M. Plotkine

M. Plotkine, I. Margaill, Sophie Batteur-Parmentier, 2000, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Beneficial effects of PJ34 and INO-1001, two novel water-soluble poly(ADP-ribose) polymerase inhibitors, on the consequences of traumatic brain injury in rat

C. Szabó, V. Besson, M. Plotkine, 2005, Brain Research.

Neuroprotective Effects of (S)-N-[4-[4-[(3,4-Dihydro-6-hydroxy-2,5,7,8 -tetramethyl-2H-1-benzopyran-2-yl)carbonyl]-1-piperazinyl]phenyl]-2 -thiophenecarboximid-amide (BN 80933), an Inhibitor of Neuronal Nitric-Oxide Synthase and an Antioxidant, in Model of Transient Focal Cerebral Ischemia in Mice

B. Palmier, M. Plotkine, I. Margaill, 2003, Journal of Pharmacology and Experimental Therapeutics.

Short Therapeutic Window for MK-801 in Transient Focal Cerebral Ischemia in Normotensive Rats

M. Plotkine, J. Callebert, I. Margaill, 1996, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Concomitant increases in the extracellular concentrations of excitatory and inhibitory amino acids in the rat hippocampus during forebrain ischemia

M. Plotkine, J. Callebert, D. Lekieffre, 1992, Neuroscience Letters.

Effect of riluzole on focal cerebral ischemia in rats.

F. Wahl, M. Plotkine, R. Boulu, 1993, European journal of pharmacology.

Deleterious poly(ADP-ribose)polymerase-1 pathway activation in traumatic brain injury in rat

V. Besson, M. Plotkine, C. Marchand-Verrecchia, 2003, Brain Research.

Early Endonuclease Activation following Reversible Focal Ischemia in the Rat Brain

Y. Ben-Ari, C. Charriaut-Marlangue, M. Plotkine, 1995, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Polymorphonuclear neutrophils contribute to infarction and oxidative stress in the cortex but not in the striatum after ischemia–reperfusion in rats

M. Plotkine, I. Margaill, N. Croci, 2003, Brain Research.

Down-regulation of striatal enkephalinergic (PPA) messenger RNA without prior apoptotic features following reversible focal ischemia in rat

Y. Ben-Ari, C. Charriaut-Marlangue, M. Plotkine, 1997, Brain Research.

Detrimental role of bradykinin B2 receptor in a murine model of diffuse brain injury.

B. Palmier, F. Hellal, M. Plotkine, 2003, Journal of neurotrauma.

Kynurenic acid antagonizes hippocampal quinolinic acid neurotoxicity: Behavioral and histological evaluation

M. Plotkine, D. Lekieffre, R. Boulu, 1990, Neuroscience Letters.

Reduction of the neurological deficit in mice with traumatic brain injury by nitric oxide synthase inhibitors.

M. Plotkine, C. Verrecchia, M. Allix, 1996, Journal of neurotrauma.

Do anticonvulsant drugs exert protective effect against hypoxia?

M. Plotkine, P. Rossignol, C. Caillard, 1975, Life sciences.

Induction of Type 2 Iodothyronine Deiodinase in Astrocytes after Transient Focal Cerebral Ischemia in the Rat

M. Plotkine, I. Margaill, M. Ramaugé, 2005, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

3-Aminobenzamide reduces brain infarction and neutrophil infiltration after transient focal cerebral ischemia in mice

M. Plotkine, I. Margaill, Li Ding-Zhou, 2003, Experimental Neurology.

Pattern of cerebral edema and hemorrhage in a mice model of diffuse brain injury

B. Palmier, D. Bonnefont-Rousselot, F. Hellal, 2004, Neuroscience Letters.

Influence of Anesthesia Protocol in Experimental Traumatic Brain Injury

F. Wahl, J. Stutzmann, M. Plotkine, 2000, Journal of neurosurgical anesthesiology.

Morphine and morphine metabolite kinetics in the rat brain as assessed by transcortical microdialysis.

M. Plotkine, J. Scherrmann, M. Barjavel, 1994, Life sciences.

NG-nitro-L-arginine methyl ester reduces necrotic but not apoptotic cell death induced by reversible focal ischemia in rat.

