D. Serreze

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Defective activation of T suppressor cell function in nonobese diabetic mice. Potential relation to cytokine deficiencies.

E. Leiter, D. Serreze, 1988, Journal of immunology.

Hematopoietic stem-cell defects underlying abnormal macrophage development and maturation in NOD/Lt mice: defective regulation of cytokine receptors and protein kinase C.

J. Gaedeke, E. Leiter, D. Serreze, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Genetic Disassociation of Autoimmunity and Resistance to Costimulation Blockade-Induced Transplantation Tolerance in Nonobese Diabetic Mice1

L. Wicker, D. Greiner, T. Pearson, 2003, The Journal of Immunology.

Beta cell expression of endogenous xenotropic retrovirus distinguishes diabetes-susceptible NOD/Lt from resistant NON/Lt mice.

K. Hamaguchi, H. Gaskins, E. Leiter, 1992, The Journal of clinical investigation.

This information is current as Myotonica Kinase Identified Widely Expressed Dystrophia Three Islet Antigens , Including the Newly T Cell Reactivity to + Unique Patterns of CD 8 Individual Nonobese Diabetic Mice Exhibit

Bingye Han, S. Lieberman, P. Santamaria, 2004 .

Th1 to Th2 Cytokine Shifts in Nonobese Diabetic Mice: Sometimes an Outcome, Rather Than the Cause, of Diabetes Resistance Elicited by Immunostimulation1

W. Suarez-Pinzon, A. Rabinovitch, D. Serreze, 2001, The Journal of Immunology.

CD11c+ Cells Are Gatekeepers for Lymphocyte Trafficking to Infiltrated Islets During Type 1 Diabetes

M. Seibold, C. Rios, K. Haskins, 2019, Front. Immunol..

NOR/Lt Mice: MHC-Matched Diabetes-Resistant Control Strain for NOD Mice

W. Frankel, E. Leiter, D. Serreze, 1992, Diabetes.

Use of recombinant congenic and congenic strains of NOD mice to identify a new insulin-dependent diabetes resistance gene

E. Leiter, M. Bridgett, D. Serreze, 1994, The Journal of experimental medicine.

Autoreactive diabetogenic T-cells in NOD mice can efficiently expand from a greatly reduced precursor pool.

Y. Yoshimura, S. Nathenson, D. Serreze, 2001, Diabetes.

Development and function of diabetogenic T-cells in B-cell-deficient nonobese diabetic mice.

J. Danska, D. Serreze, P. Chiu, 2001, Diabetes.

B lymphocytes are critical antigen-presenting cells for the initiation of T cell-mediated autoimmune diabetes in nonobese diabetic mice.

R. Tisch, E. Leiter, D. Serreze, 1998, Journal of immunology.

Nonobese Diabetic Mice T Cell-Mediated Autoimmune Diabetes in Antigen-Presenting Cells for the Initiation of B Lymphocytes Are Critical

R. Tisch, E. Leiter, D. Serreze, 1998 .

B lymphocytes are essential for the initiation of T cell-mediated autoimmune diabetes: analysis of a new "speed congenic" stock of NOD.Ig mu null mice

M. Zeleňáková, E. Leiter, L. Shultz, 1996, The Journal of experimental medicine.

Autoimmune manifestations in aged mice arise from early-life immune dysregulation

T. Mustelin, M. Atkinson, C. Wasserfall, 2016, Science Translational Medicine.

Targeting of a T Cell Agonist Peptide to Lysosomes by DNA Vaccination Induces Tolerance in the Nonobese Diabetic Mouse

F. Rodríguez, T. Stratmann, J. Driver, 2011, The Journal of Immunology.

Genetic and Small Molecule Disruption of the AID/RAD51 Axis Similarly Protects Nonobese Diabetic Mice from Type 1 Diabetes through Expansion of Regulatory B Lymphocytes

Nina M. Donghia, K. Mills, M. Atkinson, 2017, The Journal of Immunology.

Idd Loci Synergize to Prolong Islet Allograft Survival Induced by Costimulation Blockade in NOD Mice

L. Wicker, D. Greiner, T. Pearson, 2009, Diabetes.

Major Histocompatibility Complex Class I-Deficient NOD-B2mnull Mice are Diabetes and Insulitis Resistant

E. Leiter, D. Roopenian, D. Greiner, 1994, Diabetes.

DEC-205-mediated antigen targeting to steady-state dendritic cells induces deletion of diabetogenic CD8⁺ T cells independently of PD-1 and PD-L1.

G. Freeman, A. Sharpe, P. Santamaria, 2013, International immunology.

The preferential ability of B lymphocytes to act as diabetogenic APC in NOD mice depends on expression of self‐antigen‐specific immunoglobulin receptors

R. Tisch, D. Serreze, P. Silveira, 2002, European journal of immunology.

Islet allograft survival induced by costimulation blockade in NOD mice is controlled by allelic variants of Idd3.

L. Wicker, D. Greiner, T. Pearson, 2004, Diabetes.

Defects in the differentiation and function of antigen presenting cells in NOD/Lt mice.

H. Gaskins, E. Leiter, D. Serreze, 1993, Journal of immunology.

Islet-Specific CTL Cloned from a Type 1 Diabetes Patient Cause Beta-Cell Destruction after Engraftment into HLA-A2 Transgenic NOD/SCID/IL2RG Null Mice

J. Drijfhout, M. Kester, M. Griffioen, 2012, PloS one.

Diabetes Autoantigens of Potential Clinical Relevance Humanized NOD Mice Recognize HLA-A * 0201-Restricted T Cells from

C. Mathews, R. Bottino, M. Trucco, 2006 .

HLA-A*0201-Restricted T Cells from Humanized NOD Mice Recognize Autoantigens of Potential Clinical Relevance to Type 1 Diabetes1

C. Mathews, R. Bottino, M. Trucco, 2006, The Journal of Immunology.

Major histocompatibility complex class I-restricted T cells are required for all but the end stages of diabetes development in nonobese diabetic mice and use a prevalent T cell receptor alpha chain gene rearrangement.

