D. Kulms

发表

Vemurafenib Potently Induces Endoplasmic Reticulum Stress–Mediated Apoptosis in BRAFV600E Melanoma Cells

D. Schadendorf, K. Flaherty, C. Busch, 2013, Science Signaling.

Analysing the Role of UVB-Induced Translational Inhibition and PP2Ac Deactivation in NF-κB Signalling Using a Minimal Mathematical Model

Oliver Sawodny, Michael Ederer, Thomas Sauter, 2012, PloS one.

Identification of PP2A as a crucial regulator of the NF-κB feedback loop: its inhibition by UVB turns NF-κB into a pro-apoptotic factor

H. Walczak, D. Kulms, S. Barisic, 2008, Cell Death and Differentiation.

Inhibition of PI3K-AKT-mTOR signaling sensitizes melanoma cells to cisplatin and temozolomide.

K. Flaherty, C. Garbe, B. Schittek, 2009, The Journal of investigative dermatology.

Combined targeting of MAPK and AKT signalling pathways is a promising strategy for melanoma treatment

C. Garbe, B. Schittek, F. Meier, 2007, The British journal of dermatology.

Anti-Apoptotic NF-κB and “Gain of Function” mutp53 in Concert Act Pro-Apoptotic in Response to UVB+IL-1 via Enhanced TNF Production

S. Beissert, D. Kulms, Ines Müller, 2014, The Journal of investigative dermatology.

Caspase-3 cleaves XIAP in a positive feedback loop to sensitize melanoma cells to TRAIL-induced apoptosis

D. Kulms, H. Kashkar, N. Peters, 2011, Oncogene.

Systemic network analysis identifies XIAP and IκBα as potential drug targets in TRAIL resistant BRAF mutated melanoma

T. Sauter, P. Lucarelli, R. Kontermann, 2018, npj Systems Biology and Applications.

PI3K Pathway Inhibition Achieves Potent Antitumor Activity in Melanoma Brain Metastases In Vitro and In Vivo

A. Schmid, C. Calaminus, K. Flaherty, 2016, Clinical Cancer Research.

XIAP promotes melanoma growth by inducing tumour neutrophil infiltration

T. Tüting, P. Zigrino, C. Mauch, 2022, EMBO reports.

Apoptosis in BRAFV600E Melanoma Cells Vemurafenib Potently Induces Endoplasmic Reticulum Stress-Mediated `

D. Schadendorf, K. Flaherty, C. Busch, 2013 .

The farnesyl transferase inhibitor lonafarnib inhibits mTOR signaling and enforces sorafenib-induced apoptosis in melanoma cells.

D. Schadendorf, K. Flaherty, C. Garbe, 2011, The Journal of investigative dermatology.

Bortezomib sensitises TRAIL-resistant HPV-positive head and neck cancer cells to TRAIL through a caspase-dependent, E6-independent mechanism

N. Raulf, H. Walczak, M. Tavassoli, 2014, Cell Death and Disease.

Identifying and targeting cancer-specific metabolism with network-based drug target prediction

Maria Pires Pacheco, T. Sauter, S. Haan, 2019, EBioMedicine.

PI 3 K pathway inhibition achieves potent antitumor activity in melanoma brain metastases in vitro and in vivo

A. Schmid, C. Calaminus, K. Flaherty, 2017 .

Resistance of human melanoma cells against the death ligand TRAIL is reversed by ultraviolet-B radiation via downregulation of FLIP.

M. Weichenthal, D. Kulms, T. Schwarz, 2004, The Journal of investigative dermatology.

The molecular determinants of sunburn cell formation

G. Murphy, D. Kulms, T. Schwarz, 2001, Experimental dermatology.

Apoptosis induced by disruption of the actin cytoskeleton is mediated via activation of CD95 (Fas/APO-1)

H. Düssmann, S. Ständer, D. Kulms, 2002, Cell Death and Differentiation.

Ultraviolet Radiation Inhibits Interleukin-2-induced Tyrosine Phosphorylation and the Activation of STAT5 in T Lymphocytes*

D. Kulms, Thomas Schwarz, 2001, The Journal of Biological Chemistry.

Nuclear and cell membrane effects contribute independently to the induction of apoptosis in human cells exposed to UVB radiation.

T. Luger, J. Krutmann, D. Yarosh, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Molecular Mechanisms Involved in UV-Induced Apoptotic Cell Death

D. Kulms, T. Schwarz, 2002, Skin Pharmacology and Physiology.

Independent contribution of three different pathways to ultraviolet-B-induced apoptosis.

D. Kulms, T. Schwarz, 2002, Biochemical pharmacology.

Neutrophil-Derived Proteases Escalate Inflammation through Activation of IL-36 Family Cytokines.

