K. Kirkwood

发表

Periodontitis: Consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.

P. Papapanou, T. Kocher, G. Seymour, 2018, Journal of periodontology.

Efficient production of bioactive insulin from human epidermal keratinocytes and tissue-engineered skin substitutes: implications for treatment of diabetes.

S. G. Laychock, S. Andreadis, P. Lei, 2007, Tissue engineering.

Tristetraprolin regulates interleukin‐6, which is correlated with tumor progression in patients with head and neck squamous cell carcinoma

N. D’Silva, T. Carey, C. Bradford, 2011, Cancer.

Tristetraprolin regulates interleukin-6 expression through p38 MAPK-dependent affinity changes with mRNA 3' untranslated region.

N. D’Silva, Min Liu, K. Kirkwood, 2011, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

MKP-1 regulates cytokine mRNA stability through selectively modulation subcellular translocation of AUF1.

Hong-gang Yu, V. Palanisamy, C. Haycraft, 2011, Cytokine.

MKK 3 / 6p 38 MAPK Signaling Is Required for IL-1 and TNF-- Induced RANKL Expression in Bone Marrow Stromal Cells

Min Liu, K. Kirkwood, C. Rossa, 2009 .

MKK3/6-p38 MAPK Signaling Is Required for IL-1β and TNF-α-Induced RANKL Expression in Bone Marrow Stromal Cells

Min Liu, K. Kirkwood, C. Rossa, 2006 .

Non-surgical chemotherapeutic treatment strategies for the management of periodontal diseases.

K. Kirkwood, R. Leite, J. W. Krayer, 2010, Dental clinics of North America.

Targeting MAPK/MKP Signaling as a Therapeutic Axis in Periodontal Disease

K. Kirkwood, 2020 .

Potent anti-inflammatory effects of systemically administered curcumin modulate periodontal disease in vivo.

L. C. Spolidorio, K. Kirkwood, C. Rossa, 2011, Journal of periodontal research.

Novel host response therapeutic approaches to treat periodontal diseases.

J. Cirelli, W. Giannobile, K. Kirkwood, 2007, Periodontology 2000.

A p38α Selective Mitogen-Activated Protein Kinase Inhibitor Prevents Periodontal Bone Loss

N. D’Silva, J. Kreider, K. Kirkwood, 2007, Journal of Pharmacology and Experimental Therapeutics.

Actinobacillus actinomycetemcomitans lipopolysaccharide-mediated experimental bone loss model for aggressive periodontitis.

W. Giannobile, K. Kirkwood, C. Rossa, 2007, Journal of periodontology.

Sexual Dimorphism in MAPK-Activated Protein Kinase-2 (MK2) Regulation of RANKL-Induced Osteoclastogenesis in Osteoclast Progenitor Subpopulations

M. Gaestel, K. Kirkwood, M. Valerio, 2015, PloS one.

Simvastatin Inhibits LPS-induced Alveolar Bone Loss during Metabolic Syndrome

X. Zhang, M. Lopes-Virella, K. Kirkwood, 2014, Journal of dental research.

Hematopoietic Stem Cells as a Novel Source of Dental Tissue Cells

S. Mehrotra, A. Larue, M. Ogawa, 2018, Scientific Reports.

Periodontal Diseases and Oral Bone Loss

K. Kirkwood, Mary G. Lee, 2013 .

Expansion of myeloid-derived suppressor cells contributes to metabolic osteoarthritis through subchondral bone remodeling

J. Marzo, Ashley Lau, M. Anders, 2021, Arthritis Research & Therapy.

In vitro mineralization studies with substrate-immobilized bone morphogenetic protein peptides.

K. Dee, K. Kirkwood, Brian Rheude, 2003, The Journal of oral implantology.

Novel Preosteoclast Populations in Obesity-Associated Periodontal Disease

J. Sohn, K. Kirkwood, R. Thiyagarajan, 2021, Journal of dental research.

A p38 mitogen-activated protein kinase inhibitor arrests active alveolar bone loss in a rat periodontitis model.

