J. Vázquez-Prado

发表

The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer

S. Seshagiri, T. Handel, I. Kufareva, 2013, Nature Reviews Cancer.

Gβγ mediates activation of Rho guanine nucleotide exchange factor ARHGEF17 that promotes metastatic lung cancer progression

J. Vázquez-Prado, I. García-Jiménez, Rodolfo Daniel Cervantes-Villagrana, 2021, The Journal of biological chemistry.

Protumoral bone marrow-derived cells migrate via Gβγ-dependent signaling pathways and exhibit a complex repertoire of RhoGEFs

J. Vázquez-Prado, Rodolfo Daniel Cervantes-Villagrana, G. Reyes-Cruz, 2019, Journal of Cell Communication and Signaling.

Calcium-sensing-receptor (CaSR) controls IL-6 secretion in metastatic breast cancer MDA-MB-231 cells by a dual mechanism revealed by agonist and inverse-agonist modulators

J. Vázquez-Prado, Érika González-Domínguez, C. Sánchez-Torres, 2016, Molecular and Cellular Endocrinology.

Lysophosphatidic acid modulates alpha(1b)-adrenoceptor phosphorylation and function: roles of Gi and phosphoinositide 3-kinase.

J. A. García-Sáinz, J. Vázquez-Prado, P. Casas-González, 2000, Molecular pharmacology.

Alpha 1-adrenoceptors: subtypes, signaling, and roles in health and disease.

R. Villalobos-Molina, J. Vázquez-Prado, J. García-Sainz, 1999, Archives of medical research.

Potent Activation of RhoA by Gαq and Gq-coupled Receptors*

J. Gutkind, H. Miyazaki, H. Chikumi, 2002, Journal of Biological Chemistry.

Chemotactic and proangiogenic role of calcium sensing receptor is linked to secretion of multiple cytokines and growth factors in breast cancer MDA-MB-231 cells.

J. Vázquez-Prado, G. Reyes-Cruz, M. A. Hernández-Bedolla, 2015, Biochimica et biophysica acta.

P-Rex1 Signaling Hub in Lower Grade Glioma Patients, Found by In Silico Data Mining, Correlates With Reduced Survival and Augmented Immune Tumor Microenvironment

J. Vázquez-Prado, Yarely Mabell Beltrán-Navarro, G. Reyes-Cruz, 2022, Frontiers in Oncology.

Calcium-sensing receptor endocytosis links extracellular calcium signaling to parathyroid hormone-related peptide secretion via a Rab11a-dependent and AMSH-sensitive mechanism.

J. Vázquez-Prado, G. Reyes-Cruz, Alejandro García-Regalado, 2007, Molecular endocrinology.

α1-Adrenoceptor subtype activation increases proto-oncogene mRNA levels. Role of protein kinase C

R. Alcántara-Hernández, J. Vázquez-Prado, J. A. Garcı́a-Sáinz, 1998 .

Differential inhibitor of Gbetagamma signaling to AKT and ERK derived from phosducin-like protein: effect on sphingosine 1-phosphate-induced endothelial cell migration and in vitro angiogenesis.

J. Gutkind, J. Vázquez-Prado, G. Reyes-Cruz, 2009, The Journal of biological chemistry.

Regulation of the human bradykinin B2 receptor expressed in sf21 insect cells: A possible role for tyrosine kinases

L. Vaca, W. Müller-Esterl, J. Vázquez-Prado, 2000, Journal of cellular biochemistry.

Calcium‐sensing receptor inhibits TGF‐β‐signaling by decreasing Smad2 phosphorylation

M. Macías-Silva, J. Vázquez-Prado, G. Vázquez-Victorio, 2013, IUBMB life.

α1-Adrenoceptors: function and phosphorylation

J. Vázquez-Prado, J. A. Garcı́a-Sáinz, L. D. C. Medina, 2000 .

Protein kinase C-mediated phosphorylation and desensitization of human alpha(1b)-adrenoceptors.

A. Gottfried-Blackmore, J. Vázquez-Prado, M. Romero-Ávila, 1999, European journal of pharmacology.

Crosstalk: phosphorylation of α1b‐adrenoceptors induced through activation of bradykinin B2 receptors

M. Torres-Padilla, A. Mendoza-Mendoza, J. Vázquez-Prado, 1998, FEBS letters.

Sphingosine-1-phosphate receptor S1P1 is regulated by direct interactions with P-Rex1, a Rac guanine nucleotide exchange factor.

