B. Lopez

发表

Characterisation of homologous recombination induced by replication inhibition in mammalian cells

D. Averbeck, G. Vares, Y. Saintigny, 2020 .

CtIP fusion to Cas9 enhances transgene integration by homology-dependent repair

J. Concordet, S. Geny, L. Tesson, 2018, Nature Communications.

Role of RAD51 in sister-chromatid exchanges in mammalian cells

S. Lambert, B. Lopez, 2001, Oncogene.

An xrcc4 defect or Wortmannin stimulates homologous recombination specifically induced by double-strand breaks in mammalian cells.

M. Jasin, T. Stamato, F. Delacôte, 2002, Nucleic acids research.

AKT1 represses gene conversion induced by different genotoxic stresses and induces supernumerary centrosomes and aneuploidy in hamster ovary cells

B. Lopez, I. Plo, 2009, Oncogene.

Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells

Jean Gautier, Isabelle Plo, J. Gautier, 2009, Nature Structural &Molecular Biology.

Mammalian RAD51 prevents non-conservative alternative end-joining and single strand annealing through non-catalytic mechanisms

J. Masson, E. Le Cam, J. Guirouilh-Barbat, 2019 .

S-phase progression stimulates both the mutagenic KU-independent pathway and mutagenic processing of KU-dependent intermediates, for nonhomologous end joining

J. Guirouilh-Barbat, B. Lopez, S. Huck, 2008, Oncogene.

Oxidative stress induces an ATM‐independent senescence pathway through p38 MAPK‐mediated lamin B1 accumulation

B. Lopez, C. Le Chalony, G. Pennarun, 2012, The EMBO journal.

Oxidative stress induces an ATM-independent senescence pathway through p 38 MAPK-mediated lamin B 1 accumulation

B. Lopez, G. Pennarun, P. Bertrand, 2011 .

[Direct role of p53 on homologous recombination].

Y. Saintigny, B. Lopez, P. Bertrand, 2005, Medecine sciences : M/S.

Chronic exposure to sublethal doses of radiation mimetic Zeocin selects for clones deficient in homologous recombination.

L. Deriano, Y. Saintigny, F. Delacôte, 2007, Mutation research.

Mutant p53 proteins stimulate spontaneous and radiation-induced intrachromosomal homologous recombination independently of the alteration of the transactivation activity and of the G1 checkpoint

T. Soussi, Y. Saintigny, B. Lopez, 1999, Oncogene.

Analysis of intrachromosomal homologous recombination in mammalian cell, using tandem repeat sequences.

F. Amiot, Y. Saintigny, F. Delacôte, 1999, Mutation research.

Characterization of two nuclear mammalian homologous DNA-pairing activities that do not require associated exonuclease activity.

B. Lopez, P. Bertrand, A. Akhmedov, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Molecular analysis of homologous recombination catalysed by human nuclear extract: fidelity and DNase protection.

J. Coppey, B. Lopez, 1989, Biochemical and biophysical research communications.

Promotion of double-strand break repair by human nuclear extracts preferentially involves recombination with intact homologous DNA.

J. Coppey, B. Lopez, 1987, Nucleic acids research.

Chromosome translocation based on illegitimate recombination in human tumors.

G. Thomas, J. Zucman‐Rossi, J. Victor, 1998, Proceedings of the National Academy of Sciences of the United States of America.

SAMHD1 acts at stalled replication forks to prevent interferon induction

V. Costanzo, M. Benkirane, P. Pasero, 2018, Nature.

Signaling from Mus81-Eme2-Dependent DNA Damage Elicited by Chk1 Deficiency Modulates Replication Fork Speed and Origin Usage.

M. Debatisse, B. Lopez, O. Brison, 2016, Cell reports.

Bax and Bid, two proapoptotic Bcl-2 family members, inhibit homologous recombination, independently of apoptosis regulation

F. Lebrun, J. Vayssière, Y. Saintigny, 2006, Oncogene.

Human RAD52 stimulates the RAD51-mediated homology search

J. Masson, E. Le Cam, G. Mazón, 2022, bioRxiv.

A homologous recombination defect affects replication-fork progression in mammalian cells

F. Daboussi, M. Debatisse, S. Benhamou, 2008, Journal of Cell Science.

DNA polymerase beta overexpression stimulates the Rad51-dependent homologous recombination in mammalian cells.