K. Kirkwood, S. Medicherla, L. Higgins, 2007, Journal of periodontology.

Aggregatibacter actinomycetemcomitans, a potent immunoregulator of the periodontal host defense system and alveolar bone homeostasis.

K. Kirkwood, B. Herbert, C. M. Novince, 2016, Molecular oral microbiology.

blunts oral squamous cancer development and dampens the functional expansion of myeloid-derived suppressor cells

Hong-gang Yu, Yongliang Zhang, Zihai Li, 2016 .

CD24 blunts oral squamous cancer development and dampens the functional expansion of myeloid-derived suppressor cells

Hong-gang Yu, Yongliang Zhang, Zihai Li, 2016, Oncoimmunology.

DUSP1 phosphatase regulates the proinflammatory milieu in head and neck squamous cell carcinoma.

N. D’Silva, Hong-gang Yu, J. Hyer, 2014, Cancer research.

Sexual dimorphism in periapical inflammation and bone loss from mitogen-activated protein kinase phosphatase-1 deficient mice.

Hong-gang Yu, K. Kirkwood, Qiyan Li, 2012, Journal of endodontics.

Sexual Dimorphism in Periapical Inflammation and Bone Loss from MAP Kinase Phosphatase-1 Deficient Mice

K. Kirkwood, Qiyan Li, Justin McAbee, 2012 .

Anti-inflammatory effect of MAPK phosphatase-1 local gene transfer in inflammatory bone loss

C. R. Júnior, K. Kirkwood, Qiyan Li, 2011, Gene Therapy.

MAP Kinase Phosphatase-1 Protects against Inflammatory Bone Loss

F. Li, K. Kirkwood, R. Sartori, 2009, Journal of dental research.

The potential of p38 MAPK inhibitors to modulate periodontal infections.

K. Kirkwood, C. Rossa, 2009, Current drug metabolism.

Antibiotic Class Agent Effect Target Organisms Limitation Penicillin Amoxicillin Bacteriocidal Gram + and Gram-Penicillinase sensitive Patient hypersensitivity Augmentin

K. Kirkwood, R. Leite, 2018 .

Present and Future Non-Surgical Therapeutic Strategies for the Management of Periodontal Diseases

K. Kirkwood, R. Leite, 2012 .

Mean annual attachment, bone level, and tooth loss: A systematic review

A. Petrie, T. Kocher, R. Garcia, 2018, Journal of clinical periodontology.

p38alpha stabilizes interleukin-6 mRNA via multiple AU-rich elements.

Min Liu, K. Kirkwood, Wenpu Zhao, 2008, The Journal of biological chemistry.

CD36 is upregulated in mice with periodontitis and metabolic syndrome and involved in macrophage gene upregulation by palmitate.

M. Lopes-Virella, K. Kirkwood, Y. Huang, 2017, Oral diseases.

Dietary carbohydrate intake is associated with the subgingival plaque oral microbiome abundance and diversity in a cohort of postmenopausal women

J. Freudenheim, J. Wactawski‐Wende, M. Buck, 2022, Scientific Reports.

Inositol trisphosphate receptor gene expression and hormonal regulation in osteoblast‐like cell lines and primary osteoblastic cell cultures

P. Bradford, K. Kirkwood, R. Dziak, 1996, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Prostaglandin production by human gingival fibroblasts inhibited by triclosan in the presence of cetylpyridinium chloride.

K. Kirkwood, C. Rossa, Young Joon Kim, 2005, Journal of periodontology.

MKP-1 is essential for canonical vitamin D-induced signaling through nuclear import and regulates RANKL expression and function.

M. Kern, K. Kirkwood, Alfred C. Griffin, 2012, Molecular endocrinology.

Critical role of MKP-1 in lipopolysaccharide-induced osteoclast formation through CXCL1 and CXCL2.

Hong-gang Yu, K. Kirkwood, M. Valerio, 2015, Cytokine.

p38 MAPK Regulates IL‐1β Induced IL‐6 Expression Through mRNA Stability in Osteoblasts

K. Kirkwood, C. Rossa, C. Patil, 2004, Immunological investigations.

Periodontal condition in patients with rheumatoid arthritis.

