D. Lajeunesse

发表

Bone remodeling signaled by a dihydropyridine- and phenylalkylamine-sensitive calcium channel.

S. Snyder, J. Wagner, S. Guggino, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Role of proinflammatory cytokines in the pathophysiology of osteoarthritis

Johanne Martel-Pelletier, Jean-Pierre Pelletier, Mohit Kapoor, 2011, Nature Reviews Rheumatology.

Subchondral bone sclerosis in osteoarthritis: not just an innocent bystander

J. Martel-Pelletier, J. Pelletier, D. Lajeunesse, 2003, Modern rheumatology.

Abnormal regulation of urokinase plasminogen activator by insulin-like growth factor 1 in human osteoarthritic subchondral osteoblasts.

J. Martel-Pelletier, J. Pelletier, D. Lajeunesse, 1999, Arthritis and rheumatism.

Elevated Dickkopf‐2 levels contribute to the abnormal phenotype of human osteoarthritic osteoblasts

D. Lajeunesse, Thomas F. Chan, D. Couchourel, 2011, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Altered mineralization of human osteoarthritic osteoblasts is attributable to abnormal type I collagen production.

J. Pelletier, J. Martel-Pelletier, M. Lavigne, 2009, Arthritis and rheumatism.

Involvement of ICAM-1 in bone metabolism: a potential target in the treatment of bone diseases?

Q. Shi, J. Fernandes, M. Benderdour, 2005, Expert opinion on biological therapy.

The inhibition of subchondral bone resorption in the early phase of experimental dog osteoarthritis by licofelone is associated with a reduction in the synthesis of MMP-13 and cathepsin K.

J. Pelletier, J. Martel-Pelletier, S. Laufer, 2004, Bone.

The shunt from the cyclooxygenase to lipoxygenase pathway in human osteoarthritic subchondral osteoblasts is linked with a variable expression of the 5-lipoxygenase-activating protein

J. Pelletier, J. Martel-Pelletier, D. Lajeunesse, 2006, Arthritis research & therapy.

Osteocalcin secretion by the human osteosarcoma cell line MG‐63

B. Sacktor, D. Lajeunesse, C. Frondoza, 1990, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanases

J. Pelletier, J. Martel-Pelletier, S. Laufer, 2005, Arthritis research & therapy.

Can altered production of interleukin-1beta, interleukin-6, transforming growth factor-beta and prostaglandin E(2) by isolated human subchondral osteoblasts identify two subgroups of osteoarthritic patients.

J. Martel-Pelletier, J. Pelletier, M. Benderdour, 2002, Osteoarthritis and cartilage.

Modulation of OPG, RANK and RANKL by human chondrocytes and their implication during osteoarthritis.

J. Pelletier, J. Martel-Pelletier, S. Kwan Tat, 2009, Rheumatology.

Expression of ICAM-1 by osteoblasts in healthy individuals and in patients suffering from osteoarthritis and osteoporosis.

Q. Shi, J. Fernandes, M. Benderdour, 2004, Bone.

Identification of two populations of osteoarthritic osteoblasts according to the 1,25[OH]₂ vitamin D₃ potency to stimulate osteocalcin.

P. Reboul, D. Lajeunesse, D. Mainard, 2015, Bio-medical materials and engineering.

Hypoxia and vitamin D differently contribute to leptin and dickkopf-related protein 2 production in human osteoarthritic subchondral bone osteoblasts

P. Reboul, D. Lajeunesse, P. Netter, 2014, Arthritis Research & Therapy.

Differential modulation of RANKL isoforms by human osteoarthritic subchondral bone osteoblasts: influence of osteotropic factors.

J. Pelletier, J. Martel-Pelletier, H. Fahmi, 2008, Bone.

Influence of insulin on phosphate uptake by brush border membranes from human placenta

C. Ramachandran, D. Lajeunesse, J. Lafond, 1989, Molecular and Cellular Endocrinology.

Modulation of insulin-like growth factor 1 levels in human osteoarthritic subchondral bone osteoblasts.