J. Capp, Y. Canitrot, B. Lopez, 2004, Nucleic acids research.

Is Non-Homologous End-Joining Really an Inherently Error-Prone Process?

M. Bétermier, B. Lopez, Mireille Bétermier, 2014, PLoS genetics.

The secret life of Bcl-2: apoptosis-independent inhibition of DNA repair by Bcl-2 family members.

B. Lopez, C. Laulier, Corentin Laulier, 2012, Mutation research.

AKT1 inhibits homologous recombination by inducing cytoplasmic retention of BRCA1 and RAD51.

F. Lebrun, F. Calvo, L. Gauthier, 2008, Cancer research.

AKT 1 Inhibits Homologous Recombination by Inducing Cytoplasmic Retention of BRCA 1 and RAD 51

F. Lebrun, F. Calvo, L. Gauthier, 2008 .

Human 75-kDa DNA-pairing Protein Is Identical to the Pro-oncoprotein TLS/FUS and Is Able to Promote D-loop Formation*

D. Ron, B. Lopez, M. Kuroda, 1999, The Journal of Biological Chemistry.

XRCC4 in G1 suppresses homologous recombination in S/G2, in G1 checkpoint-defective cells

D. Averbeck, Y. Saintigny, F. Delacôte, 2007, Oncogene.

Multiplicity reactivation and mutagenesis of trimethylpsoralen-damaged herpes virus in normal and Fanconi's anaemia cells.

J. Coppey, B. Lopez, M. Sala-Trepat, 1989, Mutagenesis.

SAMHD1 acts at stalled replication forks to prevent interferon induction

V. Costanzo, M. Benkirane, P. Pasero, 2018, Nature.

Down-regulation of BRCA1 expression by miR-146a and miR-146b-5p in triple negative sporadic breast cancers

R. Lidereau, S. Mazoyer, R. Rimokh, 2011, EMBO molecular medicine.

Is homologous recombination really an error-free process?

J. Guirouilh-Barbat, S. Lambert, B. Lopez, 2014, Front. Genet..

Homologous recombination in mammalian cells: From molecular mechanisms to pathology

B. Lopez, Melissa Thomas, Gabriel E. Matos-Rodrigues, 2021, Genome Stability.

Combining Homologous Recombination and Phosphopeptide-binding Data to Predict the Impact of BRCA1 BRCT Variants on Cancer Risk

Jean-Christophe Aude, Etienne Rouleau, Sandrine M. Caputo, 2018, Molecular Cancer Research.

PARP2 controls double-strand break repair pathway choice by limiting 53BP1 accumulation at DNA damage sites and promoting end-resection

J. Guirouilh-Barbat, B. Lopez, M. Amor-Guéret, 2017, Nucleic acids research.

Polo-like kinase 3 regulates CtIP during DNA double-strand break repair in G1

M. Steinlage, Olivia Barton, J. Künzel, 2014, The Journal of cell biology.

PARP3 affects the relative contribution of homologous recombination and nonhomologous end-joining pathways

V. Schreiber, P. Rondé, Marie-Elise Bonnet, 2014, Nucleic acids research.

A role for BLM in double-strand break repair pathway choice: prevention of CtIP/Mre11-mediated alternative nonhomologous end-joining.

I. Hickson, J. Guirouilh-Barbat, B. Lopez, 2013, Cell reports.

Bcl-2 inhibits nuclear homologous recombination by localizing BRCA1 to the endomembranes.

J. Verbavatz, J. Guirouilh-Barbat, B. Lopez, 2011, Cancer research.

Homozygous hypomorphic BRCA2 variant in primary ovarian insufficiency without cancer or Fanconi anaemia trait

G. Livera, S. Caburet, S. Messiaen, 2020, Journal of Medical Genetics.

An adaptive pre-DNA-damage-response protects genome integrity

E. Solary, J. Ravanat, N. Droin, 2020, bioRxiv.

Replication Stress, DNA Damage, Inflammatory Cytokines and Innate Immune Response

B. Lopez, Gabriel E. Matos-Rodrigues, S. Ragu, 2020, Genes.

The causes of replication stress and their consequences on genome stability and cell fate.