M. Bértolo, K. Kirkwood, C. Rossa, 2008, Brazilian oral research.

Myeloid-Derived Suppressor Cells at the Intersection of Inflammaging and Bone Fragility

K. Seldeen, B. Troen, K. Kirkwood, 2018, Immunological investigations.

Sex‐based differential regulation of bacterial‐induced bone resorption

K. Kirkwood, Michael B Chavez, M. Valerio, 2017, Journal of periodontal research.

LPS Induces Greater Bone and PDL Loss in SPARC-null Mice

C. Rossa, K. Kirkwood, H. Yu, 2011, Journal of dental research.

Is Monocyte Chemotactic Protein 1 Elevated in Aseptic Loosening of TKA?: A Pilot Study

S. Gaffen, K. Kirkwood, W. Mihalko, 2012, Clinical orthopaedics and related research.

Curcumin modulates the immune response associated with LPS-induced periodontal disease in rats

L. C. Spolidorio, K. Kirkwood, C. Rossa, 2012, Innate immunity.

Tristetraprolin limits age-related expansion of myeloid-derived suppressor cells

P. Blackshear, K. Seldeen, S. Abrams, 2022, Frontiers in Immunology.

Chemically modified tetracyclines selectively inhibit IL-6 expression in osteoblasts by decreasing mRNA stability.

S. Andreadis, K. Kirkwood, Young Joon Kim, 2003, Biochemical pharmacology.

Autoimmunity to deltaNp63alpha in Chronic Ulcerative Stomatitis

K. Kirkwood, M. Zwick, L. Solomon, 2007, Journal of dental research.

Activation of vitamin D in the gingival epithelium and its role in gingival inflammation and alveolar bone loss.

Jungnam Lee, G. Diamond, K. Kirkwood, 2019, Journal of periodontal research.

Non‐antimicrobial and Antimicrobial Tetracyclines Inhibit IL‐6 Expression in Murine Osteoblasts

P. Bradford, L. Golub, K. Kirkwood, 1999, Annals of the New York Academy of Sciences.

Silencing Mitogen-Activated Protein Kinase-Activated Protein Kinase-2 Arrests Inflammatory Bone Loss

Hong-gang Yu, Angen Liu, K. Kirkwood, 2011, Journal of Pharmacology and Experimental Therapeutics.

SUBSTRATE-IMMOBILIZED BONE MORPHOGENETIC PROTEIN PEPTIDES

K. Kirkwood, Young Joon Kim, 2022 .

Acid Sphingomyelinase Deficiency Exacerbates LPS-Induced Experimental Periodontitis.

M. Lopes-Virella, K. Kirkwood, Y. Huang, 2019, Oral diseases.

Silencing matrix metalloproteinase-13 (Mmp-13) reduces inflammatory bone resorption associated with LPS-induced periodontal disease in vivo

S. Valentini, L. C. Spolidorio, K. Kirkwood, 2020, Clinical Oral Investigations.

MKK3/6—p38 MAPK negatively regulates murine MMP-13 gene expression induced by IL-1β and TNF-α in immortalized periodontal ligament fibroblasts

Min Liu, K. Kirkwood, C. Rossa, 2005 .

Metabolic Syndrome Exacerbates Inflammation and Bone Loss in Periodontitis

Yan Huang, X. Zhang, M. Lopes-Virella, 2015, Journal of dental research.

Silencing matrix metalloproteinase-13 (Mmp-13) reduces inflammatory bone resorption associated with LPS-induced periodontal disease in vivo

S. Valentini, L. C. Spolidorio, K. Kirkwood, 2020, Clinical Oral Investigations.

MKK3/6-p38 MAPK negatively regulates murine MMP-13 gene expression induced by IL-1beta and TNF-alpha in immortalized periodontal ligament fibroblasts.

Min Liu, K. Kirkwood, C. Rossa, 2005, Matrix biology : journal of the International Society for Matrix Biology.