J. Pelletier, J. Martel-Pelletier, J. Fernandes, 2006, Bone.

Alteration of Wnt5a expression and of the non-canonical Wnt/PCP and Wnt/PKC-Ca2+ pathways in human osteoarthritis osteoblasts

J. Pelletier, J. Martel-Pelletier, D. Lajeunesse, 2017, PloS one.

Human Adult Chondrocytes Express Hepatocyte Growth Factor (HGF) Isoforms but Not HGF: Potential Implication of Osteoblasts on the Presence of HGF in Cartilage

J. Pelletier, J. Martel-Pelletier, P. Reboul, 2003, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Role of abnormal neutral endopeptidase-like activities in Hyp mouse bone cells in renal phosphate transport.

D. Lajeunesse, A. Delalandre, G. Boileau, 2002, American journal of physiology. Cell physiology.

Calcium transport through the luminal membrane of the distal tubule. I. Interrelationship with sodium.

M. Brunette, D. Lajeunesse, J. Mailloux, 1992, Kidney international.

Calcitonin receptor in human placental syncytiotrophoblast brush border and basal plasma membranes

R. Savard, D. Lajeunesse, J. Lafond, 1994, Molecular and Cellular Endocrinology.

Beneficial effect of resveratrol on phenotypic features and activity of osteoarthritic osteoblasts

D. Lajeunesse, É. Abed, A. Delalandre, 2017, Arthritis Research & Therapy.

PPARγ deficiency results in severe, accelerated osteoarthritis associated with aberrant mTOR signalling in the articular cartilage

Y. Rampersaud, J. Pelletier, J. Martel-Pelletier, 2015, Annals of the rheumatic diseases.

Proteinase-activated receptor (PAR)-2 activation impacts bone resorptive properties of human osteoarthritic subchondral bone osteoblasts.

J. Pelletier, J. Martel-Pelletier, D. Lajeunesse, 2009, Bone.

Endogenous Prostaglandin E2 and Insulin‐like Growth Factor 1 Can Modulate the Levels of Parathyroid Hormone Receptor in Human Osteoarthritic Osteoblasts

J. Pelletier, J. Martel-Pelletier, J. Fernandes, 2001, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Up-regulation of liver glucose-6-phosphatase in x-linked hypophosphatemic mice.

D. Lajeunesse, G. van de Werve, S. Dubois, 2002, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

The mechanism of parathyroid hormone action on calcium reabsorption by the distal tubule.

D. Lajeunesse, M. Brunette, I. Bouhtiauy, 1991, Endocrinology.

R-spondins are newly recognized players in osteoarthritis that regulate Wnt signaling in osteoblasts.

J. Pelletier, J. Martel-Pelletier, D. Lajeunesse, 2011, Arthritis and rheumatism.

Effect of 17β-estradiol on the human osteosarcoma cell line MG-63

D. Lajeunesse, 1994 .

Abnormal insulin-like growth factor 1 signaling in human osteoarthritic subchondral bone osteoblasts

J. Pelletier, J. Martel-Pelletier, J. Fernandes, 2006, Arthritis research & therapy.

Calcitonin receptor in human placental syncytiotrophoblast brush border and basal plasma membranes

R. Savard, D. Lajeunesse, J. Lafond, 1994, Molecular and Cellular Endocrinology.

The hypocalciuric effect of thiazides: subcellular localization of the action

D. Lajeunesse, M. Brunette, 2004, Pflügers Archiv.

Carprofen simultaneously reduces progression of morphological changes in cartilage and subchondral bone in experimental dog osteoarthritis.

