J. Sacha

发表

Broadly targeted CD8+ T cell responses restricted by major histocompatibility complex E

B. Korber, L. Picker, A. McMichael, 2016, Science.

A live-attenuated RhCMV/SIV vaccine shows long-term efficacy against heterologous SIV challenge

L. Picker, J. Lifson, K. Früh, 2019, Science Translational Medicine.

Vaccination against Endogenous Retrotransposable Element Consensus Sequences Does Not Protect Rhesus Macaques from SIVsmE660 Infection and Replication

D. Nixon, M. Ostrowski, E. Rakasz, 2014, PloS one.

The TRIM5α Genotype of Rhesus Macaques Affects Acquisition of Simian Immunodeficiency Virus SIVsmE660 Infection after Repeated Limiting-Dose Intrarectal Challenge

D. Watkins, T. Friedrich, W. Koff, 2011, Journal of Virology.

Neutralizing Polyclonal IgG Present during Acute Infection Prevents Rapid Disease Onset in Simian-Human Immunodeficiency Virus SHIVSF162P3-Infected Infant Rhesus Macaques

N. Haigwood, D. Burton, A. Legasse, 2013, Journal of Virology.

Title Neutralizing Polyclonal IgG Present during Acute Infection Prevents Rapid Disease Onset in Simian-Human Immunodeficiency Virus SHIV SF 162 P 3-Infected Infant Rhesus Macaques Permalink

D. Burton, A. Legasse, M. Axthelm, 2013 .

Improved delivery of broadly neutralizing antibodies by nanocapsules suppresses SHIV infection in the CNS of infant rhesus macaques

N. Haigwood, J. Mascola, A. Pegu, 2021, PLoS pathogens.

Single-dose bNAb cocktail or abbreviated ART post-exposure regimens achieve tight SHIV control without adaptive immunity

N. Haigwood, J. Mascola, M. Axthelm, 2020, Nature Communications.

Gag-Specific CD 8 T Lymphocytes Recognize Infected Cells before AIDS-Virus Integration and Viral Protein Expression 1

D. Watkins, O. Yang, J. Lifson, 2007 .

Gag-Specific CD8+ T Lymphocytes Recognize Infected Cells before AIDS-Virus Integration and Viral Protein Expression1

D. Watkins, O. Yang, J. Lifson, 2007, The Journal of Immunology.

Two-Year Follow-Up of Macaques Developing Intermittent Control of the Human Immunodeficiency Virus Homolog Simian Immunodeficiency Virus SIVmac251 in the Chronic Phase of Infection

M. Biffoni, D. Montefiori, E. Arts, 2015, Journal of Virology.

The human IL-15 superagonist ALT-803 directs SIV-specific CD8+ T cells into B-cell follicles.

D. Nixon, A. Legasse, E. Connick, 2018, Blood advances.

A neonatal nonhuman primate model of gestational Zika virus infection with evidence of microencephaly, seizures and cardiomyopathy

J. B. Kempton, C. Kroenke, Xiaojie Wang, 2020, PloS one.

Disruption of the CCL5/RANTES-CCR5 Pathway Restores Immune Homeostasis and Reduces Plasma Viral Load in Critical COVID-19

M. Corley, L. Ndhlovu, J. Sacha, 2020, medRxiv.

CCR5 inhibition in critical COVID-19 patients decreases inflammatory cytokines, increases CD8 T-cells, and decreases SARS-CoV2 RNA in plasma by day 14

Eisa Mahyari, M. Corley, E. Akalin, 2020, International Journal of Infectious Diseases.

Effect of Chronic Viral Infection on Epitope

J. Sacha, K. Tewari, Xiao-Han Gao, 2004 .

Technical Advance: Liposomal alendronate depletes monocytes and macrophages in the nonhuman primate model of human disease

G. Golomb, A. Legasse, B. Burwitz, 2014, Journal of leukocyte biology.

MHC-E–Restricted CD8+ T Cells Target Hepatitis B Virus–Infected Human Hepatocytes

L. Picker, K. Früh, S. Hansen, 2020, The Journal of Immunology.

Recombinant Yellow Fever Vaccine Virus 17D Expressing Simian Immunodeficiency Virus SIVmac239 Gag Induces SIV-Specific CD8+ T-Cell Responses in Rhesus Macaques

D. Watkins, E. Rakasz, J. Sadoff, 2010, Journal of Virology.

Pyrosequencing Reveals Restricted Patterns of CD8 (cid:1) T Cell Escape-Associated Compensatory Mutations in Simian Immunodeﬁciency Virus (cid:1) ‡