Cementoblasts maintain expression of osteocalcin in the presence of mineral trioxide aggregate.

M. Somerman, K. Kirkwood, J. Berry, 2003, Journal of endodontics.

Periodontitis: Consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.

David Herrera, Magda Feres, William V Giannobile, 2018, Journal of clinical periodontology.

Interactions between extracellular signal‐regulated kinase 1/2 and P38 Map kinase pathways in the control of RUNX2 phosphorylation and transcriptional activity

C. Ge, Hong-gang Yu, Qian Yang, 2012, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Functionalized nanoparticles containing MKP-1 agonists reduce periodontal bone loss.

F. Alexis, K. Kirkwood, M. Valerio, 2019, Journal of periodontology.

Inhibition of acid sphingomyelinase by imipramine abolishes the synergy between metabolic syndrome and periodontitis on alveolar bone loss.

M. Lopes-Virella, K. Kirkwood, Zhongyang Lu, 2021, Journal of periodontal research.

Tristetraprolin Is Required for Alveolar Bone Homeostasis

D. Stumpo, P. Blackshear, A. Alekseyenko, 2018, Journal of dental research.

Simvastatin inhibits lipopolysaccharide-induced osteoclastogenesis and reduces alveolar bone loss in experimental periodontal disease.

X. Zhang, M. Lopes-Virella, C. Haycraft, 2014, Journal of periodontal research.

Molecular Biology of the Host-Microbe Interaction in Periodontal Diseases

K. Kirkwood, C. Rossa, 2012 .

Control of Cytokine mRNA Expression by RNA-binding Proteins and microRNAs

N. D’Silva, V. Palanisamy, K. Kirkwood, 2012, Journal of dental research.

Curcumin abrogates LPS-induced pro-inflammatory cytokines in RAW 264.7 macrophages. Evidence for novel mechanisms involving SOCS-1, -3 and p38 MAPK.

L. C. Spolidorio, K. Kirkwood, C. Rossa, 2013, Archives of oral biology.

An orthotopic floor-of-mouth model for locoregional growth and spread of human squamous cell carcinoma.

N. D’Silva, T. Carey, B. Henson, 2007, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

Kaposi's Sarcoma-Associated Herpesvirus Suppression of DUSP1 Facilitates Cellular Pathogenesis following De Novo Infection

F. Peruzzi, B. Toole, Z. Qin, 2012, Journal of Virology.

The Periodontal Microenvironment: a Potential Reservoir for Intestinal Pathobionts in Crohn’s Disease

R. Genco, Yijun Sun, J. Sohn, 2020, Current Oral Health Reports.

Inactivation or Loss of TTP Promotes Invasion in Head and Neck Cancer via Transcript Stabilization and Secretion of MMP9, MMP2, and IL-6

N. D’Silva, T. Carey, C. Bradford, 2013, Clinical Cancer Research.

Discovering Myeloid Cell Heterogeneity in Mandibular Bone – Cell by Cell Analysis

S. Abrams, J. Bard, K. Kirkwood, 2021, Frontiers in Physiology.

The p38/MKP-1 signaling axis in oral cancer: Impact of tumor-associated macrophages.

K. Kirkwood, Zhenning Li, Fayu Liu, 2020, Oral oncology.

Low-abundance biofilm species orchestrates inflammatory periodontal disease through the commensal microbiota and complement.

John D Lambris, R. Jotwani, J. Lambris, 2011, Cell host & microbe.

Mitogen-Activated Protein Kinase 2 Signaling Shapes Macrophage Plasticity in Aggregatibacter actinomycetemcomitans-Induced Bone Loss

M. Gaestel, H. Steinkamp, K. Kirkwood, 2016, Infection and Immunity.

Mitogen-activated protein kinase phosphatase 1 regulates bone mass, osteoblast gene expression, and responsiveness to parathyroid hormone.

