B. Broughton

发表

Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient

P. Jeggo, S. Jackson, A. Doherty, 1999, Current Biology.

Five polymorphisms in the coding sequence of the xeroderma pigmentosum group D gene.

H. Steingrimsdottir, A. Lehmann, B. Broughton, 1996, Mutation research.

Xeroderma pigmentosum and trichothiodystrophy are associated with different mutations in the XPD (ERCC2) repair/transcription gene.

A. Lehmann, C. Arlett, A. Sarasin, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Mutations in the general transcription factor TFIIH result in beta-thalassaemia in individuals with trichothiodystrophy.

J. Tolmie, R. Winter, D. Higgs, 2001, Human molecular genetics.

Assignment of ten DNA repair genes from Schizosaccharomyces pombe to chromosomal NotI restriction fragments

F. Z. Watts, A. Carr, A. Lehmann, 1991, Molecular and General Genetics MGG.

DNA repair and ultraviolet mutagenesis in cells from a new patient with xeroderma pigmentosum group G and cockayne syndrome resemble xeroderma pigmentosum cells.

I. Rapin, J. Hoeijmakers, W. Vermeulen, 1996, The Journal of investigative dermatology.

Molecular and cellular analysis of the DNA repair defect in a patient in xeroderma pigmentosum complementation group D who has the clinical features of xeroderma pigmentosum and Cockayne syndrome.

J. Hoeijmakers, J. Cole, W. Vermeulen, 1995, American journal of human genetics.

Cloning theRAD51homologue ofSchizosaccharomyces pombe

A. Carr, A. Lehmann, B. Broughton, 1993 .

Defects in the DNA repair and transcription gene ERCC2(XPD) in trichothiodystrophy.

L. Thompson, A. Lehmann, K. Takayama, 1996, American journal of human genetics.

Relationship between pyrimidine dimers, 6-4 photoproducts, repair synthesis and cell survival: studies using cells from patients with trichothiodystrophy.

D. Mitchell, A. Lehmann, F. Beemer, 1990, Mutation research.

Trichothiodystrophy, a human DNA repair disorder with heterogeneity in the cellular response to ultraviolet light.

H. Steingrimsdottir, A. Natarajan, A. Lehmann, 1988, Cancer research.

Localization of a DNA repair gene (XRCC5) involved in double-strand-break rejoining to human chromosome 2.

P. Jeggo, M. Hafezparast, R. Athwal, 1992, Proceedings of the National Academy of Sciences of the United States of America.

The influence of caffeine on cell survival in excision-proficient and excision-deficient xeroderma pigmentosum and normal human cell strains following ultraviolet-light irradiation.

C. Arlett, B. Broughton, S. A. Harcourt, 1975, Mutation research.

Inhibition of DNA replication by ionizing radiation is mediated by a trans-acting factor.

J. Lamb, M. Green, A. Lehmann, 1989, International journal of radiation biology.

A biochemical defect in the repair of alkylated DNA in cells from an immunodeficient patient (46BR).

M. James, P. Karran, A. Lehmann, 1983, Carcinogenesis.

The action of AF 2 on cultured hamster and human cells under aerobic and hypoxic conditions.

D. R. McCalla, B. Broughton, C. Arlett, 1978, Chemico-biological interactions.

An adaptive response to the cytotoxic effects of N-methyl-N-nitrosourea is apparently absent in normal human fibroblasts.

P. Karran, C. Arlett, B. Broughton, 1982, Biochimie.

Two individuals with features of both xeroderma pigmentosum and trichothiodystrophy highlight the complexity of the clinical outcomes of mutations in the XPD gene.

A. Lehmann, J. Krutmann, S. Queillé, 2001, Human molecular genetics.

Poly(ADP-ribosylation) reduces the steady-state level of breaks in DNA following treatment of human cells with alkylating agents.

A. Lehmann, B. Broughton, 1984, Carcinogenesis.

Molecular analysis of mutations in DNA polymerase η in xeroderma pigmentosum-variant patients

A. Sarasin, F. Hanaoka, A. Lehmann, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Domain structure, localization, and function of DNA polymerase eta, defective in xeroderma pigmentosum variant cells.

L. Mullenders, F. Hanaoka, A. Lehmann, 2001, Genes & development.

Cloning the RAD51 homologue of Schizosaccharomyces pombe.

A. Carr, A. Lehmann, A. Pastink, 1993, Nucleic acids research.

Mutagenic Effects in Human and Mouse Cells by a Nitropyrene

C. Arlett, B. Broughton, J. Cole, 1982 .

Analysis of mutations in the XPD gene in Italian patients with trichothiodystrophy: site of mutation correlates with repair deficiency, but gene dosage appears to determine clinical severity.

A. Lehmann, M. Stefanini, T. Nardò, 1998, American journal of human genetics.

Relation between the human fibroblast strain 46BR and cell lines representative of Bloom's syndrome.

M. James, H. Steingrimsdottir, T. Lindahl, 1988, Cancer research.

Cells from an immunodeficient patient (46BR) with a defect in DNA ligation are hypomutable but hypersensitive to the induction of sister chromatid exchanges.

A. Lehmann, C. Arlett, B. Broughton, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Multiple hypersensitivity to mutagens in a cell strain (46BR) derived from a patient with immuno-deficiencies.

C. Arlett, A. Priestley, B. Broughton, 1983, Mutation research.

Novel human and mouse homologs of Saccharomyces cerevisiae DNA polymerase eta.

J. Epstein, R. Woodgate, A. Lehmann, 1999, Genomics.

Mutations in the xeroderma pigmentosum group D DNA repair/transcription gene in patients with trichothiodystrophy

H. Steingrimsdottir, A. Lehmann, B. Broughton, 1994, Nature Genetics.

Transcript Levels Pigmentosum and Consequences at the Cell, Protein, and Mutations in the XPC Gene in Families with Xeroderma

D. Pietra, B. Broughton, F. Chavanne, 2013 .

Mutations in the XPC gene in families with xeroderma pigmentosum and consequences at the cell, protein, and transcript levels.

A. Lehmann, M. Stefanini, T. Nardò, 2000, Cancer research.

The ultraviolet sensitivity of Cockayne syndrome cells is not a consequence of reduced cellular NAD content.

A. Lehmann, L. Mayne, B. Broughton, 1984, American journal of human genetics.

Cell killing and mutagenesis by 8‐methoxypsoralen in mammalian (rodent) cells

C. Arlett, J. Heddle, B. Broughton, 1980, Clinical and experimental dermatology.