R. Lapointe

发表

Indoleamine 2,3-Dioxygenase Expression in Human Cancers: Clinical and Immunologic Perspectives

C. Piccirillo, J. Godin-Ethier, L. Hanafi, 2011, Clinical Cancer Research.

Cancer classification using the Immunoscore: a worldwide task force

F. Marincola, P. Gibbs, M. Mihm, 2012, Journal of Translational Medicine.

Two distinct chimeric potexviruses share antigenic cross-presentation properties of MHC class I epitopes.

J. Routy, F. Dufour, D. Leclerc, 2010, Vaccine.

Immunization against Endogenous Retroviral Tumor-associated Antigens 1

Willem, P. Hwu, J. Yang, 2001 .

Immunization against endogenous retroviral tumor-associated antigens.

P. Hwu, R. Wang, N. Restifo, 2001, Cancer research.

Human Activated T Lymphocytes Modulate IDO Expression in Tumors through Th1/Th2 Balance1

J. Routy, M. Forget, J. Godin-Ethier, 2009, The Journal of Immunology.

Requirement of Oxidation-dependent CD40 Homodimers for CD154/CD40 Bidirectional Signaling*

R. Lapointe, W. Mourad, Ehssan Sharif-Askari, 2007, Journal of Biological Chemistry.

Stimulation of Wnt/ß-Catenin Pathway in Human CD8+ T Lymphocytes from Blood and Lung Tumors Leads to a Shared Young/Memory Phenotype

A. Mes-Masson, A. Reuben, M. Liberman, 2012, PloS one.

CD40-stimulated B lymphocytes pulsed with tumor antigens are effective antigen-presenting cells that can generate specific T cells.

P. Hwu, F. Housseau, J. Thibodeau, 2003, Cancer research.

CD 40-stimulated B Lymphocytes Pulsed with Tumor Antigens Are Effective Antigen-presenting Cells That Can Generate Specific T Cells 1

P. Hwu, F. Housseau, J. Thibodeau, 2003 .

Simian Virus 40 Large Tumor Antigen Modulates the Raf Signaling Pathway*

T. Roberts, O. Gjoerup, A. Vultur, 2001, The Journal of Biological Chemistry.

Failed immune responses across multiple pathologies share pan-tumor and circulating lymphocytic targets.

I. Jurisica, D. Kaufmann, J. Routy, 2019, The Journal of clinical investigation.

Proteasome-Independent Major Histocompatibility Complex Class I Cross-Presentation Mediated by Papaya Mosaic Virus-Like Particles Leads to Expansion of Specific Human T Cells

D. Leclerc, R. Lapointe, D. Beauseigle, 2006, Journal of Virology.

Identification of T-cell Epitopes by a Novel mRNA PCR-basedEpitope Chase Technique

R. Lapointe, D. Gauchat, J. Doucet, 2011, Journal of immunotherapy.

Efficient gene transfer to human peripheral blood monocyte-derived dendritic cells using human immunodeficiency virus type 1-based lentiviral vectors.

P. Hwu, R. Morgan, F. Candotti, 2000, Human gene therapy.

Mobilization of Dendritic Cell Precursors in Patients With Cancer by Flt3 Ligand Allows the Generation of Higher Yields of Cultured Dendritic Cells

S. Rosenberg, P. Hwu, A. Mixon, 2002, Journal of immunotherapy.

A new clinically relevant approach to expand myelin specific T cells.

J. Antel, R. Lapointe, N. Arbour, 2006, Journal of immunological methods.

HLA‐DO transduced in human monocyte‐derived dendritic cells modulates MHC class II antigen processing

J. Routy, J. Thibodeau, R. Lapointe, 2005, Journal of leukocyte biology.

Balance IDO Expression in Tumors through Th1/Th2 Human Activated T Lymphocytes Modulate

M. Forget, J. Godin-Ethier, L. Hanafi, 2009 .

Expression of a "self-"antigen by human tumor cells enhances tumor antigen-specific CD4(+) T-cell function.

S. Rosenberg, P. Hwu, P. Robbins, 2002, Cancer research.

Human dendritic cells require multiple activation signals for the efficient generation of tumor antigen‐specific T lymphocytes

P. Hwu, H. Young, R. Lapointe, 2000, European journal of immunology.

Melanosomal targeting sequences from gp100 are essential for MHC class II-restricted endogenous epitope presentation and mobilization to endosomal compartments.

R. Lapointe, S. Lepage, 2006, Cancer research.

Novel Plant Virus-Based Vaccine Induces Protective Cytotoxic T-Lymphocyte-Mediated Antiviral Immunity through Dendritic Cell Maturation

D. Leclerc, R. Lapointe, A. Lamarre, 2007, Journal of Virology.

Alemtuzumab for Immune-Related Myocarditis Due to PD-1 Therapy.

