F. Minutolo

发表

Past, present, and future of Bcr-Abl inhibitors: from chemical development to clinical efficacy

Federico Rossari, F. Minutolo, E. Orciuolo, 2018, Journal of Hematology & Oncology.

The effect of lactate dehydrogenase-A inhibition on intracellular nucleotides and mitochondrial respiration in pancreatic cancer cells

E. Giovannetti, G. Peters, F. Minutolo, 2022, Nucleosides, nucleotides & nucleic acids.

Carbazole-containing arylcarboxamides as BACE1 inhibitors.

S. Moro, J. Mason, A. Bortolato, 2011, Bioorganic & medicinal chemistry letters.

Constituents of Polygala flavescens ssp. flavescens and Their Activity as Inhibitors of Human Lactate Dehydrogenase.

L. Peruzzi, M. De Leo, T. Tuccinardi, 2017, Journal of natural products.

Receptor-based virtual screening evaluation for the identification of estrogen receptor β ligands

T. Tuccinardi, A. Martinelli, F. Minutolo, 2015, Journal of enzyme inhibition and medicinal chemistry.

Spirocyclic benzopyran-based derivatives as new anti-ischemic activators of mitochondrial ATP-sensitive potassium channel.

M. Breschi, S. Rapposelli, V. Calderone, 2008, Journal of medicinal chemistry.

Risks and benefits related to alimentary exposure to xenoestrogens

F. Minutolo, C. Granchi, Ilaria Paterni, 2017, Critical reviews in food science and nutrition.

Binding investigation and preliminary optimisation of the 3-amino-1,2,4-triazin-5(2H)-one core for the development of new Fyn inhibitors

T. Langer, T. Tuccinardi, F. Rizzolio, 2018, Journal of enzyme inhibition and medicinal chemistry.

Development of terphenyl-2-methyloxazol-5(4H)-one derivatives as selective reversible MAGL inhibitors

T. Tuccinardi, A. Martinelli, F. Rizzolio, 2017, Journal of enzyme inhibition and medicinal chemistry.

The Dichotomous Role of the Glycolytic Metabolism Pathway in Cancer Metastasis: Interplay with the Complex Tumor Microenvironment and Novel Therapeutic Strategies.

E. Giovannetti, N. Funel, G. Peters, 2020, Seminars in cancer biology.

A specific inhibitor of lactate dehydrogenase overcame the resistance toward gemcitabine in hypoxic mesothelioma cells, and modulated the expression of the human equilibrative transporter-1

E. Giovannetti, G. Peters, F. Minutolo, 2016, Nucleosides, nucleotides & nucleic acids.

Estrogen receptors alpha (ERα) and beta (ERβ): Subtype-selective ligands and clinical potential

J. Katzenellenbogen, F. Minutolo, C. Granchi, 2014, Steroids.

Diaryl-substituted salicyl- and anthranyl-ketoximes as potential estrogen receptor ligands.

J. Katzenellenbogen, K. Carlson, S. Rapposelli, 2004, Farmaco.

Design, Synthesis, and Evaluation of GLUT Inhibitors.

T. Tuccinardi, F. Minutolo, C. Granchi, 2018, Methods in molecular biology.

Characterization of the Saffron Derivative Crocetin as an Inhibitor of Human Lactate Dehydrogenase 5 in the Antiglycolytic Approach against Cancer.

P. Hergenrother, T. Tuccinardi, H. Lee, 2017, Journal of agricultural and food chemistry.

Stable propylphosphonic acid analogues of geranylgeranyl diphosphate possessing inhibitory activity on geranylgeranyl protein transferase.

S. Rapposelli, G. Giannaccini, S. Bertini, 2004, Farmaco.

Synthesis of aniline-type analogues of farnesyl diphosphate and their biological assays for prenyl protein transferase inhibitory activity.

S. Rapposelli, G. Giannaccini, S. Bertini, 2003, Farmaco.

New benzopyran-based openers of the mitochondrial ATP-sensitive potassium channel with potent anti-ischemic properties.