D. Roopenian, S. Nathenson, D. Serreze, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Acceleration of type 1 diabetes by a coxsackievirus infection requires a preexisting critical mass of autoreactive T-cells in pancreatic islets.

M. Atkinson, C. Gauntt, D. Serreze, 2000, Diabetes.

MHC ANTIGEN INDUCTION BY INTERFERON y ON CULTURED MOUSE PANCREATIC a CELLS AND MACROPHAGES

E. Leiter, D. Serreze, A. Ting, 2003 .

MHC antigen induction by interferon gamma on cultured mouse pancreatic beta cells and macrophages. Genetic analysis of strain differences and discovery of an "occult" class I-like antigen in NOD/Lt mice

E. Leiter, D. Serreze, A. Ting, 1989, The Journal of experimental medicine.

The good turned ugly: immunopathogenic basis for diabetogenic CD8+ T cells in NOD mice

D. Serreze, T. DiLorenzo, 2005, Immunological reviews.

Adenovirus early region 3(E3) immunomodulatory genes decrease the incidence of autoimmune diabetes in NOD mice.

S. Efrat, M. Horwitz, D. Serreze, 2001, Diabetes.

Adenovirus early region 3 antiapoptotic 10.4K, 14.5K, and 14.7K genes decrease the incidence of autoimmune diabetes in NOD mice.

S. Efrat, M. Horwitz, D. Serreze, 2003, Diabetes.

A MusD Retrotransposon Insertion in the Mouse Slc6a5 Gene Causes Alterations in Neuromuscular Junction Maturation and Behavioral Phenotypes

R. Burgess, D. Serreze, H. Chapman, 2012, PloS one.

Genetic Separation of the Transplantation Tolerance and Autoimmune Phenotypes in NOD Mice

L. Wicker, D. Greiner, T. Pearson, 2003, Reviews in Endocrine and Metabolic Disorders.

Islet Cell Autoimmunity and Transplantation Tolerance: Two Distinct Mechanisms?

L. Wicker, D. Greiner, T. Pearson, 2003, Annals of the New York Academy of Sciences.

CD70 Inversely Regulates Tregs and iNKT Cells and Modulates Type 1 Diabetes in NOD Mice

M. Wiles, T. Brusko, D. Serreze, 2021 .

CD70 Inversely Regulates Regulatory T Cells and Invariant NKT Cells and Modulates Type 1 Diabetes in NOD Mice

M. Wiles, J. Driver, T. Brusko, 2020, The Journal of Immunology.

Cholera toxin subunit B peptide fusion proteins reveal impaired oral tolerance induction in diabetes‐prone but not in diabetes‐resistant mice

L. Teyton, T. Stratmann, D. Serreze, 2013, European journal of immunology.

Near Death Experience Cells Escaping a Non-MHC Gene-Controlled Enhanced Pathogenicity of Diabetogenic T

C. Choisy-Rossi, D. Serreze, H. Chapman, 2004 .

Initiation of autoimmune diabetes in NOD/Lt mice is MHC class I-dependent.

E. Leiter, L. Shultz, D. Serreze, 1997, Journal of immunology.

Unusual resistance of ALR/Lt mouse β cells to autoimmune destruction: Role for β cell-expressed resistance determinants

C. Mathews, E. Leiter, D. Serreze, 2001 .

Genes and cellular requirements for autoimmune diabetes susceptibility in nonobese diabetic mice.

E. Leiter, D. Serreze, 2001, Current directions in autoimmunity.

Targeted Disruption of CD38 Accelerates Autoimmune Diabetes in NOD/Lt Mice by Enhancing Autoimmunity in an ADP-Ribosyltransferase 2-Dependent Fashion1

J. Chen, Chul-Ho Lee, E. Leiter, 2006, The Journal of Immunology.

Enhancing Autoimmunity in an Autoimmune Diabetes in NOD/Lt Mice by Targeted Disruption of CD38 Accelerates

Chul-Ho Lee, E. Leiter, F. Koch-Nolte, 2006 .

ADP-Ribosyltransferase 2-Dependent Enhancing Autoimmunity in an Autoimmune Diabetes in NOD / Lt Mice by Targeted Disruption of CD 38 Accelerates

J. Chen, Chul-Ho Lee, E. Leiter, 2006 .

Autoimmune diabetes results from genetic defects manifest by antigen presenting cells

D. Serreze, 1993, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Antigen-Specific Mediated Suppression of β Cell Autoimmunity by Plasmid DNA Vaccination1

R. Tisch, J. Arthos, D. Serreze, 2001, The Journal of Immunology.

A Glutamic Acid Decarboxylase 65-Specific Th2 Cell Clone Immunoregulates Autoimmune Diabetes in Nonobese Diabetic Mice1

R. Tisch, R. Friedline, M. Atkinson, 2001, The Journal of Immunology.

Mice Autoimmune Diabetes in Nonobese Diabetic Th2 Cell Clone Immunoregulates A Glutamic Acid Decarboxylase 65-Specific

R. Tisch, R. Friedline, M. Atkinson, 2001 .

Disease Is Epitope Dependent Autoimmune Diabetes at Late Stages of 65-Specific Th 2 Cells and Suppression of Induction of Glutamic Acid Decarboxylase

R. Tisch, D. Serreze, Bo Wang, 1999 .

Induction of glutamic acid decarboxylase 65-specific Th2 cells and suppression of autoimmune diabetes at late stages of disease is epitope dependent.

R. Tisch, B. Wang, D. Serreze, 1999, Journal of immunology.

Invariant Natural Killer T-Cell Control of Type 1 Diabetes: A Dendritic Cell Genetic Decision of a Silver Bullet or Russian Roulette

J. Driver, D. Serreze, Felix Scheuplein, 2009, Diabetes.

Tolerance in the Nonobese Diabetic Mouse Lysosomes by DNA Vaccination Induces Targeting of a T Cell Agonist Peptide to

T. Stratmann, J. Driver, D. Serreze, 2011 .

NOD mice have a generalized defect in their response to transplantation tolerance induction.