N. Johnson, W. Miller, R. Lapointe, 2019, The New England journal of medicine.

Peripheral and local predictive immune signatures identified in a phase II trial of ipilimumab with carboplatin/paclitaxel in unresectable stage III or stage IV melanoma

K. Bélanger, W. Miller, J. Cailhier, 2017, Journal of Immunotherapy for Cancer.

CD40-Activated B Cells Can Efficiently Prime Antigen-Specific Naïve CD8+ T Cells to Generate Effector but Not Memory T cells

Jean Daudelin, N. Labrecque, R. Lapointe, 2012, PloS one.

Phosphorylation of eIF4E in the stroma drives the production and spatial organisation of collagen type I in the mammary gland.

C. Borchers, C. Gonçalves, L. Postovit, 2022, Matrix biology : journal of the International Society for Matrix Biology.

Advances in Brief Expression of a “ Self-” Antigen by Human Tumor Cells Enhances Tumor Antigen-specific CD 4 T-Cell Function

S. Rosenberg, P. Hwu, P. Robbins, 2002 .

MHC class I and class II presentation of tumor antigen in retrovirally and adenovirally transduced dendritic cells

P. Hwu, P. Robbins, N. Restifo, 2002, Cancer Gene Therapy.

IDO expression by human B lymphocytes in response to T lymphocyte stimuli and TLR engagement is biologically inactive.

D. Leclerc, Jean-Baptiste Duvignaud, J. Godin-Ethier, 2011, Molecular immunology.

Injectable T cell delivery scaffolds for cancer immunotherapy

S. Lerouge, R. Lapointe, A. Monette, 2018 .

CD40 Ligand Binds to α5β1 Integrin and Triggers Cell Signaling*

J. Wilkins, Y. Merhi, R. Lapointe, 2007, Journal of Biological Chemistry.

MHC class I antigen cross-presentation mediated by PapMV nanoparticles in human antigen-presenting cells is dependent on autophagy

D. Leclerc, L. Hanafi, R. Lapointe, 2021, PloS one.

Endogenously expressed matrix protein M1 and nucleoprotein of influenza A are efficiently presented by class I and class II major histocompatibility complexes.

Ronan N. Rouxel, V. von Messling, M. Forget, 2011, The Journal of general virology.

Lymphocytic Microparticles Modulate Angiogenic Properties of Macrophages in Laser-induced Choroidal Neovascularization

E. Vaucher, F. Rodier, J. Cailhier, 2016, Scientific Reports.

Soluble CD40‐ligand (sCD40L, sCD154) plays an immunosuppressive role via regulatory T cell expansion in HIV infection

C. Tremblay, J. Routy, D. Radzioch, 2014, Clinical and experimental immunology.

CD40/CD40 Homodimers Are Required for CD40-induced Phosphatidylinositol 3-Kinase-dependent Expression of B7.2 by Human B Lymphocytes*

R. Lapointe, W. Mourad, C. Reyes-Moreno, 2004, Journal of Biological Chemistry.

Tyrosine kinase and cAMP‐dependent protein kinase activities in CD40‐activated human B lymphocytes

M. Olivier, R. Lemieux, R. Lapointe, 1996, European journal of immunology.

CD40 ligand and lipopolysaccharide enhance the in vitro generation of melanoma-reactive T-cells.

P. Hwu, R. Lapointe, J. Toso, 2002, Journal of immunological methods.

Human Dendritic Cells Results in the Indoleamine 2 , 3-Dioxygenase Production by

Milton W. Taylor, P. Hwu, R. Lapointe, 2000 .

CD40 ligand binds to alpha5beta1 integrin and triggers cell signaling.

J. Wilkins, Y. Merhi, R. Lapointe, 2007, The Journal of biological chemistry.

Interference of HIV‐1 Nef in the sphingomyelin transduction pathway activated by tumour necrosis factor‐α in human glial cells

G. Robichaud, S. Bourgoin, R. Lapointe, 1997, AIDS.

Indoleamine 2,3-Dioxygenase Production by Human Dendritic Cells Results in the Inhibition of T Cell Proliferation

Milton W. Taylor, P. Hwu, H. Young, 2000, The Journal of Immunology.

Productive infection of normal CD40‐activated human B lymphocytes by HIV‐1

S. Moir, R. Lapointe, A. Darveau, 1994, AIDS.

Biomaterials for enhanced immunotherapy

S. Lerouge, R. Lapointe, Nicholas Cunningham, 2022, APL bioengineering.

Targeting the MHC Class II antigen presentation pathway in cancer immunotherapy

Jacques Thibodeau, M. Bourgeois-Daigneault, J. Thibodeau, 2012, Oncoimmunology.

