Kelin Li

发表

Identification and analysis of hepatitis C virus NS3 helicase inhibitors using nucleic acid binding assays

Alicia M. Hanson, Noreena L. Sweeney, S. Mukherjee, 2012, Nucleic acids research.

Optimization of potent hepatitis C virus NS3 helicase inhibitors isolated from the yellow dyes thioflavine S and primuline.

Jeffrey Aubé, Kelin Li, Alicia M. Hanson, 2012, Journal of medicinal chemistry.

Hepatitis C Virus NS3 Helicase Inhibitor Discovery

Alicia M. Hanson, Noreena L. Sweeney, Craig A. Belon, 2013 .

Bis(pyrazole)- and bis(pyrazolyl)-palladium complexes as phenylacetylene polymerization catalysts

I. Guzei, Kelin Li, P. Shumbula, 2008 .

OvoAMtht from Methyloversatilis thermotolerans ovothiol biosynthesis is a bifunction enzyme: thiol oxygenase and sulfoxide synthase activities

S. Elliott, M. Grinstaff, Lixin Zhang, 2022, Chemical science.

Trifluoroacetic acid-mediated hydroarylation: synthesis of dihydrocoumarins and dihydroquinolones.

Kelin Li, J. Tunge, Lindsay N. Foresee, 2005, The Journal of organic chemistry.

Bioactivation of Trimethoprim to Protein-Reactive Metabolites in Human Liver Microsomes

J. S. Leeder, J. Goldman, Kelin Li, 2016, Drug Metabolism and Disposition.

In Vitro and In Vivo Inhibition of the Mycobacterium tuberculosis Phosphopantetheinyl Transferase PptT by Amidinoureas

J. Sacchettini, J. Vendôme, V. Feher, 2022, Journal of medicinal chemistry.

Evaluating p97 Inhibitor Analogues for Potency against p97–p37 and p97–Npl4–Ufd1 Complexes

Henry J. Lin, T. Chou, F. Schoenen, 2016, ChemMedChem.

Structure-Based Design of Inhibitors with Improved Selectivity for Steroidogenic Cytochrome P450 17A1 over Cytochrome P450 21A2.

J. Aubé, Kelin Li, E. Scott, 2018, Journal of medicinal chemistry.

Single-Cell Transcriptional Profiling Reveals Signatures of Helper, Effector, and Regulatory MAIT Cells during Homeostasis and Activation

C. Leslie, L. Mazutis, M. Glickman, 2022, The Journal of Immunology.

AGC Kinase Inhibitors Regulate STING Signaling Through SGK-Dependent and SGK-Independent Mechanisms

Zhigang Zhang, Pengda Liu, B. Damania, 2022, bioRxiv.

Enzymatic Synthesis of Diverse Heterocycles by a Noncanonical Nonribosomal Peptide Synthetase.

Bo Li, Bo Li, J. Aubé, 2021, ACS chemical biology.

Use of a MAIT-Activating Ligand, 5-OP-RU, as a Mucosal Adjuvant in a Murine Model of Vibrio cholerae O1 Vaccination

D. Leung, E. Ryan, J. Aubé, 2022, bioRxiv.

Synthesis, stabilization, and characterization of the MR1 ligand precursor 5-amino-6-D-ribitylaminouracil (5-A-RU)

A. Rudensky, M. Glickman, J. Altman, 2018, PloS one.

Dual-signal amplified photoelectrochemical biosensor for detection of N6-methyladenosine based on BiVO4-110-TiO2 heterojunction, Ag+-mediated cytosine pairs.

Geoffrey I N Waterhouse, Yunlei Zhou, Hai Lin, 2018, Biosensors & bioelectronics.

SHAPE-enabled fragment-based ligand discovery for RNA

K. Weeks, A. Serganov, O. Favorov, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Synthesis and evaluation of substituted pyrazoles palladium(II) complexes as ethylene polymerization catalysts

I. Guzei, Kelin Li, S. Mapolie, 2002 .

Fluorescent primuline derivatives inhibit hepatitis C virus NS3-catalyzed RNA unwinding, peptide hydrolysis and viral replicase formation.