D. Watkins, D. O’Connor, N. Wilson, 2011 .

The Majority of Freshly Sorted Simian Immunodeﬁciency Virus (SIV)-Speciﬁc CD8 (cid:1) T Cells Cannot Suppress Viral Replication in SIV-Infected Macrophages

M. Stevenson, N. Wilson, J. Sacha, 2012 .

Efﬁcacious Early Antiviral Activity of HIV Gag- and Pol-Speciﬁc HLA-B*2705-Restricted CD8 (cid:1) T Cells (cid:1)

S. Buus, J. Prado, R. Phillips, 2010 .

Robust, vaccine-induced CD8(+) T lymphocyte response against an out-of-frame epitope.

D. Watkins, M. Citron, Xiao-ping Liang, 2010, Journal of immunology.

Acute Viral Escape Selectively Impairs Nef-Mediated Major Histocompatibility Complex Class I Downmodulation and Increases Susceptibility to Antiviral T Cells

T. Friedrich, E. Rakasz, A. Panganiban, 2015, Journal of Virology.

Cytotoxicity on HIV-1 Mediates Antibody-Dependent Cellular Ancestral Endogenous Virus Glycoproteins Cutting Edge: An Antibody Recognizing

Jeffrey N. Martin, D. Nixon, S. Deeks, 2014 .

Pandemic 1918 Influenza Virus Does Not Cause Lethal Infection in Rhesus or Cynomolgus Macaques

J. Audet, A. Bello, D. Kobasa, 2022, Journal of virology.

Reduced Cell Surface Levels of C-C Chemokine Receptor 5 and Immunosuppression in Long Coronavirus Disease 2019 Syndrome

O. Yang, S. Hansen, N. Gaylis, 2022, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Comparison of the Superagonist Complex, ALT-803, to IL15 as Cancer Immunotherapeutics in Animal Models

H. Hong, W. Cai, H. Wong, 2015, Cancer Immunology Research.

Strategies to target non-T-cell HIV reservoirs

L. Ndhlovu, J. Sacha, 2016, Current opinion in HIV and AIDS.

ADVANCES IN TARGETING NON-CD4 T-CELL SOURCES OF HIV PERSISTENCE: RELEVANCE OF LOCATION

L. Ndhlovu, J. Sacha, 2016 .

Therapeutic neutralizing monoclonal antibody administration protects against lethal Yellow Fever infection

D. Burton, D. Watkins, M. Axthelm, 2022, bioRxiv.

Synchronous infection of SIV and HIV in vitro for virology, immunology and vaccine-related studies

D. Watkins, J. Sacha, 2010, Nature Protocols.

T Cell Inactivation by Poxviral B22 Family Proteins Increases Viral Virulence

K. Früh, A. Legasse, M. Axthelm, 2014, PLoS pathogens.

Vaccine-Mediated Inhibition of the Transporter Associated with Antigen Processing Is Insufficient To Induce Major Histocompatibility Complex E-Restricted CD8+ T Cells in Nonhuman Primates

L. Picker, K. Früh, A. Legasse, 2019, Journal of Virology.

T Cells Target APOBEC3 Proteins in Human Immunodeficiency Virus Type 1-Infected Humans and Simian Immunodeficiency Virus-Infected Indian Rhesus Macaques

Jeffrey N. Martin, D. Nixon, M. Ostrowski, 2013, Journal of Virology.

Long-term hepatitis B virus infection of rhesus macaques requires suppression of host immunity

G. Golomb, Majd Agbaria, Lei Wei, 2022, Nature Communications.

Differential Antigen Presentation Kinetics of CD8+ T-Cell Epitopes Derived from the Same Viral Protein

D. Watkins, T. Friedrich, N. Wilson, 2008, Journal of Virology.

Natural Killer Cell Evasion Is Essential for Infection by Rhesus Cytomegalovirus

L. Picker, K. Früh, A. Legasse, 2016, PLoS pathogens.

Early short-term treatment with neutralizing human monoclonal antibodies halts SHIV infection in newborn macaques

N. Haigwood, J. Mascola, B. Graham, 2016, Nature Medicine.

Optimization and use of near infrared imaging to guide lymph node collection in rhesus macaques (Macaca mulatta)

