J. Brábek

发表

The molecular mechanisms of transition between mesenchymal and amoeboid invasiveness in tumor cells

M. Novotný, K. Pánková, D. Rösel, 2009, Cellular and Molecular Life Sciences.

The Analysis of Inflammation-Related Proteins in a Cargo of Exosomes Derived from the Serum of Uveal Melanoma Patients Reveals Potential Biomarkers of Disease Progression

W. Suchorska, D. Rösel, J. Brábek, 2021, Cancers.

The role of the tissue microenvironment in the regulation of cancer cell motility and invasion

Ben Fabry, Pavel Veselý, Jan Brábek, 2010, Cell Communication and Signaling.

Mechanosensors in integrin signaling: the emerging role of p130Cas.

Jan Brábek, D. Rösel, J. Brábek, 2014, European journal of cell biology.

Src kinase: key effector in mechanosignalling.

J. Brábek, L. Koudelková, D. Rosel, 2020, The international journal of biochemistry & cell biology.

Tyrosine phosphorylation within the SH3 domain regulates CAS subcellular localization, cell migration, and invasiveness

S. Hanks, D. Rösel, J. Brábek, 2011, Molecular biology of the cell.

Up-Regulation of Rho/ROCK Signaling in Sarcoma Cells Drives Invasion and Increased Generation of Protrusive Forces

Ben Fabry, Philip Kollmannsberger, Daniel P. Zitterbart, 2008, Molecular Cancer Research.

The fission yeast ortholog of the coregulator SKIP interacts with the small subunit of U2AF.

P. Folk, F. Půta, J. Brábek, 2001, Biochemical and biophysical research communications.

Pediatric Inflammatory Multisystem Syndrome (PIMS) - Potential role for cytokines such Is IL-6.

J. Zeman, K. Smetana, J. Brábek, 2021, Physiological research.

A homozygous stop-gain variant in ARHGAP42 is associated with childhood interstitial lung disease, systemic hypertension, and immunological findings

Jill A. Madden, C. Brownstein, K. Schmitz‐Abe, 2021, PLoS genetics.

Sustained Inflammatory Signalling through Stat1/Stat2/IRF9 Is Associated with Amoeboid Phenotype of Melanoma Cells

D. Rösel, J. Brábek, Aneta Gandalovičová, 2020, Cancers.

Thermo- and ROS-Responsive Self-Assembled Polymer Nanoparticle Tracers for 19F MRI Theranostics.

Z. Starcuk, M. Šlouf, P. Švec, 2021, Biomacromolecules.

Simultaneous targeting of mitochondrial metabolism and immune checkpoints as a new strategy for renal cancer therapy

L. Andĕra, J. Neuzil, J. Šmigová, 2022, Clinical and translational medicine.

ARHGAP42 is activated by Src-mediated tyrosine phosphorylation to promote cell motility

S. Hanks, Weifeng Luo, J. Brábek, 2017, Journal of Cell Science.

Crk-Associated Substrate Tyrosine Phosphorylation Sites Are Critical for Invasion and Metastasis of Src-Transformed Cells

Sábata S Constancio, A. Pozzi, S. Hanks, 2005, Molecular Cancer Research.

Intermediate Filaments as Potential Target for Cancer 2 Treatment

J. Brábek, M. Gregor, D. Rosel, 2019 .

Autoimmunity, cancer and COVID-19 abnormally activate wound healing pathways: critical role of inflammation

P. Gál, K. Smetana, J. Brábek, 2022, Histochemistry and Cell Biology.

COVID-19, corticosteroids and public health: a reappraisal

J. Brábek, M. Fernandes, Michael Fernandes, 2021, Public Health.

Pentamethinium salts suppress key metastatic processes by regulating mitochondrial function and inhibiting dihydroorotate dehydrogenase respiration.

M. Masařík, K. Vesela, J. Neuzil, 2022, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

CAS promotes invasiveness of Src-transformed cells

Alissa M. Weaver, Sábata S Constancio, A. Pozzi, 2004, Oncogene.

Interleukin-6: a molecule with complex biological impact in cancer.

K. Smetana, V. Král, J. Brábek, 2019, Histology and histopathology.

Cancer, checkpoint inhibitors, and confusion.

J. Brábek, M. Fernandes, Michael Fernandes, 2017, The Lancet. Oncology.

Phosphorylation of tyrosine 90 in SH3 domain is a new regulatory switch controlling Src kinase

D. Rösel, J. Brábek, L. Koudelková, 2022, bioRxiv.

Interleukin-6: Molecule in the Intersection of Cancer, Ageing and COVID-19

F. Vellieux, K. Smetana, J. Novotný, 2020, International journal of molecular sciences.

Metastasis of aggressive amoeboid sarcoma cells is dependent on Rho/ROCK/MLC signaling

Daniela Pankova, J. Plachy, D. Rösel, 2013, Cell Communication and Signaling.

