S. Dimeloe

发表

A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small cell lung cancer treated with PD-1 blockade

C. Klein, T. Schumacher, K. Mertz, 2018, Nature Medicine.

Human regulatory T cells lack the cyclophosphamide‐extruding transporter ABCB1 and are more susceptible to cyclophosphamide‐induced apoptosis

C. Hess, S. Dimeloe, Corina Frick, 2014, European journal of immunology.

Regulatory T cells, inflammation and the allergic response—The role of glucocorticoids and Vitamin D

C. Hawrylowicz, A. Nanzer, S. Dimeloe, 2010, The Journal of Steroid Biochemistry and Molecular Biology.

Tumor-derived TGF-β inhibits mitochondrial respiration to suppress IFN-γ production by human CD4+ T cells

C. Hess, D. Thommen, S. Dimeloe, 2019, Science Signaling.

Autoimmune disease and interconnections with vitamin D

K. Raza, J. Fletcher, M. Hewison, 2022, Endocrine connections.

A direct role for vitamin D-binding protein in the pathogenesis of COPD?

C. Hawrylowicz, S. Dimeloe, 2011, Thorax.

Rapid effector function of memory CD8+ T cells requires an immediate-early glycolytic switch

C. Hess, S. Dimeloe, M. Fischer, 2013, Nature Immunology.

Vitamin D and Regulatory T Cells

C. Hawrylowicz, Z. Urry, S. Dimeloe, 2012 .

Translating immunometabolism: towards curing human diseases by targeting metabolic processes underpinning the immune response

S. Dimeloe, C. Mauro, 2019, Clinical and experimental immunology.

Vitamin D and Immune Regulation: Antibacterial, Antiviral, Anti‐Inflammatory

John H. White, M. Hewison, S. Dimeloe, 2020, JBMR plus.

Journal of Steroid Biochemistry and Molecular Biology Vitamin D (1,25(OH) 2 D3) induces α -1-antitrypsin synthesis by CD4 + T cells, which is required for 1,25(OH) 2 D3-driven IL-10

P. Pfeffer, C. Hawrylowicz, J. Raynes, 2022 .

T cells producing the anti‐inflammatory cytokine IL‐10 regulate allergen‐specific Th2 responses in human airways

C. Hawrylowicz, T. Lee, C. Corrigan, 2012, Allergy.

The role of 1α,25‐dihydroxyvitamin D3 and cytokines in the promotion of distinct Foxp3+and IL‐10+ CD4+ T cells

C. Hawrylowicz, A. Bush, A. O’Garra, 2012, European journal of immunology.

Succinate uptake by T cells suppresses their effector function via inhibition of mitochondrial glucose oxidation

D. Bending, D. Tennant, S. Dimeloe, 2022, Cell reports.

The Induction of Alpha-1 Antitrypsin by Vitamin D in Human T Cells Is TGF-β Dependent: A Proposed Anti-inflammatory Role in Airway Disease

P. Pfeffer, C. Hawrylowicz, B. Gooptu, 2021, Frontiers in Nutrition.

1α,25-Dihydroxyvitamin D3 promotes CD200 expression by human peripheral and airway-resident T cells

C. Hawrylowicz, A. Bush, D. Richards, 2012, Thorax.

A glutamine ‘tug-of-war’: targets to manipulate glutamine metabolism for cancer immunotherapy

Linda V. Sinclair, L. Sinclair, A. Schurich, 2021, Immunotherapy advances.

1,25-Dihydroxyvitamin D3 suppresses CD4+ T-cell effector functionality by inhibition of glycolysis

D. Tennant, D. Chauss, M. Hewison, 2022, Immunology.

Tissue Distribution Dynamics of Human NK Cells Inferred from Peripheral Blood Depletion Kinetics after Sphingosine‐1‐Phosphate Receptor Blockade

M. Mehling, C. Hess, V. Brinkmann, 2015, Scandinavian journal of immunology.

Vitamin D binding protein and asthma severity in children.

C. Hawrylowicz, A. Bush, D. Richards, 2012, The Journal of allergy and clinical immunology.

The Immune-Metabolic Basis of Effector Memory CD4+ T Cell Function under Hypoxic Conditions

S. Tay, M. Mehling, C. Hess, 2016, The Journal of Immunology.

Multiomics analysis couples mRNA turnover and translational control of glutamine metabolism to the differentiation of the activated CD4+ T cell

Louise S. Matheson, Manuel D. Díaz-Muñoz, R. Newman, 2022, Scientific Reports.