J. Vázquez-Prado, M. Guzmán-Hernández, Alejandro García-Regalado, 2010, Biochemical and biophysical research communications.

Fibronectin-derived fragments as inducers of adhesion and chemotaxis of Entamoeba histolytica trophozoites.

I. Meza, J. Vázquez-Prado, E. Franco, 1997, The Journal of infectious diseases.

Gβγ interacts with mTOR and promotes its activation.

J. Vázquez-Prado, G. Reyes-Cruz, M. Guzmán-Hernández, 2014, Biochemical and biophysical research communications.

Calcium sensing receptor activates the NLRP3 inflammasome via a chaperone-assisted degradative pathway involving Hsp70 and LC3-II.

J. Vázquez-Prado, G. Reyes-Cruz, Tania Yareli Gutiérrez-López, 2018, Biochemical and biophysical research communications.

G protein-coupled receptor-promoted trafficking of Gbeta1gamma2 leads to AKT activation at endosomes via a mechanism mediated by Gbeta1gamma2-Rab11a interaction.

T. Balla, J. Vázquez-Prado, G. Reyes-Cruz, 2008, Molecular biology of the cell.

Norepinephrine- and Phorbol Ester-induced Phosphorylation of α1a-Adrenergic Receptors

C. González-Espinosa, J. Vázquez-Prado, M. Romero-Ávila, 2000, The Journal of Biological Chemistry.

Cross-talk between receptors with intrinsic tyrosine kinase activity and alpha1b-adrenoceptors.

J. Vázquez-Prado, J. A. Garcı́a-Sáinz, L. del Carmen Medina, 2000, The Biochemical journal.

Differential inhibitor of Gbetagamma signaling to AKT and ERK derived from phosducin-like protein: effect on sphingosine 1-phosphate-induced endothelial cell migration and in vitro angiogenesis.

J. Gutkind, J. Vázquez-Prado, G. Reyes-Cruz, 2009, The Journal of biological chemistry.

Gβγ recruits and activates P-Rex1 via two independent binding interfaces.

J. Vázquez-Prado, I. García-Jiménez, Rodolfo Daniel Cervantes-Villagrana, 2021, Biochemical and biophysical research communications.

VPS28, an ESCRT-I protein, regulates mitotic spindle organization via Gβγ, EG5 and TPX2.

J. Vázquez-Prado, G. Reyes-Cruz, Tania Yareli Gutiérrez-López, 2018, Biochimica et biophysica acta. Molecular cell research.

Activation of Endothelin ETA Receptors Induces Phosphorylation of α1b-Adrenoreceptors in Rat-1 Fibroblasts*

J. Vázquez-Prado, J. A. Garcı́a-Sáinz, L. D. C. Medina, 1997, The Journal of Biological Chemistry.

P-Rex1 links mTOR signaling to Rac activation and cell migration

J. Gutkind, H. Rosenfeldt, J. Vázquez-Prado, 2007 .

Endothelial cell sprouting driven by RhoJ directly activated by a membrane-anchored Intersectin 1 (ITSN1) RhoGEF module.

J. Vázquez-Prado, I. García-Jiménez, Rodolfo Daniel Cervantes-Villagrana, 2020, Biochemical and biophysical research communications.

ACCELERATED COMMUNICATION : G a s activates Cdc 42 via PDZ-RhoGEF

J. Gutkind, J. Vázquez-Prado, I. García-Jiménez, 2020 .

Protein Kinase A (PKA) Type I Interacts with P-Rex1, a Rac Guanine Nucleotide Exchange Factor

Susan S. Taylor, N. Mochizuki, S. Fukuhara, 2016, The Journal of Biological Chemistry.

AMSH regulates calcium-sensing receptor signaling through direct interactions.

