Sushil Kumar

发表

Combined Antitumor Therapy with Metronomic Topotecan and Hypoxia-Activated Prodrug, Evofosfamide, in Neuroblastoma and Rhabdomyosarcoma Preclinical Models

S. Baruchel, P. Thorner, Libo Zhang, 2015, Clinical Cancer Research.

Combination of carbonic anhydrase inhibitor, acetazolamide, and sulforaphane, reduces the viability and growth of bronchial carcinoid cell lines

H. Yeger, K. Adeli, M. Yazdanpanah, 2013, BMC Cancer.

Acetazolamide potentiates the anti-tumor potential of HDACi, MS-275, in neuroblastoma

S. Baruchel, H. Yeger, Sushil Kumar, 2017, BMC Cancer.

Human bronchial carcinoid tumor initiating cells are targeted by the combination of acetazolamide and sulforaphane

H. Yeger, L. Muscarella, H. Cheng, 2019, BMC Cancer.

Inhibition of MICA and MICB Shedding Elicits NK-Cell–Mediated Immunity against Tumors Resistant to Cytotoxic T Cells

Charles H. Yoon, K. Wucherpfennig, Adrienne M. Luoma, 2020, Cancer Immunology Research.

Intratumoral macrophages contribute to epithelial-mesenchymal transition in solid tumors

R. Schwendener, V. Tischler, A. Soltermann, 2012, BMC Cancer.

Silibinin strongly inhibits the growth kinetics of colon cancer stem cell-enriched spheroids by modulating interleukin 4/6-mediated survival signals

R. Agarwal, C. Agarwal, Sushil Kumar, 2014, Oncotarget.

Epithelial IL-15 Is a Critical Regulator of γδ Intraepithelial Lymphocyte Motility within the Intestinal Mucosa

J. Turner, B. Jabri, Sushil Kumar, 2018, The Journal of Immunology.

Target identification of grape seed extract in colorectal cancer using drug affinity responsive target stability (DARTS) technique: role of endoplasmic reticulum stress response proteins.

R. Agarwal, C. Agarwal, Manisha N. Patel, 2014, Current cancer drug targets.

Silibinin and colorectal cancer chemoprevention: a comprehensive review on mechanisms and efficacy

R. Agarwal, Sushil Kumar, K. Raina, 2015, Journal of biomedical research.

Combination therapy in combating cancer

Herman Yeger, H. Yeger, Sushil Kumar, 2017, Oncotarget.

Next-generation multimodality of nutrigenomic cancer therapy: sulforaphane in combination with acetazolamide actively target bronchial carcinoid cancer in disabling the PI3K/Akt/mTOR survival pathway and inducing apoptosis

H. Yeger, L. Muscarella, Bessi Qorri, 2021, Oncotarget.

Estrogen Receptor β-Mediated Inhibition of Actin-Based Cell Migration Suppresses Metastasis of Inflammatory Breast Cancer

Qi Long, R. Chakrabarti, S. Krishnamurthy, 2021, Cancer Research.

Preclinical models for pediatric solid tumor drug discovery: current trends, challenges and the scopes for improvement

S. Baruchel, H. Yeger, Sushil Kumar, 2012, Expert opinion on drug discovery.

Hypoxia-Targeting Drug Evofosfamide (TH-302) Enhances Sunitinib Activity in Neuroblastoma Xenograft Models1

S. Baruchel, H. Yeger, F. Meng, 2018, Translational oncology.

Axl and Mertk Receptors Cooperate to Promote Breast Cancer Progression by Combined Oncogenic Signaling and Evasion of Host Antitumor Immunity

R. Birge, S. Kotenko, Yun-juan Chang, 2020, Cancer Research.

Contribution of Defective PS Recognition and Efferocytosis to Chronic Inflammation and Autoimmunity

R. Birge, Yi Wu, Sushil Kumar, 2014, Front. Immunol..

Abstract 3133: The anti-tumor effects of acetazolamide and sulforaphane on bronchial carcinoids: Preclinical modeling and mechanism

H. Yeger, K. Adeli, H. Cheng, 2014 .

Recent advancements in role of TAM receptors on efferocytosis, viral infection, autoimmunity, and tissue repair.

Sushil Kumar, Annika Ranta, 2020, International review of cell and molecular biology.