B. Woda, R. Noelle, R. Noelle, 1999, Diabetes.

Intrathymic Islet Cell Transplantation Reduces β-Cell Autoimmunity and Prevents Diabetes in NOD/Lt Mice

E. Leiter, D. Serreze, I. Gerling, 1992, Diabetes.

Antigen presenting cells and the immunogenetics of autoimmune diabetes in NOD mice.

E. Leiter, D. Serreze, 1992, Regional immunology.

Genetic Control of Diabetogenesis in NOD/Lt Mice: Development and Analysis of Congenic Stocks

E. Leiter, D. Serreze, M. Procházka, 1989, Diabetes.

Cellular Expression Requirements for Inhibition of Type 1 Diabetes by a Dominantly Protective Major Histocompatibility Complex Haplotype

D. Serreze, P. Silveira, H. Chapman, 2007, Diabetes.

Partial versus Full Allogeneic Hemopoietic Chimerization Is a Preferential Means to Inhibit Type 1 Diabetes as the Latter Induces Generalized Immunosuppression1

D. Greiner, T. Pearson, D. Serreze, 2006, The Journal of Immunology.

Generalized Immunosuppression Inhibit Type 1 Diabetes as the Latter Induces Chimerization Is a Preferential Means to Partial versus Full Allogeneic Hemopoietic

D. Greiner, T. Pearson, D. Serreze, 2006 .

Of mice and men: use of animal models to identify possible interventions for the prevention of autoimmune type 1 diabetes in humans.

D. Serreze, Yi-Guang Chen, 2005, Trends in immunology.

Genetic and pathogenic basis of autoimmune diabetes in NOD mice.

E. Leiter, D. Serreze, 1994, Current opinion in immunology.

Idd9/11 Genetic Locus Regulates Diabetogenic Activity of CD4 T-Cells in Nonobese Diabetic (NOD) Mice

S. Tsaih, D. Serreze, Felix Scheuplein, 2008, Diabetes.

The Idd 9 / 11 genetic locus regulates diabetogenic activity of CD 4 T-cells in non-obese diabetic ( NOD ) mice

S. Tsaih, D. Serreze, Felix Scheuplein, 2008 .

In Vivo Cytotoxicity of Insulin-Specific CD8+ T-Cells in HLA-A*0201 Transgenic NOD Mice

Irene Jarchum, D. Serreze, M. Marron, 2007, Diabetes.

MHC Class II Molecules Play a Role in the Selection of Autoreactive Class I-Restricted CD8 T Cells That Are Essential Contributors to Type 1 Diabetes Development in Nonobese Diabetic Mice1

C. Choisy-Rossi, S. Lieberman, D. Serreze, 2004, The Journal of Immunology.

The role of B lymphocytes as key antigen-presenting cells in the development of T cell-mediated autoimmune type 1 diabetes.

D. Serreze, P. Silveira, 2002, Current directions in autoimmunity.

Diabetic Mice to Type 1 Diabetes Development in Nonobese CD 8 T Cells That Are Essential Contributors Selection of Autoreactive Class I-Restricted MHC Class II Molecules Play a Role in the DiLorenzo

C. Choisy-Rossi, S. Lieberman, D. Serreze, 2003 .

MHC Class II Molecules Play a Role in the Selection of Autoreactive Class I-Restricted CD8 T Cells That Are Essential Contributors to Type 1 Diabetes Development in Nonobese Diabetic Mice

C. Choisy-Rossi, S. Lieberman, D. Serreze, 2003 .

During the early prediabetic period in NOD mice, the pathogenic CD8(+) T-cell population comprises multiple antigenic specificities.

S. Honda, S. Nathenson, S. Lieberman, 2002, Clinical immunology.

Genes Including a Possible Diabetogenic Role for SusceptibilityNOD / Lt Mice : Evidence for Several Locus in Idd 13 Subcongenic Analysis

E. Leiter, M. Bridgett, D. Serreze, 1998 .

Subcongenic Analysis of theIdd13 Locus in NOD/Lt Mice: Evidence for Several Susceptibility Genes Including a Possible

E. Leiter, M. Bridgett, D. Serreze, 1998 .

Subcongenic analysis of the Idd13 locus in NOD/Lt mice: evidence for several susceptibility genes including a possible diabetogenic role for beta 2-microglobulin.

E. Leiter, M. Bridgett, D. Serreze, 1998, Journal of immunology.

Quantitative thresholds of MHC class II I-E expressed on hemopoietically derived antigen-presenting cells in transgenic NOD/Lt mice determine level of diabetes resistance and indicate mechanism of protection.

M. Atkinson, E. Leiter, N. Maclaren, 1996, Journal of immunology.

Loss of Intra-Islet CD20 Expression May Complicate Efficacy of B-Cell–Directed Type 1 Diabetes Therapies

M. Atkinson, M. Kehry, J. Driver, 2011, Diabetes.

Comparative therapeutic effects of orally administered 1,25‐dihydroxyvitamin D3 and 1alpha‐hydroxyvitamin D3 on type‐1 diabetes in non‐obese diabetic mice fed a normal‐calcaemic diet

C. Mathieu, J. Driver, O. Foreman, 2007, Clinical and Experimental Immunology.

-Chain Transgene b Receptor g Cytokine-Deficient by Expression of an IFN-Nonobese Diabetic Mice Made Th1 Paralytic Autoimmune Myositis Develops in

R. Bronson, P. Rothman, G. Cox, 2003 .

Paralytic Autoimmune Myositis Develops in Nonobese Diabetic Mice Made Th1 Cytokine-Deficient by Expression of an IFN-γ Receptor β-Chain Transgene1

R. Bronson, P. Rothman, G. Cox, 2003, The Journal of Immunology.

Emv30null NOD-scid Mice: An Improved Host for Adoptive Transfer of Autoimmune Diabetes and Growth of Human Lymphohematopoietic Cells

E. Leiter, D. Greiner, L. Shultz, 1995, Diabetes.

Rapid identification of MHC class I-restricted antigens relevant to autoimmune diabetes using retrogenic T cells.