M. Breschi, S. Rapposelli, V. Calderone, 2006, Journal of medicinal chemistry.

Impact of hypoxia on chemoresistance of mesothelioma mediated by the proton-coupled folate transporter, and preclinical activity of new anti-LDH-A compounds

E. Giovannetti, A. Avan, N. Funel, 2020, British Journal of Cancer.

First Examples of H2S-Releasing Glycoconjugates: Stereoselective Synthesis and Anticancer Activities.

G. Signore, V. Calderone, F. Minutolo, 2019, Bioconjugate chemistry.

N6‐isopentenyladenosine arrests tumor cell proliferation by inhibiting farnesyl diphosphate synthase and protein prenylation

G. Portella, S. Bertini, F. Minutolo, 2006, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

New PIN1 inhibitors identified through a pharmacophore-driven, hierarchical consensus docking strategy

A. Giordano, V. Canzonieri, T. Tuccinardi, 2021, Journal of enzyme inhibition and medicinal chemistry.

Anticancer Agents That Counteract Tumor Glycolysis

F. Minutolo, C. Granchi, 2012, ChemMedChem.

Study of Apoptosis Induction and Deoxycytidine Kinase/Cytidine Deaminase Modulation in the Synergistic Interaction of a Novel Ceramide Analog and Gemcitabine in Pancreatic Cancer Cells

E. Giovannetti, N. Funel, G. Peters, 2010, Nucleosides, nucleotides & nucleic acids.

4-[6-(Dansylamino)hexylamino]-7-methyl-2-phenyl-1,8-naphthyridine as a new potential fluorescent probe for studying A1-adenosine receptor.

D. Tuscano, C. Martini, S. Bertini, 2002, Farmaco.

7-Nitrobenzofurazan (NBD) derivatives of 5'-N-ethylcarboxamidoadenosine (NECA) as new fluorescent probes for human A(3) adenosine receptors.

K. Klotz, D. Tuscano, C. Martini, 2001, Bioorganic & medicinal chemistry letters.

Targeting GLUT1 in acute myeloid leukemia to overcome cytarabine resistance

Peng Huang, J. Hansen, R. Venskutonytė, 2020, Haematologica.

New NO-releasing pharmacodynamic hybrids of losartan and its active metabolite: design, synthesis, and biopharmacological properties.

M. Breschi, S. Rapposelli, A. Rossello, 2006, Journal of medicinal chemistry.

NO-sartans: a new class of pharmacodynamic hybrids as cardiovascular drugs.

M. Breschi, S. Rapposelli, V. Calderone, 2004, Journal of medicinal chemistry.

Discovery of a new ATP-citrate lyase (ACLY) inhibitor identified by a pharmacophore-based virtual screening study

T. Tuccinardi, L. Ciccone, F. Rizzolio, 2020, Journal of biomolecular structure & dynamics.

MAGL inhibitor NanoMicellar formulation (MAGL-NanoMicellar) for the development of an antiglaucoma eye drop.

D. Monti, F. Minutolo, S. Burgalassi, 2022, International journal of pharmaceutics.

Optimization of a Benzoylpiperidine Class Identifies a Highly Potent and Selective Reversible Monoacylglycerol Lipase (MAGL) Inhibitor.

J. Gertsch, T. Tuccinardi, F. Rizzolio, 2019, Journal of medicinal chemistry.

Heparin in COVID-19 Patients Is Associated with Reduced In-Hospital Mortality: The Multicenter Italian CORIST Study (cid:1)

W. Ageno, M. Vinceti, F. Santilli, 2021 .

Cyclic Ketoximes as Estrogen Receptor β Selective Agonists

J. Katzenellenbogen, K. Carlson, T. Tuccinardi, 2016, ChemMedChem.

Heterogeneous asymmetric epoxidation of unfunctionalized olefins catalyzed by polymer-bound (salen)manganese complexes

A. Petri, F. Minutolo, P. Salvadori, 1996 .

Sirtuin 1-Activating Compounds: Discovery of a Class of Thiazole-Based Derivatives

T. Tuccinardi, V. Calderone, F. Minutolo, 2022, Molecules.

New N-arylsulfonyl-N-alkoxyaminoacetohydroxamic acids as selective inhibitors of gelatinase A (MMP-2).