Improvement of the PapMV nanoparticle adjuvant property through an increased of its avidity for the antigen [influenza NP].

D. Leclerc, M. Forget, R. Lapointe, 2012, Vaccine.

Defining the critical hurdles in cancer immunotherapy

Zhigang Tian, Sylvia Janetzki, Cedrik M Britten, 2011, Journal of Translational Medicine.

Single-dose replicating poxvirus vector-based RBD vaccine drives robust humoral and T cell immune response against SARS-CoV-2 infection

J. Diallo, Stephen Boulton, J. Cailhier, 2021, Molecular Therapy.

Immunogenicity of papaya mosaic virus-like particles fused to a hepatitis C virus epitope: evidence for the critical function of multimerization.

D. Leclerc, R. Lapointe, P. Tessier, 2007, Virology.

Inflammation enhances the vaccination potential of CD40‐activated B cells in mice

Jean Daudelin, N. Labrecque, R. Lapointe, 2017, European journal of immunology.

Targeting the mTOR pathway uncouples the efficacy and toxicity of PD-1 blockade in renal transplantation

N. Johnson, M. Hudson, W. Miller, 2019, Nature Communications.

Spatially mapping the immune landscape of melanoma using imaging mass cytometry

H. Najafabadi, A. Mes-Masson, Luke Anderson-Trocmé, 2022, Science Immunology.

Moving towards personalized treatments of immune-related adverse events

M. Hudson, W. Miller, B. Routy, 2020, Nature Reviews Clinical Oncology.

Spatially distinct tumor immune microenvironments stratify triple-negative breast cancers

Benjamin Haibe-Kains, M. Hallett, R. Salgado, 2019, The Journal of clinical investigation.

Founder BRCA1/BRCA2/PALB2 pathogenic variants in French-Canadian breast cancer cases and controls

A. Mes-Masson, W. Foulkes, N. Hamel, 2020, Scientific Reports.

TGF-alpha as a candidate tumor antigen for renal cell carcinomas

L. Gunaratnam, R. Lapointe, N. Arbour, 2009, Cancer Immunology, Immunotherapy.

CD40-Mediated Induction of CD4 and CXCR4 on B Lymphocytes Correlates with Restricted Susceptibility to Human Immunodeficiency Virus Type 1 Infection: Potential Role of B Lymphocytes as a Viral Reservoir

M. Ostrowski, T. Chun, M. Baseler, 1999, Journal of Virology.

Characterization of the intra-prostatic immune cell infiltration in androgen-deprived prostate cancer patients.

A. Mes-Masson, F. Saad, R. Lapointe, 2009, Journal of immunological methods.

The Wnt pathway regulator DKK1 is preferentially expressed in hormone-resistant breast tumours and in some common cancer types

S. Turcotte, M. Forget, J. Godin-Ethier, 2007, British Journal of Cancer.

Correction: Distinct Tryptophan Catabolism and Th17/Treg Balance in HIV Progressors and Elite Controllers

C. Tremblay, J. Routy, D. Radzioch, 2014, PLoS ONE.

Distinct Tryptophan Catabolism and Th17/Treg Balance in HIV Progressors and Elite Controllers

C. Tremblay, J. Routy, D. Radzioch, 2013, PloS one.

University of Groningen Distinct Tryptophan Catabolism and Th 17 / Treg Balance in HIV Progressors and Elite

C. Tremblay, D. Radzioch, I. Kema, 2013 .

MARCH1 down-regulation in IL-10-activated B cells increases MHC class II expression.

S. Ishido, V. Steimle, Tristan Galbas, 2012, Cytokine.

HIV-1 induces phenotypic and functional perturbations of B cells in chronically infected individuals

T. Chun, C. Hallahan, M. Baseler, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Counteracting Subversion of MHC Class II Antigen Presentation by Tumors

M. Bourgeois-Daigneault, J. Thibodeau, R. Lapointe, 2011 .

The hemochromatosis protein HFE 20 years later: An emerging role in antigen presentation and in the immune system

Manuela M. Santos, A. Reuben, R. Lapointe, 2017, Immunity, inflammation and disease.

A Randomized Controlled Study to Evaluate the Safety and Reactogenicity of a Novel rVLP-Based Plant Virus Nanoparticle Adjuvant Combined with Seasonal Trivalent Influenza Vaccine Following Single Immunization in Healthy Adults 18–50 Years of Age

J. Langley, J. Cailhier, P. Savard, 2020, Vaccines.

Chitosan thermogels for local expansion and delivery of tumor-specific T lymphocytes towards enhanced cancer immunotherapies.

