A. Hague

发表

Apoptosis is induced by the active metabolite of vitamin D3 and its analogue EB1089 in colorectal adenoma and carcinoma cells: possible implications for prevention and therapy.

C. Paraskeva, L. Binderup, G. D. Díaz, 2000, Cancer research.

Nuclear BAG-1 expression inhibits apoptosis in colorectal adenoma-derived epithelial cells

G. Packham, C. Paraskeva, A. Williams, 2005, Apoptosis.

Cell motility assays

Gareth E. Jones, A. Hague, G. Jones, 2008, Cell Biology and Toxicology.

Sodium butyrate induces apoptosis in human colonic tumour cell lines in a p53‐independent pathway: Implications for the possible role of dietary fibre in the prevention of large‐bowel cancer

A. Manning, C. Paraskeva, L. Huschtscha, 1993, International journal of cancer.

The cyclooxygenase 2-selective inhibitor NS398 inhibits proliferation of oral carcinoma cell lines by mechanisms dependent and independent of reduced prostaglandin E2 synthesis.

D. Elder, J. Eveson, A. Hague, 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

Therapy Carcinoma Cells : Possible Implications for Prevention and and Its Analogue EB 1089 in Colorectal Adenoma and 3 Apoptosis Is Induced by the Active Metabolite of Vitamin D Updated

C. Paraskeva, L. Binderup, G. D. Díaz, 2000 .

Cell-cell contact and specific cytokines inhibit apoptosis of colonic epithelial cells: growth factors protect against c-myc-independent apoptosis.

D. Hicks, C. Paraskeva, T. Bracey, 1997, British Journal of Cancer.

Butyrate- but not TGFβ1-induced apoptosis of colorectal adenoma cells is associated with increased expression of the differentiation markers E-cadherin and alkaline phosphatase

C. Paraskeva, A. Butt, A. Hague, 1997, Cell Death and Differentiation.

Differential Growth Inhibition by the Aspirin Metabolite Salicylate in Human Colorectal Tumor Cell Lines: Enhanced Apoptosis in Carcinoma and in Vitro-transformed Adenoma Relative to Adenoma Cell Lines

D. Hicks, C. Paraskeva, D. Elder, 1996 .

BAG-1 inhibits PPARγ-induced cell death, but not PPARγ-induced transcription, cell cycle arrest or differentiation in breast cancer cells

G. Packham, S. Crabb, A. Hague, 2008 .

BAG-1 suppresses expression of the key regulatory cytokine transforming growth factor beta [TGF-β1] in colorectal tumour cells

P. Townsend, A. C. Williams, C. Paraskeva, 2012, Oncogene.

Over‐expression of TGF‐β1 in Smad4‐deficient human oral carcinoma cells causes tumour regression in vivo by mechanisms that sensitize cells to apoptosis

A. Hague, S. Prime, I. Paterson, 2005, The Journal of pathology.

The retinoblastoma protein (Rb) as an anti-apoptotic factor: expression of Rb is required for the antiapoptotic function of BAG-1 protein in colorectal tumour cells: Rb increases nuclear localisation and function of BAG-1. Cell Death and Disease, 3, [e408].

P. Townsend, C. Paraskeva, A. Hague, 2012 .

The retinoblastoma protein (Rb) as an anti-apoptotic factor: expression of Rb is required for the anti-apoptotic function of BAG-1 protein in colorectal tumour cells

P. Townsend, C. Paraskeva, A. Williams, 2012, Cell Death and Disease.

BAG-1 is up-regulated in colorectal tumour progression and promotes colorectal tumour cell survival through increased NF-kappaB activity.

A. C. Williams, G. Packham, C. Paraskeva, 2008, Carcinogenesis.

BAG-1L promotes keratinocyte differentiation in organotypic culture models and changes in relative BAG-1 isoform abundance may lead to defective stratification.

A. Williams, T. Benn, A. Hague, 2011, Experimental cell research.

Butyrate acts as a survival factor for colonic epithelial cells: further fuel for the in vivo versus in vitro debate.