J. Pelletier, J. Martel-Pelletier, J. Fernandes, 2000, The Journal of rheumatology.

Thiazide Diuretics Affect Osteocalcin Production in Human Osteoblasts at the Transcription Level Without Affecting Vitamin D3 Receptors

S. Guggino, D. Lajeunesse, A. Delalandre, 2000, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Activation of Maxi-K Channels by Parathyroid Hormone and Prostaglandin E2 in Human Osteoblast Bone Cells

D. Lajeunesse, J. Lapointe, R. Moreau, 1996, The Journal of Membrane Biology.

Study of the role of leukotriene B()4 in abnormal function of human subchondral osteoarthritis osteoblasts: effects of cyclooxygenase and/or 5-lipoxygenase inhibition.

J. Pelletier, J. Martel-Pelletier, S. Laufer, 2002, Arthritis and rheumatism.

Simultaneous isolation and biochemical characterization of connecting and collecting tubules by ficoll gradient.

R. Hébert, D. Lajeunesse, L. Regnier, 1995, Kidney international.

The differential expression of osteoprotegerin (OPG) and receptor activator of nuclear factor kappaB ligand (RANKL) in human osteoarthritic subchondral bone osteoblasts is an indicator of the metabolic state of these disease cells.

J. Pelletier, J. Martel-Pelletier, H. Fahmi, 2008, Clinical and experimental rheumatology.

Elevated hepatocyte growth factor levels in osteoarthritis osteoblasts contribute to their altered response to bone morphogenetic protein-2 and reduced mineralization capacity.

P. Reboul, D. Lajeunesse, J. Jouzeau, 2015, Bone.

Diacerein reduces the excess synthesis of bone remodeling factors by human osteoblast cells from osteoarthritic subchondral bone.

J. Pelletier, J. Martel-Pelletier, J. Fernandes, 2001, The Journal of rheumatology.

Pharmacological and Biochemical Evidence for the Regulation of Osteocalcin Secretion by Potassium Channels in Human Osteoblast‐like MG–63 Cells

R. Aubin, D. Lajeunesse, J. Lapointe, 1997, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Subchondral and trabecular bone metabolism regulation in canine experimental knee osteoarthritis.

J. Martel-Pelletier, J. Pelletier, Q. Shi, 2005, Osteoarthritis and cartilage.

Hyaluronic acid reverses the abnormal synthetic activity of human osteoarthritic subchondral bone osteoblasts.

J. Pelletier, J. Martel-Pelletier, D. Lajeunesse, 2003, Bone.

Selective effect of thiazides on the human osteoblast-like cell line MG-63.

R. Aubin, D. Lajeunesse, P. Ménard, 1996, Kidney international.

Carprofen reduces the structural changes and the abnormal subchondral bone metabolism of experimental osteoarthritis.

J. Pelletier, J. Martel-Pelletier, J. Fernandes, 1999, Osteoarthritis and cartilage.

Treatment with licofelone prevents abnormal subchondral bone cell metabolism in experimental dog osteoarthritis

J. Martel-Pelletier, J. Pelletier, S. Laufer, 2003, Annals of the rheumatic diseases.

An active role for soluble and membrane intercellular adhesion molecule-1 in osteoclast activity in vitro

Q. Shi, J. Fernandes, M. Benderdour, 2008, Journal of Bone and Mineral Metabolism.

Influence of Aluminum on the Regulation of PTH‐ and 1,25(OH)2D3‐Dependent Pathways in the Rat Osteosarcoma Cell Line ROS 17/2.8

S. Guggino, D. Lajeunesse, J. Lafond, 1998, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Surface potential changes on energization of mycoplasma cell membranes.

C. le Grimellec, J. Rigaud, D. Lajeunesse, 1985, Archives of biochemistry and biophysics.

Effects of energization on membrane organization in mycoplasma.

C. le Grimellec, J. Rigaud, D. Lajeunesse, 1982, Biochimica et biophysica acta.

Platelet rich plasma (PRP) induces chondroprotection via increasing autophagy, anti‐inflammatory markers, and decreasing apoptosis in human osteoarthritic cartilage

N. Alaaeddine, D. Lajeunesse, G. Hilal, 2017, Experimental cell research.

Biochemical Factors in Joint Articular Tissue Degradation in Osteoarthritis

J. Martel-Pelletier, D. Lajeunesse, J. Battista, 1999 .

Osteoblast-like cells from human subchondral osteoarthritic bone demonstrate an altered phenotype in vitro: possible role in subchondral bone sclerosis.