Y. Fukazawa, S. Hansen, D. Sather, 2022, Journal of medical primatology.

Rhesus Cytomegalovirus-Specific CD8+ Cytotoxic T Lymphocytes Do Not Become Functionally Exhausted in Chronic SIVmac239 Infection

D. Watkins, E. Rakasz, J. Sacha, 2020, Frontiers in Immunology.

Improving rigor and reproducibility in nonhuman primate research

J. Morrison, E. Buffalo, R. Colman, 2021, American journal of primatology.

Vaccination with Cancer- and HIV Infection-Associated Endogenous Retrotransposable Elements Is Safe and Immunogenic

B. Pierce, D. Nixon, M. Ostrowski, 2012, The Journal of Immunology.

Cross-Species Rhesus Cytomegalovirus Infection of Cynomolgus Macaques

L. Picker, K. Früh, A. Legasse, 2016, PLoS pathogens.

The Majority of Freshly Sorted Simian Immunodeficiency Virus (SIV)-Specific CD8+ T Cells Cannot Suppress Viral Replication in SIV-Infected Macrophages

D. Watkins, M. Stevenson, N. Wilson, 2012, Journal of Virology.

Immune clearance of highly pathogenic SIV infection

Matthew S. Lewis, L. Picker, J. Lifson, 2013, Nature.

HERV-K-specific T cells eliminate diverse HIV-1/2 and SIV primary isolates.

Nabil F. Faruk, D. Nixon, M. Ostrowski, 2012, The Journal of clinical investigation.

Hepatocytic expression of human sodium-taurocholate cotransporting polypeptide enables hepatitis B virus infection of macaques

N. Haigwood, Tonya Swanson, A. Legasse, 2017, Nature Communications.

Cytomegalovirus-vaccine-induced unconventional T cell priming and control of SIV replication is conserved between primate species.

Leanne S. Whitmore, L. Picker, J. Lifson, 2022, Cell host & microbe.

Modulation of MHC-E transport by viral decoy ligands is required for RhCMV/SIV vaccine efficacy

L. Picker, J. Lifson, K. Früh, 2020, Science.

Cytomegaloviral determinants of CD8+ T cell programming and RhCMV/SIV vaccine efficacy

L. Picker, J. Lifson, K. Früh, 2020, Science Immunology.

Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding

L. Picker, A. McMichael, P. Borrow, 2018, Nature Communications.

Addendum: Immune clearance of highly pathogenic SIV infection

Matthew S. Lewis, L. Picker, J. Lifson, 2017, Nature.

Cytomegalovirus Vectors Violate CD8+ T Cell Epitope Recognition Paradigms

Matthew S. Lewis, L. Picker, J. Lifson, 2013, Science.

Human Galectin-9 Is a Potent Mediator of HIV Transcription and Reactivation

Marion C Lanteri, T. Niki, S. Pillai, 2015, PLoS pathogens.

Genome-wide DNA methylation profiling of peripheral blood reveals an epigenetic signature associated with severe COVID-19

M. Peluso, A. Borczuk, R. Schwartz, 2021, Journal of leukocyte biology.

The Role of MHC-E in T Cell Immunity Is Conserved among Humans, Rhesus Macaques, and Cynomolgus Macaques

D. O’Connor, L. Picker, A. McMichael, 2018, The Journal of Immunology.

HLA-E–restricted, Gag-specific CD8+ T cells can suppress HIV-1 infection, offering vaccine opportunities

L. Picker, A. McMichael, P. Borrow, 2021, Science Immunology.

TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection

M. Ostrowski, F. Hecht, A. Korman, 2016, PLoS pathogens.

The human IL-15 superagonist N-803 promotes migration of virus-specific CD8+ T and NK cells to B cell follicles but does not reverse latency in ART-suppressed, SHIV-infected macaques

J. Safrit, M. Axthelm, Shiho Tanaka, 2020, PLoS pathogens.

Microbial Translocation and Inflammation Occur in Hyperacute Immunodeficiency Virus Infection and Compromise Host Control of Virus Replication

Trent M. Prall, D. O’Connor, J. Brenchley, 2016, PLoS pathogens.

Lytic granule loading of CD8+ T cells is required for HIV-infected cell elimination associated with immune control.