D. Vignali, D. Serreze, T. DiLorenzo, 2008, Journal of immunological methods.

T Cell Clonotype AI4 + CD8the Induction of Diabetes by the Promiscuous for d and H-2K b Requirement for Both H-2D

S. Lieberman, P. Santamaria, D. Serreze, 2004 .

Are Diabetes and Insulitis Resistant

E. Leiter, D. Roopenian, D. Greiner, 1994 .

Molecular Mimicry Between Insulin and Retroviral Antigen p73: Development of Cross-Reactive Autoantibodies in Sera of NOD and C57BL/KsJ db/db Mice

E. Leiter, D. Serreze, K. Ishizaka, 1988, Diabetes.

Autoimmune diabetes and resistance to xenograft transplantation tolerance in NOD mice.

L. Wicker, D. Greiner, L. Shultz, 2005, Diabetes.

The Presence and Preferential Activation of Regulatory T Cells Diminish Adoptive Transfer of Autoimmune Diabetes by Polyclonal Nonobese Diabetic (NOD) T Cell Effectors into NSG versus NOD-scid Mice

E. Leiter, D. Greiner, L. Shultz, 2015, The Journal of Immunology.

B lymphocytes are essential for the initiation of T cell-mediated autoimmune diabetes: analysis of a new "speed congenic" stock of NOD.Ig mu null mice

E. Leiter, L. Shultz, D. Serreze, 1996, The Journal of experimental medicine.

Unexpected functional consequences of xenogeneic transgene expression in β‐cells of NOD mice

A. Chervonsky, C. Choisy-Rossi, M. Hara, 2007, Diabetes, obesity & metabolism.

B-Lymphocyte Phenotype Determines T-Lymphocyte Subset Differentiation in Autoimmune Diabetes

T. Stratmann, J. Carrascal, M. Vives-Pi, 2019, Front. Immunol..

Transient BAFF Blockade Inhibits Type 1 Diabetes Development in Nonobese Diabetic Mice by Enriching Immunoregulatory B Lymphocytes Sensitive to Deletion by Anti-CD20 Cotherapy

M. Atkinson, C. Wasserfall, D. Serreze, 2017, The Journal of Immunology.

In Vivo Detection of Peripherin-Specific Autoreactive B Cells during Type 1 Diabetes Pathogenesis

T. Stratmann, J. Carrascal, J. Verdaguer, 2014, The Journal of Immunology.

Subcongenic Analyses Reveal Complex Interactions between Distal Chromosome 4 Genes Controlling Diabetogenic B Cells and CD4 T Cells in Nonobese Diabetic Mice

S. Tsaih, D. Serreze, T. Stearns, 2012, The Journal of Immunology.

CD4 T Cells in Nonobese Diabetic Mice Genes Controlling Diabetogenic B Cells and Interactions between Distal Chromosome 4 Subcongenic Analyses Reveal Complex

S. Tsaih, D. Serreze, T. Stearns, 2012 .

Invasion of the killer B's in type 1 diabetes.

S. Grey, D. Serreze, P. Silveira, 2007, Frontiers in bioscience : a journal and virtual library.

Genes within the Idd5 and Idd9/11 Diabetes Susceptibility Loci Affect the Pathogenic Activity of B Cells in Nonobese Diabetic Mice1

L. Wicker, D. Serreze, K. Hunter, 2006, The Journal of Immunology.

Diabetes Acceleration or Prevention by a Coxsackievirus B4 Infection: Critical Requirements for both Interleukin-4 and Gamma Interferon

M. Atkinson, B. O'Donnell, C. Wasserfall, 2005, Journal of Virology.

Nonobese Diabetic Mice Development of Diabetogenic APCs in B Cell Selection Defects Underlie the

D. Nemazee, D. Serreze, P. Silveira, 2004 .

B Cell Selection Defects Underlie the Development of Diabetogenic APCs in Nonobese Diabetic Mice1

D. Nemazee, D. Serreze, P. Silveira, 2004, The Journal of Immunology.

Diabetic Mice Blockade-Induced Transplantation Tolerance Resistance to Costimulation Genetic Disassociation of Autoimmunity and

L. Wicker, D. Greiner, T. Pearson, 2003 .

Involvement of Multiple APC Subtypes Expression : Additive , But Unequal , Restoration of H 2E MHC Class II Nonobese Diabetic Mice by Transgenic Inhibition of Autoimmune Diabetes in

E. Leiter, D. Serreze, P. Silveira, 2001 .

Inhibition of Autoimmune Diabetes in Nonobese Diabetic Mice by Transgenic Restoration of H2-E MHC Class II Expression: Additive, But Unequal, Involvement of Multiple APC Subtypes1

E. Leiter, D. Serreze, P. Silveira, 2001, The Journal of Immunology.

Control of Autoimmune Diabetes

M. Atkinson, D. Serreze, T. Ellis, 2000, Science.

Interferon-Receptor Signaling Is Dispensable in the Development of Autoimmune Type 1 Diabetes in NOD Mice

P. Rothman, D. Serreze, H. Chapman, 2000 .

Pancreas-infiltrating Th1 cells and diabetes develop in IL-12-deficient nonobese diabetic mice.

L. Adorini, G. Penna, D. Serreze, 1999, Journal of immunology.

PathogenesisAutoreactive B Cells during Type 1 Diabetes In Vivo Detection of Peripherin-Specific

D. Serreze, Cristina Izquierdo, H. Chapman, 2022 .

Crosses of NOD Mice With the Related NON Strain: A Polygenic Model for IDDM

N. Schork, J. Todd, L. Wicker, 1995, Diabetes.

NOD congenic mice genetically protected from autoimmune diabetes remain resistant to transplantation tolerance induction.

