D. Sansom

D. Sansom, D. Gardner, L. Jeffery, 2014, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

A transendocytosis perspective on the CD28/CTLA-4 pathway.

B. Soskic, D. Sansom, T. Hou, 2014, Advances in immunology.

Integration of CD28 and CTLA‐4 function results in differential responses of T cells to CD80 and CD86

D. Sansom, Claire N. Manzotti, Yong Zheng, 2006, European journal of immunology.

What is the basis for HLA-DQ associations with autoimmune disease?

D. Altmann, S. Marsh, D. Sansom, 1991, Immunology today.

Exocytosis of CTLA-4 Is Dependent on Phospholipase D and ADP Ribosylation Factor-1 and Stimulated during Activation of Regulatory T Cells1

M. Wakelam, D. Sansom, Claire N. Manzotti, 2005, The Journal of Immunology.

Regulatory T Cells Factor-1 and Stimulated during Activation of Phospholipase D and ADP Ribosylation Exocytosis of CTLA-4 Is Dependent on

M. Wakelam, D. Sansom, Claire N. Manzotti, 2005 .

Measuring CTLA-4-Dependent Suppressive Function in Regulatory T Cells.

D. Sansom, T. Hou, O. Qureshi, 2019, Methods in molecular biology.

Expression and function of the autoimmune regulator (Aire) gene in non‐thymic tissue

P. Narendran, D. Sansom, S. Eldershaw, 2011, Clinical and experimental immunology.

Whole genome sequencing of a sporadic primary immunodeficiency cohort

William J. Astle, Sri V. V. Deevi, Kenneth G. C. Smith, 2018, Nature.

CTLA-4 controls follicular helper T-cell differentiation by regulating the strength of CD28 engagement

L. Walker, D. Sansom, F. Heuts, 2014, Proceedings of the National Academy of Sciences.

Inhibition of human T cell proliferation by CTLA‐4 utilizes CD80 and requires CD25+ regulatory T cells

P. Blair, D. Sansom, Claire N. Manzotti, 2002, European journal of immunology.

1 Whole genome sequencing of a sporadic primary immunodeficiency cohort 2

Lynch, Gilmour, Sri V. V. Deevi, 2020 .

HLA-DP in rheumatoid arthritis.

P. Wernet, G. Pawelec, D. Sansom, 1988, Tissue antigens.

CTLA-4 Controls Regulatory T Cell Peripheral Homeostasis and Is Required for Suppression of Pancreatic Islet Autoimmunity1

A. Sharpe, A. Abbas, M. Goodall, 2009, The Journal of Immunology.

Decreased proliferative capacity and increased susceptibility to activation-induced cell death in late-passage human cd4+ tcr2+ cultured T cell clones

G. Pawelec, D. Sansom, M. Adibzadeh, 1996, Experimental Gerontology.

University of Birmingham Comparison of the intracellular trafficking itinerary of ctla-4 orthologues

D. Sansom, S. Kaur, O. Qureshi, 2013 .

Decreased sensitivity to 1,25-dihydroxyvitamin D3 in T cells from the rheumatoid joint

A. Filer, K. Raza, M. Hewison, 2017, Journal of autoimmunity.

Extra-renal 25-hydroxyvitamin D3-1alpha-hydroxylase in human health and disease.

J. Adams, M. Hewison, D. Sansom, 2007, The Journal of steroid biochemistry and molecular biology.

Thymus transplantation for complete DiGeorge syndrome: European experience

Kathryn L. Parsley, N. Sebire, A. Worth, 2017, Journal of Allergy and Clinical Immunology.

Ligation of the T cell co‐stimulatory receptor CD28 activates the serine‐threonine protein kinase protein kinase B

B. Hemmings, R. Parry, S. Ward, 1997, European journal of immunology.

The Role of Endogenous Peptides in the Direct Pathway of Alloreactivity to Human MHC Class II Molecules Expressed on CHO Cells

G. Pawelec, J. Zeuthen, H. Kalbacher, 1996, Immunological reviews.

Role of three quantitatively dominant endogenous peptides from HLA-DRB1*0401 molecules in class II specific alloreactivity.