Alicia M. Hanson, Noreena L. Sweeney, S. Mukherjee, 2012, Antiviral research.

Enhancing Mucosal-Associated Invariant T (MAIT) cell function and expansion with human selective serum

D. Leung, J. Aubé, Kelin Li, 2022, bioRxiv.

Simultaneously Targeting the NS3 Protease and Helicase Activities for More Effective Hepatitis C Virus Therapy.

Akbar Ali, Kelin Li, Alicia M. Hanson, 2015, ACS chemical biology.

Air- and moisture-stable cationic (diphosphine)palladium(II) complexes as hydroamination catalysts: X-ray crystal structures of two [(diphosphine)Pd(NCMe)(OH2)]2+[OTf]−2 complexes

K. K. Hii, M. Hursthouse, Kelin Li, 2003 .

Benzenedicarbonyl and benzenetricarbonyl linker pyrazolyl complexes of palladium(ii): synthesis, X-ray structures and evaluation as ethylene polymerisation catalystsElectronic supplementary information (ESI) available: molecular structures and bond lengths and angles for L2, L3, L6 and 2. See http:/

I. Guzei, Kelin Li, S. Mapolie, 2003 .

Sequential Pd(II)-Pd(0) catalysis for the rapid synthesis of coumarins.

Kelin Li, Benjamin Neuenswander, Kelin Li, 2005, The Journal of organic chemistry.

Enantioselective addition of amines to alkenoyl-N-oxazolidinones

K. K. Hii, Kelin Li, P. Phua, 2005 .

Development of an Aryloxazole Class of Hepatitis C Virus Inhibitors Targeting the Entry Stage of the Viral Replication Cycle.

M. Ferrer, Noel Southall, Shanshan He, 2017, Journal of medicinal chemistry.

Chemical libraries via sequential C-H functionalization of phenols.

Kelin Li, J. Tunge, 2008, Journal of combinatorial chemistry.

Polymerization of Phenylacetylene Catalyzed by Diphosphinopalladium(II) Complexes

Kelin Li, S. Pollack, J. Darkwa, 2002 .

Identification of β-Lactams Active against Mycobacterium tuberculosis by a Consortium of Pharmaceutical Companies and Academic Institutions

Robert H Bates, M. Vieth, P. Hipskind, 2022, ACS infectious diseases.

Insertion of sulfur dioxide into metalcarbon bonds of chloro(methyl)palladium complexes

I. Guzei, Kelin Li, J. Darkwa, 2003 .

Dicationic [(BINAP)Pd(solvent)2]2+[TfO-]2: enantioselective hydroamination catalyst for alkenoyl-N-oxazolidinones.

K. K. Hii, Kelin Li, 2003, Chemical communications.

Asymmetric Synthesis of β-Amino Acid and Amide Derivatives by Catalytic Conjugate Addition of Aromatic Amines to N-Alkenoylcarbamates

K. K. Hii, Kelin Li, Xiao-nong Cheng, 2004 .

Reduction of pyrrolyl- and indolylamides with BH3 x THF: cyclodeoxygenation versus deoxygenation.

Kelin Li, J. Tunge, 2008, The Journal of organic chemistry.

Dual-Pharmacophore Pyrithione-Containing Cephalosporins Kill Both Replicating and Nonreplicating Mycobacterium tuberculosis.

C. Nathan, M. Zimmerman, J. Aubé, 2019, ACS infectious diseases.

Implications for an imidazol-2-yl carbene intermediate in the rhodanase-catalyzed C-S bond formation reaction of anaerobic ergothioneine biosynthesis.

Q. Cui, M. Grinstaff, Chao Peng, 2021, ACS catalysis.

Aliphatic amine responsive organogel system based on a simple naphthalimide derivative.