Y. Ben-Ari, C. Charriaut-Marlangue, M. Plotkine, 1996, European journal of pharmacology.

Electrically induced arterial thrombosis model in the conscious rat.

M. Plotkine, L. Massad, R. Boulu, 1987, Thrombosis research.

Caspase Inhibition after Neonatal Ischemia in the Rat Brain

J. Mariani, C. Charriaut-Marlangue, M. Plotkine, 2004, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Apoptosis and Necrosis after Reversible Focal Ischemia: An in Situ DNA Fragmentation Analysis

Y. Ben-Ari, A. Represa, C. Charriaut-Marlangue, 1996, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

The neuroprotective effect of a nitric oxide inhibitor in a rat model of focal cerebral ischaemia

A. Buisson, M. Plotkine, R. Boulu, 1992, British journal of pharmacology.

Ultrastructural Morphology of Neuronal Death Following Reversible Focal Ischemia in the Rat

Y. Ben-Ari, A. Represa, C. Charriaut-Marlangue, 1998, Apoptosis.

Apoptotic mitochondrial pathway in neurones and astrocytes after neonatal hypoxia‐ischaemia in the rat brain

B. Palmier, C. Charriaut-Marlangue, M. Plotkine, 2003, Neuropathology and applied neurobiology.

Distribution of Poly(ADP-ribosyl)ation and Cell Death After Cerebral Ischemia in the Neonatal Rat

C. Charriaut-Marlangue, M. Plotkine, L. Joly, 2003, Pediatric Research.

Deleterious Activation of Poly(ADP-Ribose)Polymerase-1 in Brain after In Vivo Oxidative Stress

V. Besson, M. Plotkine, I. Margaill, 2003, Free radical research.

Plasma concentrations of arginine and related amino acids following traumatic brain injury: Proline as a promising biomarker of brain damage severity.

M. Plotkine, C. Marchand-Leroux, L. Cynober, 2007, Nitric oxide : biology and chemistry.

Antioxidant strategies in the treatment of stroke.

M. Plotkine, I. Margaill, Dominique Lerouet, 2005, Free radical biology & medicine.

Nitric oxide: an endogenous anticonvulsant substance

A. Buisson, M. Plotkine, R. Boulu, 1993, Neuroreport.

Impairment of lymphocyte function in head-injured rats: effects of standard and immune-enhancing diets for enteral nutrition.

S. Richon, S. Walrand, C. Moinard, 2006, Clinical nutrition.

NMDA Receptor Activation Inhibits α-Secretase and Promotes Neuronal Amyloid-β Production

E. Mackenzie, C. Gabriel, C. Ali, 2005, The Journal of Neuroscience.

Fenofibrate, a peroxisome proliferator-activated receptor α agonist, exerts neuroprotective effects in traumatic brain injury

X. Chen, V. Besson, M. Plotkine, 2005, Neuroscience Letters.

Blockade of acute microglial activation by minocycline promotes neuroprotection and reduces locomotor hyperactivity after closed head injury in mice: a twelve-week follow-up study.

T. Piaggio, F. Noble, M. Plotkine, 2010, Journal of neurotrauma.

Oxidative stress implication in a new phenotype of amyotrophic quadricipital syndrome with cardiac involvement due to lamin A/C mutation

A. Legrand, D. Bonnefont-Rousselot, M. Plotkine, 2007, Free radical research.

Deleterious Ca‐independent NOS activity after oxidative stress in rat striatum

M. Plotkine, I. Margaill, L. Lecanu, 1998, Neuroreport.

Etazolate, an α-secretase activator, reduces neuroinflammation and offers persistent neuroprotection following traumatic brain injury in mice

M. Plotkine, C. Marchand-Leroux, Gemma Llufriu-Dabén, 2013, Neuropharmacology.

Minocycline restores olfactory bulb volume and olfactory behavior after traumatic brain injury in mice.

M. Plotkine, C. Marchand-Leroux, S. Calabria, 2012, Journal of neurotrauma.

1400W, a potent selective inducible NOS inhibitor, improves histopathological outcome following traumatic brain injury in rats.