G. Pawelec, H. Kalbacher, D. Sansom, 1994, Transplant immunology.

Study of an extended family with CTLA-4 deficiency suggests a CD28/CTLA-4 independent mechanism responsible for differences in disease manifestations and severity.

Q. Pan-Hammarström, L. Hammarström, S. Burns, 2018, Clinical immunology.

Cutting Edge: Cell-Extrinsic Immune Regulation by CTLA-4 Expressed on Conventional T Cells

L. Walker, D. Sansom, Claire N. Manzotti, 2012, The Journal of Immunology.

Vitamin D deficiency contributes directly to the acute respiratory distress syndrome (ARDS)

G. Perkins, E. Sapey, D. Thickett, 2015, Thorax.

Costimulation of human CD4+ T lymphocytes with B7 and lymphocyte function-associated antigen-3 results in distinct cell activation profiles.

M. Björklund, E. Parra, H. Sjögren, 1994, Journal of immunology.

A Transendocytosis Model of CTLA-4 Function Predicts Its Suppressive Behavior on Regulatory T Cells

S. Young, L. Walker, D. Sansom, 2015, The Journal of Immunology.

HLA DQα and DQβ restriction fragment length polymorphisms associated with Felty's syndrome and DR4-positive rheumatoid arthritis

G. Campion, D. Sansom, P. Maddison, 1987 .

Suppression of Pancreatic Islet Peripheral Homeostasis and Is Required for CTLA-4 Controls Regulatory T Cell

A. Sharpe, M. Goodall, D. Sansom, 2008 .

Activation of human T cells with superantigen (staphylococcal enterotoxin B) and CD28 confers resistance to apoptosis via CD95.

L. Walker, D. Sansom, G. Boulougouris, 1998, Journal of immunology.

CD28 costimulation: Walking the immunological tightrope

L. Walker, D. Sansom, 2013, European journal of immunology.

Loss of CD28 expression by liver-infiltrating T cells contributes to pathogenesis of primary sclerosing cholangitis.

G. Reynolds, D. Adams, P. Trivedi, 2014, Gastroenterology.

Differences in CD80 and CD86 transendocytosis reveal CD86 as a key target for CTLA-4 immune regulation

A. Kennedy, B. Soskic, L. Walker, 2022, Nature Immunology.

Immune deficiency and autoimmunity in patients with CTLA‐4 (CD152) mutations

N. Verma, S. Burns, L. Walker, 2017, Clinical and experimental immunology.

Immune deficiency and autoimmunity in patients with CTLA-4 mutations

N. Verma, S. Burns, L. Walker, 2017 .

Availability of 25-Hydroxyvitamin D3 to APCs Controls the Balance between Regulatory and Inflammatory T Cell Responses

K. Raza, D. Sansom, T. Hou, 2012, The Journal of Immunology.

Mutually exclusive binding of peptide and invariant chain to major histocompatibility complex class II antigens.

M. Sundström, D. Charron, D. Sansom, 1994, The Journal of biological chemistry.

B7/BB1, the ligand for CD28, is expressed on repeatedly activated human T cells in vitro

D. Sansom, N. Hall, 1993, European journal of immunology.

Ligation of CD28 receptor by B7 induces formation of D‐3 phosphoinositides in T lymphocytes independently of T cell receptor/CD3 activation

J. Westwick, S. Ward, D. Sansom, 1993, European journal of immunology.

Therapeutic gene editing of T cells to correct CTLA-4 insufficiency

A. Kennedy, S. Burns, E. Morris, 2022, Science Translational Medicine.

Identifying functional defects in patients with immune dysregulation due to LRBA and CTLA-4 mutations.

A. Worth, N. Verma, A. Kennedy, 2017, Blood.

University of Birmingham Availability of 25-hydroxyvitamin D(3) to APCs controls the balance between regulatory and inflammatory T cell responses

K. Raza, D. Sansom, T. Hou, 2012 .

Regulatory and Inflammatory T Cell APCs Controls the Balance between to 3 Availability of 25-Hydroxyvitamin

D. Sansom, S. Kaur, O. Qureshi, 2012 .

Human vascular endothelial cells process and present autoantigen to human T cell lines.