S. Goldstein, A. Abou-Samra, J. Kreider, 2011, The Journal of endocrinology.

Functional Cooperation between Interleukin-17 and Tumor Necrosis Factor-α Is Mediated by CCAAT/Enhancer-binding Protein Family Members*

Sarah L. Gaffen, Soji Kasayama, S. Gaffen, 2004, Journal of Biological Chemistry.

p38α Stabilizes Interleukin-6 mRNA via Multiple AU-rich Elements*

Min Liu, K. Kirkwood, Wenpu Zhao, 2008, Journal of Biological Chemistry.

MKP-1 signaling events are required for early osteoclastogenesis in lineage defined progenitor populations by disrupting RANKL-induced NFATc1 nuclear translocation.

K. Kirkwood, Elizabeth G. Hill, Zhuang Wan, 2014, Bone.

Commensal Gut Microbiota Immunomodulatory Actions in Bone Marrow and Liver have Catabolic Effects on Skeletal Homeostasis in Health

H. Steinkamp, K. Kirkwood, C. Westwater, 2017, Scientific Reports.

p38 MAPK Signaling in Oral-related Diseases

K. Kirkwood, C. Patil, 2007, Journal of dental research.

Kaposi sarcoma-associated herpesvirus (KSHV) induces a functional tumor-associated phenotype for oral fibroblasts.

B. Toole, Z. Qin, L. Dai, 2012, Cancer letters.

Inhibition of human breast cancer cell proliferation in tissue culture by the neuroleptic agents pimozide and thioridazine.

K. Kirkwood, J. Worley, J. S. Strobl, 1990, Cancer research.

Inhibition of the histone demethylase KDM4B leads to activation of KDM1A, attenuates bacterial-induced pro-inflammatory cytokine release, and reduces osteoclastogenesis

P. Woster, K. Kirkwood, J. Kirkpatrick, 2018, Epigenetics.

MAPK Usage in Periodontal Disease Progression

K. Kirkwood, Qiyan Li, M. Valerio, 2012, Journal of signal transduction.

Inflammaging

K. Kirkwood, 2018, Immunological investigations.

Mean annual attachment, bone level, and tooth loss: A systematic review

A. Petrie, T. Kocher, R. Garcia, 2018, Journal of periodontology.

Periodontal disease is associated with increased gut colonization of pathogenic Haemophilus parainfluenzae in patients with Crohn’s disease

H. Tettelin, D. Smiraglia, R. Genco, 2023, Cell reports.

Oral squamous carcinoma cells secrete RANKL directly supporting osteolytic bone loss.

Fei Li, N. D’Silva, Min Liu, 2013, Oral oncology.

Loss of Expression and Function of SOCS3 Is an Early Event in HNSCC: Altered Subcellular Localization as a Possible Mechanism Involved in Proliferation, Migration and Invasion

S. Rosenzweig, D. Watson, L. C. Spolidorio, 2012, PloS one.

Alveolar Bone Homeostasis in Health and Disease

K. Kirkwood, C. M. Novince, 2018, Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism.

A dominant function of p38 mitogen-activated protein kinase signaling in receptor activator of nuclear factor-kappaB ligand expression and osteoclastogenesis induction by Aggregatibacter actinomycetemcomitans and Escherichia coli lipopolysaccharide.

K. Kirkwood, C. Rossa, M. Liu, 2008, Journal of periodontal research.

The effect of bone morphogenetic protein-7 on the expression of type I inositol 1,4,5-trisphosphate receptor in G-292 osteosarcoma cells and primary osteoblast cultures.

P. Bradford, K. Kirkwood, J. M. Maglich, 2000, Archives of oral biology.

Cloning and Characterization of the Type I Inositol 1,4,5-Trisphosphate Receptor Gene Promoter

P. Bradford, K. Kirkwood, K. Homick, 1997, The Journal of Biological Chemistry.

The G Protein–Coupled Receptor GALR2 Promotes Angiogenesis in Head and Neck Cancer

N. D’Silva, Min Liu, P. Polverini, 2014, Molecular Cancer Therapeutics.

Cancer Biology and Signal Transduction The G Protein – Coupled Receptor GALR 2 Promotes Angiogenesis in Head and Neck Cancer

N. D’Silva, Min Liu, P. Polverini, 2014 .

Actinobacillus actinomycetemcomitans lipopolysaccharide induces interleukin-6 expression through multiple mitogen-activated protein kinase pathways in periodontal ligament fibroblasts.