J. Vázquez-Prado, G. Reyes-Cruz, M. Valadez-Sánchez, 2006, Biochemical and biophysical research communications.

Plexin B Regulates Rho through the Guanine Nucleotide Exchange Factors Leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF*

J. Gutkind, J. Vázquez-Prado, V. Perrot, 2002, The Journal of Biological Chemistry.

Protumoral bone marrow-derived cells migrate via Gβγ-dependent signaling pathways and exhibit a complex repertoire of RhoGEFs

J. Vázquez-Prado, Rodolfo Daniel Cervantes-Villagrana, G. Reyes-Cruz, 2019, Journal of Cell Communication and Signaling.

Calcium sensing receptor stimulates breast cancer cell migration via the Gβγ-AKT-mTORC2 signaling pathway

J. Vázquez-Prado, I. García-Jiménez, Jorge Eduardo del-Río-Robles, 2021, Journal of Cell Communication and Signaling.

Regulation of mTORC1 Complex Assembly and Signaling by GRp58/ERp57

J. Vázquez-Prado, G. Reyes-Cruz, Aleida Vázquez-Macías, 2011, Molecular and Cellular Biology.

Phosphatidylinositol 3,4,5-Triphosphate-Dependent Rac Exchanger 1 (P-Rex-1), a Guanine Nucleotide Exchange Factor for Rac, Mediates Angiogenic Responses to Stromal Cell-Derived Factor-1/Chemokine Stromal Cell Derived Factor-1 (SDF-1/CXCL-12) Linked to Rac Activation, Endothelial Cell Migration, and

J. Vázquez-Prado, G. Reyes-Cruz, J. Heller Brown, 2010, Molecular Pharmacology.

mTORC1‐ and mTORC2‐interacting proteins keep their multifunctional partners focused

J. Vázquez-Prado, Paola Moreno-Álvarez, Evelyn Robles-Molina, 2011, IUBMB life.

The calcium sensing receptor (CaSR) promotes Rab27B expression and activity to control secretion in breast cancer cells.

J. Vázquez-Prado, I. García-Jiménez, Jorge Eduardo del-Río-Robles, 2021, Biochimica et biophysica acta. Molecular cell research.

Pro-adhesive phenotype of normal endothelial cells responding to metastatic breast cancer cell conditioned medium is linked to NFκB-mediated transcriptomic regulation.

L. Orozco, P. Gariglio, J. L. Ventura-Gallegos, 2016, International journal of oncology.

P-Rex1 Links Mammalian Target of Rapamycin Signaling to Rac Activation and Cell Migration*

J. Gutkind, H. Rosenfeldt, J. Vázquez-Prado, 2007, Journal of Biological Chemistry.

Gβγ signaling to the chemotactic effector P-REX1 and mammalian cell migration is directly regulated by Gαq and Gα13 proteins

E. Kostenis, J. Gutkind, G. König, 2018, The Journal of Biological Chemistry.

Gβγ Pathways in Cell Polarity and Migration Linked to Oncogenic GPCR Signaling: Potential Relevance in Tumor Microenvironment

J. Vázquez-Prado, Rodolfo Daniel Cervantes-Villagrana, G. Reyes-Cruz, 2016, Molecular Pharmacology.

Direct Interaction of p21-Activated Kinase 4 with PDZ-RhoGEF, a G Protein-linked Rho Guanine Exchange Factor*

J. Gutkind, Yi Zheng, J. Basile, 2004, Journal of Biological Chemistry.

Zonula occludens-2 regulates Rho proteins activity and the development of epithelial cytoarchitecture and barrier function.

J. Vázquez-Prado, B. Chávez-Munguía, L. González-Mariscal, 2017, Biochimica et biophysica acta. Molecular cell research.

Natural anticoagulants in systemic lupus erythematosus. Deficiency of protein S bound to C4bp associates with recent history of venous thromboses, antiphospholipid antibodies, and the antiphospholipid syndrome.

D. Alarcón-Segovia, A. Villa, R. Ortíz-López, 1991, The Journal of rheumatology.

Alpha 1-adrenoceptors: function and phosphorylation.

J. Vázquez-Prado, J. García-Sáinz, L. del Carmen Medina, 2000, European journal of pharmacology.

cAMP-dependent activation of the Rac guanine exchange factor P-REX1 by type I protein kinase A (PKA) regulatory subunits

Susan S. Taylor, J. Gutkind, J. Vázquez-Prado, 2018, The Journal of Biological Chemistry.

Direct targeting of Gαq and Gα11 oncoproteins in cancer cells

P. Kolb, E. Kostenis, Xiaodong Feng, 2019, Science Signaling.

Cell adhesion controlled by adhesion G protein–coupled receptor GPR124/ADGRA2 is mediated by a protein complex comprising intersectins and Elmo–Dock

J. Gratton, J. Côté, J. Vázquez-Prado, 2017, The Journal of Biological Chemistry.

G protein-coupled receptor cross-talk: pivotal roles of protein phosphorylation and protein-protein interactions.