Salmonella cancer therapy metabolically disrupts tumours at the collateral cost of T cell immunity

D. Bending, W. Hardt, H. Ohno, 2023, bioRxiv.

Complement Regulates Nutrient Influx and Metabolic Reprogramming during Th1 Cell Responses

M. Kolev, C. Hess, Julie K. Watson, 2015, Immunity.

T‐cell metabolism governing activation, proliferation and differentiation; a modular view

C. Hess, S. Dimeloe, Jasmin Grählert, 2017, Immunology.

Targeting Metabolic Symbiosis to Overcome Resistance to Anti-angiogenic Therapy

G. Christofori, C. Hess, J. Hagmann, 2015, Cell reports.

Memory CD8(+) T Cells Require Increased Concentrations of Acetate Induced by Stress for Optimal Function.

E. Ma, Russell G. Jones, S. Hapfelmeier, 2016, Immunity.

Mitochondria‐Endoplasmic Reticulum Contact Sites Function as Immunometabolic Hubs that Orchestrate the Rapid Recall Response of Memory CD8+ T Cells

P. Romero, C. Hess, R. Steiner, 2018, Immunity.

Intrinsic and Extrinsic Determinants of T Cell Metabolism in Health and Disease

S. Dimeloe, H. Munford, 2019, Front. Mol. Biosci..

Diapedesis-Induced Integrin Signaling via LFA-1 Facilitates Tissue Immunity by Inducing Intrinsic Complement C3 Expression in Immune Cells.

S. Holland, M. Kolev, A. Cope, 2020, Immunity.

Control of T Cell Metabolism by Cytokines and Hormones

S. Dimeloe, E. Bishop, N. Gudgeon, 2021, Frontiers in Immunology.

Early effector maturation of naïve human CD8+ T cells requires mitochondrial biogenesis

C. Hess, R. Steiner, U. Sauder, 2018, European journal of immunology.

Inter-individual differences in HLA expression can impact the CDC crossmatch.

C. Hess, S. Schaub, S. Dimeloe, 2015, Tissue antigens.

A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small cell lung cancer treated with PD-1 blockade

C. Klein, T. Schumacher, K. Mertz, 2018, Nature Network Boston.

Tolerogenic effects of 1,25-dihydroxyvitamin D on dendritic cells involve induction of fatty acid synthesis

C. Evelo, D. Tennant, S. Coort, 2021, The Journal of Steroid Biochemistry and Molecular Biology.

JAK2 mutant hematopoietic cells display metabolic alterations that can be targeted to treat myeloproliferative neoplasms.

M. Gassmann, A. Lane, N. Kröger, 2019, Blood.

SDHA gain-of-function engages inflammatory mitochondrial retrograde signaling via KEAP1–Nrf2

E. Ma, Russell G. Jones, C. Hess, 2019, Nature Immunology.

Canagliflozin impairs T cell effector function via metabolic suppression in autoimmunity.

E. Ma, K. Vousden, D. Veale, 2023, Cell metabolism.

Defective IL-10 expression and in vitro steroid-induced IL-17A in paediatric severe therapy-resistant asthma

C. Hawrylowicz, A. Bush, E. S. Chambers, 2013, Thorax.

Rapid effector function of memory CD8+ T cells requires an immediate-early glycolytic switch

C. Hess, S. Dimeloe, M. Fischer, 2013, Nature Immunology.

Canagliflozin impairs T cell effector function via metabolic suppression in autoimmunity.

David K. Finlay, Linda V. Sinclair, E. Ma, 2023, Cell metabolism.

Uptake of long-chain fatty acids from the bone marrow suppresses CD8+ T-cell metabolism and function in multiple myeloma

A. Cribbs, A. Mahmood, S. Basu, 2023, Blood advances.

1α,25-Dihydroxyvitamin D3 promotes CD200 expression by human peripheral and airway-resident T cells

C. Hawrylowicz, A. Bush, D. Richards, 2012, Thorax.

TNF-α signals through ITK-Akt-mTOR to drive CD4+ T cell metabolic reprogramming, which is dysregulated in rheumatoid arthritis

S. Dimeloe, Victoria Stavrou, T. Fulton-Ward, 2024, Science Signaling.