P. Pasero, S. Lambert, B. Lopez, 2014, Seminars in cell & developmental biology.

Role of the double-strand break repair pathway in the maintenance of genomic stability

J. Guirouilh-Barbat, B. Lopez, S. Ragu, 2014, Molecular & cellular oncology.

An in vitro enzymatic assay coupled to proteomics analysis reveals a new DNA processing activity for Ewing sarcoma and TAF(II)68 proteins

J. Rossier, D. Praseuth, V. Labas, 2006, Proteomics.

Human POMp75 is identified as the pro-oncoprotein TLS/FUS: both POMp75 and POMp100 DNA homologous pairing activities are associated to cell proliferation

A. Durrbach, F. Delacôte, B. Lopez, 1999, Oncogene.

Importance of the cell cycle phase for the choice of the appropriate DSB repair pathway, for genome stability mintenance: the trans-S double-strand break repair model

F. Delacôte, B. Lopez, 2008, Cell cycle.

p53's double life: transactivation-independent repression of homologous recombination.

Y. Saintigny, B. Lopez, P. Bertrand, 2004, Trends in genetics : TIG.

Targeting acute myeloid leukemia dependency on VCP-mediated DNA repair through a selective second-generation small-molecule inhibitor

S. Carr, K. Lage, K. Stegmaier, 2021, Science Translational Medicine.

BRCA1-Ku80 Protein Interaction Enhances End-joining Fidelity of Chromosomal Double-strand Breaks in the G1 Phase of the Cell Cycle*

E. Yang, G. Jiang, F. Xia, 2013, The Journal of Biological Chemistry.

AKT1/BRCA1 in the control of homologous recombination and genetic stability: the missing link between hereditary and sporadic breast cancers

J. Guirouilh-Barbat, B. Lopez, Therese Wilhelm, 2010, Oncotarget.

DNA double-strand break repair signalling: the case of RAD51 post-translational regulation.

Fayza Daboussi, F. Daboussi, F. Delacôte, 2002, Cellular signalling.

A novel role for the Bcl‐2 protein family: specific suppression of the RAD51 recombination pathway

Y. Saintigny, S. Lambert, B. Lopez, 2001, The EMBO journal.

Homologous Recombination is Involved in the Repair Response of Mammalian Cells to Low Doses of Tritium

Y. Saintigny, B. Lopez, Delphine Meynard, 2008, Radiation research.

A threshold of endogenous stress is required to engage cellular response to protect against mutagenesis

Sonia Hem, J. Radicella, A. Bravard, 2016, Scientific Reports.

Genomic rearrangements induced by unscheduled DNA double strand breaks in somatic mammalian cells

J. Guirouilh-Barbat, B. Lopez, Ayeong So, 2017, The FEBS journal.

Impact of the KU80 pathway on NHEJ-induced genome rearrangements in mammalian cells.

C. Desmaze, L. Sabatier, J. Guirouilh-Barbat, 2004, Molecular cell.

53BP1 Protects against CtIP-Dependent Capture of Ectopic Chromosomal Sequences at the Junction of Distant Double-Strand Breaks

J. Guirouilh-Barbat, R. Scully, B. Lopez, 2016, PLoS genetics.

Replication Stress in Mammalian Cells and Its Consequences for Mitosis

B. Lopez, C. Gelot, I. Magdalou, 2015, Genes.

Defects in XRCC4 and KU80 differentially affect the joining of distal nonhomologous ends

J. Guirouilh-Barbat, B. Lopez, I. Plo, 2007, Proceedings of the National Academy of Sciences.

A nonsense mutation in the DNA repair factor Hebo causes mild bone marrow failure and microcephaly

J. Soulier, P. Revy, I. Callebaut, 2016, The Journal of experimental medicine.

Homologous recombination induced by replication inhibition, is stimulated by expression of mutant p53

Y. Saintigny, B. Lopez, 2002, Oncogene.

Polo like kinase 3 regulates CtIP during DNA double strand break repair in G 1

M. Steinlage, Olivia Barton, J. Künzel, 2014 .

Human 100-kDa homologous DNA-pairing protein is the splicing factor PSF and promotes DNA strand invasion.