Seamus J. Martin, Graeme P. Sullivan, C. M. Henry, 2016, Cell reports.

Interleukin-12 suppresses ultraviolet radiation-induced apoptosis by inducing DNA repair

H. Steeg, S. Ständer, J. Krutmann, 2002, Nature Cell Biology.

Sensitization of melanoma cells to TRAIL by UVB-induced and NF-κB-mediated downregulation of xIAP

D. Kulms, N. Peters, B. Thayaparasingham, 2009, Oncogene.

Ultraviolet Light Induces Apoptosis via Direct Activation of CD95 (Fas/APO-1) Independently of Its Ligand CD95L

Thomas A. Luger, Dagmar Kulms, Thomas Schwarz, 1998, The Journal of cell biology.

Computational models of melanoma

Philippe Lucarelli, Dagmar Kulms, Thomas Sauter, 2020, Theoretical Biology and Medical Modelling.

Molecular mechanisms of UV‐induced apoptosis

D. Kulms, T. Schwarz, D. Kulms, 2000, Photodermatology, photoimmunology & photomedicine.

Mechanistically Coupled PK (MCPK) Model to Describe Enzyme Induction and Occupancy Dependent DDI of Dabrafenib Metabolism

T. Sauter, Y. Kogan, M. Albrecht, 2022, Pharmaceutics.

A 3D Organotypic Melanoma Spheroid Skin Model

Dagmar Kulms, D. Kulms, Ines Müller, 2018, Journal of visualized experiments : JoVE.

Development of a human three-dimensional organotypic skin-melanoma spheroid model for in vitro drug testing

S. Beissert, H. Walczak, H. Walles, 2013, Cell Death and Disease.

Mechanisms of UV‐Induced Signal Transduction

D. Kulms, T. Schwarz, 2002, The Journal of dermatology.

Potent pro-apoptotic combination therapy is highly effective in a broad range of cancers

M. El-Bahrawy, H. Walczak, D. Kulms, 2021, Cell Death & Differentiation.

The Role of AKT/mTOR Pathway in Stress Response to UV-Irradiation: Implication in Skin Carcinogenesis by Regulation of Apoptosis, Autophagy and Senescence

D. Kulms, E. Strozyk, 2013, International journal of molecular sciences.

Interleukin-1 Protects Transformed Keratinocytes from Tumor Necrosis Factor-related Apoptosis-inducing Ligand*

T. Luger, M. Kubin, D. Kulms, 1998, The Journal of Biological Chemistry.

NFκB: cell survival or cell death?

D. Kulms, E. Strozyk, 2005 .

NF-?B and Cytokines

D. Kulms, T. Schwarz, 2006 .

Cancer Cells Employ Nuclear Caspase-8 to Overcome the p53-Dependent G2/M Checkpoint through Cleavage of USP28.

D. Green, M. Gleave, L. Fazli, 2019, Molecular cell.

Combined inhibition of MAPK and mTOR signaling inhibits growth, induces cell death, and abrogates invasive growth of melanoma cells.

K. Flaherty, C. Garbe, B. Schittek, 2008, The Journal of investigative dermatology.

DNA damage, death receptor activation and reactive oxygen species contribute to ultraviolet radiation-induced apoptosis in an essential and independent way

Dagmar Kulms, Thomas Schwarz, D. Kulms, 2002, Oncogene.

In vitro models of melanoma

F. Meier, D. Kulms, 2018 .

Down-regulation of interferon γ-activated STAT1 by UV light

Y. Aragane, T. Luger, D. Kulms, 1997 .

NFκB-dependent Down-regulation of Tumor Necrosis Factor Receptor-associated Proteins Contributes to Interleukin-1-mediated Enhancement of Ultraviolet B-induced Apoptosis*

Dagmar Kulms, Thomas Schwarz, D. Kulms, 2005, Journal of Biological Chemistry.

Interleukin-1 Protects Transformed Keratinocytes from Tumor Necrosis Factor-related Apoptosis-inducing Ligand- and CD95-induced Apoptosis but Not from Ultraviolet Radiation-induced Apoptosis*

Thomas A. Luger, Dagmar Kulms, T. Luger, 1999, The Journal of Biological Chemistry.

Keratinocytes control skin immune homeostasis through de novo–synthesized glucocorticoids

T. Brunner, D. Legler, D. Kulms, 2021, Science Advances.

Convergence of pathway analysis and pattern recognition predicts sensitization to latest generation TRAIL therapeutics by IAP antagonism

C. Praetorius, R. Kontermann, M. Rehm, 2020, Cell Death & Differentiation.

Kinase inhibitor library screening identifies synergistic drug combinations effective in sensitive and resistant melanoma cells

Dagmar Kulms, Stephanie Kreis, D. Philippidou, 2019, Journal of Experimental & Clinical Cancer Research.