C. Paraskeva, A. Hague, B. Singh, 1997, Gastroenterology.

Association of differential β‐catenin expression with Oct‐4 and Nanog in oral squamous cell carcinoma and their correlation with clinicopathological factors and prognosis

H. Devaraj, K. Kingsley, S. Sawant, 2015, Head & neck.

Bag-1 proteins in oral squamous cell carcinoma.

A. Hague, J. Wood, San San. Lee, 2009, Oral oncology.

Subcellular localisation of BAG-1 and its regulation of vitamin D receptor-mediated transactivation and involucrin expression in oral keratinocytes: implications for oral carcinogenesis.

A. C. Williams, C. Carlberg, G. Packham, 2007, Experimental cell research.

Caspase‐3 expression is reduced, in the absence of cleavage, in terminally differentiated normal oral epithelium but is increased in oral squamous cell carcinomas and correlates with tumour stage

M. MacFarlane, J. Eveson, A. Hague, 2004, The Journal of pathology.

BAG-1 expression and function in human cancer

P. Townsend, G. Packham, A. Bateman, 2002, British Journal of Cancer.

Anticancer effects of putative and validated BH3-mimetic drugs in head and neck squamous cell carcinomas: An overview of current knowledge.

E. K. Parkinson, A. Hague, E. Rivero, 2022, Oral oncology.

Akt as a potential prognostic marker in neuroendocrine tumors: a possibility?

A. Hague, H. L. Robbins, Helen L Robbins, 2016 .

A study of mitotic division fidelity and numerical chromosome changes in ageing Syrian hamster dermal cells.

E. Parry, J. Parry, A. Hague, 1990, Mutation research.

Induction of apoptotic cell death in human colorectal carcinoma cell lines by a cyclooxygenase-2 (COX-2)-selective nonsteroidal anti-inflammatory drug: independence from COX-2 protein expression.

C. Paraskeva, D. Elder, A. Hague, 1997, Clinical cancer research : an official journal of the American Association for Cancer Research.

The short-chain fatty acid butyrate induces apoptosis in colorectal tumour cell lines.

C. Paraskeva, A. Hague, 1995, European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation.

Escape from negative regulation of growth by transforming growth factor β and from the induction of apoptosis by the dietary agent sodium butyrate may be important in colorectal carcinogenesis

A. Manning, C. Paraskeva, A. Hague, 1993, Cancer and Metastasis Reviews.

The PI3K/Akt Pathway in Tumors of Endocrine Tissues

A. Hague, H. L. Robbins, Helen L Robbins, 2016, Front. Endocrinol..

BAG-1 interacts with the p50-p50 homodimeric NF-κB complex: implications for colorectal carcinogenesis

N. Perkins, P. Townsend, C. Paraskeva, 2011, Oncogene.

Co-overexpression of Bag-1 and heat shock protein 70 in human epidermal squamous cell carcinoma: Bag-1-mediated resistance to 5-fluorouracil-induced apoptosis

C. Proby, J. Eveson, A. Hague, 2011, British Journal of Cancer.

Deregulated Bag‐1 protein expression in human oral squamous cell carcinomas and lymph node metastases

G. Packham, J. Eveson, A. Hague, 2002, The Journal of pathology.

bcl‐2 and bak may play a pivotal role in sodium butyrate‐induced apoptosis in colonic epithelial cells; however overexpression of bcl‐2 does not protect against bak‐mediated apoptosis

John Calvin Reed, S. Krajewski, D. Hicks, 1997, International journal of cancer.

Apoptosis in colorectal tumour cells: Induction by the short chain fatty acids butyrate, propionate and acetate and by the bile salt deoxycholate

D. Hicks, C. Paraskeva, D. Elder, 1995, International journal of cancer.

BCL-2 expression in human colorectal adenomas and carcinomas.

D. Hicks, C. Paraskeva, M. Moorghen, 1994, Oncogene.

The retinoblastoma protein interacts with Bag‐1 in human colonic adenoma and carcinoma derived cell lines

P. Townsend, G. Packham, C. Paraskeva, 2003, International journal of cancer.

The role of butyrate in human colonic epithelial cells: an energy source or inducer of differentiation and apoptosis?