NG2-mediated Rho activation promotes amoeboid invasiveness of cancer cells.

Daniela Pankova, D. Rösel, J. Brábek, 2012, European journal of cell biology.

CAS directly interacts with vinculin to control mechanosensing and focal adhesion dynamics

W. H. Goldmann, B. Fabry, W. Goldmann, 2013, Cellular and Molecular Life Sciences.

Solid cancer: the new tumour spread endpoint opens novel opportunities

J. Brábek, D. Rosel, M. Fernandes, 2019, British Journal of Cancer.

The Role of IL-6 in Cancer Cell Invasiveness and Metastasis—Overview and Therapeutic Opportunities

K. Smetana, M. Kolář, J. Brábek, 2022, Cells.

Simultaneous blocking of IL-6 and IL-8 is sufficient to fully inhibit CAF-induced human melanoma cell invasiveness

K. Smetana, D. Rösel, J. Brábek, 2016, Histochemistry and Cell Biology.

Urea-functionalized organoselenium compounds as promising anti-HepG2 and apoptosis-inducing agents.

S. Shaaban, D. Rösel, J. Brábek, 2021, Future medicinal chemistry.

6-Substituted purines as ROCK inhibitors with anti-metastatic activity.

M. Strnad, V. Kryštof, K. Doležal, 2019, Bioorganic chemistry.

Targeting Mitochondrial Iron Metabolism Suppresses Tumor Growth and Metastasis by Inducing Mitochondrial Dysfunction and Mitophagy

J. Neuzil, J. Štursa, Natalia Torrealba, 2021, Cancer Research.

The interaction of p130Cas with PKN3 promotes malignant growth

J. Brábek, L. Koudelková, D. Rosel, 2018, bioRxiv.

Focal adhesion kinase signaling activities and their implications in the control of cell survival and motility.

S. Hanks, N. Shin, J. Brábek, 2003, Frontiers in bioscience : a journal and virtual library.

Exosomes produced by melanoma cells significantly influence the biological properties of normal and cancer-associated fibroblasts

J. Šmigová, K. Smetana, J. Novotný, 2021, Histochemistry and Cell Biology.

Engine shutdown: migrastatic strategies and prevention of metastases.

M. Masařík, D. Rösel, J. Brábek, 2023, Trends in cancer.

TLR4-Mediated Recognition of Mouse Polyomavirus Promotes Cancer-Associated Fibroblast-Like Phenotype and Cell Invasiveness

J. Forstová, I. Hirsch, D. Rösel, 2021, Cancers.

Migrastatics—Anti-metastatic and Anti-invasion Drugs: Promises and Challenges

P. Heneberg, V. Sanz-Moreno, P. Veselý, 2017, Trends in cancer.

Vimentin Intermediate Filaments as Potential Target for Cancer Treatment

J. Brábek, M. Gregor, D. Rosel, 2020, Cancers.

Increased Level of Long Non-Coding RNA MALAT1 Is a Common Feature of Amoeboid Invasion

S. Diederichs, Tony Gutschner, D. Rösel, 2020, Cancers.

Are We Ready for Migrastatics?

D. Rösel, J. Brábek, H. Gil-Henn, 2021, Cells.

Microtubule-targeting agents and their impact on cancer treatment.

J. Kovář, D. Rösel, J. Brábek, 2020, European journal of cell biology.

Invasive cells in animals and plants: searching for LECA machineries in later eukaryotic life

F. Cvrčková, D. Rösel, J. Brábek, 2013, Biology Direct.

Cell polarity signaling in the plasticity of cancer cell invasiveness

T. Vomastek, J. Brábek, D. Rosel, 2016, Oncotarget.

Structural characterization of CAS SH3 domain selectivity and regulation reveals new CAS interaction partners

V. Veverka, M. Novotný, M. Lepšík, 2017, Scientific Reports.

The emerging role of microtubules in invasion plasticity

D. Rösel, J. Brábek, A. Škarková, 2023, Frontiers in Oncology.

RNA-seq Characterization of Melanoma Phenotype Switch in 3D Collagen after p38 MAPK Inhibitor Treatment

D. Rösel, J. Brábek, V. Palušová, 2021, Biomolecules.

Migrastatics – Anti-metastatic Drugs Targeting Cancer Cell Invasion

D. Rösel, J. Brábek, Aneta Gandalovičová, 2020 .

Anti-metastatic and Anti-invasion Drugs: Promises and Challenges

P. Heneberg, V. Sanz-Moreno, P. Veselý, 2017 .

Wnt Signaling Cascades and the Roles of Syndecan Proteoglycans

J. Couchman, J. Brábek, Csilla A Pataki, 2015, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Contractile forces in tumor cell migration.