B. Lopez, A. Akhmedov, 2000, Nucleic acids research.

Spontaneous slow replication fork progression elicits mitosis alterations in homologous recombination-deficient mammalian cells

M. Debatisse, B. Lopez, A. Barascu, 2013, Proceedings of the National Academy of Sciences.

The helicase FBH1 is tightly regulated by PCNA via CRL4(Cdt2)-mediated proteolysis in human cells

J. Charbonnier, P. Kannouche, B. Lopez, 2013, Nucleic acids research.

Control of alternative end joining by the chromatin remodeler p400 ATPase

D. Trouche, J. Guirouilh-Barbat, Y. Canitrot, 2015, Nucleic acids research.

Initiation of DNA double strand break repair: signaling and single-stranded resection dictate the choice between homologous recombination, non-homologous end-joining and alternative end-joining.

J. Guirouilh-Barbat, B. Lopez, A. Grabarz, 2012, American journal of cancer research.

Homologous Recombination in Mammals

B. Lopez, A. Grabarz, A. Barascu, 2013 .

In vivo inactivation of RAD51-mediated homologous recombination leads to premature aging, but not to tumorigenesis

G. Livera, V. Barroca, P. Romeo, 2022, bioRxiv.

Combined therapy of colon carcinomas with an oncolytic adenovirus and valproic acid

P. Opolon, O. Bawa, D. Majhen, 2017, OncoTarget.

Inactivation of the RAD51 recombination pathway stimulates UV-induced mutagenesis in mammalian cells

S. Lambert, B. Lopez, 2002, Oncogene.

Mouse Models for Deciphering the Impact of Homologous Recombination on Tumorigenesis

B. Lopez, Gabriel E. Matos-Rodrigues, E. Martini, 2021, Cancers.

RhoB Promotes γH2AX Dephosphorylation and DNA Double-Strand Break Repair

G. Favre, O. Sordet, J. Faye, 2014, Molecular and Cellular Biology.

RAD51 promotes non-homologous genetic rearrangements that are prevented by 53BP1

M. Stern, C. Lescale, L. Deriano, 2019, bioRxiv.

Phospho-Ku70 induced by DNA damage interacts with RNA Pol II and promotes the formation of phospho-53BP1 foci to ensure optimal cNHEJ

M. Hullo, V. Barroca, D. Biard, 2021, Nucleic acids research.

Involvement of DNA polymerase μ in the repair of a specific subset of DNA double-strand breaks in mammalian cells

J. Capp, F. Boudsocq, Y. Canitrot, 2007, Nucleic Acids Research.

The DNA polymerase λ is required for the repair of non-compatible DNA double strand breaks by NHEJ in mammalian cells

P. Pourquier, J. Capp, A. Laroche-Clary, 2006, Nucleic acids research.

CtIP fusion to Cas9 enhances transgene integration by homology-dependent repair

J. Concordet, S. Geny, L. Tesson, 2018, Nature Communications.

Terminal deoxynucleotidyl transferase requires KU80 and XRCC4 to promote N-addition at non-V(D)J chromosomal breaks in non-lymphoid cells

B. Lopez, F. Rougeon, Aurélie Claes, 2012, Nucleic acids research.

[Double strand break repair, one mechanism can hide another: alternative non-homologous end joining].

B. Lopez, P. Bertrand, E. Rass, 2012, Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique.

Homologous recombination, cancer and the ‘RAD51 paradox’

J. Guirouilh-Barbat, B. Lopez, Gabriel E. Matos-Rodrigues, 2021, NAR cancer.

Characterization of mammalian RAD51 double strand break repair using non‐lethal dominant‐negative forms

S. Lambert, B. Lopez, 2000, The EMBO journal.

Homologous pairing between single-stranded DNA immobilized on a nitrocellulose membrane and duplex DNA is specific for RecA activity in bacterial crude extract.

