D. Vučić, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Activity of Protein Kinase RIPK3 Determines Whether Cells Die by Necroptosis or Apoptosis

L. Komuves, S. Warming, V. Dixit, 2014, Science.

Improved Quantitative Mass Spectrometry Methods for Characterizing Complex Ubiquitin Signals

R. Kelley, V. Dixit, D. Arnott, 2010, Molecular & Cellular Proteomics.

Antagonists Induce a Conformational Change in cIAP1 That Promotes Autoubiquitination

S. Hymowitz, A. M. Giannetti, W. Fairbrother, 2011, Science.

Inhibitor of Apoptosis Proteins (IAPs) and Their Antagonists Regulate Spontaneous and Tumor Necrosis Factor (TNF)-induced Proinflammatory Cytokine and Chemokine Production*

S. Cullen, Seamus J. Martin, C. Kearney, 2012, The Journal of Biological Chemistry.

The Indian cobra reference genome and transcriptome enables comprehensive identification of venom toxins

Markus S. Schröder, Brendan K Faherty, Oommen K. Mathew, 2020, Nature Genetics.

RIP1 post-translational modifications.

D. Vučić, E. Varfolomeev, 2022, The Biochemical journal.

XIAP promotes melanoma growth by inducing tumour neutrophil infiltration

T. Tüting, P. Zigrino, C. Mauch, 2022, EMBO reports.

Smac mimetic bypasses apoptosis resistance in FADD- or caspase-8-deficient cells by priming for tumor necrosis factor α-induced necroptosis.

A. Schier, M. Bertrand, P. Vandenabeele, 2011, Neoplasia.

Pathophysiological Complexity of Amiodarone-Induced Hypothyroidism (AIH) in patient With Congenital Heart Disease- Ebstein Anomaly: a case report

D. Vučić, Zvonimir Bosnić, L. Majnarić, 2021 .

Coordinated ubiquitination and phosphorylation of RIP1 regulates necroptotic cell death

J. Webster, D. Kirkpatrick, K. Newton, 2016, Cell Death and Differentiation.

A solid-phase approach for the synthesis of muramyl dipeptide conjugates for detection of NOD2.

L. Komuves, Aimin Song, D. Vučić, 2021, Bioorganic chemistry.

RIP1 kinase activity is critical for skin inflammation but not for viral propagation

Min Xu, J. Webster, Summer Park, 2020, Journal of leukocyte biology.

Cellular IAP proteins and LUBAC differentially regulate necrosome-associated RIP1 ubiquitination

K. Newton, D. Vučić, T. Goncharov, 2015, Cell Death and Disease.

Perfusate Oncotic Pressure During Cardiopulmonary Bypass

P. Schüpbach, D. Vučić, W. Schilt, 1978 .

Pathophysiological association of catecholamine stress in a patient with Takotsubo cardiomyopathy and chronic kidney disease

D. Vučić, N. Leko, B. Miškić, 2021, Medicina Fluminensis.

Antagonism of c-IAP and XIAP proteins is required for efficient induction of cell death by small-molecule IAP antagonists.

S. Hymowitz, W. Fairbrother, K. Deshayes, 2009, ACS chemical biology.

Masking MALT1: the paracaspase's potential for cancer therapy

V. Dixit, D. Vučić, 2009, The Journal of experimental medicine.

Effect of Iron Deficiency Anemia and Other Clinical Conditions on Hemoglobin A1c Levels

D. Vučić, Zvonimir Bosnić, Karolina Veselski, 2019 .

Antagonists of IAP proteins as cancer therapeutics.

D. Vučić, Jasmin N. Dynek, 2013, Cancer letters.

The Development of Small-Molecule IAP Antagonists for the Treatment of Cancer

K. Deshayes, J. Murray, D. Vučić, 2012 .

Kinase inhibition in autoimmunity and inflammation

A. Zarrin, P. Lupardus, D. Vučić, 2020, Nature reviews. Drug discovery.

c-IAP1 AND c-IAP2 ARE CRITICAL MEDIATORS OF TNF α -INDUCED NF- κ B ACTIVATION

W. Fairbrother, K. Deshayes, K. Zobel, 2008 .

Diagnostic complexity of rifampicin-induced coagulopathy in a patient with spontaneous muscle bleeding

D. Vučić, B. Miškić, Krešimir Gabaldo, 2021, Medicine.

Requirement of nuclear factor κB for Smac mimetic-mediated sensitization of pancreatic carcinoma cells for gemcitabine-induced apoptosis.

S. Fulda, K. Deshayes, K. Debatin, 2011, Neoplasia.

Development of novel drugs targeting inhibitors of apoptosis.