Ben Fabry, Claudia Tanja Mierke, Jan Brábek, 2008, European journal of cell biology.

Cancer-Associated Fibroblasts Influence the Biological Properties of Malignant Tumours via Paracrine Secretion and Exosome Production

K. Smetana, M. Kolář, J. Brábek, 2022, International journal of molecular sciences.

Src transformation of colonic epithelial cells: Enhanced anchorage‐independent growth in an Apc+/min background

S. Hanks, J. Brábek, Sabata S. Constancio‐Lund, 2009, Molecular carcinogenesis.

Assaying protein kinase activity.

S. Hanks, J. Brábek, 2004, Methods in molecular biology.

Regulation and localization of CAS substrate domain tyrosine phosphorylation.

S. Hanks, N. Shin, Jiong Wu, 2004, Cellular signalling.

Global impact of oncogenic Src on a phosphotyrosine proteome.

A. Pandey, R. Chaerkady, S. Hanks, 2008, Journal of proteome research.

Novel FRET-Based Src Biosensor Reveals Mechanisms of Src Activation and Its Dynamics in Focal Adhesions.

K. Anderson, J. Brábek, Andreea Csilla Pataki, 2019, Cell chemical biology.

Translation in solid cancer: are size‐based response criteria an anachronism?

D. Rösel, J. Brábek, D. Rosel, 2014, Clinical and Translational Oncology.

PKCα promotes the mesenchymal to amoeboid transition and increases cancer cell invasiveness

D. Rösel, J. Brábek, Aneta Gandalovičová, 2015, BMC Cancer.

High-throughput transcriptomic and proteomic profiling of mesenchymal-amoeboid transition in 3D collagen

D. Rösel, J. Brábek, K. Harant, 2020, Scientific Data.

High-throughput transcriptomic and proteomic profiling of mesenchymal-amoeboid transition in 3D collagen

D. Rösel, J. Brábek, K. Harant, 2020, Scientific Data.

Drugs for solid cancer: the productivity crisis prompts a rethink

P. Veselý, D. Rösel, J. Brábek, 2013, OncoTargets and therapy.

Simultaneous blocking of IL-6 and IL-8 is sufficient to fully inhibit CAF-induced human melanoma cell invasiveness

K. Smetana, D. Rösel, J. Brábek, 2016, Histochemistry and Cell Biology.

Limits to Precision Cancer Medicine.

J. Brábek, D. Rosel, M. Fernandes, 2017, The New England journal of medicine.

Pragmatic medicine in solid cancer: a translational alternative to precision medicine

J. Brábek, D. Rosel, M. Fernandes, 2016, OncoTargets and therapy.

In-vitro screening with holographic incoherent quantitative phase imaging focuses on finding medicaments for repurposing as anti-metastatic agents designated as migrastatics

Radim Chmelík, Pavel Veselý, Daniel Zicha, 2021, European Conference on Biomedical Optics.

Migrastatics: Redirecting R&D in Solid Cancer Towards Metastasis?

V. Sanz-Moreno, J. Brábek, D. Rosel, 2019, Trends in cancer.

Quantitative phase imaging unravels new insight into dynamics of mesenchymal and amoeboid cancer cell invasion

R. Chmelík, P. Veselý, A. Křížová, 2018, Scientific Reports.

The structure of invadopodia in a complex 3D environment.

P. Veselý, P. Folk, D. Rösel, 2010, European journal of cell biology.

Neoplastic progression of the human breast cancer cell line G3S1 is associated with elevation of cytoskeletal dynamics and upregulation of MT1-MMP.

Daniela Pankova, C. Mierke, P. Veselý, 2010, International journal of oncology.

Estrogen Receptor Modulators in Viral Infections Such as SARS−CoV−2: Therapeutic Consequences

F. Vellieux, K. Smetana, R. Kaplánek, 2021, International journal of molecular sciences.

SH3 Domain Tyrosine Phosphorylation – Sites, Role and Evolution

M. Novotný, D. Rösel, J. Brábek, 2012, PloS one.

A Screen for PKN3 Substrates Reveals an Activating Phosphorylation of ARHGAP18

D. Rösel, J. Brábek, Michal Dibus, 2020, International journal of molecular sciences.

Role of Interleukin-6 in Lung Complications in Patients With COVID-19: Therapeutic Implications.