L. Wicker, D. Greiner, T. Pearson, 2003, Diabetes.

MHC characterization of ALR and ALS mice: respective similarities to the NOD and NON strains

C. Mathews, E. Leiter, D. Serreze, 1999, Immunogenetics.

Selective delivery of β cell antigen to dendritic cells in vivo leads to deletion and tolerance of autoreactive CD8+ T cells in NOD mice

R. Steinman, Irene Jarchum, T. Hanafusa, 2008, Proceedings of the National Academy of Sciences.

Human Clonal CD8 Autoreactivity to an IGRP Islet Epitope Shared between Mice and Men

J. Drijfhout, M. Kester, B. Roep, 2007, Annals of the New York Academy of Sciences.

Testing the Role of P2X7 Receptors in the Development of Type 1 Diabetes in Nonobese Diabetic Mice

E. Leiter, J. Driver, D. Serreze, 2011, The Journal of Immunology.

Reevaluation of the major histocompatibility complex genes of the NOD-progenitor CTS/Shi strain.

C. Mathews, E. Leiter, D. Serreze, 2000, Diabetes.

Unusual resistance of ALR/Lt mouse beta cells to autoimmune destruction: role for beta cell-expressed resistance determinants.

C. Mathews, E. Leiter, D. Serreze, 2001, Proceedings of the National Academy of Sciences of the United States of America.

The genetics and epidemiology of diabetes in NOD mice.

E. Leiter, D. Serreze, M. Procházka, 1990, Immunology today.

Diabetic mouse incorrectly typed

D. Coleman, E. Leiter, R. Jackson, 1988, Science.

Nfkbid Overexpression in Nonobese Diabetic Mice Elicits Complete Type 1 Diabetes Resistance in Part Associated with Enhanced Thymic Deletion of Pathogenic CD8 T Cells and Increased Numbers and Activity of Regulatory T Cells

G. Stafford, D. Serreze, I. Schmitz, 2022, The Journal of Immunology.

This information is current as Mice scid Effectors into NSG versus NOD-Polyclonal Nonobese Diabetic ( NOD ) T Cell Transfer of Autoimmune Diabetes by Regulatory T Cells Diminish Adoptive The Presence and Preferential Activation of

E. Leiter, D. Greiner, L. Shultz, 2015 .

“Humanized” HLA Transgenic NOD Mice to Identify Pancreatic β Cell Autoantigens of Potential Clinical Relevance to Type 1 Diabetes

D. Serreze, M. Marron, T. DiLorenzo, 2007, Annals of the New York Academy of Sciences.

Rapid Destruction of Encapsulated Islet Xenografts by NOD Mice is CD4-Dependent and Facilitated by B-cells: Innate Immunity and Autoimmunity Do Not Play Significant Roles

Hua Yang, Rebecca Macintosh, D. Serreze, 2005, Transplantation.

Activated NKT Cells Inhibit Autoimmune Diabetes through Tolerogenic Recruitment of Dendritic Cells to Pancreatic Lymph Nodes1

G. Besra, C. Choisy-Rossi, D. Roopenian, 2005, The Journal of Immunology.

Crosses of NOD mice with the related NON strain. A polygenic model for IDDM.

J. Copeman, S. M. Palmer, D. Serreze, 1995, Diabetes.

T Cells from NOD-PerIg Mice Target Both Pancreatic and Neuronal Tissue

Jacqueline K. White, R. Burgess, J. Wotton, 2020, The Journal of Immunology.

Therapeutic administration of Tregitope-Human Albumin Fusion with Insulin Peptides to promote Antigen-Specific Adaptive Tolerance Induction

J. White, A. D. De Groot, D. Serreze, 2019, Scientific Reports.

Subcongenic analysis of genetic basis for impaired development of invariant NKT cells in NOD mice

J. Driver, D. Serreze, P. Silveira, 2007, Immunogenetics.

This information is current as Diabetic Mice Development of Type 1 Diabetes in Nonobese Receptors in the 7 Testing the Role of P 2 X

E. Leiter, J. Driver, D. Serreze, 2011 .

CD38 Is Required for the Peripheral Survival of Immunotolerogenic CD4+ Invariant NK T Cells in Nonobese Diabetic Mice1

G. Besra, E. Leiter, S. Porcelli, 2006, The Journal of Immunology.

Cells in Nonobese Diabetic Mice Invariant NK T + of Immunotolerogenic CD4 CD38 Is Required for the Peripheral Survival

G. Besra, E. Leiter, S. Porcelli, 2006 .

Nonobese Diabetic Mice T Cells in + of Autoreactive Diabetogenic CD8 Contributes to the Impaired Thymic Deletion Region Gene(s) Interactively Idd7 Levels, an Through Regulation of TCR Expression

C. Choisy-Rossi, D. Roopenian, D. Serreze, 2008 .

MHC Class I-Mediated Antigen Presentation and Induction of CD8+ Cytotoxic T-Cell Responses in Autoimmune Diabetes-Prone NOD Mice

E. Leiter, D. Roopenian, K. Croitoru, 1996, Diabetes.

Peripherin-reactive antibodies in mouse, rabbit, and human blood.

A. Strom, D. Serreze, M. Mojibian, 2010, Journal of proteome research.

Novel leptin receptor mutation in NOD/LtJ mice suppresses type 1 diabetes progression: II. Immunologic analysis.

M. Atkinson, J. Chen, Chul-Ho Lee, 2006, Diabetes.

Development of diabetogenic T cells from NOD/Lt marrow is blocked when an allo-H-2 haplotype is expressed on cells of hemopoietic origin, but not on thymic epithelium.

