J. Parnes

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Molecular biology and function of CD4 and CD8.

J. Parnes, 1989, Advances in immunology.

Tezepelumab improves patient-reported outcomes in patients with severe, uncontrolled asthma in PATHWAY.

K. Salapa, J. Corren, J. Parnes, 2020, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

Immune Complex Formation Is Associated With Loss of Tolerance and an Antibody Response to Both Drug and Target

Troy E. Barger, H. Hsu, M. C. Teixeira dos Santos, 2021, Frontiers in Immunology.

CD6 attenuates early and late signaling events, setting thresholds for T-cell activation

S. Davis, S. Fabre, G. Bismuth, 2011, European journal of immunology.

Pharmacokinetics, Safety, and Tolerability of Tezepelumab (AMG 157) in Healthy and Atopic Dermatitis Adult Subjects

J. T. Sullivan, J. Parnes, Li Chen, 2019, Clinical pharmacology and therapeutics.

Immunogenicity assessment of bispecific antibody-based immunotherapy in oncology

H. L. Penny, J. Parnes, M. Kroenke, 2022, Journal for ImmunoTherapy of Cancer.

Signal for T-cell differentiation to a CD4 cell lineage is delivered by CD4 transmembrane region and/or cytoplasmic tail

R. Seong, J. Parnes, J. Chamberlain, 1992, Nature.

Enhancement of T-cell responsiveness by the lymphocyte-specific tyrosine protein kinase p56lck

N. Abraham, A. Veillette, J. Parnes, 1991, Nature.

Effect of tezepelumab on airway inflammatory cells, remodelling, and hyperresponsiveness in patients with moderate-to-severe uncontrolled asthma (CASCADE): a double-blind, randomised, placebo-controlled, phase 2 trial.

C. Brightling, S. Wenzel, M. Wechsler, 2021, The Lancet. Respiratory medicine.

CASCADE: a phase 2, randomized, double-blind, placebo-controlled, parallel-group trial to evaluate the effect of tezepelumab on airway inflammation in patients with uncontrolled asthma

C. Brightling, G. Colice, C. Emson, 2020, Respiratory Research.

Mouse splenic B lymphocyte activation using different activation stimuli induces in vitro splicing of tumor necrosis factor-alpha nuclear pre-mRNA.

C. Edwards, J. Parnes, M. Bao, 2006, Molecular immunology.

Dual regulation of BCR‐mediated growth inhibition signaling by CD72

N. Fusaki, N. Hozumi, J. Parnes, 2005, European journal of immunology.

CD72-deficient mice reveal nonredundant roles of CD72 in B cell development and activation.

N. Baumgarth, J. Parnes, C. Pan, 1999, Immunity.

CD72, a negative regulator of B‐cell responsiveness

J. Parnes, C. Pan, C. Pan, 2000 .

Safety and efficacy of AMG 714 in patients with type 2 refractory coeliac disease: a phase 2a, randomised, double-blind, placebo-controlled, parallel-group study.

E. Macintyre, C. Mulder, G. Bouma, 2019, The lancet. Gastroenterology & hepatology.

Effects of an anti-TSLP antibody on allergen-induced asthmatic responses.

L. Boulet, P. O'Byrne, D. Cockcroft, 2014, The New England journal of medicine.

Modulation of peripheral B cell tolerance by CD72 in a murine model.

G. Crabtree, M. Winslow, A. Chen, 2008, Arthritis and rheumatism.

Positive-negative selection gene targeting with the diphtheria toxin A-chain gene in mouse embryonic stem cells

D. Solter, R. Seong, B. Knowles, 1993, Transgenic Research.

Targeting TSLP in Asthma

J. Corren, J. Parnes, A. Menzies-Gow, 2022, Journal of asthma and allergy.

Biochemical identity of the mouse Ly-19.2 and Ly-32.2 alloantigens with the B cell differentiation antigen Lyb-2/CD72.

W. Robinson, J. Parnes, H. Schäfer, 1993, Journal of immunology.

Molecular linkage of the mouseCD5 andCD6 genes

B. Birren, D. Vollrath, J. Parnes, 2007, Immunogenetics.

Long-term engagement of CD6 and ALCAM is essential for T-cell proliferation induced by dendritic cells.

C. Figdor, J. Parnes, R. Torensma, 2006, Blood.

Mechanisms of CD8beta-mediated T cell response enhancement: interaction with MHC class I/beta2-microglobulin and functional coupling to TCR/CD3.