C. Hallahan, S. Migueles, M. Connors, 2008, Immunity.

Efficacious Early Antiviral Activity of HIV Gag- and Pol-Specific HLA-B*2705-Restricted CD8+ T Cells

S. Buus, J. Prado, R. Phillips, 2010, Journal of Virology.

Pyrosequencing Reveals Restricted Patterns of CD8+ T Cell Escape-Associated Compensatory Mutations in Simian Immunodeficiency Virus

D. Watkins, D. O’Connor, N. Wilson, 2011, Journal of Virology.

Simian Immunodeficiency Virus-Specific CD8+ T Cells Recognize Vpr- and Rev-Derived Epitopes Early after Infection

D. Watkins, N. Wilson, J. Sacha, 2010, Journal of Virology.

Effective Simian Immunodeficiency Virus-Specific CD8+ T Cells Lack an Easily Detectable, Shared Characteristic

D. Watkins, R. Johnson, E. Rakasz, 2009, Journal of Virology.

Gag- and Nef-specific CD4+ T cells recognize and inhibit SIV replication in infected macrophages early after infection

D. Watkins, T. Friedrich, N. Wilson, 2009, Proceedings of the National Academy of Sciences.

Tertiary Mutations Stabilize CD8+ T Lymphocyte Escape-Associated Compensatory Mutations following Transmission of Simian Immunodeficiency Virus

D. O’Connor, T. Friedrich, T. Matano, 2013, Journal of Virology.

Achieving Potent Autologous Neutralizing Antibody Responses against Tier 2 HIV-1 Viruses by Strategic Selection of Envelope Immunogens

N. Haigwood, L. Stamatatos, D. Montefiori, 2016, The Journal of Immunology.

Early Antigen Presentation of Protective HIV-1 KF11Gag and KK10Gag Epitopes from Incoming Viral Particles Facilitates Rapid Recognition of Infected Cells by Specific CD8+ T Cells

J. Prado, O. Yang, P. Goulder, 2012, Journal of Virology.

Suppression of human and simian immunodeficiency virus replication with the CCR5-specific antibody Leronlimab in two species

S. Hansen, M. Corley, L. Ndhlovu, 2022, PLoS pathogens.

Antibody-based CCR5 blockade protects Macaques from mucosal SHIV transmission

N. Haigwood, S. Hansen, S. Abdulhaqq, 2021, Nature Communications.

CD8+ and CD4+ cytotoxic T cell escape mutations precede breakthrough SIVmac239 viremia in an elite controller

B. Burwitz, J. Sacha, Alexander T. Bean, 2012, Retrovirology.

Rapid Induction of Multifunctional Antibodies in Rabbits and Macaques by Clade C HIV-1 CAP257 Envelopes Circulating During Epitope-Specific Neutralization Breadth Development

N. Haigwood, H. Robins, D. Sather, 2020, Frontiers in Immunology.

Combination Adenovirus and Protein Vaccines Prevent Infection or Reduce Viral Burden after Heterologous Clade C Simian-Human Immunodeficiency Virus Mucosal Challenge

H. Liao, B. Haynes, N. Haigwood, 2017, Journal of Virology.

Trans-activation, post-transcriptional maturation, and induction of antibodies to HERV-K (HML-2) envelope transmembrane protein in HIV-1 infection

Jeffrey N. Martin, D. Nixon, F. Hecht, 2014, Retrovirology.

OP 6.3 – 00150 Delivery and long-term expression of CCR5-blocking monoclonal antibody Leronlimab with AAV for ART-free remission from SHIV viremia

Geoffrey I. Webb, J. Sacha, S. Fuchs, 2022, Journal of virus eradication.

OP 6.7 – 00044 Long-term ART-free SIV Remission Following Allogeneic Hematopoietic Cell Transplantation in Mauritian Cynomolgus Macaques

M. Kumar, J. Siliciano, J. Sacha, 2022, Journal of virus eradication.

Allogeneic stem cell transplantation in fully MHC-matched Mauritian cynomolgus macaques recapitulates diverse human clinical outcomes

Tonya Swanson, A. Legasse, M. Axthelm, 2017, Nature Communications.

Pol-Specific CD8+ T Cells Recognize Simian Immunodeficiency Virus-Infected Cells Prior to Nef-Mediated Major Histocompatibility Complex Class I Downregulation

D. Watkins, J. Lifson, T. Friedrich, 2007, Journal of Virology.

Viral opportunistic infections in Mauritian cynomolgus macaques undergoing allogeneic stem cell transplantation mirror human transplant infectious disease complications

Eisa Mahyari, Tonya Swanson, A. Legasse, 2020, Xenotransplantation.