E. Leiter, D. Serreze, 1991, Journal of immunology.

Enhanced responsiveness to T‐cell help causes loss of B‐lymphocyte tolerance to a β‐cell neo‐self‐antigen in type 1 diabetes prone NOD mice

A. Basten, J. Counotte, N. Hallahan, 2010, European journal of immunology.

Autoimmune diabetes in the nonobese diabetic mouse: suppression of immune defects by bone marrow transplantation and implications for therapy.

E. Leiter, D. Serreze, 1991, Clinical immunology and immunopathology.

Self-reactive CD8 T Cells Pancreas-Specific Damage Mediated by B7x in the Periphery Abrogates

P. Loke, J. Allison, Jun Sik Lee, 2012 .

Antibiotic-associated Manipulation of the Gut Microbiota and Phenotypic Restoration in NOD Mice.

D. Serreze, B. Lyons, Jeremy J. Racine, 2017, Comparative medicine.

iNKT-cell control of Type-1 Diabetes: a Dendritic Cell Genetic Decision of a Silver Bullet or Russian Roulette

J. Driver, D. Serreze, Felix Scheuplein, 2009 .

NOD Marrow Stem Cells Adoptively Transfer Diabetes to Resistant (NOD × NON)F1 Mice

E. Leiter, L. Shultz, D. Serreze, 1988, Diabetes.

Rapid Publication NOD Marrow Stem Cells Adoptively Transfer Diabetes to Resistant (NOD x NON)F1 Mice

E. Leiter, L. Shultz, D. Serreze, 1988 .

Insulin (auto)antibodies from human IDDM cross-react with retroviral antigen p73.

J. Palmer, D. Mcculloch, J. L. Neifing, 1993, Journal of autoimmunity.

By Altering Ocular Immune Privilege, Bone Marrow–derived Cells Pathogenically Contribute to DBA/2J Pigmentary Glaucoma

Michael G. Anderson, Richard S. Smith, B. Ksander, 2003, The Journal of experimental medicine.

Single domain antibodies: promising experimental and therapeutic tools in infection and immunity

M. Seman, Jan Reyelt, A. Cauerhff, 2009, Medical Microbiology and Immunology.

A Hypermorphic Nfkbid Allele Contributes to Impaired Thymic Deletion of Autoreactive Diabetogenic CD8+ T Cells in NOD Mice

V. Sarsani, A. Geurts, D. Serreze, 2018, The Journal of Immunology.

Effect of Processing Method and Storage Time on the Nutrient Composition of Fiddlehead Greens

R. Bushway, D. Serreze, A. Bushway, 1985 .

TRPV1+ Sensory Neurons Control β Cell Stress and Islet Inflammation in Autoimmune Diabetes

Michael W. Salter, M. Salter, H. Dosch, 2006, Cell.

B7x in the Periphery Abrogates Pancreas-Specific Damage Mediated by Self-reactive CD8 T Cells

P. Loke, J. Allison, Jun Sik Lee, 2012, The Journal of Immunology.

Mouse models for the study of autoimmune type 1 diabetes: a NOD to similarities and differences to human disease

J. Driver, D. Serreze, Yi-Guang Chen, 2010, Seminars in Immunopathology.

Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice.

G. Weinmaster, D. Serreze, T. Gridley, 1998, Genes & development.

A hypermorphic Nfkbid allele represents an Idd7 locus gene contributing to impaired thymic deletion of autoreactive diabetogenic CD8+ T-cells in NOD mice

V. Sarsani, A. Geurts, D. Serreze, 2018, bioRxiv.

Mapping to Chromosomes 1 and 12 of mouse homologs of human protein tyrosine phosphatase, receptor-type, related genes encoding pancreatic beta cell autoantigens

M. Lan, E. Leiter, A. Notkins, 1997, Mammalian Genome.

Through Regulation of TCR Expression Levels, an Idd7 Region Gene(s) Interactively Contributes to the Impaired Thymic Deletion of Autoreactive Diabetogenic CD8+ T Cells in Nonobese Diabetic Mice1

B. King, C. Choisy-Rossi, D. Roopenian, 2008, The Journal of Immunology.

Conditioning the genome identifies additional diabetes resistance loci in Type I diabetes resistant NOR/Lt mice

E. Leiter, D. Serreze, P. Silveira, 2005, Genes and Immunity.

Three recessive loci required for insulin-dependent diabetes in nonobese diabetic mice.

D. Coleman, E. Leiter, D. Serreze, 1987, Science.

Bridging Mice to Men: Using HLA Transgenic Mice to Enhance the Future Prediction and Prevention of Autoimmune Type 1 Diabetes in Humans.

D. Serreze, T. DiLorenzo, J. Kulik, 2016, Methods in molecular biology.

Functional evidence for the mediation of diabetogenic T cell responses by HLA-A2.1 MHC class I molecules through transgenic expression in NOD mice

D. Serreze, M. Marron, H. Chapman, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Transgenic rescue implicates β2-microglobulin as a diabetes susceptibility gene in nonobese diabetic (NOD) mice

D. Serreze, M. Marron, A. Müllbacher, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Identification of a CD8 T Cell That Can Independently Mediate Autoimmune Diabetes Development in the Complete Absence of CD4 T Cell Helper Functions1

D. Roopenian, S. Nathenson, D. Serreze, 2000, The Journal of Immunology.

Transplantation analysis of B cell destruction in (NOD x CBA)F1 mouse bone marrow chimeras

E. Leiter, L. Shultz, D. Serreze, 1990, Diabetologia.

Requirement for Both H-2Db and H-2Kd for the Induction of Diabetes by the Promiscuous CD8+ T Cell Clonotype AI41

Bingye Han, S. Lieberman, P. Santamaria, 2004, The Journal of Immunology.

Unmasking Genes in a Type 1 Diabetes–Resistant Mouse Strain That Enhances Pathogenic CD8 T-Cell Responses

J. Driver, D. Serreze, Yi-Guang Chen, 2011, Diabetes.

Immunostimulation circumvents diabetes in NOD/Lt mice.