A. Albini, S. Rapposelli, E. Orlandini, 2004, Bioorganic & medicinal chemistry.

α‐Naphthylaminopropan‐2‐ol Derivatives as BACE1 Inhibitors

Marco Macchia, Andrea Bortolato, Carlotta Granchi, 2008, ChemMedChem.

Curaxins: A New Family of Non‐genotoxic Multitargeted Anticancer Agents

F. Minutolo, Valeria Di Bussolo, 2011, ChemMedChem.

Ceramide analogues in apoptosis: a new strategy for anticancer drug development.

E. Giovannetti, R. Danesi, S. Fogli, 2003, Farmaco.

New Synthetic Analogues of Natural Polyphenols as Sirtuin 1-Activating Compounds

T. Tuccinardi, V. Calderone, F. Minutolo, 2022, Pharmaceuticals.

Polymer-bound chiral (salen)Mn(III) complex as heterogeneous catalyst in rapid and clean enantioselective epoxidation of unfunctionalised olefins

F. Minutolo, P. Salvadori, D. Pini, 1996 .

Disentangling the Association of Hydroxychloroquine Treatment with Mortality in Covid-19 Hospitalized Patients through Hierarchical Clustering

R. de Caterina, W. Ageno, M. Vinceti, 2021, medRxiv.

Monoacylglycerol lipase (MAGL) inhibitors based on a diphenylsulfide-benzoylpiperidine scaffold.

G. Demontis, T. Tuccinardi, Ivana Barravecchia, 2021, European journal of medicinal chemistry.

Design, synthesis and biological evaluation of second-generation benzoylpiperidine derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors.

E. Giovannetti, V. Canzonieri, T. Perin, 2020, European journal of medicinal chemistry.

Anomalous Face-Selectivity in Sharpless Asymmetric Dihydroxylation of o-Allylbenzamides.

F. Minutolo, P. Salvadori, S. Superchi, 1996, The Journal of organic chemistry.

Synthesis of heteroaromatic analogues of (2-aryl-1-cyclopentenyl-1-alkylidene)-(arylmethyloxy)amine COX-2 inhibitors: effects on the inhibitory activity of the replacement of the cyclopentene central core with pyrazole, thiophene or isoxazole ring.

F. Mancini, S. Rapposelli, M. Pinza, 2003, European journal of medicinal chemistry.

Asymmetric Synthesis of the Dihydroisocoumarin Moiety of AI-77-B via Copper-Mediated Cross-Coupling and Sharpless Asymmetric Dihydroxylation.

F. Minutolo, P. Salvadori, S. Superchi, 1996, The Journal of organic chemistry.

Reversible Monoacylglycerol Lipase Inhibitors: Discovery of a New Class of Benzylpiperidine Derivatives

E. Giovannetti, A. Avan, E. Dreassi, 2022, Journal of medicinal chemistry.

Highly Selective Salicylketoxime-Based Estrogen Receptor β Agonists Display Antiproliferative Activities in a Glioma Model

B. Katzenellenbogen, J. Katzenellenbogen, K. Carlson, 2015, Journal of medicinal chemistry.

Estrogen receptor β ligands: Recent advances and biomedical applications

Marco Macchia, Filippo Minutolo, B. Katzenellenbogen, 2011, Medicinal research reviews.

Metal Salt Promoted Aldol Reaction of Silyl Enol Ethers with Aldehydes.

Cristina Gardelli, F. Minutolo, M. Pineschi, 1994 .

Synthesis and COX-2 inhibitory properties of N-phenyl- and N-benzyl-substituted amides of 2-(4-methylsulfonylphenyl)cyclopent-1-ene-1-carboxylic acid and of their pyrazole, thiophene and isoxazole analogs.

A. Lapucci, S. Rapposelli, M. Pinza, 2004, Farmaco.

Synthesis of a resveratrol analogue with high ceramide-mediated proapoptotic activity on human breast cancer cells.

S. Rapposelli, N. Sacchi, S. Bertini, 2005, Journal of medicinal chemistry.

Synthesis of sulfonamide-containing N-hydroxyindole-2-carboxylates as inhibitors of human lactate dehydrogenase-isoform 5.