Kelin Li, Qiuli Cheng, Aiping Gao, 2014, Organic & biomolecular chemistry.

Application of the DP4 Probability Method to Flexible Cyclic Peptides with Multiple Independent Stereocenters: The True Structure of Cyclocinamide A.

J. Aubé, J. Cooper, David A. Coppage, 2018, Organic letters.

Light-driven Oxidative Demethylation Reaction Catalyzed by a Rieske-type Non-heme Iron Enzyme Stc2.

S. Elliott, M. Grinstaff, Kelin Li, 2022, ACS catalysis.

Single cell transcriptional profiling reveals helper, effector, and regulatory MAIT cell populations enriched during homeostasis and activation

C. Leslie, L. Mazutis, M. Glickman, 2020, bioRxiv.

Benzothiazole and Pyrrolone Flavivirus Inhibitors Targeting the Viral Helicase.

Alicia M. Hanson, Noreena L. Sweeney, B. Geiss, 2015, ACS infectious diseases.

Stereochemical control in the reduction of 2-chromanols.

K. Vanka, Kelin Li, J. Tunge, 2006, Organic letters.

Helicase-catalyzed ATP Hydrolysis Stimulate Hepatitis C Virus NS 3 Primuline Derivatives That Mimic RNA to Enzymology :

Noreena L. Sweeney, S. Mukherjee, F. Schoenen, 2013 .

Discovery of Small Molecule Kappa Opioid Receptor Agonist and Antagonist Chemotypes through a HTS and Hit Refinement Strategy.

M. Caron, T. Chung, M. Hedrick, 2012, ACS chemical neuroscience.

MAIT cells are imprinted by the microbiota in early life and promote tissue repair

Jonathan L. Linehan, M. Fischbach, E. Adams, 2019, Science.

Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways

Steven J Brown, R. Deshaies, T. Chou, 2011, Proceedings of the National Academy of Sciences.

Primuline Derivatives That Mimic RNA to Stimulate Hepatitis C Virus NS3 Helicase-catalyzed ATP Hydrolysis*

Noreena L. Sweeney, S. Mukherjee, F. Schoenen, 2013, The Journal of Biological Chemistry.

A Selective ATP-Binding Cassette Subfamily G Member 2 Efflux Inhibitor Revealed via High-Throughput Flow Cytometry

Tudor I. Oprea, Terry D. Foutz, Brooks E. Maki, 2013, Journal of biomolecular screening.

Evaluating p97 Inhibitor Analogues for Their Domain Selectivity and Potency against the p97–p47 Complex

Henry J. Lin, T. Chou, F. Schoenen, 2015, ChemMedChem.

Specific inhibition of p97/VCP ATPase and kinetic analysis demonstrate interaction between D1 and D2 ATPase domains.

Henry J. Lin, M. Walters, M. Arkin, 2014, Journal of molecular biology.

Structure–Activity Relationship Study Reveals ML240 and ML241 as Potent and Selective Inhibitors of p97 ATPase

R. Deshaies, T. Chou, F. Schoenen, 2013, ChemMedChem.

Fluoxazolevir inhibits hepatitis C virus infection in humanized chimeric mice by blocking viral membrane fusion

Noel Southall, Zongyi Hu, Xin Hu, 2020, Nature Microbiology.

Fluoxazolevir inhibits hepatitis C virus infection in humanized chimeric mice by blocking viral membrane fusion

Noel Southall, Zongyi Hu, Xin Hu, 2020, Nature microbiology.

An Interrupted Schmidt Reaction: C-C Bond Formation Arising from Nitrilium Ion Capture.

J. Aubé, Kelin Li, Manwika Charaschanya, 2018, Organic letters.

Visualizing an Allosteric Intermediate Using CuAAC Stabilization of an NMR Mixed Labeled Dimer.

Andrew L. Lee, P. Sapienza, D. Goldfarb, 2021, ACS chemical biology.