HLA-E restricted, HIV-1 suppressing, Gag specific CD8+ T cells offer universal vaccine opportunities

L. Picker, A. McMichael, P. Borrow, 2020, bioRxiv.

Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding

L. Picker, A. McMichael, P. Borrow, 2018, Nature Communications.

DNA/Ad5 vaccination with SIV epitopes induced epitope-specific CD4⁺ T cells, but few subdominant epitope-specific CD8⁺ T cells.

D. Watkins, A. McDermott, D. Fuller, 2011, Vaccine.

Anti-HERV-K (HML-2) capsid antibody responses in HIV elite controllers

Jeffrey N. Martin, D. Nixon, F. Hecht, 2017, Retrovirology.

Expansion of Dysfunctional Tim-3–Expressing Effector Memory CD8+ T Cells during Simian Immunodeficiency Virus Infection in Rhesus Macaques

M. Ostrowski, M. Kuroda, S. Hansen, 2014, The Journal of Immunology.

CCR5 Receptor Occupancy Analysis Reveals Increased Peripheral Blood CCR5+CD4+ T Cells Following Treatment With the Anti-CCR5 Antibody Leronlimab

A. Sylwester, S. Hansen, Colette M. Hughes, 2021, Frontiers in Immunology.

Disruption of CCR5 signaling to treat COVID-19-associated cytokine storm: Case series of four critically ill patients treated with leronlimab

S. Gross, J. Sacha, J. Lalezari, 2021, Journal of Translational Autoimmunity.

Modified Adenovirus Prime-Protein Boost Clade C HIV Vaccine Strategy Results in Reduced Viral DNA in Blood and Tissues Following Tier 2 SHIV Challenge

N. Haigwood, H. Robins, M. Axthelm, 2021, Frontiers in Immunology.

Clinical Characteristics and Outcomes of Coronavirus Disease 2019 Patients Who Received Compassionate-Use Leronlimab

O. Yang, A. Naeim, J. Fulcher, 2020, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Identification and spontaneous immune targeting of an endogenous retrovirus K envelope protein in the Indian rhesus macaque model of human disease

Robert J. Gifford, R. Gifford, J. Sacha, 2016, Retrovirology.

MR1 Restricted Mucosal-Associated Invariant T (MAIT) Cells Respond to Mycobacterial Vaccination and Infection in Nonhuman Primates

Thurston H. Y. Dang, E. Adams, L. Picker, 2016, Mucosal Immunology.

Novel Translation Products from Simian Immunodeficiency Virus SIVmac239 Env-Encoding mRNA Contain both Rev and Cryptic T-Cell Epitopes

D. Watkins, E. Rakasz, N. Wilson, 2009, Journal of Virology.

Terumo spectra optia leukapheresis of cynomolgus macaques for hematopoietic stem cell and T cell collection

Tonya Swanson, A. Legasse, M. Axthelm, 2020, Journal of clinical apheresis.

Corrigendum: Immune clearance of highly pathogenic SIV infection

Matthew S. Lewis, L. Picker, J. Lifson, 2014, Nature.

Hepatocytic expression of human sodium-taurocholate cotransporting polypeptide enables hepatitis B virus infection of macaques

N. Haigwood, Tonya Swanson, A. Legasse, 2017, Nature Communications.

Allogeneic stem cell transplantation in fully MHC-matched Mauritian cynomolgus macaques recapitulates diverse human clinical outcomes

Charles R. Thomas, Tonya Swanson, A. Legasse, 2017, Nature Communications.

Allogeneic immunity clears latent virus following allogeneic stem cell transplantation in SIV-infected ART-suppressed macaques.

R. Siliciano, J. Siliciano, Tonya Swanson, 2023, Immunity.

Timothy Ray Brown: The Serendipitous Hero of HIV Cure Research.

P. Cannon, N. Klatt, J. Sacha, 2020, AIDS research and human retroviruses.

CD8+ and CD4+ cytotoxic T cell escape mutations precede breakthrough SIVmac239 viremia in an elite controller

R. Rudersdorf, B. Burwitz, J. Sacha, 2012, Retrovirology.

Effect of Chronic Viral Infection on Epitope Selection, Cytokine Production, and Surface Phenotype of CD8 T Cells and the Role of IFN-γ Receptor in Immune Regulation1

M. Suresh, J. Sacha, K. Tewari, 2004, The Journal of Immunology.

IFN-Phenotype of CD 8 T Cells and the Role of Selection , Cytokine Production , and Surface Effect of Chronic Viral Infection on Epitope

M. Suresh, J. Sacha, K. Tewari, 2004 .