G. Giannaccini, A. Lucacchini, T. Tuccinardi, 2011, Bioorganic & medicinal chemistry letters.

N-Hydroxyindole-based inhibitors of lactate dehydrogenase against cancer cell proliferation.

E. Giovannetti, G. Peters, G. Giannaccini, 2011, European journal of medicinal chemistry.

Triazole-substituted N-hydroxyindol-2-carboxylates as inhibitors of isoform 5 of human lactate dehydrogenase (hLDH5)

G. Giannaccini, A. Lucacchini, T. Tuccinardi, 2011 .

Discovery of N-hydroxyindole-based inhibitors of human lactate dehydrogenase isoform A (LDH-A) as starvation agents against cancer cells.

E. Giovannetti, G. Peters, P. Hergenrother, 2011, Journal of medicinal chemistry.

Assessing the differential action on cancer cells of LDH-A inhibitors based on the N-hydroxyindole-2-carboxylate (NHI) and malonic (Mal) scaffolds.

P. Hergenrother, T. Tuccinardi, A. Martinelli, 2013, Organic & biomolecular chemistry.

A Polymer-Supported Phosphazine as a Stable and Practical Reagent in the Three-Component Synthesis of Substituted (Cyclopentadienyl)tricarbonylrhenium Complexes.

J. Katzenellenbogen, F. Minutolo, 1999, Angewandte Chemie.

Anomalous Face‐Selectivity in Sharpless Asymmetric Dihydroxylation of o‐Allylbenzamides.

F. Minutolo, P. Salvadori, S. Superchi, 1996 .

Asymmetric Synthesis of the Dihydroisocoumarin Moiety of AI-77-B via Copper-Mediated Cross-Coupling and Sharpless Asymmetric Dihydroxylation.

F. Minutolo, P. Salvadori, S. Superchi, 1996, The Journal of organic chemistry.

Synthesis of Stable Analogues of Geranylgeranyl Diphosphate Possessing a (Z,E,E)‐Geranylgeranyl Side Chain, Docking Analysis, and Biological Assays for Prenyl Protein Transferase Inhibition

R. Danesi, S. Rapposelli, G. Giannaccini, 2006, ChemMedChem.

Bioreductively Activated Lysyl Oxidase Inhibitors against Hypoxic Tumours

J. Erler, A. Giaccia, F. Minutolo, 2009, ChemMedChem.

Three-Component Synthesis of Substituted η5-Cyclopentadienyltricarbonylrhenium Complexes: Scope, Limitations, and Mechanistic Interpretations

J. Katzenellenbogen, F. Minutolo, 1999 .

Small-molecule inhibitors of human LDH5.

F. Minutolo, Reshma Rani, C. Granchi, 2013, Future medicinal chemistry.

Phenylpropanoids and flavonoids from Phlomis kurdica as inhibitors of human lactate dehydrogenase.

T. Tuccinardi, A. Martinelli, N. de Tommasi, 2015, Phytochemistry.

Effect of Tumor Relevant Acidic Environment in the Interaction of a N-hydroxyindole-2-Carboxylic Derivative with the Phospholipid Bilayer

D. Monti, A. Piras, F. Minutolo, 2018, Pharmaceutical Research.

Efficient application of lipase-catalyzed transesterification to the resolution of γ-hydroxy ketones

F. Minutolo, M. Pineschi, P. Crotti, 1996 .

QSAR models for predicting enzymatic hydrolysis of new chemical entities in 'soft-drug' design.

A. Bianucci, I. Massarelli, F. Minutolo, 2009, Bioorganic & medicinal chemistry.

Glycoconjugated Metal Complexes as Cancer Diagnostic and Therapeutic Agents

F. Minutolo, S. Di Pietro, C. Granchi, 2020, ChemMedChem.

Synthesis and antiviral properties of 9-[(2-methyleneaminoxyethoxy)methyl]guanine derivatives as novel Acyclovir analogues.

O. Turriziani, G. Antonelli, E. Orlandini, 2000, Farmaco.

Synthesis and antiviral properties of novel analogues of monophosphate and diphosphate bioactive forms of acyclovir.