K. Hamaguchi, E. Leiter, D. Serreze, 1989, Journal of autoimmunity.

Interleukin-27 is essential for type 1 diabetes development and Sjögren syndrome-like inflammation

M. Atkinson, S. Lieberman, A. Geurts, 2021, Cell reports.

Compensatory Mechanisms Allow Undersized Anchor-Deficient Class I MHC Ligands To Mediate Pathogenic Autoreactive T Cell Responses

S. Almo, T. Kay, D. Serreze, 2014, The Journal of Immunology.

Identification of the β cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes

J. Shabanowitz, D. Hunt, Bingye Han, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Prevention of “Humanized” Diabetogenic CD8 T-Cell Responses in HLA-Transgenic NOD Mice by a Multipeptide Coupled-Cell Approach

T. Kay, D. Greiner, D. Serreze, 2011, Diabetes.

Improved Murine MHC-Deficient HLA Transgenic NOD Mouse Models for Type 1 Diabetes Therapy Development

C. Lutz, D. Roopenian, D. Serreze, 2018, Diabetes.

Genetic analysis of resistance to Type-1 Diabetes in ALR/Lt mice, a NOD-related strain with defenses against autoimmune-mediated diabetogenic stress

G. Churchill, C. Mathews, Renhua Li, 2003, Immunogenetics.

Genetic Analysis of Substrain Divergence in Non-Obese Diabetic (NOD) Mice

G. Churchill, Hyuna Yang, E. Leiter, 2015, G3: Genes, Genomes, Genetics.

Genetic Analysis of Substrain Divergence in NOD Mice

G. Churchill, Hyuna Yang, E. Leiter, 2014, bioRxiv.

Microbiota-dependent proteolysis of gluten subverts diet-mediated protection against type 1 diabetes.

Aly A. Khan, D. Antonopoulos, A. Chervonsky, 2022, Cell host & microbe.

Hematological and physiological effects of viral erythrocytic necrosis (VEN) in Atlantic cod and herring.

D. Serreze, P. Reno, B. Nicholson, 1985 .

Non-specific cytotoxic activity of teleost leukocytes.

D. Serreze, C. Moody, P. Reno, 1985, Developmental and comparative immunology.

Interleukin 4 reverses T cell proliferative unresponsiveness and prevents the onset of diabetes in nonobese diabetic mice

A Jaramillo, J. Danska, A. Jaramillo, 1993, The Journal of experimental medicine.

Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity

J. Rogers, J. Todd, S. Gregory, 2007, Nature Genetics.

Mouse Invariant Monoclonal Antibody NKT14: A Novel Tool to Manipulate iNKT Cell Function In Vivo

R. Mashal, R. Schaub, D. Serreze, 2015, PloS one.

The CD137 Ligand Is Important for Type 1 Diabetes Development but Dispensable for the Homeostasis of Disease-Suppressive CD137+ FOXP3+ Regulatory CD4 T Cells

A. Geurts, W. Ridgway, D. Serreze, 2020, The Journal of Immunology.

Human CD8+ T-cells Require Glycolysis to Elicit Effector Function

C. Mathews, T. Angelini, Brittney N. Newby, 2020, bioRxiv.

Interleukin-15 Receptor α Chain Knockout NOD-SCID mice have reduced numbers of NK cells, develop thymic lymphomas and fail to engraft human hematopoietic cells

A. Vecchione, M. Wiles, M. Sykes, 2021, bioRxiv.

Enhanced Pathogenicity of Diabetogenic T Cells Escaping a Non-MHC Gene-Controlled Near Death Experience1

C. Choisy-Rossi, D. Serreze, H. Chapman, 2004, The Journal of Immunology.

Near Death Experience Cells Escaping a Non-MHC Gene-Controlled Enhanced Pathogenicity of Diabetogenic

C. Choisy-Rossi, D. Serreze, H. Chapman, 2004 .

Interferon-γ Limits Diabetogenic CD8+ T-Cell Effector Responses in Type 1 Diabetes

Todd M. Brusko, C. Mathews, J. Driver, 2016, Diabetes.

Individual Nonobese Diabetic Mice Exhibit Unique Patterns of CD8+ T Cell Reactivity to Three Islet Antigens, Including the Newly Identified Widely Expressed Dystrophia Myotonica Kinase1

Bingye Han, S. Lieberman, P. Santamaria, 2004, The Journal of Immunology.

B-Lymphocytes Expressing an Ig Specificity Recognizing the Pancreatic β-Cell Autoantigen Peripherin Are Potent Contributors to Type 1 Diabetes Development in NOD Mice

T. Stratmann, J. Carrascal, J. Verdaguer, 2016, Diabetes.

CTLA-4–Ig Activates Forkhead Transcription Factors and Protects Dendritic Cells from Oxidative Stress in Nonobese Diabetic Mice

U. Grohmann, M. L. Belladonna, C. Orabona, 2004, The Journal of experimental medicine.

Interferon-gamma receptor signaling is dispensable in the development of autoimmune type 1 diabetes in NOD mice.

P. Rothman, D. Serreze, H D Chapman, 2000, Diabetes.

Combined congenic mapping and nuclease-based gene targeting for studying allele-specific effects of Tnfrsf9 within the Idd9.3 autoimmune diabetes locus

D. Serreze, Yi-Guang Chen, Matthew H. Forsberg, 2019, Scientific Reports.

Interleukin-27 Is Essential for Type 1 Diabetes Development and Sjögren Syndrome-like Inflammation

M. Atkinson, S. Lieberman, A. Geurts, 2019, Cell reports.

Decreased pancreatic acinar cell number in type 1 diabetes

Diane C. Saunders, D. Harlan, C. Dai, 2020, Diabetologia.

Sudden acquired retinal degeneration syndrome (SARDS) - a review and proposed strategies toward a better understanding of pathogenesis, early diagnosis, and therapy.