Phosphatidylserine Sensing by TAM Receptors Regulates AKT-Dependent Chemoresistance and PD-L1 Expression

R. Birge, S. Kotenko, A. Krantz, 2017, Molecular Cancer Research.

Requirement of Gamma-Carboxyglutamic Acid Modification and Phosphatidylserine Binding for the Activation of Tyro3, Axl, and Mertk Receptors by Growth Arrest-Specific 6

R. Birge, V. Kholodovych, S. Kotenko, 2017, Front. Immunol..

Acetazolamide potentiates the anti-tumor potential of HDACi, MS-275, in neuroblastoma

S. Baruchel, H. Yeger, Sushil Kumar, 2017, BMC Cancer.

CARM1 Inhibition Enables Immunotherapy of Resistant Tumors by Dual Action on Tumor cells and T cells.

John G Doench, S. Elledge, X. Liu, 2021, Cancer discovery.

The Next-Generation of Combination Cancer Immunotherapy: Epigenetic Immunomodulators Transmogrify Immune Training to Enhance Immunotherapy

N. Ashayeri, H. Yeger, Bessi Qorri, 2021, Cancers.

The role of Sulforaphane in cancer chemoprevention and health benefits: a mini-review

H. Yeger, Sushil Kumar, Tina S. Homayouni, 2018, Journal of Cell Communication and Signaling.

Rice varietal differences in bioactive bran components for inhibition of colorectal cancer cell growth.

R. Agarwal, E. Ryan, A. McClung, 2013, Food chemistry.

Integrin αvβ6-TGFβ-SOX4 Pathway Drives Immune Evasion in Triple-Negative Breast Cancer.

A. Giobbie-Hurder, X. Liu, D. Dillon, 2020, Cancer cell.

Crk at the Quarter Century Mark: Perspectives in Signaling and Cancer

R. Birge, J. Fajardo, Sushil Kumar, 2014, Journal of cellular biochemistry.

Reciprocal regulation of Abl kinase by Crk Y251 and Abi1 controls invasive phenotypes in glioblastoma

P. Hornbeck, R. Birge, S. Hossain, 2015, Oncotarget.

Tumor dynamics in response to antiangiogenic therapy with oral metronomic topotecan and pazopanib in neuroblastoma xenografts.

S. Baruchel, H. Yeger, Sushil Kumar, 2013, Translational oncology.

Metronomic Oral Topotecan with Pazopanib Is an Active Antiangiogenic Regimen in Mouse Models of Aggressive Pediatric Solid Tumor

S. Baruchel, R. Kerbel, S. Man, 2011, Clinical Cancer Research.

H. Yeger, L. Muscarella, Bessi Qorri, 2021, Oncotarget.

Notch ligand Dll1 mediates cross-talk between mammary stem cells and the macrophageal niche

H. Clevers, Yibin Kang, R. Chakrabarti, 2018, Science.

Metronomic Chemotherapy in Pediatric Malignancies

S. Baruchel, Sushil Kumar, R. Mokhtari, 2014 .

&Dgr;Np63-driven recruitment of myeloid-derived suppressor cells promotes metastasis in triple-negative breast cancer

R. Chakrabarti, S. Sinha, D. Gabrilovich, 2018, The Journal of clinical investigation.

Loss of ELF5–FBXW7 stabilizes IFNGR1 to promote the growth and metastasis of triple-negative breast cancer through interferon-γ signalling

J. Tobias, R. Chakrabarti, S. Sinha, 2020, Nature Cell Biology.

Inhibition of Haspin kinase promotes cell-intrinsic and extrinsic anti-tumor activity.

D. Schadendorf, T. Brinker, P. Sorger, 2019, Cancer research.

3D Multicellular Stem-Like Human Breast Tumor Spheroids Enhance Tumorigenicity of Orthotopic Xenografts in Athymic Nude Rat Model

H. Yeger, Bessi Qorri, M. Szewczuk, 2021, Cancers.

Inducible knockout of ∆Np63 alters cell polarity and metabolism during pubertal mammary gland development

R. Chakrabarti, S. Sinha, E. Flores, 2019, FEBS letters.

Combination of carbonic anhydrase inhibitor, acetazolamide, and sulforaphane, reduces the viability and growth of bronchial carcinoid cell lines

H. Yeger, K. Adeli, M. Yazdanpanah, 2013, BMC Cancer.

The Role of Tumour Suppressor Tyrosine Kinase SYK in Glioblastoma and Breast Cancer

Sushil Kumar, 2007 .

Transcriptome and metabolome changes induced by bitter melon (Momordica charantia)- intake in a high-fat diet induced obesity model

R. Agarwal, B. Tabakoff, C. Cruickshank-Quinn, 2021, Journal of traditional and complementary medicine.

Beneficial effects of the naturally occurring flavonoid silibinin on the prostate cancer microenvironment: role of monocyte chemotactic protein-1 and immune cell recruitment.