O. Turriziani, G. Antonelli, S. Bertini, 2000, Farmaco.

Purification, Enzymatic Characterization, and Inhibition of theZ-Farnesyl Diphosphate Synthase from Mycobacterium tuberculosis *

P. Brennan, D. Crick, S. Bertini, 2001, The Journal of Biological Chemistry.

Synthesis, binding affinity, and transcriptional activity of hydroxy- and methoxy-Substituted 3,4-Diarylsalicylaldoximes on estrogen receptors α and β

J. Katzenellenbogen, K. Carlson, S. Rapposelli, 2003 .

Lactate dehydrogenase-A inhibition induces human glioblastoma multiforme stem cell differentiation and death

M. Trincavelli, C. Martini, C. Giacomelli, 2015, Scientific Reports.

Increased Lactate Secretion by Cancer Cells Sustains Non-cell-autonomous Adaptive Resistance to MET and EGFR Targeted Therapies.

E. Giannoni, K. Ferrari, C. Isella, 2018, Cell metabolism.

First-of-its-kind STARD3 Inhibitor: In Silico Identification and Biological Evaluation as Anticancer Agent.

V. Canzonieri, T. Tuccinardi, F. Rizzolio, 2019, ACS medicinal chemistry letters.

Aromatic substituent effect on the stereoselectivity of the gas-phase acid-induced ring opening in 9,10-oxides derived from trans-1,2,3,4,4a,10a-hexahydrophenanthrene

F. Minutolo, P. Crotti, A. Lombardozzi, 1993 .

Synthesis and biological evaluation of non-glucose glycoconjugated N-hydroyxindole class LDH inhibitors as anticancer agents.

P. Hergenrother, T. Tuccinardi, A. Martinelli, 2015, RSC advances.

An update on therapeutic opportunities offered by cancer glycolytic metabolism.

Carlotta Granchi, Filippo Minutolo, F. Minutolo, 2014, Bioorganic & medicinal chemistry letters.

Salicylaldoxime derivatives as new leads for the development of carbonic anhydrase inhibitors.

Tiziano Tuccinardi, Adriano Martinelli, Marco Macchia, 2013, Bioorganic & medicinal chemistry.

Identification of LDH-A as a therapeutic target for cancer cell killing via (i) p53/NAD(H)-dependent and (ii) p53-independent pathways

J. Milner, F. Minutolo, R. Phillips, 2014, Oncogenesis.

Phospho-Akt overexpression is prognostic and can be used to tailor the synergistic interaction of Akt inhibitors with gemcitabine in pancreatic cancer

E. Giovannetti, A. Avan, N. Funel, 2017, Journal of Hematology & Oncology.

Lactate dehydrogenase acetylation adds another piece to the puzzle of metabolic reprogramming in pancreatic cancer

E. Giovannetti, G. Peters, F. Minutolo, 2014 .

Synthesis of heterocycle-based analogs of resveratrol and their antitumor and vasorelaxing properties.

T. Tuccinardi, A. Martinelli, V. Calderone, 2010, Bioorganic & medicinal chemistry.

Metabolically labile cannabinoid esters: a 'soft drug' approach for the development of cannabinoid-based therapeutic drugs.

T. Bisogno, M. Cascio, V. Di Marzo, 2007, Bioorganic & medicinal chemistry letters.

Use of hydroxychloroquine in hospitalised COVID-19 patients is associated with reduced mortality: Findings from the observational multicentre Italian CORIST study

R. de Caterina, W. Ageno, M. Vinceti, 2020, European Journal of Internal Medicine.

Liposomal delivery of a Pin1 inhibitor complexed with cyclodextrins as new therapy for high‐grade serous ovarian cancer

V. Canzonieri, M. Agostini, L. De Stefano, 2018, Journal of controlled release : official journal of the Controlled Release Society.

Systems Structural Biology Analysis of Ligand Effects on ERα Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.