M. Dutreix, J. Coppey, B. Lopez, 1993, Nucleic acids research.

The cohesin complex prevents the end-joining of distant DNA double-strand ends in S phase: Consequences on genome stability maintenance

J. Guirouilh-Barbat, B. Lopez, C. Gelot, 2016, Nucleus.

The Cohesin Complex Prevents the End Joining of Distant DNA Double-Strand Ends.

J. Guirouilh-Barbat, Y. Canitrot, B. Lopez, 2016, Molecular cell.

Increase of spontaneous intrachromosomal homologous recombination in mammalian cells expressing a mutant p53 protein

T. Soussi, B. Lopez, C. Levalois, 1997, Oncogene.

Slow Replication Fork Velocity of Homologous Recombination-Defective Cells Results from Endogenous Oxidative Stress

M. Debatisse, J. Guitton, B. Lopez, 2016, PLoS genetics.

Double-Strand Break Repair

B. Lopez, S. Ragu, C. Gelot, 2016 .

A homozygous hypomorphic BRCA2 variant causes primary ovarian insufficiency without cancer or Fanconi anemia traits

G. Livera, S. Caburet, S. Messiaen, 2019, bioRxiv.

Noncanonical Roles of RAD51

J. Guirouilh-Barbat, B. Lopez, C. Dubacq, 2023, Cells.

ATRIP protects progenitor cells against DNA damage in vivo

T. Hofmann, P. Grigaravičius, B. Lopez, 2020, Cell Death & Disease.

Involvement of the FOXO6 transcriptional factor in breast carcinogenesis

F. Lallemand, S. Vacher, I. Bièche, 2017, OncoTarget.

Genetic interactions between RAD51 and its paralogues for centrosome fragmentation and ploidy control, independently of the sensitivity to genotoxic stresses

F. Daboussi, J. Thacker, B. Lopez, 2005, Oncogene.

Characterization of Reca Mediated homologous pairing on nitrocellulose membrane.

B. Lopez, P. Bertrand, A. Akhmedov, 1995, Biochimie.

The high protein expression of FOXO3, but not that of FOXO1, is associated with markers of good prognosis

F. Lallemand, S. Vacher, I. Bièche, 2020, Scientific Reports.

The nucleoporin 153, a novel factor in double-strand break repair and DNA damage response

M. Goldberg, E. Soutoglou, L. Brino, 2012, Oncogene.

Overexpression of mammalian Rad51 does not stimulate tumorigenesis while a dominant-negative Rad51 affects centrosome fragmentation, ploidy and stimulates tumorigenesis, in p53-defective CHO cells

S. Lambert, B. Lopez, P. Bertrand, 2003, Oncogene.

, and DNA Double-Strand Break Repair H 2 AX Dephosphorylation γ RhoB Promotes

G. Favre, O. Sordet, J. Faye, 2014 .

[SAMHD1 acts at stalled replication forks to prevent interferon induction].

V. Costanzo, M. Benkirane, P. Pasero, 2020, Comptes rendus biologies.

A noncanonical response to replication stress protects genome stability through ROS production, in an adaptive manner

E. Solary, J. Ravanat, N. Droin, 2023, Cell Death & Differentiation.

Structural effect of donor DNA on the initiation of recombination for double strand break repair in human nuclear extracts.

J. Coppey, B. Lopez, E. Corteggiani, 1992, Nucleic acids research.

Structural effect ofdonorDNAontheinitiation of recombination fordouble strand breakrepair inhuman nuclear extracts

B. Lopez, E. Corteggiani, P. Bertrand-Mercat, 1992 .

Yeast cells reveal the misfolding and the cellular mislocalization of the human BRCA1 protein

A. Nicolas, V. Lejour, Graça Raposo-Benedetti, 2016, Journal of Cell Science.

The Cohesion complex maintains genome stability by preventing end joining of distant DNA ends in S phase

J. Guirouilh-Barbat, B. Lopez, C. Gelot, 2018, Molecular & cellular oncology.

Directional recombination is initiated at a double strand break in human nuclear extracts.

J. Coppey, B. Lopez, E. Corteggiani, 1992, Nucleic acids research.