K. Smetana, J. Brábek, 2020, In vivo.

Metastasis of aggressive amoeboid sarcoma cells is dependent on Rho/ROCK/MLC signaling

Daniela Pankova, J. Plachy, D. Rösel, 2013, Cell Communication and Signaling.

ROCK inhibitors as emerging therapeutic candidates for sarcomas.

D. Rösel, J. Brábek, A. Ryška, 2010, Current cancer drug targets.

Dynamics and morphology of focal adhesions in complex 3D environment.

P. Veselý, D. Rösel, J. Brábek, 2012, Folia biologica.

Raloxifene and Bazedoxifene Could Be Promising Candidates for Preventing the COVID-19 Related Cytokine Storm, ARDS and Mortality

K. Smetana, J. Brábek, D. Rosel, 2020, In Vivo.

Cytoplasmic Tail of MT1-MMP: A Hub of MT1-MMP Regulation and Function

J. Brábek, D. Rosel, O. Tolde, 2023, International journal of molecular sciences.

Invadopodia Structure in 3D Environment Resolved by Near-Infrared Branding Protocol Combining Correlative Confocal and FIB-SEM Microscopy

A. Benda, D. Rösel, J. Brábek, 2021, International journal of molecular sciences.

Fibroblasts potentiate melanoma cells in vitro invasiveness induced by UV-irradiated keratinocytes

K. Smetana, M. Kolář, D. Rösel, 2018, Histochemistry and Cell Biology.

Fibronectin-replating experiment: procedure and analysis.

F. Půta, D. Rösel, J. Brábek, 2009, Folia biologica.

Primary assessment of medicines for expected migrastatic potential with holographic incoherent quantitative phase imaging

V. Jůzová, R. Chmelík, P. Veselý, 2023, Biomedical optics express.

RNA-seq of macrophages of amoeboid or mesenchymal migratory phenotype due to specific structure of environment

J. Fucikova, R. Spíšek, D. Rösel, 2018, Scientific Data.

The SH3 domain of Src can downregulate its kinase activity in the absence of the SH2 domain-pY527 interaction.

D. Mojzita, P. Folk, F. Půta, 2002, Biochemical and biophysical research communications.

eIF3e and eIF3d control expression of riboproteins and key components of the MAPK signaling pathway

L. Valášek, T. Vomastek, Farkas Kerényi, 2023, bioRxiv.

Confocal microscopy reveals Myzitiras and Vthela morphotypes as new signatures of malignancy progression.

E. Matoušková, Daniela Pankova, J. Bereiter-Hahn, 2009, Scanning.

Structural characterization of CAS SH3 domain selectivity and regulation reveals new CAS interaction partners

V. Veverka, M. Novotný, M. Lepšík, 2017, Scientific Reports.

Crk-Associated Substrate Tyrosine Phosphorylation Sites Are Critical for Invasion and Metastasis of Src-Transformed Cells

A. Pozzi, S. Hanks, N. Shin, 2005, Molecular Cancer Research.

NG2-mediated Rho activation promotes amoeboid invasiveness of cancer cells.

Daniela Pankova, D. Rösel, J. Brábek, 2012, European Journal of Cell Biology.

Quantitative phase imaging unravels new insight into dynamics of mesenchymal and amoeboid cancer cell invasion

Radim Chmelík, Pavel Veselý, Aneta Křížová, 2018, Scientific Reports.

The molecular mechanisms of transition between mesenchymal and amoeboid invasiveness in tumor cells

D. Rösel, J. Brábek, K. Pánková, 2009, Cellular and Molecular Life Sciences.

Mitochondrial HER2 stimulates respiration and promotes tumorigenicity.

Katerina Rohlenova, J. Brábek, J. Rohlena, 2024, European journal of clinical investigation.

NDRG1 acts as an oncogene in triple-negative breast cancer and its loss sensitizes cells to mitochondrial iron chelation

J. Brábek, Cristian Sandoval-Acuña, L. Werner, 2024, Frontiers in pharmacology.

CAS directly interacts with vinculin to control mechanosensing and focal adhesion dynamics

W. H. Goldmann, B. Fabry, T. Dey, 2013, Cellular and Molecular Life Sciences.

Educate, not kill: treating cancer without triggering its defenses.

J. Brábek, A. Škarková, Daniel Rosel, 2024, Trends in molecular medicine.

Microtubule-associated NAV3 regulates invasive phenotypes in glioblastoma cells.

D. Rösel, J. Brábek, A. Škarková, 2024, Brain pathology.