T. Potter, J. Parnes, J. Chen, 1998, Journal of immunology.

An immunological role for the CD8 β-chain

J. Parnes, C. Wheeler, P. Hoegen, 1992, Nature.

T Cell Receptor (TCR) Engagement Leads to Activation-induced Splicing of Tumor Necrosis Factor (TNF) Nuclear Pre-mRNA

J. Parnes, Yang Yang, Ju-Fay Chang, 1998, The Journal of experimental medicine.

A SECOND CHAIN OF HUMAN CD8 IS EXPRES PERIPHERAL BLOOD LYMPHOCYTES

S. D. Gorman, J. Parnes, S. Gorman, 2003 .

A SECOND CHAIN OF HUMAN CD8 IS EXPRES PERIPHERAL BLOOD LYMPHOCYTES

S. D. Gorman, J. Parnes, S. Gorman, 2003 .

Chromosomal mapping of the second humanCD8B gene locus

H. Heng, L. Tsui, J. Parnes, 2004, Immunogenetics.

Rescue of Daudi cell HLA expression by transfection of the mouse beta 2- microglobulin gene

A. Krensky, R. Seong, J. Parnes, 1988, The Journal of experimental medicine.

Limitation of differential expression of HLA-A,B,C antigens on choriocarcinoma cell lines by messenger RNA for HLA heavy chain but not by beta 2-microglobulin.

L. Herzenberg, S. Sekiya, J. Parnes, 1984, Cancer research.

Multiple mRNA species with distinct 3′ termini are transcribed from the β2-microglobulin gene

R. R. Robinson, J. Seidman, J. Parnes, 1983, Nature.

Requirement for CD100-CD72 interactions in fine-tuning of B-cell antigen receptor signaling and homeostatic maintenance of the B-cell compartment.

M. Tamura, Kazuhiro Suzuki, H. Kikutani, 2005, International immunology.

The level of CD4 surface protein influences T cell selection in the thymus.

J. Parnes, G. D. Frank, 1998, Journal of immunology.

Cell Selection in the Thymus The Level of CD 4 Surface Protein Influences T

J. Parnes, G. D. Frank, 1998 .

Inability of CD8α′polypeptides to associate with p56 lck correlates with impaired function in vitro and lack of expression in vivo

S. D. Gorman, R. Zamoyska, J. Bolen, 1989, Nature.

A unique CD72 epitope suggests a potential interaction with Fc gamma RII/CD32 on B lineage lymphocytes.

K. Coggeshall, H. Phee, P. Kincade, 2006, Hybridoma.

A Balance between B Cell Receptor and Inhibitory Receptor Signaling Controls Plasma Cell Differentiation by Maintaining Optimal Ets1 Levels

A. Satterthwaite, L. Garrett-Sinha, R. Rickert, 2014, The Journal of Immunology.

The B-cell surface protein CD72/Lyb-2 is the ligand for CDS

H. Velde, K. Thielemans, J. Parnes, 1991, Nature.

Coordinate induction of Ia alpha, beta, and Ii mRNA in a macrophage cell line.

J. Parnes, P. P. Jones, Y. Freund, 1985, Journal of immunology.

Alteration of T cell lineage commitment by expression of a hybrid CD8/CD4 transgene.

R. Seong, J. Parnes, 1992, Advances in experimental medicine and biology.

Gene for the human T cell differentiation antigen Leu-2/T8 is closely linked to the kappa light chain locus on chromosome 2

M. Isobe, C. Croce, V. Sukhatme, 1985, The Journal of experimental medicine.

The T/B Cell Antigen, CD5, and the B‐Cell Surface Protein, CD72, Form a Pair of Interacting Receptors a

H. Velde, K. Thielemans, J. Parnes, 1992, Annals of the New York Academy of Sciences.

Tezepelumab Reduces Exacerbations Across All Seasons in Patients with Severe, Uncontrolled Asthma: A Post Hoc Analysis of the PATHWAY Phase 2b Study

G. Colice, J. Corren, J. Parnes, 2021, Journal of asthma and allergy.

Baseline type 2 biomarker levels and response to tezepelumab in severe asthma

K. Salapa, J. Corren, J. Parnes, 2021, Allergy.

Efficacy of Tezepelumab in Patients with Severe, Uncontrolled Asthma and Perennial Allergy.

