Keqian Yang

发表

A genetic biosensor for identification of transcriptional repressors of target promoters

K. Fan, Weishan Wang, Xiao Li, 2015, Scientific Reports.

Iterative Combinatorial Mutagenesis as an Effective Strategy for Generation of Deacetoxycephalosporin C Synthase with Improved Activity toward Penicillin G

K. Fan, Keqian Yang, Junjie Ji, 2012, Applied and Environmental Microbiology.

Genome-wide identification and evaluation of constitutive promoters in streptomycetes

Weishan Wang, Xiao Li, Shanshan Li, 2015, Microbial Cell Factories.

Discovery of New Substrates for LuxAB Bacterial Bioluminescence

Yuemao Shen, Minyong Li, Weishan Wang, 2016, Chemical biology & drug design.

High-throughput synergy screening identifies microbial metabolites as combination agents for the treatment of fungal infections

Jian Wang, Jiang Bian, Yu Zhang, 2007, Proceedings of the National Academy of Sciences.

Induction of Holomycin Production and Complex Metabolic Changes by the argR Mutation in Streptomyces clavuligerus NP1

Yuan-ming Luo, K. Fan, Xu Yang, 2012, Applied and Environmental Microbiology.

“Pseudo” γ-Butyrolactone Receptors Respond to Antibiotic Signals to Coordinate Antibiotic Biosynthesis*

Juan Wang, K. Fan, H. Tan, 2010, Journal of Biological Chemistry.

A novel signal transduction system for development of uric acid biosensors

F. Qi, Weishan Wang, Lixin Zhang, 2018, Applied Microbiology and Biotechnology.

Development of small molecule biosensors by coupling the recognition of the bacterial allosteric transcription factor with isothermal strand displacement amplification.

K. Fan, Weishan Wang, W. Xiang, 2018, Chemical communications.

Cell wall proteome of Clostridium thermocellum and detection of glycoproteins.

Yuan-ming Luo, Keqian Yang, Tingting Yu, 2012, Microbiological research.

Overproduction and identification of butyrolactones SCB1-8 in the antibiotic production superhost Streptomyces M1152.

C. Corre, Lijiang Song, Weishan Wang, 2016, Organic & biomolecular chemistry.

[Construction and evaluation of DnaB split intein high expression vector and a six amino acids cyclic peptide library].

Xiushan Yang, Keqian Yang, Shenglan Wang, 2008, Sheng wu gong cheng xue bao = Chinese journal of biotechnology.

Targeted activation of silent natural product biosynthesis pathways by reporter-guided mutant selection.

M. Metsä-Ketelä, Keqian Yang, Sihai Xiang, 2015, Metabolic engineering.

A simplified diphenylamine colorimetric method for growth quantification

Keqian Yang, Sihai Xiang, Youbao Zhao, 2013, Applied Microbiology and Biotechnology.

Improvement of stress tolerance and riboflavin production of Bacillus subtilis by introduction of heat shock proteins from thermophilic bacillus strains

K. Fan, Zhen Xu, Weishan Wang, 2019, Applied Microbiology and Biotechnology.

Evaluation of the cytotoxic activity of new jadomycin derivatives reveals the potential to improve its selectivity against tumor cells

Yuan-ming Luo, K. Fan, M. Geng, 2012, The Journal of Antibiotics.

Autoregulation of antibiotic biosynthesis by binding of the end product to an atypical response regulator

K. Fan, H. Tan, Keqian Yang, 2009, Proceedings of the National Academy of Sciences.

A method to type the potential angucycline producers in actinomycetes isolated from marine sponges

Lianwu Xie, Guanghua Wang, S. Dai, 2011, Antonie van Leeuwenhoek.

An Autoregulated Fine-Tuning Strategy for Titer Improvement of Secondary Metabolites Using Native Promoters in Streptomyces.

Weishan Wang, Zilong Li, W. Xiang, 2017, ACS synthetic biology.

Development of a Synthetic Oxytetracycline-Inducible Expression System for Streptomycetes Using de Novo Characterized Genetic Parts.