J. Heckenlively, P. MohanKumar, S. Petersen-Jones, 2016, Veterinary ophthalmology.

Title Sudden acquired retinal degeneration syndrome ( SARDS )-a review and proposed strategies toward a better understanding of pathogenesis , early diagnosis , and therapy

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Response to Comments on “Aberrant type 1 immunity drives susceptibility to mucosal fungal infections”

Mark S. Anderson, S. Pittaluga, Y. Belkaid, 2021, Science.

Aberrant type 1 immunity drives susceptibility to mucosal fungal infections

Mark S. Anderson, S. Pittaluga, Y. Belkaid, 2021, Science.

HLA-B*39:06 Efficiently Mediates Type 1 Diabetes in a Mouse Model Incorporating Reduced Thymic Insulin Expression

D. Serreze, T. DiLorenzo, Jeremy J. Racine, 2018, The Journal of Immunology.

Tracking autoimmune T cells in diabetes.

E. Leiter, D. Serreze, 2003, The Journal of clinical investigation.

Genetic control of murine invariant natural killer T-cell development dynamically differs dependent on the examined tissue type

S. Tsaih, D. Serreze, Y-G Chen, 2011, Genes and Immunity.

International Workshop on Lessons From Animal Models for Human Type 1 Diabetes: identification of insulin but not glutamic acid decarboxylase or IA-2 as specific autoantigens of humoral autoimmunity in nonobese diabetic mice.

E. Bonifacio, M. Atkinson, G. Eisenbarth, 2001, Diabetes.

Autoimmunity's next top models

L. Fugger, H. Wekerle, G. Schett, 2012, Nature Medicine.

Faculty Opinions recommendation of Amplification of autoimmune response through induction of dendritic cell maturation in inflamed tissues.

D. Serreze, 2009 .

CD226 Deletion Reduces Type 1 Diabetes in the NOD Mouse by Impairing Thymocyte Development and Peripheral T Cell Activation

M. Atkinson, M. Campbell-Thompson, S. Lieberman, 2020, Frontiers in Immunology.

Calcium insufficiency accelerates type 1 diabetes in vitamin D receptor-deficient nonobese diabetic (NOD) mice.

C. Mathieu, C. Gysemans, J. Driver, 2011, Endocrinology.

HLA-B*39:06 Efficiently Mediates Type 1 Diabetes in a Mouse Model Incorporating Reduced Thymic Insulin Expression1

D. Serreze, T. DiLorenzo, Jeremy J. Racine, 2018, bioRxiv.

International Workshop on Lessons from Animal Models for Human Type 1 Diabetes

E. Bonifacio, M. Atkinson, G. Eisenbarth, 2002, Annals of the New York Academy of Sciences.

Toll-Like Receptor 7 Is Required for Lacrimal Gland Autoimmunity and Type 1 Diabetes Development in Male Nonobese Diabetic Mice

S. Lieberman, A. Geurts, D. Serreze, 2020, International journal of molecular sciences.

A recombinant heavy chain antibody approach blocks ART2 mediated deletion of an iNKT cell population that upon activation inhibits autoimmune diabetes.

F. Koch-Nolte, J. Driver, D. Serreze, 2010, Journal of autoimmunity.

Congenic mapping identifies a novel Idd9 subregion regulating type 1 diabetes in NOD mice

D. Serreze, E. Mackinney, Yi-Guang Chen, 2017, Immunogenetics.

Editorial: Genetic basis of tolerance induction defects underlying the development of autoimmune pathologies

L. Morel, D. Serreze, Jeremy J. Racine, 2022, Frontiers in Immunology.

Reevaluation of the Major Histocompatibility Complex Genes of the NOD-Progenitor C T S / S h i S t r a i n

C. Mathews, E. Leiter, D. Serreze, 1999 .

Transporters from H-2b, H-2d, H-2s, H-2k, and H-2g7 (NOD/Lt) haplotype translocate similar sets of peptides.

T. Schumacher, H. Ploegh, D. Roopenian, 1994, Proceedings of the National Academy of Sciences of the United States of America.

A locus on mouse Chromosome 13 inversely regulates CD1d expression and the development of invariant natural killer T-cells

S. Tsaih, D. Serreze, Yi-Guang Chen, 2014, Genes and Immunity.

Testing the Role of P2X7 Receptors in the Development of Type 1 Diabetes in Nonobese Diabetic Mice

E. Leiter, J. Driver, D. Serreze, 2011, The Journal of Immunology.

Deletion of Vβ3+CD4+ T cells by endogenous mouse mammary tumor virus 3 prevents type 1 diabetes induction by autoreactive CD8+ T cells.

D. Serreze, Yi-Guang Chen, Clayton E. Mathews, 2023, Proceedings of the National Academy of Sciences of the United States of America.

Murine MHC-Deficient Nonobese Diabetic Mice Carrying Human HLA-DQ8 Develop Severe Myocarditis and Myositis in Response to Anti-PD-1 Immune Checkpoint Inhibitor Cancer Therapy.

S. Sattler, D. Serreze, Jeremy J. Racine, 2024, Journal of immunology.

Mapping the genetic landscape establishing a tumor immune microenvironment favorable for anti-PD-1 response in mice and humans

L. Reinholdt, F. Menghi, Elise T. Courtois, 2024, bioRxiv.

Faculty Opinions recommendation of Autoreactive T cells revealed in the normal repertoire: escape from negative selection and peripheral tolerance.

D. Serreze, 2002 .

CTLA-4–Ig Activates Forkhead Transcription Factors and Protects Dendritic Cells from Oxidative Stress in Nonobese Diabetic Mice

U. Grohmann, M. L. Belladonna, C. Orabona, 2004, The Journal of experimental medicine.

Major Histocompatibility Complex-Linked Diabetes Susceptibility in NOD/Lt Mice: Subcongenic Analysis Localizes a Component of Idd16 at the H2-D End of the Diabetogenic H2g7 Complex.

C. Mathews, E. Leiter, D. Serreze, 2005 .