C. Ambrose, K. Salapa, J. Corren, 2021, The journal of allergy and clinical immunology. In practice.

Tezepelumab decreases matrix remodelling and inflammatory pathways in patients with asthma

S. Sridhar, W. White, Wei Zhao, 2019, Airway pharmacology and treatment.

Tezepelumab normalizes serum interleukin-5 and -13 levels in patients with severe, uncontrolled asthma.

J. Parnes, J. Griffiths, Tuyet-Hang Pham, 2021, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

Efficacy of Tezepelumab in Patients with Severe, Uncontrolled Asthma with and without Nasal Polyposis: A Post Hoc Analysis of the Phase 2b PATHWAY Study

G. Colice, K. Salapa, J. Corren, 2021, Journal of asthma and allergy.

Tezepelumab Treatment Effect on Annualized Rate of Exacerbations by Baseline Biomarkers in Uncontrolled Severe Asthma Patients: Phase 2b PATHWAY Study

J. Corren, J. Parnes, E. Garcia Gil, 2019, B15. IMMUNOTHERAPY FOR LUNG DISEASE.

Tezepelumab Reduces Multiple Key Inflammatory Biomarkers in Patients with Severe, Uncontrolled Asthma in the Phase 2b PATHWAY Study

J. Parnes, J. Griffiths, Tuyet-Hang Pham, 2019, B21. SEVERE ASTHMA: CLINICAL AND MECHANISTIC STUDIES.

Acquisition of an additional antigen specificity after mouse CD4 gene transfer into a T helper hybridoma

T. Mak, P. Ohashi, A. Reske-Kunz, 1988, The Journal of experimental medicine.

The Lck SH2 phosphotyrosine binding site is critical for efficient TCR-induced processive tyrosine phosphorylation of the zeta-chain and IL-2 production.

L. A. Lewis, J. Parnes, J. Chen, 1997, Journal of immunology.

Ly-1 (CD5), a membrane glycoprotein of mouse T lymphocytes and a subset of B cells, is a natural ligand of the B cell surface protein Lyb-2 (CD72).

H. Van de Velde, K. Thielemans, I. von Hoegen, 1992, Journal of immunology.

Induction of tolerance in peripheral T cells with monoclonal antibodies

H. Waldmann, S. Cobbold, J. Parnes, 1990, European journal of immunology.

A mutational hot‐spot within an intron of the mouse beta 2‐microglobulin gene.

J. Seidman, J. Parnes, R. Hyman, 1986, The EMBO journal.

Pharmacokinetic and Pharmacodynamic Modeling of Tezepelumab to Guide Phase 3 Dose Selection for Patients With Severe Asthma

Neang S. Ly, B. Agoram, L. Roskos, 2020, Journal of clinical pharmacology.

Mouse beta 2-microglobulin cDNA clones: a screening procedure for cDNA clones corresponding to rare mRNAs.

J. Seidman, A. Felsenfeld, E. Appella, 1981, Proceedings of the National Academy of Sciences of the United States of America.

CD72 Down-Modulates BCR-Induced Signal Transduction and Diminishes Survival in Primary Mature B Lymphocytes1

A. Snow, I. Tarner, J. Parnes, 2006, The Journal of Immunology.

Primary Mature B Lymphocytes Transduction and Diminishes Survival in CD72 Down-Modulates BCR-Induced Signal

I. Tarner, J. Parnes, J. Tung, 2006 .

CD 72 Down-Modulates BCR-Induced Signal Transduction and Diminishes Survival in Primary Mature B Lymphocytes 1

A. Snow, I. Tarner, J. Parnes, 2006 .

CD6: expression during development, apoptosis and selection of human and mouse thymocytes.

L. Beretta, J. Bromberg, D. Fox, 2002, International immunology.

Adhesion versus coreceptor function of CD4 and CD8: role of the cytoplasmic tail in coreceptor activity.

J. Parnes, P. von Hoegen, M. Miceli, 1991, Proceedings of the National Academy of Sciences of the United States of America.

An immunological role for the CD8 beta-chain.

J. Parnes, C. Wheeler, P. von Hoegen, 1992, Nature.

Tezepelumab, an anti–thymic stromal lymphopoietin monoclonal antibody, in the treatment of moderate to severe atopic dermatitis: A randomized phase 2a clinical trial

E. Simpson, D. She, J. Parnes, 2019, Journal of the American Academy of Dermatology.

Control of expression of histocompatibility antigens (H-2) and beta 2-microglobulin in F9 teratocarcinoma stem cells.