V. Besson, M. Plotkine, G. Bohme, 2005, Nitric oxide : biology and chemistry.

Effect on Cerebral Blood Flow of Orally Administered Indomethacin‐loaded Poly(isobutylcyanoacrylate) and Poly(DL‐lactide) Nanocapsules

H. Fessi, M. Plotkine, J. Devissaguet, 1990, The Journal of pharmacy and pharmacology.

Oral administration of isosorbide dinitrate inhibits arterial thrombosis in rats.

M. Plotkine, R. Boulu, M. Allix, 1991, European journal of pharmacology.

Effect of acute poly(ADP-ribose) polymerase inhibition by 3-AB on blood-brain barrier permeability and edema formation after focal traumatic brain injury in rats.

L. Puybasset, B. Palmier, P. Méric, 2010, Journal of neurotrauma.

Minocycline effects on cerebral edema: Relations with inflammatory and oxidative stress markers following traumatic brain injury in mice

B. Palmier, M. Plotkine, C. Marchand-Leroux, 2009, Brain Research.

Combination Therapy with Fenofibrate, a Peroxisome Proliferator-Activated Receptor α Agonist, and Simvastatin, a 3-Hydroxy-3-methylglutaryl-Coenzyme A Reductase Inhibitor, on Experimental Traumatic Brain Injury

X. Chen, V. Besson, M. Plotkine, 2008, Journal of Pharmacology and Experimental Therapeutics.

Neuroprotective and deleterious effects of nitric oxide on focal cerebral ischemia-induced neurone death.

M. Plotkine, R. Boulu, C. Verrecchia, 1995, Advances in neuroimmunology.

Selective inhibition of inducible nitric oxide synthase prevents ischaemic brain injury

G. Böhme, J. Stutzmann, M. Plotkine, 1999, British journal of pharmacology.

Neurological and Histological Consequences Induced by In Vivo Cerebral Oxidative Stress: Evidence for Beneficial Effects of SRT1720, a Sirtuin 1 Activator, and Sirtuin 1-Mediated Neuroprotective Effects of Poly(ADP-ribose) Polymerase Inhibition

B. Palmier, V. Besson, M. Plotkine, 2014, PloS one.

Lack of iNOS induction in a severe model of transient focal cerebral ischemia in rats

B. Palmier, D. Bonnefont-Rousselot, M. Plotkine, 2005, Experimental Neurology.

Cortical calcium increase following traumatic brain injury represents a pitfall in the evaluation of Ca2+-independent NOS activity

D. Bonnefont-Rousselot, V. Besson, M. Plotkine, 2004, Journal of Neuroscience Methods.

Characterization of a rat model to study acute neuroinflammation on histopathological, biochemical and functional outcomes

M. Plotkine, N. Croci, M. Jafarian-Tehrani, 2005, Journal of Neuroscience Methods.

ARNT2, a transcription factor for brain neuron survival?

J. Schwartz, G. Drutel, J. Arrang, 1999, The European journal of neuroscience.

Progesterone receptors: a key for neuroprotection in experimental stroke.

M. Schumacher, C. Mattern, B. O’Malley, 2012, Endocrinology.

hypobaric hypoxia: central catecholamine levels and cortical PO2 and avoidance response in rats treated with apomorphine.

M. Plotkine, R. Boulu, F. Boismare, 1981, Aviation, space, and environmental medicine.

Glutamate induces hydroxyl radical formation in vivo via activation of nitric oxide synthase in Sprague–Dawley rats

E. Lancelot, M. Plotkine, J. Callebert, 1998, Neuroscience Letters.

Effects of transient cerebral ischemia on the hippocampal dentate theta (θ) profile in the acute rat: a study 4–5 months following recirculation

O. Houcine, P. Monmaur, F. Willig, 1990, Brain Research.

Role of the l-arginine-nitric oxide pathway in the basal hydroxyl radical production in the striatum of awake rats as measured by brain microdialysis

E. Lancelot, M. Plotkine, J. Callebert, 1995, Neuroscience Letters.

Stroke and Traumatic Brain Injury

V. Besson, M. Plotkine, Dominique Lerouet, 2014 .

Calcium‐independent NO‐synthase activity and nitrites/nitrates production in transient focal cerebral ischaemia in mice

M. Plotkine, R. Boulu, C. Verrecchia, 1997, British journal of pharmacology.

Competitive NMDA receptor blockers reduce striatal glutamate accumulation in ischaemia.