C. Corre, Weishan Wang, Shanshan Li, 2016, ACS synthetic biology.

Characterization of the Protocatechuic Acid Catabolic Gene Cluster from Streptomyces sp. Strain 2065

J. Davies, Keqian Yang, S. Iwagami, 2000, Applied and Environmental Microbiology.

Structure and Function of a C-C Bond Cleaving Oxygenase in Atypical Angucycline Biosynthesis.

K. Fan, Zhi-jie Liu, Yihua Chen, 2017, ACS chemical biology.

Improvement of oxytetracycline production mediated via cooperation of resistance genes in Streptomyces rimosus

K. Fan, Zilong Li, Keqian Yang, 2017, Science China Life Sciences.

Identification of a cluster-situated activator of oxytetracycline biosynthesis and manipulation of its expression for improved oxytetracycline production in Streptomyces rimosus

Weishan Wang, Ya-xin Zhu, Shanshan Li, 2015, Microbial Cell Factories.

A novel role of ‘pseudo’γ‐butyrolactone receptors in controlling γ‐butyrolactone biosynthesis in Streptomyces

K. Fan, Guifeng Zhang, H. Tan, 2011, Molecular microbiology.

A Blue Native-PAGE analysis of membrane protein complexes in Clostridium thermocellum

Yuan-ming Luo, K. Fan, Keqian Yang, 2011, BMC Microbiology.

JadR*‐mediated feed‐forward regulation of cofactor supply in jadomycin biosynthesis

K. Fan, H. Tan, Yanyan Zhang, 2013, Molecular microbiology.

The Oxidative Ring Cleavage in Jadomycin Biosynthesis: A Multistep Oxygenation Cascade in a Biosynthetic Black Box

U. Rix, J. Rohr, L. Vining, 2005, Chembiochem : a European journal of chemical biology.

An Engineered Strong Promoter for Streptomycetes

Juan Wang, Weishan Wang, Xiao Li, 2013, Applied and Environmental Microbiology.

Coordination of glycerol utilization and clavulanic acid biosynthesis to improve clavulanic acid production in Streptomyces clavuligerus

Keqian Yang, Youbao Zhao, Dekun Guo, 2013, Science China Life Sciences.

Cloning , sequencing and disruption of a bromoperoxidase-catalase gene in Streptomyces venezuelae : evidence that it is not required for chlorination in ch loramp hen icol biosynt hesis

Frank, C., J., 2008 .

The dynamic structure of jadomycin B and the amino acid incorporation step of its biosynthesis.

U. Rix, J. Rohr, Keqian Yang, 2004, Journal of the American Chemical Society.

Cloning, expression, and characterization of a thermostable glucose-6-phosphate dehydrogenase from Thermoanaerobacter tengcongensis

Zilong Li, Keqian Yang, Jianting Zheng, 2016, Extremophiles.

Tracing the evolution of angucyclinone monooxygenases: structural determinants for C-12b hydroxylation and substrate inhibition in PgaE.

P. Kallio, G. Belogurov, Keqian Yang, 2013, Biochemistry.

Structural basis for prokaryotic calciummediated regulation by a Streptomyces coelicolor calcium binding protein

M. Bartlam, Weihong Zhou, Keqian Yang, 2011, Protein & Cell.

A novel signal transduction system for development of uric acid biosensors

F. Qi, Weishan Wang, Lixin Zhang, 2018, Applied Microbiology and Biotechnology.

A platform for the development of novel biosensors by configuring allosteric transcription factor recognition with amplified luminescent proximity homogeneous assays.

Keqiang Fan, K. Fan, Weishan Wang, 2016, Chemical communications.

Reconstitution of TCA cycle with DAOCS to engineer Escherichia coli into an efficient whole cell catalyst of penicillin G

K. Fan, Jian Zhao, Y. Tao, 2015, Proceedings of the National Academy of Sciences.

StreptomycetesStrong Promoter for

Weishan Wang, Juan Wang, Xiao Li, 2014 .

Tailoring enzymes involved in the biosynthesis of angucyclines contain latent context-dependent catalytic activities.