J. Seidman, C. Croce, E. Appella, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Polymorphic specificity of Q1/28, a monoclonal antibody that preferentially reacts with free class I heavy chains

P. Parham, J. Madrigal, J. Parnes, 2004, Immunogenetics.

A second chain of human CD8 is expressed on peripheral blood lymphocytes

J. Parnes, S. Gorman, L. Shiue, 1988, The Journal of experimental medicine.

Extracellular Isoforms of CD6 Generated by Alternative Splicing Regulate Targeting of CD6 to the Immunological Synapse1

A. Peixoto, B. Rocha, G. Bismuth, 2007, The Journal of Immunology.

OX52 is the rat homologue of CD6: evidence for an effector function in the regulation of CD5 phosphorylation

Alexandra Moreira, J. Parnes, Raquel J. Nunes, 2003, Journal of leukocyte biology.

Safety and Biological Activity of Rozibafusp alfa, a Bispecific Inhibitor of Inducible Costimulator Ligand and B Cell Activating Factor, in Patients With Rheumatoid Arthritis: Results of a Phase 1b, Randomized, Double‐Blind, Placebo‐Controlled, Multiple Ascending Dose Study

Stanley B. Cohen, M. C. Teixeira dos Santos, B. Sullivan, 2022, ACR open rheumatology.

Mapping of the Ly-4 (L3T4) T-cell differentiation antigen on mouse chromosome 6 by the use of RFLPs in an interspecific cross

M. Seldin, A. Steinberg, B. Mock, 2004, Immunogenetics.

T‐cell differentiation antigens: Proteins, genes and function

J. Parnes, 1986, BioEssays : news and reviews in molecular, cellular and developmental biology.

Structure and function of T lymphocyte differentiation antigens

J. Parnes, 1986 .

Identification of a human protein homologous to the mouse Lyb-2 B cell differentiation antigen and sequence of the corresponding cDNA.

I. von Hoegen, J. Parnes, E. Nakayama, 1990, Journal of immunology.

Tezepelumab in Adults with Uncontrolled Asthma

J. Corren, J. Parnes, M. Mo, 2017, The New England journal of medicine.

Tezepelumab in Adults with Uncontrolled Asthma.

J. Corren, J. Parnes, M. Mo, 2019, The New England journal of medicine.

CD2-CD4-CD8- lymph node T lymphocytes in MRL lpr/lpr mice are derived from a CD2+CD4+CD8+ thymic precursor.

R. Budd, J. Parnes, R. Scollay, 1993, Journal of immunology.

Isolation of the gene encoding the human T-lymphocyte differentiation antigen Leu-2 (T8) by gene transfer and cDNA subtraction.

V. Sukhatme, L. Herzenberg, P. Kavathas, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Structure, sequence, and polymorphism of the Lyt-2 T cell differentiation antigen gene.

R. Zamoyska, C. Liaw, J. Parnes, 1986, Journal of immunology.

Amino acid transport by membrane vesicles of virally transformed and nontransformed cells: Effects of sodium gradient and cell density

K. Isselbacher, J. Parnes, T. Garvey, 1976, Journal of cellular physiology.

Human Lyb‐2 homolog CD72 is a marker for progenitor B‐cell leukemias

B. Dörken, W. Ludwig, J. Parnes, 1992, American journal of hematology.

Transcriptional control of HLA-A,B,C antigen in human placental cytotrophoblast isolated using trophoblast- and HLA-specific monoclonal antibodies and the fluorescence-activated cell sorter

L. Herzenberg, J. Parnes, M. Kawata, 1984, The Journal of experimental medicine.

Role of Na+ in alpha-aminoisobutyric acid uptake by membrane vesicles from mouse fibroblasts transformed by simian virus 40.

K. Isselbacher, H. Nishino, J. Parnes, 1978, Proceedings of the National Academy of Sciences of the United States of America.

Sodium-stimulated amino acid uptake into isolated membrane vesicles from Balb/c 3T3 cells transformed by simian virus 40.

K. Isselbacher, D. Quinlan, J. Parnes, 1976, Proceedings of the National Academy of Sciences of the United States of America.

Transfection of the CD8 gene enhances T-cell recognition

R. Zamoyska, H. Boehmer, J. Parnes, 1987, Nature.

Structure of wild-type and mutant mouse β 2-microglobulin genes

J. Seidman, J. Parnes, 1982, Cell.

Control of H-2 antigen and beta 2-microglobulin gene expression in mouse trophoblast cell clones.

J. Seidman, E. Appella, K. Tanaka, 1983, Proceedings of the National Academy of Sciences of the United States of America.