Activity-Based Protein Profiling Reveals That Cephalosporins Selectively Active on Non-replicating Mycobacterium tuberculosis Bind Multiple Protein Families and Spare Peptidoglycan Transpeptidases

J. Sacchettini, C. Nathan, J. Aubé, 2020, Frontiers in Microbiology.

Bactericidal Disruption of Magnesium Metallostasis in Mycobacterium tuberculosis Is Counteracted by Mutations in the Metal Ion Transporter CorA

C. Nathan, J. Aubé, S. Silve, 2019, mBio.

Subsite Ligand Recognition and Cooperativity in the TPP Riboswitch: Implications for Fragment-Linking in RNA Ligand Discovery.

K. Weeks, A. Serganov, J. Aubé, 2022, ACS chemical biology.

Mucosal-associated invariant and γδ T cell subsets respond to initial Mycobacterium tuberculosis infection.

M. Glickman, V. Bucci, Marc Antoine Jean Juste, 2018, JCI insight.

Endogenous CSE/Hydrogen Sulfide System Regulates the Effects of Glucocorticoids and Insulin on Muscle Protein Synthesis

H. Jiao, Xiaojuan Wang, Jingpeng Zhao, 2019, Oxidative medicine and cellular longevity.

Efficient 5-OP-RU-Induced Enrichment of Mucosa-Associated Invariant T Cells in the Murine Lung Does Not Enhance Control of Aerosol Mycobacterium tuberculosis Infection

M. Glickman, J. Aubé, C. Vorkas, 2020, Infection and Immunity.

Efficient 5-OP-RU-induced enrichment of Mucosal-associated invariant T cells in the murine lung does not enhance control of aerosol Mycobacterium tuberculosis infection

M. Glickman, J. Aubé, C. Vorkas, 2020, bioRxiv.

ATP-Binding Cassette Sub-Family G Member 2

Hadya M. Njus, Terry D. Foutz, Brooks E. Maki, 2013 .

Selective, reversible inhibitors of the AAA ATPase p97

Patrick Porubsky, Jeffrey Aubé, Kevin J. Frankowski, 2013 .

The Ex Vivo Treatment of Donor T Cells with Cosalane, an HIV Therapeutic and Small-Molecule Antagonist of CC-Chemokine Receptor 7, Separates Acute Graft-versus-Host Disease from Graft-versus-Leukemia Responses in Murine Hematopoietic Stem Cell Transplantation Models.

Nathaniel J. Moorman, J. Aubé, D. Bruce, 2019, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

Identification of Cosalane as an Inhibitor of Human and Murine CC–Chemokine Receptor 7 Signaling via a High-Throughput Screen

M. F. Sassano, W. Janzen, K. Pearce, 2018, SLAS discovery : advancing life sciences R & D.

Mycobacterium tuberculosis PptT Inhibitors Based on Heterocyclic Replacements of Amidinoureas

J. Sacchettini, C. Nathan, J. Aubé, 2023, ACS Medicinal Chemistry Letters.

Specific Inhibition of p 97 / VCP ATPase and Kinetic Analysis Demonstrate Interaction between D 1 and D 2 ATPase domains

Henry J. Lin, M. Walters, M. Arkin, 2014 .

CuAAC stabilization of an NMR mixed labeled dimer

Andrew L. Lee, P. Sapienza, J. Aubé, 2021, bioRxiv.

Application of Nanotechnology in Therapeutic Cancer Vaccines

Q. Ma, Kelin Li, Chaoyong Liu, 2023, Advanced NanoBiomed Research.

Methanol synthesis from syngas in the homogeneous system

Kelin Li, Dazhi Jiang, 1999 .

Enhancing Mucosal-Associated Invariant T Cell Function and Expansion with Human Selective Serum

D. Leung, J. Aubé, Kelin Li, 2023, ImmunoHorizons.

Evaluating p97 Inhibitor Analogues for Potency against p97–p37 and p97–Npl4–Ufd1 Complexes

Henry J. Lin, T. Chou, F. Schoenen, 2016, ChemMedChem.