Targeting hyperactivation of the AKT survival pathway to overcome therapy resistance of melanoma brain metastases

D. Schadendorf, K. Flaherty, R. Dummer, 2013, Cancer medicine.

Focal adhesion kinase plays a dual role in TRAIL resistance and metastatic outgrowth of malignant melanoma

T. Sauter, A. Ginolhac, R. Kontermann, 2022, Cell death & disease.

BRAF Inhibitors Amplify the Proapoptotic Activity of MEK Inhibitors by Inducing ER Stress in NRAS-Mutant Melanoma

K. Flaherty, C. Garbe, C. Praetorius, 2017, Clinical Cancer Research.

Tyrosine phosphatase inhibition triggers sustained canonical serine-dependent NFkappaB activation via Src-dependent blockade of PP2A.

Sandra Barisic, Dagmar Kulms, Henning Walczak, 2010, Biochemical pharmacology.

Differential response of head and neck cancer cell lines to TRAIL or Smac mimetics is associated with the cellular levels and activity of caspase-8 and caspase-10

D. Delia, N. Raulf, R. El-Attar, 2014, British Journal of Cancer.

Computational models of melanoma

T. Sauter, P. Lucarelli, M. Albrecht, 2020, Theoretical Biology and Medical Modelling.

IgG-single-chain TRAIL fusion proteins for tumour therapy

R. Kontermann, K. Pfizenmaier, M. Siegemund, 2018, Scientific Reports.

Ultraviolet Radiation-induced Interleukin 6 Release in HeLa Cells Is Mediated via Membrane Events in a DNA Damage-independent Way*

D. Kulms, D Kulms, B Pöppelmann, 2000, The Journal of Biological Chemistry.

20 years after--milestones in molecular photobiology.

Dagmar Kulms, Thomas Schwarz, D. Kulms, 2002, The journal of investigative dermatology. Symposium proceedings.

Combined inhibition of MAPK and mTOR signaling inhibits growth, induces cell death and abrogates invasive growth of melanoma cells

K. Flaherty, C. Garbe, C. Zielinski, 2008 .

Down-regulation of interferon gamma-activated STAT1 by UV light.

Y. Aragane, T. Luger, D. Kulms, 1997, Proceedings of the National Academy of Sciences of the United States of America.

The TAT-RasGAP317-326 anti-cancer peptide can kill in a caspase-, apoptosis-, and necroptosis-independent manner

J. Puyal, C. Widmann, S. Michel, 2016, Oncotarget.

Apoptotic cell death in disease—Current understanding of the NCCD 2023

S. Lipton, A. Ciechanover, T. Luedde, 2023, Cell Death & Differentiation.

Differential effects of NF-κB on apoptosis induced by DNA-damaging agents: the type of DNA damage determines the final outcome

D. Kulms, T. Schwarz, E. Strozyk, 2006, Oncogene.

Phosphoprotein patterns predict trametinib responsiveness and optimal trametinib sensitisation strategies in melanoma

L. Alexopoulos, T. Sauter, T. Sakellaropoulos, 2018, Cell Death & Differentiation.

Superior Properties of Fc-comprising scTRAIL Fusion Proteins

R. Kontermann, K. Pfizenmaier, M. Siegemund, 2017, Molecular Cancer Therapeutics.

Kinase inhibitor library screening identifies synergistic drug combinations effective in sensitive and resistant melanoma cells

D. Philippidou, S. Kreis, C. Margue, 2019, Journal of experimental & clinical cancer research : CR.

IgG-single-chain TRAIL fusion proteins for tumour therapy

R. Kontermann, K. Pfizenmaier, M. Siegemund, 2018, Scientific Reports.

Modeling time delay in the NFκB signaling pathway following low dose IL-1 stimulation

Oliver Sawodny, Michael Ederer, Thomas Sauter, 2011, EURASIP J. Bioinform. Syst. Biol..

Mechanism of PP2A-mediated IKKβ dephosphorylation: a systems biological approach

Oliver Sawodny, Frank Allgöwer, Thomas Sauter, 2009, BMC Systems Biology.

Generation of 3 D Melanoma Spheroids Via the Hanging Drop Method

D. Kulms, Ines Müller, 2018 .

Metabolic modelling-based in silico drug target prediction identifies six novel repurposable drugs for melanoma

Maria Pires Pacheco, T. Sauter, Tamara Bintener, 2023, Cell death & disease.

Molecular mechanisms of UV‐induced apoptosis

D. Kulms, T. Schwarz, 2000, Photodermatology, photoimmunology & photomedicine.

Identification of New IκBα Complexes by an Iterative Experimental and Mathematical Modeling Approach

Thomas Sauter, Johannes Witt, Dagmar Kulms, 2014, PLoS Comput. Biol..