O. Elemento, J. Nwachukwu, S. Srinivasan, 2017, Cell chemical biology.

Synergistic interaction of novel lactate dehydrogenase inhibitors with gemcitabine against pancreatic cancer cells in hypoxia

E. Giovannetti, A. Avan, N. Funel, 2013, British Journal of Cancer.

Anticancer agents interacting with membrane glucose transporters.

F. Minutolo, C. Granchi, S. Fortunato, 2016, MedChemComm.

Phosphonomethylphosphorylmethyl(oxy)-analogues of geranylgeranyl diphosphate as stable and selective geranylgeranyl protein transferase inhibitors.

R. Danesi, S. Rapposelli, G. Giannaccini, 2004, Il Farmaco.

Stable analogues of geranylgeranyl diphosphate possessing improved geranylgeranyl versus farnesyl protein transferase inhibitory selectivity.

R. Danesi, S. Rapposelli, G. Giannaccini, 2003, Bioorganic & medicinal chemistry letters.

Immune by Heart: Unexpected Observations Inspiring Perspective Therapeutic/Preventive Strategies against Cancer

F. Minutolo, 2016, ChemMedChem.

Dual Targeting of the Warburg Effect with a Glucose‐Conjugated Lactate Dehydrogenase Inhibitor

P. Hergenrother, T. Tuccinardi, A. Martinelli, 2013, Chembiochem : a European journal of chemical biology.

An updated patent review of monoacylglycerol lipase (MAGL) inhibitors (2018-present)

T. Tuccinardi, F. Rizzolio, F. Minutolo, 2020, Expert opinion on therapeutic patents.

A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017)

T. Tuccinardi, F. Rizzolio, F. Minutolo, 2017, Expert opinion on therapeutic patents.

Lopinavir/Ritonavir and Darunavir/Cobicistat in Hospitalized COVID-19 Patients: Findings From the Multicenter Italian CORIST Study

R. de Caterina, W. Ageno, M. Vinceti, 2021, Frontiers in Medicine.

Historical perspective of tumor glycolysis: a century with Otto Warburg.

T. Tuccinardi, F. Minutolo, C. Granchi, 2022, Seminars in cancer biology.

Sulfonamido-derivatives of unsubstituted carbazoles as BACE1 inhibitors.

M. Sturlese, S. Moro, S. Rapposelli, 2017, Bioorganic & medicinal chemistry letters.

Discovery of Monoacylglycerol Lipase (MAGL) Inhibitors Based on a Pharmacophore-Guided Virtual Screening Study

T. Tuccinardi, F. Minutolo, M. Macchia, 2020, Molecules.

Structural Optimization of 4-Chlorobenzoylpiperidine Derivatives for the Development of Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors.

T. Tuccinardi, A. Martinelli, F. Rizzolio, 2016, Journal of medicinal chemistry.

Identification and characterization of a new reversible MAGL inhibitor.

T. Tuccinardi, A. Martinelli, F. Rizzolio, 2014, Bioorganic & medicinal chemistry.

Computationally driven discovery of phenyl(piperazin-1-yl)methanone derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors

T. Tuccinardi, F. Rizzolio, F. Minutolo, 2019, Journal of enzyme inhibition and medicinal chemistry.

Discovery of 1,5-Diphenylpyrazole-3-Carboxamide Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors.

C. Ghelardini, J. Gertsch, L. De Stefano, 2018, Journal of medicinal chemistry.

4-Aryliden-2-methyloxazol-5(4H)-one as a new scaffold for selective reversible MAGL inhibitors

A. Giordano, T. Tuccinardi, A. Martinelli, 2016, Journal of enzyme inhibition and medicinal chemistry.

CB2-Selective Cannabinoid Receptor Ligands: Synthesis, Pharmacological Evaluation, and Molecular Modeling Investigation of 1,8-Naphthyridin-2(1H)-one-3-carboxamides

Brandie M. Ehrmann, V. Di Marzo, A. Ligresti, 2014, Journal of medicinal chemistry.

Three-Dimensional Analysis of the Interactions between hLDH5 and Its Inhibitors

T. Tuccinardi, F. Minutolo, C. Granchi, 2017, Molecules.

Estrogen receptor ligands: a patent review update

Marco Macchia, Carlotta Granchi, Filippo Minutolo, 2013, Expert opinion on therapeutic patents.