M. Plotkine, J. Callebert, O. Ghribi, 1994, Neuroreport.

Evaluation of late cognitive impairment and anxiety states following traumatic brain injury in mice: The effect of minocycline

M. Plotkine, C. Marchand-Leroux, Gemma Llufriu-Dabén, 2012, Neuroscience Letters.

Changes in oxidative stress, iNOS activity and neutrophil infiltration in severe transient focal cerebral ischemia in rats

B. Palmier, M. Plotkine, I. Margaill, 2002, Brain Research.

Housekeeping while brain's storming Validation of normalizing factors for gene expression studies in a murine model of traumatic brain injury

D. Scherman, H. Rhinn, V. Escriou, 2008, BMC Molecular Biology.

Antisense Oligodeoxynucleotide to Inducible Nitric Oxide Synthase Protects against Transient Focal Cerebral Ischemia—Induced Brain Injury

M. Plotkine, I. Margaill, S. Parmentier-Batteur, 2001, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Correction: Neurological and Histological Consequences Induced by In Vivo Cerebral Oxidative Stress: Evidence for Beneficial Effects of SRT1720, a Sirtuin 1 Activator, and Sirtuin 1-Mediated Neuroprotective Effects of Poly(ADP-ribose) Polymerase Inhibition

B. Palmier, M. Plotkine, C. Marchand-Leroux, 2014, PLoS ONE.

Biphasic modulation by nitric oxide of caspase activation due to malonate injection in rat striatum.

B. Palmier, M. Plotkine, I. Margaill, 2004, European journal of pharmacology.

Effect of indomethacin in experimental cerebral ischemia.

N. Wiernsperger, M. Plotkine, R. Boulu, 1982, Pathologie et biologie.

Acute systemic inflammation induces central mitochondrial damage and mnesic deficit in adult Swiss mice

B. Palmier, J. Warnet, F. Noble, 2007, Neuroscience Letters.

Naloxone effect on the neurological deficit induced by forebrain ischemia in rats.

M. Plotkine, D. Pruneau, R. Boulu, 1986, Life sciences.

Neutrophils do not contribute to infarction, oxidative stress, and NO synthase activity in severe brain ischemia

B. Palmier, M. Plotkine, I. Margaill, 2003, Experimental Neurology.

Selective inhibition of inducible nitric oxide synthase reduces neurological deficit but not cerebral edema following traumatic brain injury

B. Palmier, M. Plotkine, C. Marchand-Verrecchia, 2006, Neuropharmacology.

Effects of selective and non-selective cyclooxygenase inhibition against neurological deficit and brain oedema following closed head injury in mice

B. Palmier, M. Plotkine, C. Marchand-Leroux, 2013, Brain Research.

Combined therapy with PJ34, a poly(ADP‐ribose)polymerase inhibitor, reduces tissue plasminogen activator‐induced hemorrhagic transformations in cerebral ischemia in mice

M. Plotkine, C. Marchand-Leroux, I. Margaill, 2013, Fundamental & clinical pharmacology.

Investigations on the role of arachidonic acid metabolism pathways in the antithrombotic activity of nafazatrom and molsidomine.

M. Plotkine, L. Massad, R. Boulu, 1988, Thrombosis research.

Long-term histological and behavioural characterisation of a collagenase-induced model of intracerebral haemorrhage in rats

V. Besson, M. Plotkine, C. Marchand-Leroux, 2010, Journal of Neuroscience Methods.

Nigrostriatal pathway modulates striatum vulnerability to quinolinic acid

A. Buisson, M. Plotkine, R. Boulu, 1991, Neuroscience Letters.

iNOS contribution to the NMDA‐induced excitotoxic lesion in the rat striatum

M. Plotkine, I. Margaill, L. Lecanu, 1998, British journal of pharmacology.

Enhancement of endogenous excitatory amino acids by theophylline does not modify the behavioral and histological consequences of forebrain ischemia