Role of CD4 and CD8 in T cell activation and differentiation.

J. Parnes, M. Miceli, M. Miceli, 1993, Advances in immunology.

Two Lyt-2 polypeptides arise from a single gene by alternative splicing patterns of mRNA

Rose Zamoyska, R. Zamoyska, C. Liaw, 1985, Cell.

The T cell differentiation antigen Leu-2/T8 is homologous to immunoglobulin and T cell receptor variable regions

T. Hunkapiller, V. Sukhatme, J. Parnes, 1985, Cell.

The class IV semaphorin CD100 plays nonredundant roles in the immune system: defective B and T cell activation in CD100-deficient mice.

M. Ikawa, M. Okabe, T. Yasui, 2000, Immunity.

Identification of CD72 as a lymphocyte receptor for the class IV semaphorin CD100: a novel mechanism for regulating B cell signaling.

M. Matsumoto, T. Yasui, H. Kikutani, 2000, Immunity.

The CD8α Locus Is Located on the Telomere Side of the Immunoglobulin κ Locus at a Distance of 2 Mb

H. Zachau, J. Parnes, C. Huber, 1993 .

Reconstitution of MHC class I specificity by transfer of the T cell receptor and Lyt-2 genes

J. Gabert, B. Malissen, R. Zamoyska, 1987, Cell.

The roles of CD4 and CD8 in T cell activation.

J. Parnes, M C Miceli, J R Parnes, 1991, Seminars in immunology.

Regulation of mouse CD72 gene expression during B lymphocyte development.

C. Goodnow, J. I. Healy, J. Parnes, 1998, Journal of immunology.

PU.1/Spi-1 is essential for the B cell-specific activity of the mouse CD72 promoter.

J. Parnes, J. Chang, Ju-Fay Chang, 1998, Journal of immunology.

Sequence of the Lyb-2 B-cell differentiation antigen defines a gene superfamily of receptors with inverted membrane orientation.

I. von Hoegen, J. Parnes, E. Nakayama, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Identification of a mouse protein homologous to the human CD6 T cell surface protein and sequence of the corresponding cDNA.

W. Robinson, H. Robinson, J. Parnes, 1995, Journal of immunology.

Human CD6 possesses a large, alternatively spliced cytoplasmic domain

W. Robinson, J. Parnes, S. Prohaska, 1995, European journal of immunology.

Distinct stage-specific cis-active transcriptional mechanisms control expression of T cell coreceptor CD8 alpha at double- and single-positive stages of thymic development.

R. Seong, J. Parnes, J. Chamberlain, 1998, Journal of immunology.

Safety and efficacy of AMG 714 in adults with coeliac disease exposed to gluten challenge: a phase 2a, randomised, double-blind, placebo-controlled study.

M. Scheinin, M. Mäki, M. Pesu, 2019, The lancet. Gastroenterology & hepatology.

Equivalence of human and mouse CD4 in enhancing antigen responses by a mouse class II-restricted T cell hybridoma

M. Schilham, J. Parnes, P. von Hoegen, 1989, The Journal of experimental medicine.

Specific demethylation of the CD4 gene during CD4 T lymphocyte differentiation.

J. Parnes, R. Scollay, M. M. Tutt Landolfi, 1997, Molecular immunology.

CD31 mismatching affects marrow transplantation outcome.

J. Zehnder, R. Negrin, F. Grumet, 2001, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

CD6 to the Immunological Synapse Alternative Splicing Regulate Targeting of Extracellular Isoforms of CD6 Generated by

B. Rocha, G. Bismuth, A. Brown, 2017 .

CD 6 to the Immunological Synapse Alternative Splicing Regulate Targeting of Extracellular Isoforms of CD 6 Generated

Brown, G. Bismuth, J. Parnes, 2007 .

L3T4 and the Immunoglobulin Gene Superfamily: New Relationships between the Immune System and the Nervous System

T. Hunkapiller, J. Parnes, 1987, Immunological reviews.

Structure of the mouse gene encoding CD4 and an unusual transcript in brain.

J. Parnes, B. Tourvieille, S. Gorman, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Isolation and sequence of L3T4 complementary DNA clones: expression in T cells and brain.

T. Hunkapiller, J. Parnes, E. Field, 1986, Science.

Isolation of P1 bacteriophage clones containing large contiguous segments of the human and mouse loci for the T-cell coreceptor molecule CD8.

H. Heng, L. Tsui, J. Parnes, 1994, Genetic analysis, techniques and applications.