Characterisation of covalent copper and manganese organometallic complexes with Schiff bases by ionspray mass spectrometry

B. Feringa, F. Minutolo, P. Salvadori, 1998 .

Selective and potent agonists for estrogen receptor beta derived from molecular refinements of salicylaldoximes.

J. Katzenellenbogen, K. Carlson, T. Tuccinardi, 2011, European journal of medicinal chemistry.

Synthesis of anthranylaldoxime derivatives as estrogen receptor ligands and computational prediction of binding modes.

J. Katzenellenbogen, K. Carlson, S. Rapposelli, 2006, Journal of medicinal chemistry.

Diaryl-substituted salicyl- and anthranyl-ketoximes as potential estrogen receptor ligands.

J. Katzenellenbogen, K. Carlson, S. Rapposelli, 2004, Farmaco.

Inhibitors of lactate dehydrogenase isoforms and their therapeutic potentials.

S. Bertini, F. Minutolo, M. Macchia, 2010, Current medicinal chemistry.

Most cancer cells use aerobic glycolysis to fuel their growth. The enzyme lactate dehydrogenase-A (LDH-A) is key to cancer's glycolytic phenotype, catalysing the regeneration of nicotinamide adenine dinucleotide (NAD þ ) from reduced nicotinamide

J. Milner, F. Minutolo, R. Phillips, 2014 .

An Update on Patents Covering Agents That Interfere with the Cancer Glycolytic Cascade

F. Minutolo, C. Granchi, Giulia Bononi, 2018, ChemMedChem.

Discovery of long-chain salicylketoxime derivatives as monoacylglycerol lipase (MAGL) inhibitors.

J. Katzenellenbogen, K. Carlson, Sung Hoon Kim, 2018, European journal of medicinal chemistry.

RAAS inhibitors are not associated with mortality in COVID-19 patients: Findings from an observational multicenter study in Italy and a meta-analysis of 19 studies

R. de Caterina, W. Ageno, M. Vinceti, 2020, Vascular Pharmacology.

New N-n-propyl-substituted 3-aryl- and 3-cyclohexylpiperidines as partial agonists at the D4 dopamine receptor.

G. Demontis, B. Longoni, L. Cervetto, 2003, Journal of Medicinal Chemistry.

Development and Validation of a Docking-Based Virtual Screening Platform for the Identification of New Lactate Dehydrogenase Inhibitors

Gianluca Del Frate, T. Tuccinardi, A. Martinelli, 2015, Molecules.

Synthesis and dopaminergic properties of the two enantiomers of 3-(3,4-dimethylphenyl)-1-propylpiperidine, a potent and selective dopamine D4 receptor ligand.

G. Demontis, B. Longoni, L. Cervetto, 2001, Bioorganic & medicinal chemistry letters.

Design, synthesis, and characterization of the antitumor activity of novel ceramide analogues.

E. Giovannetti, R. Danesi, S. Fogli, 2001, Journal of medicinal chemistry.

Rational Development of MAGL Inhibitors.

T. Tuccinardi, A. Martinelli, F. Rizzolio, 2018, Methods in molecular biology.

Synthesis and Biological Evaluation of New Glycoconjugated LDH Inhibitors as Anticancer Agents †

T. Tuccinardi, F. Minutolo, L. Guazzelli, 2019, Molecules.

Activators of Sirtuin-1 and their Involvement in Cardioprotection.

F. Minutolo, C. Granchi, 2018, Current Medicinal Chemistry.

Conformationally restrained ceramide analogues: effects of lipophilic modifications on the antiproliferative activity.

E. Giovannetti, R. Danesi, S. Fogli, 2003, Farmaco.

Identification of New Fyn Kinase Inhibitors Using a FLAP-Based Approach

Flavio Rizzolio, Tiziano Tuccinardi, Adriano Martinelli, 2013, J. Chem. Inf. Model..