C. Savage, W. King, D. Sansom, 1995, International immunology.

Lack of activation induced cell death in human T blasts despite CD95L up‐regulation: protection from apoptosis by MEK signalling

L. Walker, D. Sansom, G. Boulougouris, 1999, Immunology.

Lack of costimulation by both sphingomyelinase and C2 ceramide in resting human T cells

D. O’Byrne, D. Sansom, 2000, Immunology.

Activation of the PI3K effector protein kinase B following ligation of CD28 or Fas.

R. Parry, K. Reif, D. Sansom, 1997, Biochemical Society transactions.

Monocyte-regulated IFN-gamma production in human T cells involves CD2 signaling.

M. Björklund, T. Olsson, H. Sjögren, 1993, Journal of immunology.

Co-stimulation with B7 and targeted superantigen is required for MHC class II-independent T-cell proliferation but not cytotoxicity.

T. Kalland, G. Hedlund, M. Dohlsten, 1993, Immunology.

Differential expression of the costimulatory molecules B7.1 (CD80) and B7.2 (CD86) in rheumatoid synovial tissue.

A. Balsa, D. Sansom, P. Maddison, 1996, British journal of rheumatology.

Human Naive and Memory T‐Helper Cells Display Distinct Adhesion Properties to ICAM‐1, LFA‐3 and B7 Molecules

E. Parra, T. Kalland, G. Hedlund, 1993, Scandinavian journal of immunology.

Vitamin D de ﬁ ciency contributes directly to the acute respiratory distress syndrome (ARDS)

G. Perkins, E. Sapey, D. Thickett, 2015 .

Constitutive Clathrin-mediated Endocytosis of CTLA-4 Persists during T Cell Activation

Natalie S. Poulter, J. Rappoport, N. Poulter, 2012, The Journal of Biological Chemistry.

The LFA‐3 Adhesion Pathway is Differently Utilized by Superantigen‐Activated Human CD4+ T‐Cell Subsets

J. Trowsdale, T. Kalland, G. Hedlund, 1992, Scandinavian journal of immunology.

CTLA-4–mediated transendocytosis of costimulatory molecules primarily targets migratory dendritic cells

Clare L. Bennett, A. Kennedy, L. Walker, 2019, Science Immunology.

Trans-Endocytosis of CD80 and CD86: A Molecular Basis for the Cell-Extrinsic Function of CTLA-4

G. Anderson, C. Futter, Jennifer L Baker, 2011, Science.

CTLA-4: a moving target in immunotherapy.

D. Sansom, Neil Halliday, Behzad Rowshanravan, 2018, Blood.

Human DEF6 deficiency underlies an immunodeficiency syndrome with systemic autoimmunity and aberrant CTLA-4 homeostasis

J. Orange, E. Meffre, W. Pickl, 2019, Nature Communications.

The origin of HLA-DR"Br": exon 2 nucleotide sequence implicates possible gene conversion of DR1 by DR4-Dw10, DR5, or DRw6-Dw18.

J. Bidwell, D. Sansom, P. Klouda, 1989, Human immunology.

CTLA4 gene polymorphism and autoimmunity

S. Gough, L. Walker, D. Sansom, 2005, Immunological reviews.

Genomic profiling of T-cell activation suggests increased sensitivity of memory T cells to CD28 costimulation

L. Jostins, G. Trynka, A. Kennedy, 2020, Genes & Immunity.

Effects of antigen presentation on superantigen‐induced apoptosis mediated by Fas/Fas ligand interactions in human T cells

D. Sansom, J. McLeod, N. Hall, 1996, Immunology.

Inhibition of CD28‐mediated T cell costimulation by the phosphoinositide 3‐kinase inhibitor wortmannin

J. Westwick, S. Ward, D. Sansom, 1995, European journal of immunology.

Normal human pregnancy is associated with an elevation in the immune suppressive CD25+ CD4+ regulatory T‐cell subset

M. Drayson, M. Kilby, D. Sansom, 2004, Immunology.

Whole-genome sequencing of a sporadic primary immunodeficiency cohort

William J. Astle, Sri V. V. Deevi, Kenneth G. C. Smith, 2020, Nature.