R. Agarwal, G. Deep, A. Jain, 2016, Carcinogenesis.

Differential effect of grape seed extract and its active constituent procyanidin B2 3,3″‐di‐O‐gallate against prostate cancer stem cells

R. Agarwal, M. Wempe, C. Agarwal, 2019, Molecular carcinogenesis.

Cyclophilin A Inhibitor Debio-025 Targets Crk, Reduces Metastasis, and Induces Tumor Immunogenicity in Breast Cancer

R. Birge, C. Kalodimos, E. Azzam, 2020, Molecular Cancer Research.

Crk Tyrosine Phosphorylation Regulates PDGF-BB–inducible Src Activation and Breast Tumorigenicity and Metastasis

P. Hornbeck, R. Birge, Sushil Kumar, 2017, Molecular Cancer Research.

Crk adaptor protein promotes PD-L1 expression, EMT and immune evasion in a murine model of triple-negative breast cancer

R. Birge, Sushil Kumar, Viralkumar Davra, 2018, Oncoimmunology.

Efferocytosis of dying cells differentially modulate immunological outcomes in tumor microenvironment

R. Birge, Sushil Kumar, D. Calianese, 2017, Immunological reviews.

Estrogen-dependent DLL1-mediated Notch signaling promotes luminal breast cancer

R. Chakrabarti, S. Fuchs, Christoforos Thomas, 2018, Oncogene.

Nab-Paclitaxel Is an Active Drug in Preclinical Model of Pediatric Solid Tumors

S. Baruchel, P. Thorner, Libo Zhang, 2013, Clinical Cancer Research.

Normalization of TAM post-receptor signaling reveals a cell invasive signature for Axl tyrosine kinase

R. Birge, A. Lewis-Antes, S. Kotenko, 2016, Cell Communication and Signaling.

Resistance to Chemotherapy Is Associated with Fibroblast Growth Factor Receptor 4 Up-Regulation

A. Ullrich, J. Bange, Sushil Kumar, 2009, Clinical Cancer Research.

Spatio-Temporal Distribution of Smads and Role of Smads/TGF-β/BMP-4 in the Regulation of Mouse Bladder Organogenesis

H. Yeger, Sushil Kumar, S. Islam, 2013, PloS one.

Dll1+ quiescent tumor stem cells drive chemoresistance in breast cancer through NF-κB survival pathway

C. Lengner, J. Tobias, Yibin Kang, 2021, Nature communications.

Insulin-like growth factor receptor signaling in breast tumor epithelium protects cells from endoplasmic reticulum stress and regulates the tumor microenvironment

R. Birge, D. Leroith, T. Wood, 2018, Breast Cancer Research.

Human bronchial carcinoid tumor initiating cells are targeted by the combination of acetazolamide and sulforaphane

H. Yeger, L. Muscarella, H. Cheng, 2019, BMC Cancer.

Small molecule inhibitors block Gas6-inducible TAM activation and tumorigenicity

S. Sarafianos, R. Birge, J. Bertino, 2017, Scientific Reports.

Loss of ELF5–FBXW7 stabilizes IFNGR1 to promote the growth and metastasis of triple-negative breast cancer through interferon-γ signalling

R. Chakrabarti, S. Sinha, L. Busino, 2020, Nature Cell Biology.

Immunosuppressive Myeloid Cells Induce Nitric Oxide–Dependent DNA Damage and p53 Pathway Activation in CD8+ T Cells

Guocheng Yuan, A. Saadatpour, K. Wucherpfennig, 2021, Cancer Immunology Research.

FUSE Binding Protein 1 Facilitates Persistent Hepatitis C Virus Replication in Hepatoma Cells by Regulating Tumor Suppressor p53

K. Klein, A. Pandey, Sushil Kumar, 2015, Journal of Virology.

Bitter melon juice exerts its efficacy against pancreatic cancer via targeting both bulk and cancer stem cells

R. Agarwal, M. Wempe, G. Deep, 2018, Molecular carcinogenesis.

Insulin-like growth factor receptor signaling in breast tumor epithelium protects cells from endoplasmic reticulum stress and regulates the tumor microenvironment

R. Birge, D. Leroith, T. Wood, 2018, Breast Cancer Research.

Functional modification of adipocytes by grape seed extract impairs their pro-tumorigenic signaling on colon cancer stem cells and the daughter cancer cells

R. Agarwal, C. Agarwal, Sushil Kumar, 2014, Oncotarget.

Albumin coated liposomes: a novel platform for macrophage specific drug delivery

R. Schwendener, Sushil Kumar, Clément Vuarchey, 2011 .

Integrin avb6–TGFb–SOX4 Pathway Drives Immune Evasion in Triple-Negative Breast Cancer

A. Giobbie-Hurder, X. Liu, D. Dillon, 2020 .