H. Greenblatt

发表

Flexibility of metal binding sites in proteins on a database scale

V. Sobolev, M. Edelman, Mariana Babor, 2005, Proteins.

J. Sussman, I. Silman, H. Greenblatt, 2007, Journal of Molecular Neuroscience.

Crystallographic snapshots of nonaged and aged conjugates of soman with acetylcholinesterase, and of a ternary complex of the aged conjugate with pralidoxime.

J. Sussman, I. Silman, M. Froment, 2009, Journal of medicinal chemistry.

The complex of a bivalent derivative of galanthamine with torpedo acetylcholinesterase displays drastic deformation of the active-site gorge: implications for structure-based drug design.

Joel L Sussman, Israel Silman, Bernard Badet, 2004, Journal of the American Chemical Society.

Crystal structures of complexes of N-butyl- and N-nonyl-deoxynojirimycin bound to acid beta-glucosidase: insights into the mechanism of chemical chaperone action in Gaucher disease.

Joel L Sussman, Israel Silman, J. Sussman, 2007, The Journal of biological chemistry.

Structure of estradiol metal chelate and estrogen receptor complex: the basis for designing a new class of selective estrogen receptor modulators.

O. Dym, S. Albeck, J. Sussman, 2011, Journal of medicinal chemistry.

Aminopeptidase from Streptomyces griseus: primary structure and comparison with other zinc-containing aminopeptidases.

G. Shoham, B. Maras, D. Barra, 1996, European journal of biochemistry.

The crystal structure of a complex of acetylcholinesterase with a bis-(-)-nor-meptazinol derivative reveals disruption of the catalytic triad.

Yun Tang, J. Sussman, Wei-Chang Fu, 2009, Journal of medicinal chemistry.

Carboxypeptidase A: native, zinc-removed and mercury-replaced forms.

P. Tucker, G. Shoham, H. Greenblatt, 1998, Acta crystallographica. Section D, Biological crystallography.

Glycosylation May Reduce Protein Thermodynamic Stability by Inducing a Conformational Distortion.

Y. Levy, Y. Gavrilov, H. Greenblatt, 2015, The journal of physical chemistry letters.

Effect of mutations within the peripheral anionic site on the stability of acetylcholinesterase.

S. Wodak, J. Sussman, I. Silman, 1999, Molecular pharmacology.

What Are the Molecular Requirements for Protein Sliding along DNA?

Y. Levy, H. Greenblatt, Lavi S. Bigman, 2021, The journal of physical chemistry. B.

Does PCNA diffusion on DNA follow a rotation-coupled translation mechanism?

H. Rozenberg, Y. Levy, H. Greenblatt, 2020, Nature Communications.

Structural studies on vertebrate and invertebrate acetylcholinesterases and their complexes with functional ligands

J. Sussman, I. Silman, H. Greenblatt, 2000 .

Acetylcholinesterase complexed with bivalent ligands related to huperzine a: experimental evidence for species-dependent protein-ligand complementarity.

Yuan-Ping Pang, Joel L Sussman, Israel Silman, 2003, Journal of the American Chemical Society.

Structure of the complex of Streptomyces griseus proteinase B and polypeptide chymotrypsin inhibitor-1 from Russet Burbank potato tubers at 2.1 A resolution.

M. James, C. Ryan, H. Greenblatt, 1989, Journal of molecular biology.

Structural insights into substrate traffic and inhibition in acetylcholinesterase

Jure Stojan, Giuseppe Zaccai, Israel Silman, 2006, The EMBO journal.

Structure of acetylcholinesterase complexed with (−)‐galanthamine at 2.3 Å resolution

J L Sussman, I Silman, J. Sussman, 1999, FEBS letters.

Refined structure of bovine carboxypeptidase A at 1.25 A resolution.

M. Glick, A. Goldblum, G. Shoham, 2003, Acta crystallographica. Section D, Biological crystallography.

Variations in Core Packing of GP2 from Old World Mammarenaviruses in their Post-Fusion Conformations Affect Membrane-Fusion Efficiencies.

Y. Levy, R. Diskin, H. Cohen-Dvashi, 2019, Journal of molecular biology.

A preliminary comparison of structural models for catalytic intermediates of acetylcholinesterase.

J L Sussman, I Silman, J. Sussman, 1999, Chemico-biological interactions.

Three-dimensional structure of a halotolerant algal carbonic anhydrase predicts halotolerance of a mammalian homolog.

J. Sussman, L. Premkumar, I. Gokhman, 2005, Proceedings of the National Academy of Sciences of the United States of America.

A structure-based design approach to the development of novel, reversible AChE inhibitors.

J L Sussman, I Silman, J. Sussman, 2001, Journal of medicinal chemistry.

Negatively charged, intrinsically disordered regions can accelerate target search by DNA-binding proteins

Y. Levy, J. Iwahara, H. Greenblatt, 2023, Nucleic acids research.

Structure of recombinant human carboxylesterase 1 isolated from whole cabbage looper larvae.