Whole Genome Sequencing of Primary Immunodeficiency reveals a role for common and rare variants in coding and non-coding sequences

Sri V. V. Deevi, Kenneth G. C. Smith, Nicholas S. Gleadall, 2018, bioRxiv.

Genomic profiling of T cell activation reveals dependency of memory T cells on CD28 costimulation

L. Jostins, G. Trynka, B. Soskic, 2018, bioRxiv.

CD28, CTLA‐4 and their ligands: who does what and to whom?

D. Sansom, D. M. Sansom, David M. Sansom, 2000, Immunology.

CD86 and CD80 Differentially Modulate the Suppressive Function of Human Regulatory T Cells1

D. Sansom, Claire N. Manzotti, Yong Zheng, 2004, The Journal of Immunology.

Autosomal-dominant immune dysregulation syndrome in humans with CTLA4 mutations

A. Schäffer, R. Backofen, S. Ehl, 2014, Nature Medicine.

Regulatory T cells and COPD

D. Sansom, R. Dancer, 2013, Thorax.

The role of CD28 and cytotoxic T‐lymphocyte antigen‐4 (CTLA‐4) in regulatory T‐cell biology

L. Walker, D. Sansom, 2006, Immunological reviews.

Vedolizumab as a successful treatment of CTLA-4-associated autoimmune enterocolitis.

M. Mehling, C. Hess, P. Hruz, 2017, The Journal of allergy and clinical immunology.

Follicular helper T cell signature in type 1 diabetes.

M. Ono, P. Narendran, L. Walker, 2015, The Journal of clinical investigation.

IL-2-independent activation and proliferation in human T cells induced by CD28.

L. Walker, D. Sansom, G Boulougouris, 1999, Journal of immunology.

Strong primary selection for the Dw4 subtype of DR4 accounts for the HLA-DQw7 association with Felty's syndrome.

Paul Wordsworth, J. Bell, J. Lanchbury, 1991, Human immunology.

Genetic variation at the CD28 locus and its impact on expansion of pro-inflammatory CD28 negative T cells in healthy individuals

M. Seldin, G. Hirschfield, B. Soskic, 2017, Scientific Reports.

Impact of CTLA-4 checkpoint antibodies on ligand binding and Transendocytosis

A. Kennedy, S. Dovedi, D. Sansom, 2022, Frontiers in Immunology.

1,25-Dihydroxyvitamin D3 and IL-2 Combine to Inhibit T Cell Production of Inflammatory Cytokines and Promote Development of Regulatory T Cells Expressing CTLA-4 and FoxP31

M. Mura, K. Raza, M. Hewison, 2009, The Journal of Immunology.

Low-level Hypermutation in T Cell–independent Germinal Centers Compared with High Mutation Rates Associated with T Cell–dependent Germinal Centers

K. Toellner, I. Maclennan, C. Vinuesa, 2002, The Journal of experimental medicine.

Dimers Aren't Forever: CD80 Breaks up with PD-L1.

L. Walker, D. Sansom, 2019, Immunity.

CD28 Costimulation and Regulatory T Cells

B. Soskic, D. Sansom, 2016 .

Positive and negative regulation of human T cell activation mediated by the CTLA-4/CD28 ligand CD80.

L. Walker, D. Sansom, G. Boulougouris, 1998, Journal of immunology.

CTLA-4 / CD 28 Ligand CD 80 Cell Activation Mediated by the Positive and Negative Regulation of Human T

L. Walker, D. Sansom, G. Boulougouris, 1998 .

The CTLA‐4 immune checkpoint protein regulates PD‐L1:PD‐1 interaction via transendocytosis of its ligand CD80

A. Kennedy, S. Dovedi, D. Sansom, 2023, The EMBO journal.

CTLA-4 regulates PD-L1-PD-1 interactions via transendocytosis of CD80

A. Kennedy, S. Dovedi, D. Sansom, 2022, bioRxiv.

Characterisation of CTLA-4 and LRBA deficiency

A. Worth, N. Verma, A. Kennedy, 2016 .

Moving CTLA-4 from the trash to recycling

D. Sansom, 2015, Science.

Vitamin D Antagonises the Suppressive Effect of Inflammatory Cytokines on CTLA-4 Expression and Regulatory Function