J. Pelletier, J. Martel-Pelletier, J. Pelletier, 1998, Arthritis and rheumatism.

Two vitamin D3-dependent calcium binding proteins increase calcium reabsorption by different mechanisms. I. Effect of CaBP 28K.

M. Brunette, S. Christakos, D. Lajeunesse, 1994, Kidney international.

Therapeutic role of dual inhibitors of 5-LOX and COX, selective and non-selective non-steroidal anti-inflammatory drugs

J. Pelletier, J. Martel-Pelletier, J. Pelletier, 2003, Annals of the rheumatic diseases.

Strontium ranelate reduces the progression of experimental dog osteoarthritis by inhibiting the expression of key proteases in cartilage and of IL-1β in the synovium

J. Pelletier, J. Martel-Pelletier, M. Kapoor, 2012, Annals of the rheumatic diseases.

Chondroitin and glucosamine sulfate in combination decrease the pro-resorptive properties of human osteoarthritis subchondral bone osteoblasts: a basic science study

J. Pelletier, J. Martel-Pelletier, H. Fahmi, 2007, Arthritis research & therapy.

IGF/IGFBP axis in cartilage and bone in osteoarthritis pathogenesis

J. Martel-Pelletier, J. Pelletier, J. D. Di Battista, 1998, Inflammation Research.

Metabolic activity of osteoblasts retrieved from osteoarthritic patients after stimulation with mediators involved in periprosthetic loosening.

Q. Shi, J. Fernandes, P. Lavigne, 2004, Bone.

The Role of Bone in the Development of Osteoarthritis

P. Reboul, D. Lajeunesse, 2007 .

Subchondral bone in osteoarthritis: a biologic link with articular cartilage leading to abnormal remodeling

P. Reboul, D. Lajeunesse, 2003, Current opinion in rheumatology.

Subchondral bone sclerosis in osteoarthritis: not just an innocent bystander

J. Martel-Pelletier, J. Pelletier, D. Lajeunesse, 2003, Modern rheumatology.

Demonstration of an osteoblast defect in two cases of human malignant osteopetrosis. Correction of the phenotype after bone marrow transplant.

L. Busque, M. Brunette, D. Lajeunesse, 1996, The Journal of clinical investigation.

Osteoarthritis: rationale for a new paradigm shift involving transforming growth factor-β1

P. Reboul, D. Lajeunesse, J. Jouzeau, 2013 .

Parathyroid hormone and hydrochlorothiazide increase calcium transport by the luminal membrane of rabbit distal nephron segments through different pathways.

D. Lajeunesse, M. Brunette, I. Bouhtiauy, 1994, Endocrinology.

Direct demonstration of a humorally-mediated inhibition of renal phosphate transport in the Hyp mouse.

D. Lajeunesse, R. Meyer, L. Hamel, 1996, Kidney international.

Calcium transport by the luminal membrane of distal tubule: II. Effect of pH, electrical potential and calcium channel inhibitors.

M. Brunette, D. Lajeunesse, J. Mailloux, 1992, Kidney international.

Is there a role for bone tissue in osteoarthritis

D. Lajeunesse, 2010 .

key WO rds: bone/cartilage cross-talk n bone marrow lesions n mineralization n osteoarthritis n subchondral bone

D. Lajeunesse, 2010 .

New thoughts on the pathophysiology of osteoarthritis: One more step toward new therapeutic targets

Johanne Martel-Pelletier, Jean-Pierre Pelletier, J. Pelletier, 2006, Current rheumatology reports.

Tiludronate treatment improves structural changes and symptoms of osteoarthritis in the canine anterior cruciate ligament model

Johanne Martel-Pelletier, Jean-Pierre Pelletier, Guy Beauchamp, 2011, Arthritis research & therapy.