C. Paraskeva, A. Butt, A. Hague, 1996, Proceedings of the Nutrition Society.

Decreased levels of p26-Bcl-2, but not p30 phosphorylated Bcl-2, precede TGFbeta1-induced apoptosis in colorectal adenoma cells.

John Calvin Reed, D. Hicks, C. Paraskeva, 1998, Carcinogenesis.

Mini review: In vitro models of colorectal carcinogenesis and the possible role of APC and Rb cleavage, and Bcl‐2 in apoptosis

C. Paraskeva, A. Butty, A. Hague, 1995 .

Loss of apc protein expressed by human colonic epithelial cells and the appearance of a specific low‐molecular‐weight form is associated with apoptosis IN vitro

C. Paraskeva, A. Butt, A. Hague, 1994, International journal of cancer.

Apoptosis and disease: a matter of cell fate

C. Paraskeva, A. Hague, 2004, Cell Death and Differentiation.

In vitro models for studying colorectal carcinogenesis: cellular and molecular events including APC and Rb cleavage in the control of proliferation, differentiation and apoptosis.

C. Paraskeva, A. Williams, D. Elder, 1996, Biochimica et biophysica acta.

Increased sensitivity to TRAIL-induced apoptosis occurs during the adenoma to carcinoma transition of colorectal carcinogenesis

M MacFarlane, G M Cohen, G. Cohen, 2005, British Journal of Cancer.

A single human colonic adenoma cell line can be converted IN VITRO to both A colorectal adenocarcinoma and A mucinous carcinoma

C. Paraskeva, A. Corfield, A. Hague, 1992, International journal of cancer.

Differential growth inhibition by the aspirin metabolite salicylate in human colorectal tumor cell lines: enhanced apoptosis in carcinoma and in vitro-transformed adenoma relative to adenoma relative to adenoma cell lines.

D. Hicks, C. Paraskeva, D. Elder, 1996, Cancer research.

In vitro models of human colorectal cancer.

A. Manning, C. Paraskeva, A. Williams, 1993, Cancer Surveys.

Thioflavin S (NSC71948) Interferes with Bcl-2-Associated Athanogene (BAG-1)-Mediated Protein-Protein Interactions

A Ganesan, A. Ganesan, P. Townsend, 2009, Journal of Pharmacology and Experimental Therapeutics.

Thioflavin S ( NSC 71948 ) Interferes with Bcl-2-Associated Athanogene ( BAG-1 )-Mediated Protein-Protein Interactions

A. Ganesan, P. Townsend, G. Packham, 2009 .

BAG-1 enhances cell-cell adhesion, reduces proliferation and induces chaperone-independent suppression of hepatocyte growth factor-induced epidermal keratinocyte migration.

A. Williams, J. Uney, A. Hague, 2010, Experimental cell research.

Colorectal carcinogenesis: sequential steps in the in vitro immortalization and transformation of human colonic epithelial cells (review).

C. Paraskeva, A. Williams, A. Corfield, 1990, Anticancer research.

The origins and consequences of numerical chromosome changes in Syrian hamster dermal cultures.

E. Parry, J. Parry, A. Hague, 1989, Progress in clinical and biological research.

LOSS OF APC PROTEIN EXPRESSED BY HUMAN COLONIC EPITHELIAL CELLS AND THE APPEARANCE OF A SPECIFIC WITH APOPTOSIS IN VITRO LOW-MOLECULAR-WEIGHT FORM IS ASSOCIATED

C. Paraskeva, A. Hague, A. Williams, 2006 .

Biological consequences of the genetic changes which occur during human colorectal carcinogenesis.

A. Manning, C. Paraskeva, A. Williams, 1993, Seminars in cancer biology.

Bag-1 proteins in oral squamous cell carcinoma.

A. Hague, J. Wood, San San. Lee, 2009, Oral oncology.

BAG-1 is up-regulated in colorectal tumour progression and promotes colorectal tumour cell survival through increased NF-kappaB activity.

G. Packham, C. Paraskeva, A. Hague, 2008, Carcinogenesis.

Association of differential β‐catenin expression with Oct‐4 and Nanog in oral squamous cell carcinoma and their correlation with clinicopathological factors and prognosis

H. Devaraj, K. Kingsley, S. Sawant, 2015, Head & neck.