J. Flygare, D. Vučić, 2009, Future oncology.

Perfusate oncotic pressure during cardiopulmonary bypass. Optimum level as determined by metabolic acidosis, tissue edema, and renal function.

P. Schüpbach, D. Vučić, W. Schilt, 1978, Vox sanguinis.

Potent and selective inhibitors of receptor-interacting protein kinase 1 that lack an aromatic back pocket group.

G. L. Hamilton, Adam R. Johnson, C. Eigenbrot, 2019, Bioorganic & medicinal chemistry letters.

Cell death pathways: intricate connections and disease implications

D. Vučić, Matthias Kist, 2021, The EMBO journal.

Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152).

Zhaoyang Wen, Brigitte Maurer, Vickie Tsui, 2012, Journal of medicinal chemistry.

Targeting IAP proteins for therapeutic intervention in cancer

S. Fulda, D. Vučić, 2012, Nature Reviews Drug Discovery.

Microphthalmia-associated transcription factor is a critical transcriptional regulator of melanoma inhibitor of apoptosis in melanomas.

J. Zha, Jinfeng Liu, W. Fairbrother, 2008, Cancer research.

Roles of c-IAP proteins in TNF receptor family activation of NF-κB signaling.

D. Vučić, E. Varfolomeev, T. Goncharov, 2015, Methods in molecular biology.

Baculovirus-based Genetic Screen for Antiapoptotic Genes Identifies a Novel IAP*

S. Seshagiri, V. Dixit, James Lee, 1999, The Journal of Biological Chemistry.

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

S. Lipton, A. Ciechanover, T. Luedde, 2018, Cell Death & Differentiation.

cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production

M. Bertrand, P. Vandenabeele, S. Fulda, 2011, Cell Death and Differentiation.

OTULIN limits cell death and inflammation by deubiquitinating LUBAC

L. Komuves, S. Warming, V. Dixit, 2018, Nature.

Kinase inhibition in autoimmunity and inflammation

A. Zarrin, P. Lupardus, D. Vučić, 2020, Nature reviews. Drug discovery.

Ubiquitin Ligases cIAP1 and cIAP2 Limit Cell Death to Prevent Inflammation.

V. Dixit, J. Webster, Jeffrey Hung, 2019, Cell reports.

Targeting IAP proteins for therapeutic intervention in cancer

Simone Fulda, S. Fulda, D. Vučić, 2012, Nature Reviews Drug Discovery.

IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis.

Vishva M Dixit, V. Dixit, J. Blankenship, 2007, Cell.

Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf

V. Dixit, D. French, S. Mariathasan, 2004, Nature.

RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases

Adam R. Johnson, M. van Lookeren Campagne, J. Webster, 2019, Cell Death & Differentiation.

The kinase IRAK4 promotes endosomal TLR and immune complex signaling in B cells and plasmacytoid dendritic cells

A. Zarrin, S. Warming, J. Hackney, 2020, Science Signaling.

Structure of human RIPK1 kinase domain in complex with GNE684

Adam R. Johnson, M. van Lookeren Campagne, J. Webster, 2019 .

Disruption of XIAP-RIP2 Association Blocks NOD2-Mediated Inflammatory Signaling.

Melinda M. Mulvihill, J. DeVoss, W. Fairbrother, 2018, Molecular cell.

The kinase TPL2 activates ERK and p38 signaling to promote neutrophilic inflammation

Z. Modrušan, J. DeVoss, A. Zarrin, 2017, Science Signaling.

c‐IAP1 and UbcH5 promote K11‐linked polyubiquitination of RIP1 in TNF signalling

W. Fairbrother, K. Deshayes, E. Dueber, 2010, The EMBO journal.

Characterization of reaper- and FADD-induced apoptosis in a lepidopteran cell line

S. Seshagiri, D. Vučić, L. Miller, 1997, Molecular and cellular biology.

Genetic inactivation of RIP1 kinase activity in rats protects against ischemic brain injury

K. Stark, J. Webster, E. Verschueren, 2021, Cell Death and Disease.

Immunoblot Analysis of the Regulation of TNF Receptor Family-Induced NF-κB Signaling by c-IAP Proteins.

D. Vučić, E. Varfolomeev, T. Goncharov, 2021, Methods in molecular biology.

IAP antagonist GDC-0917 is more potent than Debio1143 in promoting cell death, c-IAP1 degradation and tumor growth inhibition

W. Fairbrother, B. Alicke, S. Gould, 2022, Cell Death & Disease.

The inhibitor of apoptosis (IAP) proteins are critical regulators of signaling pathways and targets for anti-cancer therapy.