S. Lerouge, R. Lapointe, E. Assaad, 2016, Biomaterials.

Retrovirally Transduced Human Dendritic Cells Can Generate T Cells Recognizing Multiple MHC Class I and Class II Epitopes from the Melanoma Antigen Glycoprotein 100

P. Hwu, P. Robbins, M. Reeves, 2001, The Journal of Immunology.

T lymphocyte-derived TNF and IFN-γ repress HFE expression in cancer cells.

Manuela M. Santos, A. Reuben, J. Godin-Ethier, 2015, Molecular immunology.

The WT hemochromatosis protein HFE inhibits CD8+ T‐lymphocyte activation

Manuela M. Santos, A. Reuben, R. Lapointe, 2014, European journal of immunology.

High-dimensional analysis of the adenosine pathway in high-grade serous ovarian cancer

A. Mes-Masson, D. Provencher, L. Buisseret, 2021, Journal for ImmunoTherapy of Cancer.

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one

Charles J. Vaske, Rohan N. Borkar, Brian D. Kelly, 2016, Journal of Immunotherapy for Cancer.

Predicting developmental relationships of tumor resident and circulating T cells in ovarian cancer

A. Mes-Masson, D. Provencher, S. Petropoulos, 2023, bioRxiv.

Redox-modulating agents target NOX2-dependent IKKε oncogenic kinase expression and proliferation in human breast cancer cell lines

N. Grandvaux, R. Lapointe, P. Pagano, 2015, Redox biology.

CD40L-Stimulated B Lymphocytes Are Polarized toward APC Functions after Exposure to IL-4 and IL-21

R. Lapointe, É. Gagnon, Gabriel Pagé, 2021, The Journal of Immunology.

Phenotypic characterization and functional analysis of human tumor immune infiltration after mechanical and enzymatic disaggregation.

M. Latour, J. Cailhier, C. Piccirillo, 2011, Journal of immunological methods.

Polyfunctionality of a DKK1 self-antigen-specific CD8+ T lymphocyte clone in lung cancer

A. Reuben, S. Turcotte, M. Forget, 2011, Cancer Immunology, Immunotherapy.

Fludarabine Downregulates Indoleamine 2,3-Dioxygenase in Tumors via a Proteasome-Mediated Degradation Mechanism

D. Leclerc, Jean-Baptiste Duvignaud, N. Grandvaux, 2014, PloS one.

mRNA PCR-based epitope chase method.

R. Lapointe, D. Gauchat, J. Doucet, 2013, Methods in molecular biology.

Phenotypic characterization of chronic inflammation in a rare case of endobronchial carcinoma

F. Saad, S. Turcotte, A. Duranceau, 2010, Cancer Immunology, Immunotherapy.

Innate immunity activation in the early brain injury period following subarachnoid hemorrhage

J. Cailhier, E. Magro, R. Cayrol, 2019, Journal of Neuroinflammation.

Androgen-Regulated Expression of Arginase 1, Arginase 2 and Interleukin-8 in Human Prostate Cancer

A. Mes-Masson, F. Saad, B. Péant, 2010, PloS one.

Fecal microbiota transplantation followed by anti–PD-1 treatment in patients with advanced melanoma.

K. Bélanger, W. Miller, M. Messaoudene, 2022, Journal of Clinical Oncology.

The MNK1/2–eIF4E Axis Supports Immune Suppression and Metastasis in Postpartum Breast Cancer

Charles T. Hindmarch, G. Floris, W. Miller, 2021, Cancer Research.

Immune-enrichment of non-small cell lung cancer baseline biopsies for multiplex profiling define prognostic immune checkpoint combinations for patient stratification

I. Jurisica, A. Mes-Masson, R. Lapointe, 2019, Journal of Immunotherapy for Cancer.

A randomized phase II study of ipilimumab (IPI) with carboplatin and paclitaxel (CP) in patients with unresectable stage III or IV metastatic melanoma (MM).

K. Bélanger, W. Miller, Shirin Kazemi, 2014 .

Prostate-derived Ets transcription factor overexpression is associated with nodal metastasis and hormone receptor positivity in invasive breast cancer.

S. Turcotte, M. Forget, R. Lapointe, 2007, Neoplasia.

Fecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial

N. Segata, F. Armanini, K. Bélanger, 2023, Nature Medicine.

The pleiotropic effects of the MNK1/2-eIF4E axis support immune suppression and metastasis in a model of postpartum breast cancer

Charles T. Hindmarch, G. Floris, W. Miller, 2020, bioRxiv.

Presence of prostate cancer metastasis correlates with lower lymph node reactivity.

L. Bégin, A. Mes-Masson, F. Saad, 2006, The Prostate.

Soluble CD40‐ligand (sCD40L, sCD154) plays an immunosuppressive role via regulatory T cell expansion in HIV infection

J. Routy, I. Kema, R. Lapointe, 2014, Clinical and experimental immunology.