J. Sussman, E. Kovaleva, G. Buchman, 2012, Acta crystallographica. Section F, Structural biology and crystallization communications.

Yeast Mpd1p reveals the structural diversity of the protein disulfide isomerase family.

C. Sevier, C. Kaiser, D. Fass, 2008, Journal of molecular biology.

Identification, cDNA cloning, expression, crystallization and preliminary X-ray analysis of an exceptionally halotolerant carbonic anhydrase from Dunaliella salina.

J. Sussman, L. Premkumar, I. Gokhman, 2003, Acta crystallographica. Section D, Biological crystallography.

Criteria for selecting PEGylation sites on proteins for higher thermodynamic and proteolytic stability.

Maxim B. Prigozhin, Minnie I Langlois, Y. Levy, 2014, Journal of the American Chemical Society.

Complexes of alkylene-linked tacrine dimers with Torpedo californica acetylcholinesterase: Binding of Bis5-tacrine produces a dramatic rearrangement in the active-site gorge.

Yuan-Ping Pang, Joel L Sussman, Israel Silman, 2006, Journal of medicinal chemistry.

Crystal Structures of “Aged” Phosphorylated and Phosphonylated Torpedo Californica Acetylcholinesterase

J. Sussman, I. Silman, M. Harel, 1998 .

Streptomyces griseus aminopeptidase: X-ray crystallographic structure at 1.75 A resolution.

O. Almog, G. Shoham, B. Maras, 1997, Journal of molecular biology.

Diffusion of ring-shaped proteins along DNA: case study of sliding clamps

Y. Levy, H. Greenblatt, Dina Daitchman, 2018, Nucleic acids research.

Crystal structures of aged phosphonylated acetylcholinesterase: nerve agent reaction products at the atomic level.

J. Sussman, I. Silman, M. Harel, 1999, Biochemistry.

The 0.93A crystal structure of sphericase: a calcium-loaded serine protease from Bacillus sphaericus.

O. Almog, G. Shoham, Ana González, 2003, Journal of molecular biology.

Dynamic autoinhibition of the HMGB1 protein via electrostatic fuzzy interactions between intrinsically disordered regions.

Y. Levy, J. Iwahara, H. Greenblatt, 2021, Journal of molecular biology.

Flexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulations.

Jianhua He, Orly Dym, Joel L Sussman, 2012, Acta crystallographica. Section D, Biological crystallography.

Control of the rate of evaporation in protein crystallization by the ‘microbatch under oil’ method

J. Sussman, I. Silman, A. Futerman, 2008, Journal of applied crystallography.

Structural studies of the role of the active site metal in metalloenzymes

H. Feinberg, H. M. Greenblatt, G. Shoham, 1993, J. Chem. Inf. Comput. Sci..

Interactions of Streptomyces griseus aminopeptidase with a methionine product analogue: a structural study at 1.53 A resolution.

U. Lessel, D. Schomburg, G. Shoham, 2000, Acta crystallographica. Section D, Biological crystallography.

Flexibility of the flap in the active site of BACE 1 as revealed by crystal structures and molecular dynamics simulations

Hualiang Jiang, Yechun Xu, Xu Shen, 2011 .

Prerecognition Diffusion Mechanism of Human DNA Mismatch Repair Proteins along DNA: Msh2-Msh3 versus Msh2-Msh6

Y. Levy, Arumay Pal, H. Greenblatt, 2020, Biochemistry.

Crystal structure of YagE, a putative DHDPS‐like protein from Escherichia coli K12

Y. Peleg, O. Dym, S. Albeck, 2008, Proteins.

Inhibition of Streptomyces griseus aminopeptidase and effects of calcium ions on catalysis and binding--comparisons with the homologous enzyme Aeromonas proteolytica aminopeptidase.

U. Lessel, D. Schomburg, G. Shoham, 1998, European Journal of Biochemistry.

Flexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulations

Yechun Xu, Y. Peleg, O. Dym, 2012 .

Flexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulations.

Hualiang Jiang, Yechun Xu, Xu Shen, 2012, Acta crystallographica. Section D, Biological crystallography.

Structural insights into substrate traffic and inhibition in acetylcholinesterase

I. Silman, G. Zaccai, J. Colletier, 2006, The EMBO journal.

Sound-mediated nucleation and growth of amyloid fibrils

U. Raviv, H. Greenblatt, Anna Kozell, 2023, bioRxiv.

Crystal Structures of Complexes of N-Butyl- and N-Nonyl-Deoxynojirimycin Bound to Acid β-Glucosidase

J. Sussman, I. Silman, T. Butters, 2007, Journal of Biological Chemistry.

STRUCTURE OF CARBOXYPEPTIDASE

P. Tucker, G. Shoham, H. Greenblatt, 1997 .