K. Fan, J. Rohr, P. Kallio, 2012, Chemistry & biology.

Functional Characterization of the jadI Gene As a Cyclase Forming Angucyclinones

L. Vining, C. Hutchinson, K. Kulowski, 1999 .

Genome-wide identification and characterization of reference genes with different transcript abundances for Streptomyces coelicolor

K. Fan, Weishan Wang, Xiao Li, 2015, Scientific Reports.

Development of a colorimetric assay for rapid quantitative measurement of clavulanic acid in microbial samples

Keqian Yang, Sihai Xiang, Qiang Gao, 2012, Science China Life Sciences.

Identification of Alp1U and Lom6 as epoxy hydrolases and implications for kinamycin and lomaiviticin biosynthesis

Bertrand Aigle, Bin Wang, Keqiang Fan, 2015, Nature Communications.

Kinamycin biosynthesis employs a conserved pair of oxidases for B-ring contraction.

K. Fan, Guohui Pan, B. Aigle, 2015, Chemical communications.

Identification of JadG as the B ring opening oxygenase catalyzing the oxidative C-C bond cleavage reaction in jadomycin biosynthesis.

K. Fan, Weishan Wang, Guohui Pan, 2012, Chemistry & biology.

Crystallization and preliminary X-ray diffraction studies of the calcium-binding protein CalD from Streptomyces coelicolor.

M. Bartlam, Keqian Yang, H. Pang, 2008, Acta crystallographica. Section F, Structural biology and crystallization communications.

Inactivation of Chloramphenicol by O-Phosphorylation

W. V. Shaw, L. Vining, Keqian Yang, 1995, The Journal of Biological Chemistry.

Improvement of oxytetracycline production mediated via cooperation of resistance genes in Streptomyces rimosus

K. Fan, Zilong Li, Keqian Yang, 2017, Science China Life Sciences.

Heterologous expression of oxytetracycline biosynthetic gene cluster in Streptomyces venezuelae WVR2006 to improve production level and to alter fermentation process

Weishan Wang, Zilong Li, Keqian Yang, 2016, Applied Microbiology and Biotechnology.

Bioluminescent Probe for Detecting Mercury(II) in Living Mice.

Minyong Li, Weishan Wang, Keqian Yang, 2016, Analytical chemistry.

Engineered jadomycin analogues with altered sugar moieties revealing JadS as a substrate flexible O-glycosyltransferase

K. Fan, Guohui Pan, J. Salas, 2017, Applied Microbiology and Biotechnology.

Characterization of JadH as an FAD‐ and NAD(P)H‐Dependent Bifunctional Hydroxylase/Dehydrase in Jadomycin Biosynthesis

Keqian Yang, Tingting Yu, Yanfeng Peng, 2010, Chembiochem : a European journal of chemical biology.

Angucyclines as signals modulate the behaviors of Streptomyces coelicolor

K. Fan, Weishan Wang, Guohui Pan, 2014, Proceedings of the National Academy of Sciences.

Engineering deacetoxycephalosporin C synthase as a catalyst for the bioconversion of penicillins

K. Fan, Y. Tao, Baixue Lin, 2017, Journal of Industrial Microbiology & Biotechnology.

Development of a colorimetric assay for rapid quantitative measurement of clavulanic acid in microbial samples

Jia Li, Q. Gao, Keqian Yang, 2012, Science China Life Sciences.

A platform for the development of novel biosensors by configuring allosteric transcription factor recognition with amplified luminescent proximity homogeneous assays.

K. Fan, Weishan Wang, Lixin Zhang, 2016, Chemical communications.

Coordination of glycerol utilization and clavulanic acid biosynthesis to improve clavulanic acid production in Streptomyces clavuligerus

Keqian Yang, Youbao Zhao, Dekun Guo, 2013, Science China Life Sciences.

Development of a Synthetic Oxytetracycline-Inducible Expression System for Streptomycetes Using de Novo Characterized Genetic Parts.

C. Corre, Weishan Wang, Shanshan Li, 2016, ACS synthetic biology.

Evidence for the formation of ScbR/ScbR2 heterodimers and identification of one of the regulatory targets in Streptomyces coelicolor

C. Corre, Weishan Wang, Juan Wang, 2017, Applied Microbiology and Biotechnology.

ScbR- and ScbR2-mediated signal transduction networks coordinate complex physiological responses in Streptomyces coelicolor

Weishan Wang, Xiao Li, Shanshan Li, 2015, Scientific Reports.