M. Plotkine, J. Callebert, D. Lekieffre, 1991, Brain Research.

Loss of NADPH‐diaphorase containing neurones after reversible focal ischaemia in rats delayed by L‐NAME

C. Charriaut-Marlangue, M. Plotkine, I. Margaill, 1995, British journal of pharmacology.

Inhibition of glutamate release in rat hippocampus by kynurenic acid does not protect CA1 cells from forebrain ischemia

M. Plotkine, J. Callebert, O. Ghribi, 1992, Brain Research.

Time course of oxidative stress, lesion and edema after intrastriatal injection of malonate in rat: effect of α‐phenyl‐N‐tert‐butylnitrone

V. Besson, M. Plotkine, I. Margaill, 2005, Fundamental & clinical pharmacology.

Effect of kynurenic acid on the ischaemia-induced accumulation of glutamate in rat striatum.

M. Plotkine, J. Callebert, O. Ghribi, 1994, Neuroreport.

Recovery from global cerebral ischemia in rabbits: influence of indomethacin.

M. Plotkine, R. Boulu, C. Guéniau, 1981, European neurology.

Blockers of NMDA‐operated channels decrease glutamate and aspartate extracellular accumulation in striatum during forebrain ischaemia in rats

M. Plotkine, J. Callebert, O. Ghribi, 1995, Fundamental & clinical pharmacology.

Mechanisms Involved in the Neuroprotective Activity of a Nitric Oxide Synthase Inhibitor During Focal Cerebral Ischemia

A. Buisson, M. Plotkine, J. Callebert, 1993, Journal of neurochemistry.

l-NAME modulates glutamate accumulation induced by K+-depolarization but not by forebrain ischaemia in the rat striatum

M. Plotkine, J. Callebert, O. Ghribi, 1994, Neuroscience Letters.

Striatal dopamine participates in glutamateinduced hydroxyl radical generation

E. Lancelot, M. Plotkine, J. Callebert, 1995, Neuroreport.

Lesioning the substantia nigra reduces striatal infarct volume following focal ischemia in rats

A. Buisson, M. Plotkine, R. Boulu, 1991, Fundamental & clinical pharmacology.

Model of global forebrain ischemia in the unanesthetized rat.

M. Plotkine, D. Pruneau, R. Boulu, 1986, Journal de pharmacologie.

Dose‐ and time‐dependence of l‐NAME neuroprotection in transient focal cerebral ischaemia in rats

M. Plotkine, I. Margaill, R. Boulu, 1997, British journal of pharmacology.

Effect of three inducible NOS inhibitors on cerebral edema formation and neurological deficit in a rat model of traumatic brain injury

B. Palmier, M. Plotkine, C. Marchand-Verrecchia, 2005 .

Protective effect of melatonin in a model of traumatic brain injury in mice

M. Plotkine, I. Margaill, R. Boulu, 1998, Journal of pineal research.

Long-term histological and behavioural characterisation of a collagenase-induced model of intracerebral haemorrhage in rats

V. Besson, M. Plotkine, C. Marchand-Leroux, 2010, Journal of Neuroscience Methods.

[Methods for evaluating the neurologic deficit induced by transient cerebral ischemia in the unanesthetized rat].

M. Plotkine, R. Boulu, C. Capdeville, 1984, Journal de pharmacologie.

Simvastatin in traumatic brain injury: Effect on brain edema mechanisms

B. Palmier, V. Besson, M. Plotkine, 2011, Critical care medicine.

Experimental modeling of recombinant tissue plasminogen activator effects after ischemic stroke

D. Vivien, M. Plotkine, C. Marchand-Leroux, 2012, Experimental Neurology.

Possible non-involvement of lipoxygenase pathway in the cerebral blood flow decrease due to indomethacin.

M. Plotkine, R. Boulu, F. Russo-Marie, 1985, European journal of pharmacology.

Housekeeping while brain's storming Validation of normalizing factors for gene expression studies in a murine model of traumatic brain injury

D. Scherman, H. Rhinn, V. Escriou, 2008, BMC Molecular Biology.

Nitric Oxide and Cerebral Ischemia

A. Buisson, M. Plotkine, R. Boulu, 1994, Annals of the New York Academy of Sciences.