Madhusudhanan Sukumar

发表

Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function.

P. Muranski, C. Klebanoff, A. Lal, 2013, The Journal of clinical investigation.

Ionic immune suppression within the tumour microenvironment limits T cell effector function

W. Linehan, K. Okkenhaug, Jenny H. Pan, 2016, Nature.

Identification of essential genes for cancer immunotherapy

Feng Zhang, Neville E. Sanjana, Chi-Ping Day, 2017, Nature.

Repression of the DNA-binding inhibitor Id3 by Blimp-1 limits CD8+ T cell memory formation

F. Marincola, P. Muranski, C. Klebanoff, 2011, Nature Immunology.

Cish actively silences TCR signaling in CD8+ T cells to maintain tumor tolerance

F. Marincola, C. Klebanoff, E. Wang, 2015, Journal for ImmunoTherapy of Cancer.

Cish actively silences tcr signaling in CD8+ T cells to maintain tumor tolerance

C. Klebanoff, L. Samelson, L. Balagopalan, 2015, Journal of Immunotherapy for Cancer.

Inhibition of AKT signaling uncouples T cell differentiation from expansion for receptor-engineered adoptive immunotherapy.

C. Klebanoff, D. Stroncek, M. Kruhlak, 2017, JCI insight.

Memory T cell-driven differentiation of naive cells impairs adoptive immunotherapy.

F. Marincola, S. Rosenberg, P. Muranski, 2015, The Journal of clinical investigation.

Genome-wide profiling of druggable active tumor defense mechanisms to enhance cancer immunotherapy

Neville E. Sanjana, N. Sanjana, K. Wood, 2019, bioRxiv.

T cells and IFN-γ. These findings demonstrate that BACH2 is a key component of the molecular program of tumor immunosuppression and identify therapeutic targets for the reversal of immunosuppression in cancer. The transcription factor BACH2 promotes tumor immunosuppression

F. Marincola, K. Okkenhaug, Jenny H. Pan, 2016 .

The transcription factor BACH2 promotes tumor immunosuppression.

F. Marincola, K. Okkenhaug, Jenny H. Pan, 2016, The Journal of clinical investigation.

Metabolic reprograming of anti-tumor immunity.

N. Restifo, Madhusudhanan Sukumar, R. Kishton, 2017, Current opinion in immunology.

Host conditioning with IL-1β improves the antitumor function of adoptively transferred T cells

R. Germain, W. Paul, N. Restifo, 2019, The Journal of experimental medicine.

Targeting Akt in cell transfer immunotherapy for cancer

N. Restifo, Madhusudhanan Sukumar, Joseph G. Crompton, 2016, Oncoimmunology.

Retinoic acid controls the homeostasis of pre-cDC–derived splenic and intestinal dendritic cells

Y. Belkaid, R. Danner, P. Muranski, 2013, The Journal of experimental medicine.

Cancer genes disfavoring T cell immunity identified via integrated systems approach

Roxana A. Stefanescu, Neville E. Sanjana, N. Sanjana, 2022, Cell reports.

Arginine Arms T Cells to Thrive and Survive.

N. Restifo, Madhusudhanan Sukumar, R. Kishton, 2016, Cell metabolism.

The short and sweet of T-cell therapy

L. Gattinoni, Madhusudhanan Sukumar, M. Sukumar, 2014, Oncoimmunology.

Cish actively silences TCR signaling in CD8+ T cells to maintain tumor tolerance

F. Marincola, C. Klebanoff, E. Wang, 2015, Journal for ImmunoTherapy of Cancer.

Stromal Interferon-γ Signaling and Cross-Presentation Are Required to Eliminate Antigen-Loss Variants of B Cell Lymphomas in Mice

C. Schmitt, C. Loddenkemper, T. Blankenstein, 2012, PloS one.

Mitochondrial activity regulates T cell memory, self renewal and anti tumor function in CD8+ T cells

Mahadev Rao, T. Finkel, N. Restifo, 2013, Journal of Immunotherapy for Cancer.

T cell stemness and dysfunction in tumors are triggered by a common mechanism

J. Locasale, C. Klebanoff, Jing Huang, 2019, Science.

Akt inhibition enhances expansion of potent tumor-specific lymphocytes with memory cell characteristics.

Mark S. Sundrud, F. Marincola, S. Rosenberg, 2015, Cancer research.

BACH2 regulates CD8+ T cell differentiation by controlling access of AP-1 factors to enhancers

Yuka Kanno, Yun Ji, Yoshiyuki Wakabayashi, 2016, Nature Immunology.

Metabolic Regulation of T Cell Longevity and Function in Tumor Immunotherapy.

N. Restifo, Madhusudhanan Sukumar, R. Kishton, 2017, Cell metabolism.

Th17 cells are long lived and retain a stem cell-like molecular signature.

S. Kern, R. Danner, P. Muranski, 2011, Immunity.

Mechanisms of Rejection of High Grade B cell Lymphoma in Mice

Madhusudhanan Sukumar, M. Sukumar, 2008 .

Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche

Y. Belkaid, A. Goldrath, C. Klebanoff, 2016, Cell.

Lineage relationship of CD8+ T cell subsets is revealed by progressive changes in the epigenetic landscape

F. Marincola, Manikandan Narayanan, Suresh Cuddapah, 2015, Cellular and Molecular Immunology.

Uncoupling T‐cell expansion from effector differentiation in cell‐based immunotherapy

N. Restifo, Madhusudhanan Sukumar, Joseph G Crompton, 2014, Immunological reviews.

Type I Cytokines Synergize with Oncogene Inhibition to Induce Tumor Growth Arrest

James J. Morrow, F. Marincola, M. Raffeld, 2014, Cancer Immunology Research.

Mitochondrial Membrane Potential Identifies Cells with Enhanced Stemness for Cellular Therapy.

F. Marincola, W. Leonard, P. Muranski, 2016, Cell metabolism.

Nutrient Competition: A New Axis of Tumor Immunosuppression

N. Restifo, Madhusudhanan Sukumar, R. Roychoudhuri, 2015, Cell.

miR-155 augments CD8+ T-cell antitumor activity in lymphoreplete hosts by enhancing responsiveness to homeostatic γc cytokines

T. Waldmann, W. Telford, C. Klebanoff, 2014, Proceedings of the National Academy of Sciences.

Multi-phenotype CRISPR-Cas9 Screen Identifies p38 Kinase as a Target for Adoptive Immunotherapies.

N. Restifo, D. Palmer, Li Jia, 2020, Cancer cell.