Targeting subchondral bone for treating osteoarthritis: what is the evidence?

Johanne Martel-Pelletier, Jean-Pierre Pelletier, J. Pelletier, 2010, Best practice & research. Clinical rheumatology.

Local leptin production in osteoarthritis subchondral osteoblasts may be responsible for their abnormal phenotypic expression

M. Lavigne, D. Lajeunesse, A. Delalandre, 2010, Arthritis research & therapy.

Two vitamin D3-dependent calcium binding proteins increase calcium reabsorption by different mechanisms. II. Effect of CaBP 9K.

S. Christakos, D. Lajeunesse, M. Brunette, 1994, Kidney international.

Effect of vitamin D depletion on calcium transport by the luminal and basolateral membranes of the proximal and distal nephrons.

D. Lajeunesse, M. Brunette, I. Bouhtiauy, 1993, Endocrinology.

Sirtuins as Markers of Bone Disease: A Focus on Osteoarthritis and Osteoporosis

P. Reboul, D. Lajeunesse, Elie Abed, 2016 .

Low sirtuin 1 levels in human osteoarthritis subchondral osteoblasts lead to abnormal sclerostin expression which decreases Wnt/β-catenin activity.

J. Pelletier, J. Martel-Pelletier, D. Lajeunesse, 2014, Bone.

Osteoarthritis: A metabolic disease induced by local abnormal leptin activity?

J. Pelletier, J. Martel-Pelletier, D. Lajeunesse, 2005, Current rheumatology reports.

Effect of insulin on d-glucose transport by human placental brush border membranes

D. Lajeunesse, J. Lafond, M. Leclerc, 1990, Molecular and Cellular Endocrinology.

Effect of 17 beta-estradiol on the human osteosarcoma cell line MG-63.

D. Lajeunesse, 1994, Bone and mineral.

Activation of the receptor EphB4 by its specific ligand ephrin B2 in human osteoarthritic subchondral bone osteoblasts.

J. Pelletier, J. Martel-Pelletier, S. Kwan Tat, 2008, Arthritis and rheumatism.

The role of bone in the treatment of osteoarthritis.

D. Lajeunesse, 2004, Osteoarthritis and cartilage.

Regulation of osteocalcin secretion by human primary bone cells and by the human osteosarcoma cell line MG-63.

B. Sacktor, D. Lajeunesse, C. Frondoza, 1991, Bone and mineral.

Altered subchondral osteoblast cellular metabolism in osteoarthritis: cytokines, eicosanoids, and growth factors.

D. Lajeunesse, 2002, Journal of musculoskeletal & neuronal interactions.

Metabolic activity of osteoblasts from periprosthetic trabecular bone in failed total hip arthroplasties and osteoarthritis as markers of osteolysis and loosening.

J. Pelletier, J. Martel-Pelletier, Q. Shi, 2002, The Journal of rheumatology.

039 VALIDITY OF PAIN ASSESSMENT METHODS IN THE EXPERIMENTAL DOG POND-NUKI MODEL

G. Beauchamp, J. Pelletier, J. Martel-Pelletier, 2009 .

Sodium gradient-dependent phosphate transport in placental brush border membrane vesicles.

M. Brunette, D. Lajeunesse, Daniel Lajeunesse, 1988 .

Subchondral bone morphological and biochemical alterations in osteoarthritis.

J. Martel-Pelletier, J. Pelletier, D. Lajeunesse, 1999, Osteoarthritis and cartilage.

Low sirtuin 1 levels in human osteoarthritis subchondral osteoblasts lead to abnormal sclerostin expression which decreases Wnt/β-catenin activity.

J. Pelletier, J. Martel-Pelletier, D. Lajeunesse, 2014, Bone.

Targeting subchondral bone for treating osteoarthritis: what is the evidence?

J. Pelletier, J. Martel-Pelletier, S. Kwan Tat, 2010, Best practice & research. Clinical rheumatology.