Salicylketoximes That Target Glucose Transporter 1 Restrict Energy Supply to Lung Cancer Cells

J. Katzenellenbogen, K. Carlson, Xiaozhuo Chen, 2015, ChemMedChem.

A Virtual Screening Study for Lactate Dehydrogenase 5 Inhibitors by Using a Pharmacophore‐based Approach

T. Tuccinardi, A. Martinelli, F. Minutolo, 2016, Molecular informatics.

Aryl-substituted methyleneaminoxymethyl (MAOM) analogues of diarylcyclopentenyl cyclooxygenase-2 inhibitors: effects of some structural modifications on their biological properties.

F. Mancini, A. Lapucci, S. Rapposelli, 2002, European journal of medicinal chemistry.

A Convenient Three-Component Synthesis of Substituted Cyclopentadienyl Tricarbonyl Rhenium Complexes

J. Katzenellenbogen, F. Minutolo, 1998 .

A Convenient Three-Component Synthesis of Substituted Cyclopentadienyl Tricarbonyl Rhenium Complexes.

J. Katzenellenbogen, F. Minutolo, 1998 .

Lactate dehydrogenase A inhibition by small molecular entities: steps in the right direction

E. Giovannetti, G. Peters, F. Minutolo, 2020, Oncoscience.

A recent study by Zhao and collaborators has unraveled the key role of post-translational modification of lactate dehydrogenase (LDH) by acetylation in the control of metabolisms and proliferation of pancreatic cancer cells

E. Giovannetti, G. Peters, F. Minutolo, 2014 .

Increased Lactate Secretion by Cancer Cells Sustains Non-cell-autonomous Adaptive Resistance to MET and EGFR Targeted Therapies.

E. Giannoni, K. Ferrari, C. Isella, 2018, Cell metabolism.

Oxime-based inhibitors of glucose transporter 1 displaying antiproliferative effects in cancer cells.

Xiaozhuo Chen, T. Tuccinardi, A. Martinelli, 2013, Bioorganic & medicinal chemistry letters.

Reactive Oxygen Species Synergize To Potently and Selectively Induce Cancer Cell Death.

Elizabeth I. Parkinson, D. Panigrahy, P. Hergenrother, 2017, ACS chemical biology.

Evaluation of the NO‐releasing properties of NO‐donor linkers

S. Rapposelli, V. Calderone, F. Minutolo, 2008, The Journal of pharmacy and pharmacology.

SYNTHESIS AND AFFINITY EVALUATION FOR AT1 RECEPTOR OF PHENYLSALICYLALDOXIME-DERIVATIVES STRUCTURALLY RELATED TO SARTANS

M. Trincavelli, S. Rapposelli, A. Lucacchini, 2008 .

Discovery of N-hydroxyindole-based inhibitors of human lactate dehydrogenase isoform A (LDH-A) as starvation agents against cancer cells.

E. Giovannetti, G. Peters, P. Hergenrother, 2011, Journal of medicinal chemistry.

Combined inhibition of pyruvate dehydrogenase kinase 1 and lactate dehydrogenase a induces metabolic and signaling reprogramming and enhances lung adenocarcinoma cell killing.

E. Giovannetti, F. Minutolo, C. Granchi, 2023, Cancer letters.

PO-042 Targeting hypoxic pancreatic cancer cells with glucose conjugated lactate dehydrogenase inhibitor NHI-Glc-2

E. Giovannetti, G. Peters, F. Minutolo, 2018, ESMO Open.

Effect of Tumor Relevant Acidic Environment in the Interaction of a N-hydroxyindole-2-Carboxylic Derivative with the Phospholipid Bilayer

D. Monti, A. Piras, F. Minutolo, 2018, Pharmaceutical Research.

The Benzoylpiperidine Fragment as a Privileged Structure in Medicinal Chemistry: A Comprehensive Review

T. Tuccinardi, F. Minutolo, C. Granchi, 2024, Molecules.

SMS121, a new inhibitor of CD36, impairs fatty acid uptake and viability of acute myeloid leukemia

T. Tuccinardi, F. Minutolo, C. Granchi, 2024, Scientific reports.

α‐Naphthylaminopropan‐2‐ol Derivatives as BACE1 Inhibitors

S. Moro, A. Bortolato, S. Rapposelli, 2008, ChemMedChem.

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