K. Raza, B. Soskic, D. Sansom, 2015, PloS one.

Conventional T Cells Regulation by CTLA-4 Expressed on Cutting Edge: Cell-Extrinsic Immune

L. Walker, D. Sansom, Claire N. Manzotti, 2012 .

1,25-Dihydroxyvitamin D3 and IL-2 Combine to Inhibit T Cell Production of Inflammatory Cytokines and Promote Development of Regulatory T Cells Expressing CTLA-4 and FoxP31

M. Mura, K. Raza, M. Hewison, 2009, The Journal of Immunology.

Acquisition of Suppressive Function by Activated Human CD4+CD25− T Cells Is Associated with the Expression of CTLA-4 Not FoxP31

L. Walker, D. Sansom, Claire N. Manzotti, 2008, The Journal of Immunology.

Hematopoietic stem cell transplantation for CTLA4 deficiency.

T. Torgerson, A. Gennery, D. Hagin, 2016, The Journal of allergy and clinical immunology.

Induction of activator protein (AP)-1 and nuclear factor-kappaB by CD28 stimulation involves both phosphatidylinositol 3-kinase and acidic sphingomyelinase signals.

S. Ward, D. Sansom, C. Edmead, 1996, Journal of immunology.

Antibody ligation of CD7 leads to association with phosphoinositide 3‐kinase and phosphatidylinositol 3,4,5‐trisphosphate formation in T lymphocytes

J. Westwick, R. Parry, S. Ward, 1995, European journal of immunology.

Extra-renal 25-hydroxyvitamin D3-1α-hydroxylase in human health and disease

J. Adams, M. Hewison, D. Sansom, 2007, The Journal of Steroid Biochemistry and Molecular Biology.

HLA DQ alpha and DQ beta restriction fragment length polymorphisms associated with Felty's syndrome and DR4-positive rheumatoid arthritis.

J. Bidwell, G. Campion, D. Sansom, 1987, Human immunology.

Evidence that a kinase distinct from protein kinase C and phosphatidylinositol 3-kinase mediates ligation-dependent serine/threonine phosphorylation of the T-lymphocyte co-stimulatory molecule CD28.

J. Westwick, R. Parry, D. Sansom, 1997, The Biochemical journal.

Dqβ polymorphism and genetic susceptibility to felty's syndrome

M. Walport, D. Sansom, C. Warner, 1988 .

Quantitative characterization of CTLA4 trafficking and turnover using a combined in vitro and in silico approach

Philippe A. Robert, M. Meyer-Hermann, S. Khailaie, 2017, bioRxiv.

Identification of a Secondary Zinc-binding Site in Staphylococcal Enterotoxin C2

K. Acharya, A. Papageorgiou, D. Sansom, 2004, Journal of Biological Chemistry.

Expression and secretion of parathyroid hormone‐related protein by human bone‐derived cells in vitro: Effects of glucocorticoids

M. Birch, W. Fraser, D. Sansom, 1995, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

J. Bidwell, D. Sansom, G. Evison, 1989, British journal of rheumatology.

CTLA-4 / CD 28 Ligand CD 80 Cell Activation Mediated by the Positive and Negative Regulation of Human T

L. Walker, D. Sansom, G. Boulougouris, 1998 .

Both intratumoral regulatory T cell depletion and CTLA-4 antagonism are required for maximum efficacy of anti-CTLA-4 antibodies

Jordan A. Stinson, K. Wittrup, A. Kennedy, 2023, Proceedings of the National Academy of Sciences of the United States of America.

Identifying functional defects in patients with immune dysregulation due to LRBA and CTLA-4 mutations.

A. Worth, N. Verma, A. Kennedy, 2017, Blood.

A transendocytosis perspective on the CD28/CTLA-4 pathway.

B. Soskic, D. Sansom, T. Hou, 2014, Advances in immunology.

B7/CD28 but not LFA-3/CD2 interactions can provide 'third-party' co-stimulation for human T-cell activation.

D. Sansom, J. Lewis, N. Hall, 1993, Immunology.

Autosomal-dominant immune dysregulation syndrome in humans with CTLA4 mutations