E. Samper

发表

Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTAGGG repeats and the G‐strand overhang

M. Blasco, P. V. van Buul, P. Slijepcevic, 2000, EMBO reports.

The Absence of the DNA-Dependent Protein Kinase Catalytic Subunit in Mice Results in Anaphase Bridges and in Increased Telomeric Fusions with Normal Telomere Length and G-Strand Overhang

M. Blasco, E. Samper, F. Goytisolo, 2001, Molecular and Cellular Biology.

Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum

Tak W. Mak, José Luis de la Pompa, Hiroaki Takimoto, 1998, Nature.

Targeted gene therapy and cell reprogramming in Fanconi anemia

Luigi Naldini, Elena Almarza, Angelo Lombardo, 2014, EMBO molecular medicine.

Telomerase-Deficient Mouse Model

M. Blasco, E. Samper, Enrique Samper, 2003 .

Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA

María A Blasco, Han-Woong Lee, Peter M Lansdorp, 1997, Cell.

Mitochondrial oxidative stress causes chromosomal instability of mouse embryonic fibroblasts

S. Melov, D. Nicholls, E. Samper, 2003, Aging cell.

Brief Report: Impaired Cell Reprogramming in Nonhomologous End Joining Deficient Cells

J. Bueren, Z. Ivics, E. Samper, 2013, Stem cells.

Normal telomere length and chromosomal end capping in poly(ADP-ribose) polymerase–deficient mice and primary cells despite increased chromosomal instability

J. Cigudosa, M. Blasco, G. de Murcia, 2001, The Journal of cell biology.

The absence of p53 is critical for the induction of apoptosis by 5-aza-2′-deoxycytidine

M. Fraga, M. Esteller, M. Serrano, 2004, Oncogene.

Hyperplasia, reduced E-cadherin expression, and developmental arrest in mammary glands oxidatively stressed by loss of mitochondrial superoxide dismutase.

B. Ljung, C. Benz, S. Melov, 2005, Breast.

Telomere shortening in mTR−/− embryos is associated with failure to close the neural tube

M. Blasco, E. Samper, E. Herrera, 1999, The EMBO journal.

Breaks at telomeres and TRF2-independent end fusions in Fanconi anemia.

M. Blasco, R. Marcos, A. Creus, 2002, Human molecular genetics.

Short Telomeres Result in Organismal Hypersensitivity to Ionizing Radiation in Mammals

P. Finnon, M. Blasco, J. Flores, 2000, The Journal of experimental medicine.

Long-term repopulating ability of telomerase-deficient murine hematopoietic stem cells.

M. Blasco, A. Bernad, M. Aracil, 2002, Blood.

blockade SOCS up-regulation mobilizes autologous stem cells through CXCR4

A. Bernad, J. Rodríguez-Frade, M. C. Moreno-Ortiz, 2013 .

SOCS up-regulation mobilizes autologous stem cells through CXCR4 blockade.

A. Bernad, J. Rodríguez-Frade, M. Mellado, 2006, Blood.

Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts

S. Melov, J. Campisi, A. Krtolica, 2003, Nature Cell Biology.

Telomerase inhibition in RenCa, a murine tumor cell line with short telomeres, by overexpression of a dominant negative mTERT mutant, reveals fundamental differences in telomerase regulation between human and murine cells.

M. Blasco, R. Heicappell, M. Müller, 2001, Cancer research.

stem cells Long-term repopulating ability of telomerase-deficient murine hematopoietic

A. Bernad, M. Aracil, E. Samper, 2013 .

Culture of human mesenchymal stem cells at low oxygen tension improves growth and genetic stability by activating glycolysis

A. Dopazo, P. López-Romero, A. Bernad, 2011, Cell Death and Differentiation.

Increase in mitochondrial biogenesis, oxidative stress, and glycolysis in murine lymphomas.

A. Hubbard, S. Melov, A. Bernad, 2009, Free radical biology & medicine.

Pol II–Expressed shRNA Knocks Down Sod2 Gene Expression and Causes Phenotypes of the Gene Knockout in Mice

S. Melov, Zuoshang Xu, E. Samper, 2005, PLoS genetics.

Conservation of the Notch signalling pathway in mammalian neurogenesis.

J. Rossant, T. Mak, Stephen Brown, 1997, Development.

Generation of iPSCs from Genetically Corrected Brca2 Hypomorphic Cells: Implications in Cell Reprogramming and Stem Cell Therapy

Á. Raya, J. Segovia, J. Bueren, 2014, Stem cells.

Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes

M. Blasco, J. Jorcano, J. Flores, 2001, The EMBO journal.

Telomere length abnormalities in mammalian radiosensitive cells.

M. Blasco, S. Bouffler, A. Riches, 2001, Cancer research.

Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis

M. Blasco, J. Flores, E. Samper, 2000, Nature Genetics.

Disease states associated with telomerase deficiency appear earlier in mice with short telomeres

M. Blasco, J. Flores, J. Martı́n-Caballero, 1999, The EMBO journal.

Restoration of telomerase activity rescues chromosomal instability and premature aging in Terc−/− mice with short telomeres

M. Blasco, J. Flores, E. Samper, 2001, EMBO reports.

Human mesenchymal stem cell-replicative senescence and oxidative stress are closely linked to aneuploidy

A. Dopazo, A. Bernad, A. Benguría, 2013, Cell Death and Disease.

Telomere Length Dynamics and Chromosomal Instability in Cells Derived from Telomerase Null Mice

M. Hande, M. Blasco, P. Lansdorp, 1999, The Journal of cell biology.

Increased Learning and Brain Long-Term Potentiation in Aged Mice Lacking DNA Polymerase μ

J. Delgado-García, A. Fairén, A. Gruart, 2013, PloS one.

Altered Hematopoiesis in Mice Lacking DNA Polymerase μ Is Due to Inefficient Double-Strand Break Repair

L. Blanco, A. Bernad, J. Segovia, 2009, PLoS genetics.

Mitochondrial. A Critical Role in Aging

S. Melov, K. Morten, E. Samper, 2005 .

Alan Hubbard, Simon Melov, K. Beckman, 2007, Aging cell.

Polμ deficiency induces moderate shortening of P53-/- mouse lifespan and modifies tumor spectrum.

J. Suela, L. Blanco, A. Bernad, 2017, DNA repair.

Polμ Deficiency Increases Resistance to Oxidative Damage and Delays Liver Aging

L. Blanco, Manuel A. González, A. Bernad, 2014, PloS one.

Early induction of senescence and immortalization in PGC-1α-deficient mouse embryonic fibroblasts.

A. Zambrano, M. Monsalve, I. Prieto, 2018, Free radical biology & medicine.

Complement anaphylatoxins C3a and C5a induce a failing regenerative program in cardiac resident cells. Evidence of a role for cardiac resident stem cells other than cardiomyocyte renewal

A. Diez-Juan, A. Bernad, E. Samper, 2012, SpringerPlus.

Cardiac Cell Therapy: Boosting Mesenchymal Stem Cells Effects

A. Diez-Juan, J. Montero, P. Sepúlveda, 2013, Stem Cell Reviews and Reports.