D. Vučić, M. C. de Almagro, M. de Almagro, 2012, Experimental oncology.

Regulation of Cell Death and Immunity by XIAP.

P. Jost, D. Vučić, 2019, Cold Spring Harbor perspectives in biology.

Ubiquitin binding modulates IAP antagonist-stimulated proteasomal degradation of c-IAP1 and c-IAP2(1).

D. Arnott, J. Blankenship, W. Fairbrother, 2009, The Biochemical journal.

Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP.

K. Das, G. Salvesen, W. Fairbrother, 2005, The Biochemical journal.

A Mutational Analysis of the Baculovirus Inhibitor of Apoptosis Op-IAP*

W. Kaiser, D. Vučić, L. Miller, 1998, The Journal of Biological Chemistry.

The Drosophila inhibitor of apoptosis D‐IAP1 suppresses cell death induced by the caspase drICE

W. Kaiser, D. Vučić, Lois Miller, 1998, FEBS letters.

Inhibitor of Apoptosis Proteins Physically Interact with and Block Apoptosis Induced by Drosophila Proteins HID and GRIM

W. Kaiser, D. Vučić, Lois Miller, 1998, Molecular and Cellular Biology.

Evasion of cell death is a characteristic feature of human

S. Fulda, D. Vučić, 2012 .

IAP family of cell death and signaling regulators.

J. Silke, D. Vučić, John Silke, 2014, Methods in enzymology.

Ubiquitin Ligases in Cancer: Ushers for Degradation

K. Newton, D. Vučić, 2007, Cancer investigation.

SMAC Negatively Regulates the Anti-apoptotic Activity of Melanoma Inhibitor of Apoptosis (ML-IAP)*

V. Dixit, W. Fairbrother, K. Deshayes, 2002, The Journal of Biological Chemistry.

ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas

G. Salvesen, V. Dixit, H. Stennicke, 2000, Current Biology.

IAP Proteins and Their Therapeutic Potential

D. Vučić, 2014 .

Characterization of ML-IAP protein stability and physiological role in vivo.

J. Zha, W. Fairbrother, K. Deshayes, 2012, The Biochemical journal.

Inhibitor of Apoptosis Proteins, the Sentinels of Cell Death and Signaling

D. Vučić, M. Almagro, 2016 .

Ubiquitination profiling identifies sensitivity factors for IAP antagonist treatment.

Alexandre Masselot, Donald S Kirkpatrick, Corey E Bakalarski, 2015, The Biochemical journal.

c-IAP 1 and UbcH 5 promote K 11-linked polyubiquitination of RIP 1 in TNF signaling

W. Fairbrother, K. Deshayes, E. Dueber, 2010 .

Orally bioavailable antagonists of inhibitor of apoptosis proteins based on an azabicyclooctane scaffold.

Vickie Tsui, Frederick Cohen, Harvey Wong, 2009, Journal of medicinal chemistry.

A senescence-inflammatory switch from cancer-inhibitory to cancer-promoting mechanism.

K. Alitalo, M. Oren, T. Stiewe, 2013, Cancer cell.

Smac mimetic sensitizes glioblastoma cells to Temozolomide-induced apoptosis in a RIP1- and NF-κB-dependent manner

S. Fulda, K. Deshayes, K. Debatin, 2013, Oncogene.

(Un)expected roles of c-IAPs in apoptotic and NFkappaB signaling pathways.

D. Vučić, Domagoj Vucic, Eugene Varfolomeev, 2008, Cell cycle.

Ubiquitination in the regulation of inflammatory cell death and cancer

I. Wertz, Si-Han Chen, D. Vučić, 2021, Cell Death & Differentiation.

Impaired RIPK1 ubiquitination sensitizes mice to TNF toxicity and inflammatory cell death

L. Komuves, J. Webster, D. Dugger, 2020, Cell Death & Differentiation.

Alopecia in preexisting autoimmune thyroid disease in family medicine practice: can hyperprolactinemia induce hair loss? A case report.

D. Vučić, Zvonimir Bosnić, Ljiljana Trtica Majnarić, 2021, Acta dermatovenerologica Alpina, Pannonica, et Adriatica.

The Role of Ubiquitination in TWEAK-Stimulated Signaling

D. Vučić, 2013, Front. Immunol..

Immunoaffinity enrichment coupled to quantitative mass spectrometry reveals ubiquitin-mediated signaling events.

Donald S Kirkpatrick, D. Kirkpatrick, Lilian Phu, 2015, Journal of molecular biology.