J. Vázquez-Prado, P. Casas-González, J. Garcı́a-Sáinz, 2003, Cellular signalling.

Interferon gamma induces actin polymerization, Rac1 activation and down regulates phagocytosis in human monocytic cells.

E. Ortega, Claudia A. Garay-Canales, J. Vázquez-Prado, 2012, Cytokine.

Chimeric Gαi2/Gα13 Proteins Reveal the Structural Requirements for the Binding and Activation of the RGS-like (RGL)-containing Rho Guanine Nucleotide Exchange Factors (GEFs) by Gα13*

J. Gutkind, M. Castellone, H. Miyazaki, 2004, Journal of Biological Chemistry.

Presence of serum antibodies to coagulation protein C in patients with systemic lupus erythematosus is not associated with antigenic or functional protein c deficiencies

D. Alarcón-Segovia, A. Ruiz-Arguelles, J. Vázquez-Prado, 1993, American journal of hematology.

Chloroethylclonidine is a partial α1A-adrenoceptor agonist in cells expressing recombinant α1-adrenoceptor subtypes

R. Villalobos-Molina, J. Vázquez-Prado, J. García-Sáinz, 1997 .

Effect of phorbol myristate acetate on alpha 1-adrenergic action in cells expressing recombinant alpha 1-adrenoceptor subtypes.

J. Vázquez-Prado, J. García-Sáinz, 1996, Molecular pharmacology.

Calcium sensing receptor stimulates breast cancer cell migration via the Gβγ-AKT-mTORC2 signaling pathway

J. Vázquez-Prado, I. García-Jiménez, Jorge Eduardo del-Río-Robles, 2021, Journal of Cell Communication and Signaling.

Modular architecture and novel protein-protein interactions regulating the RGS-containing Rho guanine nucleotide exchange factors.

J. Gutkind, J. Basile, J. Vázquez-Prado, 2004, Methods in enzymology.

Endothelial RhoGEFs: A systematic analysis of their expression profiles in VEGF-stimulated and tumor endothelial cells.

M. Iruela-Arispe, J. Vázquez-Prado, G. Reyes-Cruz, 2015, Vascular pharmacology.

P‐REX2, a novel PI‐3‐kinase sensitive Rac exchange factor

J. Gutkind, H. Rosenfeldt, J. Vázquez-Prado, 2004, FEBS letters.

Guanine nucleotide exchange factors for Rho GTPases (RhoGEFs) as oncogenic effectors and strategic therapeutic targets in metastatic cancer.

J. Vázquez-Prado, I. García-Jiménez, Rodolfo Daniel Cervantes-Villagrana, 2023, Cellular signalling.

Gαs directly drives PDZ-RhoGEF signaling to Cdc42

J. Gutkind, J. Vázquez-Prado, I. García-Jiménez, 2020, The Journal of Biological Chemistry.

Protein phosphatase‐protein kinase interplay modulates α1b‐adrenoceptor phosphorylation: effects of okadaic acid

R. Alcántara-Hernández, J. Vázquez-Prado, J. García-Sáinz, 2000, British journal of pharmacology.

Intracellular Calcium and α1b-Adrenoceptor Phosphorylation

A. Mendoza-Mendoza, J. Vázquez-Prado, J. García-Sáinz, 1999 .

Ephexin3/ARHGEF5 Together with Cell Migration Signaling Partners within the Tumor Microenvironment Define Prognostic Transcriptional Signatures in Multiple Cancer Types

J. Vázquez-Prado, Yarely Mabell Beltrán-Navarro, G. Reyes-Cruz, 2023, International journal of molecular sciences.

CaSR links endocytic and secretory pathways via MADD, a Rab11A effector that activates Rab27B.

J. Vázquez-Prado, I. García-Jiménez, Jorge Eduardo del-Río-Robles, 2023, Cellular signalling.

Betaglycan sustains HGF/Met signaling in lung cancer and endothelial cells promoting cell migration and tumor growth

A. Hinck, C. Hinck, F. López‐Casillas, 2024, Heliyon.

G a s directly drives PDZ-RhoGEF signaling to Cdc42

J. Gutkind, J. Vázquez-Prado, I. García-Jiménez, 2020 .