K. Kirkwood, C. Rossa, C. Patil, 2006, Oral microbiology and immunology.

Transcriptional activation of MMP-13 by periodontal pathogenic LPS requires p38 MAP kinase

K. Kirkwood, C. Rossa, P. Bronson, 2007, Journal of endotoxin research.

Preferential attachment of human gingival fibroblasts to the resin ionomer Geristore.

K. Kirkwood, S. Shostad, Fuwad Al-Sabek, 2005, Journal of Endodontics.

Alveolar Bone Loss: Mechanisms, Potential Therapeutic Targets, and Interventions

G. Intini, K. Kirkwood, S. Yang, 2014, Advances in dental research.

GPR40 deficiency worsens metabolic syndrome-associated periodontitis in mice.

Yan Huang, S. Wank, M. Lopes-Virella, 2023, Journal of periodontal research.

CXCL13 Activation of c-Myc Induce RANK Ligand Expression in Stromal/Preosteoblast Cells in the Oral Squamous Cell Carcinoma Tumor-Bone Microenvironment

W. Ries, S. Reddy, Angen Liu, 2012, Oncogene.

A Novel Function of CXCL13 to Stimulate RANK Ligand Expression in Oral Squamous Cell Carcinoma Cells

S. Reddy, Kumaran Sundaram, J. Norris, 2009, Molecular Cancer Research.

A Novel Function of CXCL 13 to Stimulate RANK Ligand Expression in Oral Squamous Cell Carcinoma Cells

S. Reddy, Kumaran Sundaram, J. Norris, 2009 .

Rap1GAP promotes invasion via induction of matrix metalloproteinase 9 secretion, which is associated with poor survival in low N-stage squamous cell carcinoma.

N. D’Silva, T. Carey, C. Bradford, 2008, Cancer research.

Differential expression of mitogen activating protein kinases in periodontitis.

E. Slate, N. D’Silva, K. Kirkwood, 2013, Journal of clinical periodontology.

Sustained mitogen-activated protein kinase activation with Aggregatibacter actinomycetemcomitans causes inflammatory bone loss.

K. Kirkwood, H. Yu, B. Herbert, 2012, Molecular oral microbiology.

Commensal Gut Microbiota Immunomodulatory Actions in Bone Marrow and Liver have Catabolic Effects on Skeletal Homeostasis in Health

H. Steinkamp, K. Kirkwood, C. Westwater, 2017, Scientific Reports.

MKK3/6-p38 MAPK signaling is required for IL-1beta and TNF-alpha-induced RANKL expression in bone marrow stromal cells.

Min Liu, K. Kirkwood, C. Rossa, 2006, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

Poor Survival in Low N-Stage Squamous Cell Carcinoma Metalloproteinase 9 Secretion , Which Is Associated with Rap 1 GAP Promotes Invasion via Induction of Matrix

N. D’Silva, T. Carey, C. Bradford, 2008 .

T-Cell Infiltration and Immune Checkpoint Expression Increase in Oral Cavity Premalignant and Malignant Disorders

Andy Tu, W. Hicks, A. Suresh, 2022, Biomedicines.

Subgingival microbiome is associated with alveolar bone loss measured 5-years later in postmenopausal women.

Hailey R Banack, J. Wactawski‐Wende, M. Buck, 2020, Journal of periodontology.

Gene expression profile of tissue engineered skin subjected to acute barrier disruption.

S. Andreadis, D. Brazeau, Piyush Koria, 2003, The Journal of investigative dermatology.

Hematopoietic Stem Cells as a Novel Source of Dental Tissue Cells

S. Mehrotra, M. Ogawa, S. Chatterjee, 2018, Scientific Reports.

Sexual Dimorphism in Immunity to Oral Bacterial Diseases: Intersection of Neutrophil and Osteoclast Pathobiology

K. Kirkwood, M. Valerio, 2018, Journal of dental research.