Low Psychological Resilience in Older Individuals: An Association with Increased Inflammation, Oxidative Stress and the Presence of Chronic Medical Conditions

T. Wittlinger, T. Kurevija, D. Vučić, 2021, International journal of molecular sciences.

Identification of RIP1 as a critical mediator of Smac mimetic-mediated sensitization of glioblastoma cells for Drozitumab-induced apoptosis

C. Calaminus, S. Fulda, B. Pichler, 2015, Cell Death and Disease.

Smac mimetic induces cell death in a large proportion of primary acute myeloid leukemia samples, which correlates with defined molecular markers

L. Bullinger, K. Döhner, R. Schlenk, 2016, Oncotarget.

Severe difficulties in management of rare aortoiliac occlusive disease in patient with comorbidity in primary health care. Is Leriche syndrome unrecognized enough? A case report

D. Vučić, Ljiljana Trtica Majnarić, S. Guljaš, 2021, Journal of Case Reports and Images in Medicine.

Ubiquitin in inflammation: the right linkage makes all the difference

J. Corn, D. Vučić, 2014, Nature Structural &Molecular Biology.

Apoptotic cell death in disease—Current understanding of the NCCD 2023

S. Lipton, A. Ciechanover, T. Luedde, 2023, Cell Death & Differentiation.

Atypical presentation and pathogenesis of a macaque lymphocryptoviral-associated B-cell lymphoma in a cynomolgus monkey.

S. Durinck, Niraj Tripathi, W. Halpern, 2020, Veterinary clinical pathology.

Right Heart Morphology and Its Association With Excessive and Deficient Cardiac Visceral Adipose Tissue

D. Vučić, K. Selthofer-Relatić, T. Belovari, 2021, Clinical Medicine Insights. Cardiology.

Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells

A. Harris, M. Belvin, A. Jubb, 2011, Proceedings of the National Academy of Sciences.

Structure and function analysis of peptide antagonists of melanoma inhibitor of apoptosis (ML-IAP).

M. Distefano, W. Fairbrother, K. Deshayes, 2003, Biochemistry.

Genetic inactivation of RIP1 kinase does not ameliorate disease in a mouse model of ALS

K. Stark, J. Webster, O. Foreman, 2020, Cell Death & Differentiation.

Protease activity of MALT1: a mystery unravelled.

D. Kirchhofer, D. Vučić, 2012, The Biochemical journal.

Mental and Cognitive Disorders in Older People With Subclinical Thyroid Conditions

D. Vučić, Zvonimir Bosnić, L. Majnarić, 2020 .

Primary Amine Tethered Small Molecules Promote the Degradation of X-Linked Inhibitor of Apoptosis Protein.

Melinda M. Mulvihill, I. Wertz, W. Fairbrother, 2021, Journal of the American Chemical Society.

XIAP deletion sensitizes mice to TNF-induced and RIP1-mediated death

J. Webster, D. Dugger, K. Newton, 2023, Cell Death & Disease.

Targeting IAP (inhibitor of apoptosis) proteins for therapeutic intervention in tumors.

D. Vučić, 2008, Current Cancer Drug Targets.

Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs.

W. Fairbrother, K. Deshayes, K. Zobel, 2006, ACS chemical biology.

OTULIN limits cell death and inflammation by deubiquitinating LUBAC

L. Komuves, S. Warming, V. Dixit, 2018, Nature.

A phase I, randomized, ascending‐dose study to assess safety, pharmacokinetics, and activity of GDC‐8264, a RIP1 inhibitor, in healthy volunteers

Yuan Chen, M. Rothenberg, J. Mao, 2023, Clinical and translational science.

RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases

Adam R. Johnson, M. van Lookeren Campagne, J. Webster, 2019, Cell Death & Differentiation.

Inhibition of RIP1 improves immune reconstitution and reduces GVHD mortality while preserving graft-versus-leukemia effects

M. Rothenberg, D. Vučić, Alberto Utrero-Rico, 2023, Science Translational Medicine.

Association of intestinal inflammation and permeability markers with clinical manifestations of Parkinson's disease.

D. Vučić, B. Miškić, V. Pekić, 2024, Parkinsonism & related disorders.

Simultaneous substrate and ubiquitin modification recognition by bispecific antibodies enables detection of ubiquitinated RIP1 and RIP2

D. Vučić, Erick R. Castellanos, M. Matsumoto, 2024, Science Signaling.

Immunomodulatory effects and improved outcomes with cisplatin- versus carboplatin-based chemotherapy plus atezolizumab in urothelial cancer

S. Mariathasan, R. Banchereau, D. Vučić, 2024, Cell reports. Medicine.