C. Pugh

发表

Independent function of two destruction domains in hypoxia‐inducible factor‐α chains activated by prolyl hydroxylation

P. Ratcliffe, C. Pugh, P. Maxwell, 2001, The EMBO journal.

Identification of hypoxically inducible mRNAs in HeLa cells using differential-display PCR. Role of hypoxia-inducible factor-1.

P. Ratcliffe, J. O'rourke, C. Pugh, 1996, European journal of biochemistry.

Identification of the renal erythropoietin-producing cells using transgenic mice.

P. Ratcliffe, P. Maxwell, B. Doe, 1993, Kidney international.

Oxygen mediated gene regulation

C. Pugh, P. Maxwell, P. Ratcliffe, 2002 .

Oxygen mediated gene regulation

C. Pugh, P. Maxwell, P. Ratcliffe, 2002 .

Sites of erythropoietin production.

J. Iredale, P. Ratcliffe, P. Maxwell, 1997, Kidney international.

Expression of a homologously recombined erythopoietin-SV40 T antigen fusion gene in mouse liver: evidence for erythropoietin production by Ito cells.

P. Ratcliffe, P. Maxwell, B. Doe, 1994, Blood.

Inducible operation of the erythropoietin 3' enhancer in multiple cell lines: evidence for a widespread oxygen-sensing mechanism.

P. Ratcliffe, C. Pugh, P. Maxwell, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Regulation of the Drosophila bHLH-PAS protein Sima by hypoxia: functional evidence for homology with mammalian HIF-1 alpha.

B. Shilo, B. Shilo, P. Ratcliffe, 1998, Biochemical and biophysical research communications.

Production of Erythropoietin by Liver Cells in Vivo and in Vitro

P. Ratcliffe, A. Kurtz, C. Pugh, 1994, Annals of the New York Academy of Sciences.

Analysis of Cis‐acting Sequences Required for Operation of the Erythropoietin 3’Enhancer in Different Cell Lines a

B. Ebert, P. Ratcliffe, P. Maxwell, 1994, Annals of the New York Academy of Sciences.

Drosophila melanogaster SL2 cells contain a hypoxically inducible DNA binding complex which recognises mammalian HIF‐1 binding sites

B. Ebert, P. Ratcliffe, C. Pugh, 1996, FEBS letters.

Transplantation Molecular Basis of Renal Disease Beyond erythropoietin: the oxygen sensor

C. Pugh, P. Maxwell, P. J. Ratcli, 1997 .

The origins and turnover kinetics of limbocytes

C. Pugh, G. Macpherson, 1985 .

The rat mixed lymphocyte reaction: roles of a dendritic cell in intestinal lymph and T-cell subsets defined by monoclonal antibodies.

D. Mason, C. Pugh, M. Webb, 1981, Immunology.

Erythropoietin‐producing Cells in Transgenic Mice Expressing SV40 Large T Antigen Directed by Erythropoietin Control Sequences

D. Ferguson, P. Ratcliffe, P. Maxwell, 1994, Annals of the New York Academy of Sciences.

The HIF pathway: implications for patterns of gene expression in cancer.

A. Harris, C. Wykoff, P. Ratcliffe, 2001, Novartis Foundation symposium.

Characterization of nonlymphoid cells derived from rat peripheral lymph

C. Pugh, G. Macpherson, H. Steer, 1983, The Journal of experimental medicine.

Heterogeneity amongst lymph-borne "dendritic" cells.

C. Pugh, G. Macpherson, Christopher W. Pugh, 1984, Immunobiology.

Functional analysis of an oxygen-regulated transcriptional enhancer lying 3' to the mouse erythropoietin gene.

R. W. Jones, P. Ratcliffe, C. Pugh, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Activation of the HIF pathway in cancer.

P. Ratcliffe, C. Pugh, P. Maxwell, 2001, Current opinion in genetics & development.

Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3' enhancer.

B. Ebert, P. Ratcliffe, J. Firth, 1994, Proceedings of the National Academy of Sciences of the United States of America.

The pVHL-hIF-1 system. A key mediator of oxygen homeostasis.

P. Ratcliffe, P. Maxwell, C. Pugh, 2001, Advances in experimental medicine and biology.

Oxygen sensing, hypoxia-inducible factor-1 and the regulation of mammalian gene expression.

P. Ratcliffe, C. Pugh, P. Maxwell, 1998, The Journal of experimental biology.

Characterisation of functional domains within the mouse erythropoietin 3' enhancer conveying oxygen-regulated responses in different cell lines.

B. Ebert, P. Ratcliffe, C. Pugh, 1994, Biochimica et biophysica acta.

Phorbol ester inhibits erythropoietin production in human hepatoma cells (Hep G2).

D. Fabbro, P. Ratcliffe, K. Eckardt, 1992, The American journal of physiology.

Insights into the Role of the von Hippel-Lindau Gene Product

P. Ratcliffe, P. Maxwell, C. Pugh, 2001, Nephron Experimental Nephrology.

Non-lymphoid cells from rat intestinal lymph.

C. Pugh, G. Macpherson, 1982, Advances in experimental medicine and biology.

Oxygen-dependent expression of the erythropoietin gene in rat hepatocytes in vitro

P. Ratcliffe, A. Kurtz, C. Pugh, 1993, Pflügers Archiv.

Betti reaction enables efficient synthesis of 8-hydroxyquinoline inhibitors of 2-oxoglutarate oxygenases.

S. Müller, P. Ratcliffe, P. Brennan, 2015, Chemical communications.

Regulation of HIF by the von Hippel‐Lindau Tumour Suppressor: Implications for Cellular Oxygen Sensing

P. Ratcliffe, C. Pugh, P. Maxwell, 2001, IUBMB life.

Target gene selectivity of hypoxia-inducible factor-α in renal cancer cells is conveyed by post-DNA-binding mechanisms

P. Ratcliffe, R. Raval, K. W. Lau, 2007, British Journal of Cancer.